Bin Liu

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Towards proteome-wide production of monoclonal antibody by phage display
    Bin Liu
    Department of Anesthesia, University of California, San Francisco, Rm 3C 38, San Francisco General Hospital, 1001 Potrero Avenue, San Francisco, CA 94110, USA
    J Mol Biol 315:1063-73. 2002
  2. pmc Human antibodies targeting cell surface antigens overexpressed by the hormone refractory metastatic prostate cancer cells: ICAM-1 is a tumor antigen that mediates prostate cancer cell invasion
    Fraser Conrad
    Department of Anesthesia, University of California at San Francisco, 1001 Potrero Ave, 3C38, San Francisco, CA 94110, USA
    J Mol Med (Berl) 87:507-14. 2009
  3. ncbi request reprint Recombinant full-length human IgG1s targeting hormone-refractory prostate cancer
    Bin Liu
    Department of Anesthesia, University of California at San Francisco, 1001 Potrero Avenue, 3C 38, San Francisco, CA 94110, USA
    J Mol Med (Berl) 85:1113-23. 2007
  4. ncbi request reprint Exploring cell type-specific internalizing antibodies for targeted delivery of siRNA
    Bin Liu
    Department of Anesthesia, University of California at San Francisco, CA 94110, USA
    Brief Funct Genomic Proteomic 6:112-9. 2007
  5. ncbi request reprint Mapping tumor epitope space by direct selection of single-chain Fv antibody libraries on prostate cancer cells
    Bin Liu
    Department of Anesthesia and Pharmaceutical Chemistry, University of California at San Francisco, San Francisco General Hospital, California, USA
    Cancer Res 64:704-10. 2004
  6. pmc Identification of internalizing human single-chain antibodies targeting brain tumor sphere cells
    Xiaodong Zhu
    Department of Anesthesia, University of California at San Francisco, San Francisco, California 94110, USA
    Mol Cancer Ther 9:2131-41. 2010
  7. pmc Comprehensive analysis of yeast surface displayed cDNA library selection outputs by exon microarray to identify novel protein-ligand interactions
    Scott Bidlingmaier
    UCSF Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, CA 94110, USA
    Mol Cell Proteomics 10:M110.005116. 2011
  8. ncbi request reprint Anti-CD166 single chain antibody-mediated intracellular delivery of liposomal drugs to prostate cancer cells
    Audrey Roth
    Department of Anesthesia, University of California at San Francisco, Room 3C38, 1001 Potrero Avenue, San Francisco, CA 94110, USA
    Mol Cancer Ther 6:2737-46. 2007
  9. pmc The effect of internalizing human single chain antibody fragment on liposome targeting to epithelioid and sarcomatoid mesothelioma
    Arun K Iyer
    Center for Molecular and Functional Imaging, Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, CA 94143, USA
    Biomaterials 32:2605-13. 2011
  10. pmc Novel human single chain antibody fragments that are rapidly internalizing effectively target epithelioid and sarcomatoid mesotheliomas
    Arun K Iyer
    Center for Molecular and Functional Imaging, Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA
    Cancer Res 71:2428-32. 2011

Collaborators

Detail Information

Publications78

  1. ncbi request reprint Towards proteome-wide production of monoclonal antibody by phage display
    Bin Liu
    Department of Anesthesia, University of California, San Francisco, Rm 3C 38, San Francisco General Hospital, 1001 Potrero Avenue, San Francisco, CA 94110, USA
    J Mol Biol 315:1063-73. 2002
    ..Automation of this process should allow high throughput production of monoclonal phage antibodies against cellular proteins as well as proteins that are uniquely expressed under pathological conditions...
  2. pmc Human antibodies targeting cell surface antigens overexpressed by the hormone refractory metastatic prostate cancer cells: ICAM-1 is a tumor antigen that mediates prostate cancer cell invasion
    Fraser Conrad
    Department of Anesthesia, University of California at San Francisco, 1001 Potrero Ave, 3C38, San Francisco, CA 94110, USA
    J Mol Med (Berl) 87:507-14. 2009
    ....
  3. ncbi request reprint Recombinant full-length human IgG1s targeting hormone-refractory prostate cancer
    Bin Liu
    Department of Anesthesia, University of California at San Francisco, 1001 Potrero Avenue, 3C 38, San Francisco, CA 94110, USA
    J Mol Med (Berl) 85:1113-23. 2007
    ....
