Bin Liu

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc The ligase PIAS1 restricts natural regulatory T cell differentiation by epigenetic repression
    Bin Liu
    Division of Hematology Oncology, Department of Medicine, 11 934 Factor Building, 10833 Le Conte Avenue, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Science 330:521-5. 2010
  2. doi request reprint Summon SUMO to wrestle with inflammation
    Bin Liu
    Division of Hematology Oncology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Mol Cell 35:731-2. 2009
  3. pmc Control of specificity and magnitude of NF-kappa B and STAT1-mediated gene activation through PIASy and PIAS1 cooperation
    Samuel Tahk
    Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 104:11643-8. 2007
  4. ncbi request reprint Proinflammatory stimuli induce IKKalpha-mediated phosphorylation of PIAS1 to restrict inflammation and immunity
    Bin Liu
    Division of Hematology Oncology, Department of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    Cell 129:903-14. 2007
  5. pmc Negative regulation of NF-kappaB signaling by PIAS1
    Bin Liu
    Division of Hematology Oncology, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095 1678, USA
    Mol Cell Biol 25:1113-23. 2005
  6. pmc Regulation of the sumoylation system in gene expression
    Bin Liu
    Division of Hematology Oncology, Department of Medicine, University of California Los Angeles, Los Angeles, CA 90095, United States
    Curr Opin Cell Biol 20:288-93. 2008
  7. pmc PIAS1 regulates breast tumorigenesis through selective epigenetic gene silencing
    Bin Liu
    Division of Hematology Oncology, Department of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 9:e89464. 2014
  8. ncbi request reprint Regulation of gene-activation pathways by PIAS proteins in the immune system
    Ke Shuai
    Division of Hematology Oncology, Department of Medicine, University of California, Los Angeles, California 90095, USA
    Nat Rev Immunol 5:593-605. 2005
  9. ncbi request reprint Solvent effects on the two-photon absorption of distyrylbenzene chromophores
    Han Young Woo
    Mitsubishi Chemical Center for Advanced Materials, Department of Materials, University of California, Santa Barbara, California 93106, USA
    J Am Chem Soc 127:14721-9. 2005
  10. pmc Methods for strand-specific DNA detection with cationic conjugated polymers suitable for incorporation into DNA chips and microarrays
    Bin Liu
    Department of Chemistry and Biochemistry and Materials, Institute for Polymers and Organic Solids, University of California, Santa Barbara, CA 93106, USA
    Proc Natl Acad Sci U S A 102:589-93. 2005

Research Grants

Collaborators

Detail Information

Publications49

  1. pmc The ligase PIAS1 restricts natural regulatory T cell differentiation by epigenetic repression
    Bin Liu
    Division of Hematology Oncology, Department of Medicine, 11 934 Factor Building, 10833 Le Conte Avenue, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Science 330:521-5. 2010
    ..Our studies have identified an epigenetic mechanism that negatively regulates the differentiation of natural T(reg) cells...
  2. doi request reprint Summon SUMO to wrestle with inflammation
    Bin Liu
    Division of Hematology Oncology, Department of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA
    Mol Cell 35:731-2. 2009
    ..2009) report that SUMOylation of nuclear receptors LXRalpha and LXRbeta plays a critical role in the transrepression of IFN-gamma-induced STAT1-dependent inflammatory responses in brain astrocytes...
  3. pmc Control of specificity and magnitude of NF-kappa B and STAT1-mediated gene activation through PIASy and PIAS1 cooperation
    Samuel Tahk
    Molecular Biology Institute, University of California, Los Angeles, CA 90095, USA
    Proc Natl Acad Sci U S A 104:11643-8. 2007
    ..Our results demonstrate that PIASy cooperates with PIAS1 to regulate the specificity and magnitude of NF-kappaB/STAT1-mediated gene activation...
  4. ncbi request reprint Proinflammatory stimuli induce IKKalpha-mediated phosphorylation of PIAS1 to restrict inflammation and immunity
    Bin Liu
    Division of Hematology Oncology, Department of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    Cell 129:903-14. 2007
    ..Our results identify a signaling pathway in which proinflammatory stimuli activate the IKKalpha-mediated sumoylation-dependent phosphorylation of PIAS1 for the immediate repression of inflammatory gene activation...
  5. pmc Negative regulation of NF-kappaB signaling by PIAS1
    Bin Liu
    Division of Hematology Oncology, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095 1678, USA
    Mol Cell Biol 25:1113-23. 2005
    ..Consistently, Pias1 null mice showed elevated proinflammatory cytokines. Our results identify PIAS1 as a novel negative regulator of NF-kappaB...