  4. ncbi request reprint Exploring cell type-specific internalizing antibodies for targeted delivery of siRNA
    Bin Liu
    Department of Anesthesia, University of California at San Francisco, CA 94110, USA
    Brief Funct Genomic Proteomic 6:112-9. 2007
    ..The demonstrated specificity of in vivo gene silencing and the lack of nonspecific immune activation and systemic toxicity encourage further development of therapies based on cell type-specific delivery of siRNA...
  5. ncbi request reprint Mapping tumor epitope space by direct selection of single-chain Fv antibody libraries on prostate cancer cells
    Bin Liu
    Department of Anesthesia and Pharmaceutical Chemistry, University of California at San Francisco, San Francisco General Hospital, California, USA
    Cancer Res 64:704-10. 2004
    ..Targeting components of this epitope space may facilitate development of immunotherapeutic and small molecule-based strategies as well as the use of other therapeutic agents that rely upon delivery to the interior of the tumor cell...
  6. pmc Identification of internalizing human single-chain antibodies targeting brain tumor sphere cells
    Xiaodong Zhu
    Department of Anesthesia, University of California at San Francisco, San Francisco, California 94110, USA
    Mol Cancer Ther 9:2131-41. 2010
    ....
  7. pmc Comprehensive analysis of yeast surface displayed cDNA library selection outputs by exon microarray to identify novel protein-ligand interactions
    Scott Bidlingmaier
    UCSF Helen Diller Family Comprehensive Cancer Center, University of California at San Francisco, San Francisco, CA 94110, USA
    Mol Cell Proteomics 10:M110.005116. 2011
    ..In particular, this method is well suited for the study of small molecule/protein and drug/protein interactions...
  8. ncbi request reprint Anti-CD166 single chain antibody-mediated intracellular delivery of liposomal drugs to prostate cancer cells
    Audrey Roth
    Department of Anesthesia, University of California at San Francisco, Room 3C38, 1001 Potrero Avenue, San Francisco, CA 94110, USA
    Mol Cancer Ther 6:2737-46. 2007
    ..Further studies on intracellular tracking of endocytosed liposomal drugs will help identify and overcome the barriers limiting the potency of liposomal drugs...
  9. pmc The effect of internalizing human single chain antibody fragment on liposome targeting to epithelioid and sarcomatoid mesothelioma
    Arun K Iyer
    Center for Molecular and Functional Imaging, Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, CA 94143, USA
    Biomaterials 32:2605-13. 2011
    ....
  10. pmc Novel human single chain antibody fragments that are rapidly internalizing effectively target epithelioid and sarcomatoid mesotheliomas
    Arun K Iyer
    Center for Molecular and Functional Imaging, Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA
    Cancer Res 71:2428-32. 2011
    ....
  11. pmc Identification of MCAM/CD146 as the target antigen of a human monoclonal antibody that recognizes both epithelioid and sarcomatoid types of mesothelioma
    Scott Bidlingmaier
    Department of Anesthesia, San Francisco General Hospita, San Francisco, California, USA
    Cancer Res 69:1570-7. 2009
    ....
  12. pmc Targeting prostate cancer cells in vivo using a rapidly internalizing novel human single-chain antibody fragment
    Jiang He
    Department of Radiology and Biomedical Imaging, Center for Molecular and Functional Imaging, University of California at San Francisco, San Francisco, California 94143, USA
    J Nucl Med 51:427-32. 2010
    ..The objective of this study was to evaluate the tumor targeting of an internalizing human antibody fragment, a small-size platform, to provide high contrast in a mouse model of human prostate carcinoma...
  13. pmc Targeted drug delivery to mesothelioma cells using functionally selected internalizing human single-chain antibodies
    Feng An
    Department of Anesthesia, University of California San Francisco, San Francisco, CA 94110, USA
    Mol Cancer Ther 7:569-78. 2008
    ....
  14. pmc Identification of protein/target molecule interactions using yeast surface-displayed cDNA libraries
    Scott Bidlingmaier
    UCSF Comprehensive Cancer Center, University of California at San Francisco, San Francisco, CA, USA
    Methods Mol Biol 729:211-23. 2011
    ....
  15. pmc The utility and limitations of glycosylated human CD133 epitopes in defining cancer stem cells
    Scott Bidlingmaier
    Department of Anesthesia, University of California at San Francisco, 1001 Potrero Ave, 3C38, San Francisco, CA 94110, USA
    J Mol Med (Berl) 86:1025-32. 2008
    ....
  16. ncbi request reprint Identification of clinically significant tumor antigens by selecting phage antibody library on tumor cells in situ using laser capture microdissection
    Weiming Ruan
    Department of Anesthesia, University of California, San Francisco Comprehensive Cancer Center 94110, USA
    Mol Cell Proteomics 5:2364-73. 2006
    ..The ability to deliver payload intracellularly and to recognize tumor cells in situ makes these antibodies attractive candidates for the development of targeted cancer therapeutics...
  17. pmc Construction of yeast surface-displayed cDNA libraries
    Scott Bidlingmaier
    UCSF Comprehensive Cancer Center, University of California at San Francisco, San Francisco, CA, USA
    Methods Mol Biol 729:199-210. 2011
    ..In this report, we describe protocols for the construction and validation of yeast surface-displayed cDNA libraries using preexisting yeast two-hybrid cDNA libraries as a starting point...
  18. doi request reprint Large-scale synthesis of transition-metal-doped TiO2 nanowires with controllable overpotential
    Bin Liu
    Department of Chemistry, University of California, Berkeley, California 94720, USA
    J Am Chem Soc 135:9995-8. 2013
    ..With this combination of control, robustness, and scalability, the molten-salt flux scheme can provide high-quality TiO2 nanowires to satisfy a broad range of application needs from photovoltaics to photocatalysis. ..
  19. doi request reprint Photoelectrochemical properties of TiO2 nanowire arrays: a study of the dependence on length and atomic layer deposition coating
    Yun Jeong Hwang
    Department of Chemistry, University of California, Berkeley, California 94720, USA
    ACS Nano 6:5060-9. 2012
    ..Therefore, we propose that epitaxial coating on materials is a viable approach to improving their energy conversion efficiency...
  20. ncbi request reprint Interrogating yeast surface-displayed human proteome to identify small molecule-binding proteins
    Scott Bidlingmaier
    Department of Anesthesia, UCSF Comprehensive Cancer Center, University of California, San Francisco, California 94110, USA
    Mol Cell Proteomics 6:2012-20. 2007
    ..We expect that this method will be generally applicable to the study of small molecule/protein interactions and may facilitate the study of cellular signaling pathways and mechanisms of drug action or toxicity...
  21. doi request reprint A fully integrated nanosystem of semiconductor nanowires for direct solar water splitting
    Chong Liu
    Department of Chemistry, University of California, Berkeley, California 94720, USA
    Nano Lett 13:2989-92. 2013
    ..It also provides a conceptual blueprint of modular design that allows incorporation of newly discovered components for improved performance...
  22. pmc The ligase PIAS1 restricts natural regulatory T cell differentiation by epigenetic repression
    Bin Liu
    Division of Hematology Oncology, Department of Medicine, 11 934 Factor Building, 10833 Le Conte Avenue, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Science 330:521-5. 2010
    ..Our studies have identified an epigenetic mechanism that negatively regulates the differentiation of natural T(reg) cells...
  23. doi request reprint Summon SUMO to wrestle with inflammation
    Bin Liu
    Division of Hematology Oncology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Mol Cell 35:731-2. 2009
    ..2009) report that SUMOylation of nuclear receptors LXRalpha and LXRbeta plays a critical role in the transrepression of IFN-gamma-induced STAT1-dependent inflammatory responses in brain astrocytes...
  24. ncbi request reprint Silencing of human phosphatidylethanolamine-binding protein 4 sensitizes breast cancer cells to tumor necrosis factor-alpha-induced apoptosis and cell growth arrest
    Xiaojian Wang
    Institute of Immunology, Zhejiang University, Hangzhou, PR China
    Clin Cancer Res 11:7545-53. 2005
    ..The finding led us to explore a promising approach for breast cancer therapy via silencing the expression of hPEBP4...
  25. ncbi request reprint [Transfection of the exogenous PTEN-induced growth inhibition of the highly metastatic mucoepidermoid carcinoma cell line M3SP2 in vitro]
    Bin Liu
    Department of Oral Biology, Stomatological College, Fourth Military Medical University
    Hua Xi Kou Qiang Yi Xue Za Zhi 20:361-3, 373. 2002
    ..The purpose of this study was to evaluate the effects of the exogenous phosphatase and tensin homology deleted on chromosome 10 (PTEN) gene on in vitro growth of the highly metastatic mucoepidemoid carcinoma cell line M3SP2...
  26. pmc Identification and characterization of tumor antigens by using antibody phage display and intrabody strategies
    Anne Laure Goenaga
    ENS Cachan Laboratoire de Biotechnologie et Pharmacologie Génétique Appliquée LBPA, UMR CNRS 8113, 61 Avenue du President Wilson, 94235 Cachan Cedex, France
    Mol Immunol 44:3777-88. 2007
    ..This study is the proof of principle that the direct selection of phage antibody libraries on tumor cells can effectively lead to the identification and functional characterization of relevant tumor markers...