  6. pmc Regulation of the sumoylation system in gene expression
    Bin Liu
    Division of Hematology Oncology, Department of Medicine, University of California Los Angeles, Los Angeles, CA 90095, United States
    Curr Opin Cell Biol 20:288-93. 2008
    ..Finally, the sumoylation system can also be regulated through crosstalk with other post-translational modifications, including phosphorylation, ubiquitination, and acetylation...
  7. pmc PIAS1 regulates breast tumorigenesis through selective epigenetic gene silencing
    Bin Liu
    Division of Hematology Oncology, Department of Medicine, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 9:e89464. 2014
    ..Our studies identify a novel epigenetic mechanism that regulates breast tumorigenesis through selective gene silencing. ..
  8. ncbi request reprint Regulation of gene-activation pathways by PIAS proteins in the immune system
    Ke Shuai
    Division of Hematology Oncology, Department of Medicine, University of California, Los Angeles, California 90095, USA
    Nat Rev Immunol 5:593-605. 2005
    ..In this article, we review the current understanding of the molecular basis, specificity and physiological roles of PIAS proteins in the regulation of gene-activation pathways in the immune system...
  9. ncbi request reprint Solvent effects on the two-photon absorption of distyrylbenzene chromophores
    Han Young Woo
    Mitsubishi Chemical Center for Advanced Materials, Department of Materials, University of California, Santa Barbara, California 93106, USA
    J Am Chem Soc 127:14721-9. 2005
    ..Hydrogen bonding to the donor groups and aggregation of the optical units in water, which are not included in calculational analysis, may be responsible for the discrepancies between experimental results and theory...
  10. pmc Methods for strand-specific DNA detection with cationic conjugated polymers suitable for incorporation into DNA chips and microarrays
    Bin Liu
    Department of Chemistry and Biochemistry and Materials, Institute for Polymers and Organic Solids, University of California, Santa Barbara, CA 93106, USA
    Proc Natl Acad Sci U S A 102:589-93. 2005
    ....
  11. ncbi request reprint Interpolyelectrolyte complexes of conjugated copolymers and DNA: platforms for multicolor biosensors
    Bin Liu
    Department of Chemistry, Institute for Polymers and Organic Solids, University of California, Santa Barbara, California 93106, USA
    J Am Chem Soc 126:1942-3. 2004
    ..If no ss-DNA is present, the solution emits blue. With a ss-DNA that is noncomplementary to PNA-C*, green emission is observed. Red emission occurs upon addition of ss-DNA complementary to the PNA sequence...
  12. pmc PIAS1 SUMO ligase regulates the self-renewal and differentiation of hematopoietic stem cells
    Bin Liu
    Division of Hematology Oncology Department of Medicine, University of California Los Angeles, Los Angeles, CA, USA
    EMBO J 33:101-13. 2014
    ..These results identify a novel role of PIAS1 in maintaining the quiescence of dormant HSCs and in the epigenetic repression of the myeloerythroid program. ..
  13. ncbi request reprint Adenoviruses with an RGD-4C modification of the fiber knob elicit a neutralizing antibody response but continue to allow enhanced gene delivery
    Minghui Wang
    Department of Medicine, Division of Human Gene Therapy, University of Alabama at Birmingham, 618 20th Street South, OHB 538, Birmingham, AL 35294, USA
    Gynecol Oncol 96:341-8. 2005
    ....
  14. ncbi request reprint Characterization of tectoRNA assembly with cationic conjugated polymers
    Bin Liu
    Departments of Chemistry and Biochemistry and Materials, Institute for Polymers and Organic Solids, University of California, Santa Barbara, California, USA
    J Am Chem Soc 126:4076-7. 2004
    ..By focusing on [I(T) - I(NB)]/I(NB) as a function of RNA concentration, one can detect the concentration range wherein increased fluorescence is the result of dimerization...
  15. ncbi request reprint Water-soluble [2.2]paracyclophane chromophores with large two-photon action cross sections
    Han Young Woo
    Mitsubishi Chemical Center for Advanced Materials, Department of Materials, Institute for Polymers and Organic Solids, University of California, Santa Barbara, California 93106, USA
    J Am Chem Soc 127:820-1. 2005
    ..These results show that, to maximize the deltaeta in this class of chromophores, one needs to fine-tune the magnitude of the charge transfer character of the excited state, to minimize fluorescence quenching in polar media...
  16. pmc Targeting the PIAS1 SUMO ligase pathway to control inflammation
    Bin Liu
    Division of Hematology Oncology, Department of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA
    Trends Pharmacol Sci 29:505-9. 2008
    ..These findings support a hypothesis that therapies targeting the PIAS1 SUMO ligase pathway might be developed for the treatment of inflammatory disorders such as rheumatoid arthritis and atherosclerosis...