  27. pmc Loss of function of OsDCL1 affects microRNA accumulation and causes developmental defects in rice
    Bin Liu
    National Key Laboratory of Plant Genomics and Center for Plant Gene Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing
    Plant Physiol 139:296-305. 2005
    ....
  28. ncbi request reprint Transcriptional targeting of tumors with a novel tumor-specific survivin promoter
    Zeng B Zhu
    Division of Human Gene Therapy, Department of Medicine, Pathology, and the Gene Therapy Center, University of Alabama at Birmingham, Birmingham AL 35291, USA
    Cancer Gene Ther 11:256-62. 2004
    ....
  29. ncbi request reprint [The role RNA interference of alpha1, 3GT plays in resistance to complement mediated cytotoxicity of porcine endothelial cells]
    Min Zhu
    Institute of Organ Transplantation, Key Laboratory of Organ Transplantation Appointed by Ministry of Education and Ministry of Health, P R China
    Zhonghua Yi Xue Za Zhi 85:1133-6. 2005
    ..To evaluate whether RNA interference can protect porcine endothelial cells from complement mediated cytotoxicity...
  30. ncbi request reprint [Screening tumor antigens of ovarian carcinoma by Western blot, immunoprecipitation, and mass spectrometry]
    Bin Liu
    Ministry of Education Key Laboratory of Biotherapy of Human Diseases, Biotherapy and Research Center of Cancer, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, PR China
    Ai Zheng 24:890-2. 2005
    ..This study was to screen and identify tumor antigens of ovarian carcinoma by Western blot, immunoprecipitation, and mass spectrometry, and to establish a new methodological entity...
  31. ncbi request reprint [Hydrogen peroxide inhibits arsenic trioxide-induced apoptosis of Burkitt lymphoma cells]
    Di Lu
    Department of Cell Biology, First Military Medical University, Guangzhou 510515, China
    Di Yi Jun Yi Da Xue Xue Bao 24:375-8. 2004
    ..To examine the effects of hydrogen peroxide (H2O2) on arsenic trioxide (As2O3)-induced apoptosis of human Burkitt lymphoma cells and evaluate the value of fluorescence microscope in analyzing cellular apoptosis...
  32. doi request reprint Striatal 19S Rpt6 deficit is related to alpha-synuclein accumulation in MPTP-treated mice
    Bin Liu
    Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, 1 Xiannongtan Street, Xuanwu District, Beijing 100050, China
    Biochem Biophys Res Commun 376:277-82. 2008
    ..Taken together, our results imply that a deficiency in 19S Rpt6 may be partially related to the MPTP-induced increase in alpha-synuclein in the striatum...
  33. doi request reprint Activation of signal transducers and activators of transcription 3 and overexpression of its target gene CyclinD1 in laryngeal carcinomas
    Bin Liu
    Department of Otorhinolaryngology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China
    Laryngoscope 118:1976-80. 2008
    ..The study aims to investigate the expression and activation of STAT3 in laryngeal carcinoma, the relationship between activated STAT3 and its downstream target gene CyclinD1 and the related clinicopathological factors of activated STAT3...
  34. ncbi request reprint [Expression of PTEN protein in oromaxillofacial tumor cell lines]
    Bin Liu
    Department of Oral Biology, College of Stomatology, Fourth Military Medical University, Xi an 710032, China
    Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 19:35-7. 2003
    ..To investigate expression of PTEN protein in oromaxillofacial tumor cell lines and to compare the difference of PTEN protein expression between highly metastatic cancer cell lines and their parent cell lines...
  35. ncbi request reprint Complete nucleotide sequence and organization of the naphthalene catabolic plasmid pND6-1 from Pseudomonas sp. strain ND6
    Wei Li
    Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China
    Gene 336:231-40. 2004
    ..Results of this study indicated that globally distributed naphthalene catabolic genes are highly conserved among different bacterial species...
  36. doi request reprint The value of antinuclear antibodies in primary biliary cirrhosis
    Lixia Gao
    Department of Rheumatology and Immunology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China
    Clin Exp Med 8:9-15. 2008
    ..Although autoantibodies have been used for the diagnosis of primary biliary cirrhosis (PBC), their role has not been clarified. In this study, we try to explore the value of gp210 antibody and anti-centromere antibodies (ACA) in PBC...
  37. ncbi request reprint A novel human phosphatidylethanolamine-binding protein resists tumor necrosis factor alpha-induced apoptosis by inhibiting mitogen-activated protein kinase pathway activation and phosphatidylethanolamine externalization
    Xiaojian Wang
    Institute of Immunology, Zhejiang University, Hangzhou 310031, People s Republic of China
    J Biol Chem 279:45855-64. 2004
    ....
  38. doi request reprint IPP5, a novel protein inhibitor of protein phosphatase 1, promotes G1/S progression in a Thr-40-dependent manner
    Xiaojian Wang
    Institute of Immunology and National Key Laboratory of Medical Immunology, Second Military Medical University, Shanghai 200433, China
    J Biol Chem 283:12076-84. 2008
    ..Our findings suggest that IPP5, by acting as an inhibitory molecule for PP1, can promote tumor cell growth and cell cycle progression, and may be a promising target in cancer therapeutics in IPP5-highly expressing tumor cells...
  39. ncbi request reprint Identification of a novel nuclear-localized adenylate kinase from Drosophila melanogaster
    Geng Meng
    National Laboratory of Protein Engineering and Plant Genetic Engineering, Beijing, China
    Biochemistry (Mosc) 73:38-43. 2008
    ..Therefore, based on the substrate specificity, the specific nuclear localization in the cell, and the sequence similarity with human AK6, we named this novel adenylate kinase identified from the fly DAK6...
  40. ncbi request reprint Complete primary structure and genomic organization of the mouse Col14a1 gene
    Donald R Gerecke
    Department of Pharmacology and Toxicology, Environmental and Occupational Health Sciences Institute, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ 08854, USA
    Matrix Biol 22:595-601. 2004
    ..The entire mouse genomic structure has been determined and is made up of 48 exons. Alternatively spliced forms of mouse type XIV, collagen were not identified corresponding to the findings for the human form...
  41. ncbi request reprint Activation of epidermal growth factor receptor causes astrocytes to form cribriform structures
    Bin Liu
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Glia 46:153-68. 2004
    ..The EGFR pathway may be a specific, signal transduction pathway that regulates reactive astrocytes to form cavernous spaces in the glial scars following CNS injury and in the compressed optic nerve in glaucomatous optic nerve neuropathy...
  42. pmc Small RNA-directed epigenetic natural variation in Arabidopsis thaliana
    Jixian Zhai
    State Key Laboratory of Plant Genomics, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
    PLoS Genet 4:e1000056. 2008
    ..Methylation analysis revealed that 88% of the examined loci (37 out of 42) were specifically methylated in Ler but not Col, suggesting that small RNA can direct epigenetic differences between two closely related Arabidopsis ecotypes...
  43. ncbi request reprint In vivo molecular chemotherapy and noninvasive imaging with an infectivity-enhanced adenovirus
    Akseli Hemminki
    Division of Human Gene Therapy and Gene Therapy Center, Department of Medicine, University of Alabama at Birmingham, 35294 3300, USA
    J Natl Cancer Inst 94:741-9. 2002
    ..We used noninvasive imaging to investigate the in vivo antitumor efficacy of gene therapy using this adenovirus in an animal model of ovarian cancer...
  44. ncbi request reprint A canine conditionally replicating adenovirus for evaluating oncolytic virotherapy in a syngeneic animal model
    Akseli Hemminki
    Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294 2172, USA
    Mol Ther 7:163-73. 2003
    ..Therefore, immunomodulation for increased oncolytic potency could be studied with clinical trials in this population. This could eventually translate into human trials...
  45. ncbi request reprint The secretory leukoprotease inhibitor (SLPI) promoter for ovarian cancer gene therapy
    Shannon D Barker
    Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Gene Med 5:300-10. 2003
    ..We hypothesize that selective adenovirus-mediated transgene expression could be achieved through the use of the secretory leukoprotease inhibitor (SLPI) promoter in the context of ovarian cancer...
  46. ncbi request reprint PIASx is a transcriptional co-repressor of signal transducer and activator of transcription 4
    Taruna Arora
    Division of Hematology Oncology, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095 1678, USA
    J Biol Chem 278:21327-30. 2003
    ..Finally the inhibitory activity of PIASx on Stat4-mediated gene activation is abolished by the histone deacetylase inhibitor trichostatin A. Our results suggest that PIASx may function as a co-repressor of Stat4...
  47. ncbi request reprint Bioconjugated nanoparticles for DNA protection from cleavage
    Xiao xiao He
    State Key Laboratory of Chemo Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Institute of Biological Technology, Hunan University, Changsha 410082, P R China
    J Am Chem Soc 125:7168-9. 2003
    ....