  17. ncbi request reprint PIAS1 selectively inhibits interferon-inducible genes and is important in innate immunity
    Bin Liu
    Division of Hematology Oncology, Department of Medicine, University of California Los Angeles, Los Angeles, California, USA
    Nat Immunol 5:891-8. 2004
    ..Our data indicate that PIAS1 is a physiologically important negative regulator of STAT1 and suggest that PIAS1 is critical for the IFN-gamma- or IFN-beta-mediated innate immune responses...
  18. ncbi request reprint Transcriptional targeting of tumors with a novel tumor-specific survivin promoter
    Zeng B Zhu
    Division of Human Gene Therapy, Department of Medicine, Pathology, and the Gene Therapy Center, University of Alabama at Birmingham, Birmingham AL 35291, USA
    Cancer Gene Ther 11:256-62. 2004
    ....
  19. ncbi request reprint Interrogating yeast surface-displayed human proteome to identify small molecule-binding proteins
    Scott Bidlingmaier
    Department of Anesthesia, UCSF Comprehensive Cancer Center, University of California, San Francisco, California 94110, USA
    Mol Cell Proteomics 6:2012-20. 2007
    ..We expect that this method will be generally applicable to the study of small molecule/protein interactions and may facilitate the study of cellular signaling pathways and mechanisms of drug action or toxicity...
  20. ncbi request reprint Construction and application of a yeast surface-displayed human cDNA library to identify post-translational modification-dependent protein-protein interactions
    Scott Bidlingmaier
    Department of Anesthesia and UCSF Comprehensive Cancer Center, University of California, San Francisco, California 94110, USA
    Mol Cell Proteomics 5:533-40. 2006
    ....
  21. ncbi request reprint PDGF-BB enhances monocyte chemoattractant protein-1 mRNA stability in smooth muscle cells by downregulating ribonuclease activity
    Bin Liu
    Department of Medicine, University of Rochester, Box 679, 601 Elmwood Avenue, Rochester, NY 14642, USA
    J Mol Cell Cardiol 41:160-9. 2006
    ..These studies provide new insights into the mechanisms by which PDGF-BB enhances mRNA accumulation...
  22. pmc Enhanced growth inhibition of osteosarcoma by cytotoxic polymerized liposomal nanoparticles targeting the alcam cell surface receptor
    Noah Federman
    Division of Pediatric Hematology Oncology, Department of Pediatrics, Mattel Children s Hospital and Gwynne Hazen Cherry Memorial Laboratories, UCLA Jonsson Comprehensive Cancer Center, Los Angeles, CA 90095 1781, USA
    Sarcoma 2012:126906. 2012
    ..In this way, α-AL-HPLNs are a promising new strategy to specifically deliver cytotoxic agents in osteosarcoma...
  23. ncbi request reprint PIASx is a transcriptional co-repressor of signal transducer and activator of transcription 4
    Taruna Arora
    Division of Hematology Oncology, University of California Los Angeles, 10833 Le Conte Avenue, Los Angeles, CA 90095 1678, USA
    J Biol Chem 278:21327-30. 2003
    ..Finally the inhibitory activity of PIASx on Stat4-mediated gene activation is abolished by the histone deacetylase inhibitor trichostatin A. Our results suggest that PIASx may function as a co-repressor of Stat4...
  24. doi request reprint Protein kinase Cδ mediates MCP-1 mRNA stabilization in vascular smooth muscle cells
    Bin Liu
    Department of Medicine, University of Rochester Medical Center, Rochester, NY 14642, USA
    Mol Cell Biochem 344:73-9. 2010
    ..This study identifies a novel role for PKCδ in mediating mRNA stability in smooth muscle cells...
  25. ncbi request reprint Regulation of JAK-STAT signalling in the immune system
    Ke Shuai
    Division of Hematology Oncology, Department of Medicine, University of California, Los Angeles, California 90095, USA
    Nat Rev Immunol 3:900-11. 2003
  26. pmc An engineered cysteine-modified diabody for imaging activated leukocyte cell adhesion molecule (ALCAM)-positive tumors
    Katelyn E McCabe
    Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, CA, USA
    Mol Imaging Biol 14:336-47. 2012
    ..The purpose of this study was to generate and evaluate a positron emission tomography (PET) radiotracer targeting activated leukocyte cell adhesion molecule (ALCAM)...
  27. ncbi request reprint Shape-adaptable water-soluble conjugated polymers
    Bin Liu
    Department of Chemistry, Institute for Polymers and Organic Solids, University of California, Santa Barbara, California 93106, USA
    J Am Chem Soc 125:13306-7. 2003
    ..Similar results are obtained when intercalated ethidium bromide is used as the acceptor. These results indicate that there is better spatial registry between the flexible conjugated polymers and the secondary structure of DNA...
  28. ncbi request reprint Regulation of the SM-20 prolyl hydroxylase gene in smooth muscle cells
    Keon Menzies
    The Zena and Michael A Wiener Cardiovascular Institute, Department of Medicine, The Mount Sinai School of Medicine, New York, NY 10029, USA
    Biochem Biophys Res Commun 317:801-10. 2004
    ....