  48. ncbi request reprint Neural invasion in pancreatic carcinoma
    Bin Liu
    Department of General Surgery, the Affiliated Hospital of Xuzhou Medical College, Xuzhou 221002, China
    Hepatobiliary Pancreat Dis Int 1:469-76. 2002
    ..Neural invasion is a special metastatic route in pancreatic cancer and responsible for the high recurrence in curatively resected cases...
  49. ncbi request reprint Inhibition of K562 leukemia angiogenesis and growth by expression of antisense vascular endothelial growth factor (VEGF) sequence
    Rui He
    State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences and Peking Union of Medical College, Tianjin 300020, China
    Cancer Gene Ther 10:879-86. 2003
    ..These results suggest that the efficient downregulation of the VEGF production in leukemic cells using antisense-VEGF may constitute a novel strategy of treatment in leukemia...
  50. ncbi request reprint Protective effects of ginsenoside Rg2 against glutamate-induced neurotoxicity in PC12 cells
    Na Li
    Department of Physiology, Medical College of Qingdao University, Qingdao 266071, PR China
    J Ethnopharmacol 111:458-63. 2007
    ..In addition, the inhibitory effect of ginsenoside Rg2 against the formation of Abeta1-40 suggests that ginsenoside Rg2 may also represent a potential treatment strategy for Alzheimer's disease...
  51. ncbi request reprint Hemangiopoietin, a novel human growth factor for the primitive cells of both hematopoietic and endothelial cell lineages
    Yong Jun Liu
    State Key Laboratory of Experimental Hematology, Chinese Academy of Medical Sciences and Peking Union of Medical College, 288 Nanjing Road, Tianjin 300020, P R China
    Blood 103:4449-56. 2004
    ....
  52. doi request reprint Antimitochondrial antibody-negative primary biliary cirrhosis: a subset of primary biliary cirrhosis
    Bin Liu
    Department of Rheumatology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing, China
    Liver Int 28:233-9. 2008
    ..This study aimed to evaluate whether AMA-negative/positive PBC represents different clinical entities...
  53. ncbi request reprint Molecular characterization of plantain class i chitinase gene and its expression in response to infection by Gloeosporium musarum Cke and Massee and other abiotic stimuli
    Jianming Fan
    The State Key Laboratory of Biocontrol, School of Life Sciences, Sun Yat Sen University, Guangzhou 510275, China
    J Biochem 142:561-70. 2007
    ..Abscisic acid (ABA) could induce MpChi-1 transcript. These results suggest the MpChi-1 plays important role in the events of the hypersensitive reaction (HR)...
  54. ncbi request reprint Catechol 2,3-dioxygenase from Pseudomonas sp. strain ND6: gene sequence and enzyme characterization
    Yun Jiang
    Department of Microbiology, Nankai University, Tianjin 300071, China
    Biosci Biotechnol Biochem 68:1798-800. 2004
    ..The enzymology experiments indicated that the specific activity and thermostability of C23O from Pseudomonas sp. ND6 were better than those of C23O from Pseudomonas putida G7...
  55. pmc Michigan Molecular Interactions (MiMI): putting the jigsaw puzzle together
    Magesh Jayapandian
    Center for Computational Medicine and Biology, University of Michigan, Ann Arbor, MI 48109, USA
    Nucleic Acids Res 35:D566-71. 2007
    ..MiMI is part of the National Center for Integrative Biomedical Informatics (NCIBI) and is publicly available at: http://mimi.ncibi.org...
  56. pmc PKU is a reversible neurodegenerative process within the nigrostriatum that begins as early as 4 weeks of age in Pah(enu2) mice
    Jennifer E Embury
    Department of Biochemistry and Molecular Biology, PO Box 100245, College of Medicine, University of Florida, Gainesville, FL 32610, USA
    Brain Res 1127:136-50. 2007
    ....
  57. pmc Implications of an antiparallel dimeric structure of nonphosphorylated STAT1 for the activation-inactivation cycle
    Minghao Zhong
    Laboratory of Molecular Cell Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 102:3966-71. 2005
    ..We conclude that a parallel STAT1 phosphodimer not bound to DNA most likely undergoes a conformational rearrangement (parallel to antiparallel) to present the phosphotyrosine efficiently for dephosphorylation...
  58. ncbi request reprint Comparative analysis of serum proteomes: discovery of proteins associated with osteonecrosis of the femoral head
    Xiaoyun Tan
    Department of Orthopedics, The Third Affiliated Hospital of Sun Yat Sen University, Guangzhou, Guangdong, China
    Transl Res 148:114-9. 2006
    ..These results suggest that serum levels of t-PA, PAI-1, crosslaps, and anti-p53 antibody could be used as noninvasive diagnostic biomarkers for IONFH...
  59. ncbi request reprint A novel nuclear-localized protein with special adenylate kinase properties from Caenorhabditis elegans
    Ruitong Zhai
    National Laboratory of Protein Engineering and Plant Genetic Engineering, College of Life Sciences, Peking University, Beijing 100871, China
    FEBS Lett 580:3811-7. 2006
    ..These results suggest that ADLP is more likely a member of the AK6 family. Furthermore, RNAi experiments targeting ADLP were conducted and showed that RNAi treatment resulted in the suppression of worm growth...
  60. ncbi request reprint Structural analyses on intermediates in serine protease catalysis
    Bin Liu
    School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore
    J Biol Chem 281:24024-35. 2006
    ..The mechanistic proposals may have consequences for protease inhibition, in particular for the design of high energy intermediate analogues...
  61. ncbi request reprint Characterization of a recombinant thermostable xylanase from deep-sea thermophilic Geobacillus sp. MT-1 in East Pacific
    Suijie Wu
    School of Life Sciences, Xiamen University, Xiamen 361005, People s Republic of China
    Appl Microbiol Biotechnol 72:1210-6. 2006
    ..Our study, therefore, presented a rapid overexpression and purification of xylanase from deep-sea thermophile aimed at improving the enzyme yield for industrial applications and scientific research...
  62. ncbi request reprint [Proteomic analysis of proteins related to retinoid acid resistance]
    Hui Qin
    Hematology, West China Hospital, Sichuan University, Chengdu 610041, China
    Sichuan Da Xue Xue Bao Yi Xue Ban 37:133-6. 2006
    ..To evaluate the applicability of proteomic methods for shedding light on the mechanisms of All-trans retinoic acid resistance...
  63. ncbi request reprint [The mechanisms of p21WAF1/Cip-1 expression in MOLT-4 cell line induced by TSA]
    Yi Song
    Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 13:174-81. 2005
    ..It is concluded that p21(WAF1/Cip-1) plays a significant role in G(2)/M arrest and apoptosis signaling induced by TSA in MOLT-4 cells...
  64. ncbi request reprint Serum proteomics study of the squamous cell carcinoma antigen 1 in tongue cancer
    Xin Huang
    State Key Laboratory of Biotherapy, Sichuan University, Guoxuexiang 37, Chendu City 610041, PR China
    Oral Oncol 42:26-31. 2006
    ..These results indicate that squamous cell carcinoma antigen 1 may be of great potential as the biomarker of tongue cancer and as the potential therapeutic target for gene therapy...
  65. ncbi request reprint Inhibition of xenogeneic response in porcine endothelium using RNA interference
    Min Zhu
    Key Laboratory of Organ Transplantation, Ministry of Education Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China
    Transplantation 79:289-96. 2005
    ..In this study, we use siRNA for silencing of alpha1,3GT with the purpose of reducing expression of the alpha-Gal epitope and subsequently decreasing immunogenicity of porcine endothelial cells...
  66. ncbi request reprint Abnormality of CD4(+)CD25(+) regulatory T cells in idiopathic thrombocytopenic purpura
    Bin Liu
    State Key Laboratory of Experimental Hematology, Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, China
    Eur J Haematol 78:139-43. 2007
    ..The aim of this study was to explore the profile and function of CD4(+)CD25(+) regulatory T cells (Treg cells) in idiopathic thrombocytopenic purpura (ITP) patients...
  67. pmc Oryza sativa dicer-like4 reveals a key role for small interfering RNA silencing in plant development
    Bin Liu
    State Key Laboratory of Plant Genomics and National Center for Plant Gene Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing, China
    Plant Cell 19:2705-18. 2007
    ..Our results reveal a critical role of Os DCL4-mediated ta-siRNA biogenesis in rice development...
  68. ncbi request reprint The effect of conjugation to gold nanoparticles on the ability of low molecular weight chitosan to transfer DNA vaccine
    Xianfeng Zhou
    College of Life Science, Jilin University, Changchun 130012, PR China
    Biomaterials 29:111-7. 2008
    ..Additionally, in contrast to naked DNA, the Chito6-GNPs conjugates induced potent cytotoxic T lymphocyte responses at a low dose...
  69. ncbi request reprint Decreased suppression of immune stimulatory CpG motifs in plant DNA
    Yiqiang Wang
    Shandong Provincial Key Lab of Ophthalmology, Shandong Eye Institute, Qingdao, China
    Immunol Lett 114:73-80. 2007
    ..The hypothesis that CpG dependent immunomodulation is a feature of plant DNA that contributes to plant nutrition or food/pollen allergy is also discussed...
  70. ncbi request reprint A filter enhanced sampling and combinatorial scoring study for protein docking in CAPRI
    Xin Qi Gong
    College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100022, China
    Proteins 69:859-65. 2007
    ..The ligand least root mean square deviations (L_rmsds) were reduced and the hit numbers were increased. ComScore was used in the scoring test for CAPRI rounds 9-12 with good success in rounds 9 and 11...
  71. ncbi request reprint Early down-regulation of Bcl-xL expression during megakaryocytic differentiation of thrombopoietin-induced CD34+ bone marrow cells in essential thrombocythemia
    Lei Zhang
    State Key Laboratory of Experimental Hematology, National Research Center for Stem Cell Engineering and Technology, Institute of Haematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, PR China
    Haematologica 89:1199-206. 2004
    ..In this study the expression of Bcl-xL was evaluated during megakaryocytic differentiation in ET patients...
  72. ncbi request reprint [Rapid construction of full-length MnSOD cDNA of chickens by one-step 3'RACE]
    You quan Bu
    Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100 094, China
    Yi Chuan 26:519-21. 2004
    ..Compared with the conventional end-to-end PCR or subcloning, this method, called one-step 3' RACE, is fast, economical and highly specific. It especially fits the rapid construction of full-length cDNA by RACE method...
  73. ncbi request reprint Optimum conditions for transformation of Synechocystis sp. PCC 6803
    Xiaonan Zang
    College of Marine Life Sciences, Ocean University of China, Qingdao, PR China
    J Microbiol 45:241-5. 2007
    ..Moreover, recovery treatment of the cells before they were plated onto antibiotic medium also increased the transformation efficiency...
  74. ncbi request reprint Adenoviruses with an RGD-4C modification of the fiber knob elicit a neutralizing antibody response but continue to allow enhanced gene delivery
    Minghui Wang
    Department of Medicine, Division of Human Gene Therapy, University of Alabama at Birmingham, 618 20th Street South, OHB 538, Birmingham, AL 35294, USA
    Gynecol Oncol 96:341-8. 2005
    ....
  75. ncbi request reprint Proinflammatory stimuli induce IKKalpha-mediated phosphorylation of PIAS1 to restrict inflammation and immunity
    Bin Liu
    Division of Hematology Oncology, Department of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    Cell 129:903-14. 2007
    ..Our results identify a signaling pathway in which proinflammatory stimuli activate the IKKalpha-mediated sumoylation-dependent phosphorylation of PIAS1 for the immediate repression of inflammatory gene activation...
  76. ncbi request reprint Toxoplasma gondii antibodies in cancer patients
    Ziguo Yuan
    Laboratory of Parasitology, Veterinary Institute, Academy of Military Medical Sciences, Changchun, China
    Cancer Lett 254:71-4. 2007
    ..gondii infection and some kinds of cancer, especially nasopharyngeal carcinoma and rectal cancer...
  77. ncbi request reprint Characterization and neural differentiation of fetal lung mesenchymal stem cells
    Cun Gang Fan
    National Research Center for Stem Cell Engineering and Technology, State Key Laboratory of Experimental Hematology, Institute of Hematology, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, People s Republic of China
    Cell Transplant 14:311-21. 2005
    ..Our data suggest that the fetal lung MSC population is an alternative source of stem cells for cell-based therapy of neurological defects or mesenchymal-originating diseases...

Research Grants7

  1. Mapping a clinically significant internalizing tumor epitope space.
    Bin Liu; Fiscal Year: 2006
    ....
  2. Mapping a clinically significant internalizing tumor epitope space.
    Bin Liu; Fiscal Year: 2009
    ..abstract_text> ..
  3. Identifying antigens bound by novel scFvs targeting all subtypes of mesothelioma
    Bin Liu; Fiscal Year: 2010
    ....
  4. Tumor specific cell sruface epitope- molecular evolution
    Bin Liu; Fiscal Year: 2005
    ..The resulting antibodies will have a very high likelihood of recognizing clinically relevant tumor antigens. ..
  5. Mapping a clinically significant internalizing tumor epitope space.
    Bin Liu; Fiscal Year: 2010
    ..abstract_text> ..
  6. Mapping a clinically significant internalizing tumor epitope space.
    Bin Liu; Fiscal Year: 2007
    ....