  29. ncbi request reprint The secretory leukoprotease inhibitor (SLPI) promoter for ovarian cancer gene therapy
    Shannon D Barker
    Division of Human Gene Therapy, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Gene Med 5:300-10. 2003
    ..We hypothesize that selective adenovirus-mediated transgene expression could be achieved through the use of the secretory leukoprotease inhibitor (SLPI) promoter in the context of ovarian cancer...
  30. ncbi request reprint NADPH oxidase mediates lipopolysaccharide-induced neurotoxicity and proinflammatory gene expression in activated microglia
    Liya Qin
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, NIEHS, NIH, Research Triangle Park, NC 27709, USA
    J Biol Chem 279:1415-21. 2004
    ....
  31. pmc Retroviral insertions in the VISION database identify molecular pathways in mouse lymphoid leukemia and lymphoma
    Keith C Weiser
    Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Mamm Genome 18:709-22. 2007
    ..mouse-genome.bcm.tmc.edu/vision ...
  32. doi request reprint Regulation of the class II and class I MHC pathways in human THP-1 monocytic cells by interleukin-27
    Xiao Ming Feng
    State Key Laboratory of Experimental Hematology, Institute of Hematology and Hospital of Blood Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, 288 Nanjing Road, Tianjin 300020, PR China
    Biochem Biophys Res Commun 367:553-9. 2008
    ..Our data suggest that the pro-inflammatory role of IL-27 is mediated in part through increased expression of key molecules involved in the class II and class I MHC pathways...
  33. pmc ROS and p53: a versatile partnership
    Bin Liu
    Graduate Center for Toxicology, University of Kentucky, Lexington, KY 40506, USA
    Free Radic Biol Med 44:1529-35. 2008
    ..Here, we examine the newly discovered role of p53 in regulating cellular ROS generation and how ROS modulate selective transactivation of p53 target genes. The focus is on interlinks between ROS and p53...
  34. ncbi request reprint Comparison of the signal transduction pathways for the induction of gene expression of nitric oxide synthase-2 in response to two different stimuli
    Arthur H Neufeld
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, 660 South Euclid Avenue, Box 8096, St Louis, MO 63110, USA
    Nitric Oxide 8:95-102. 2003
    ..Our data suggest that activation of different sites in the promoter region of the NOS-2 gene is needed for these different stimuli to induce NOS-2...
  35. ncbi request reprint Detection of target nucleic acids and proteins by amplification of circularizable probes
    David Y Zhang
    Molecular Pathology Laboratory, Mount Sinai School of Medicine, New York, NY 10021, USA
    Expert Rev Mol Diagn 3:237-48. 2003
    ..The applications of C-probe, rolling circle amplification, ramification mechanism, in situ detection, microarray, immunoassay, single nucleotide polymorphism and whole genome amplification are discussed...
  36. ncbi request reprint Assembly of quantum dots-mesoporous silicate hybrid material for protein immobilization and direct electrochemistry
    Qian Zhang
    Department of Chemistry, University of Science and Technology of China, Hefei, China
    Biosens Bioelectron 23:695-700. 2007
    ..The experiment results demonstrate that the hybrid matrix provides a biocompatible microenvironment for protein and supplies a necessary pathway for its direct electron transfer...
  37. ncbi request reprint A filter enhanced sampling and combinatorial scoring study for protein docking in CAPRI
    Xin Qi Gong
    College of Life Science and Bioengineering, Beijing University of Technology, Beijing 100022, China
    Proteins 69:859-65. 2007
    ..The ligand least root mean square deviations (L_rmsds) were reduced and the hit numbers were increased. ComScore was used in the scoring test for CAPRI rounds 9-12 with good success in rounds 9 and 11...
  38. ncbi request reprint Role of nitric oxide in inflammation-mediated neurodegeneration
    Bin Liu
    Neuropharmacology Section, Laboratory of Pharmacology and Chemistry, National Institute of Environmental Health Sciences National Institutes of Health, Research Triangle Park, North Carolina 27710, USA
    Ann N Y Acad Sci 962:318-31. 2002
    ..Among these agents, the opioid receptor antagonist naloxone, especially its non-opioid enantiomer (+)-naloxone, promises to be of potential therapeutic value for the treatment of inflammation-related diseases...
  39. ncbi request reprint Inter-patient variation in efficacy of five oncolytic adenovirus candidates for ovarian cancer therapy
    John T Lam
    Division of Human Gene Therapy, Departments of Medicine, Pathology and Surgery, and the Gene Therapy Center, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Gene Med 6:1333-42. 2004
    ..We evaluated five CRAds as candidate clinical agents for ovarian cancer therapy: RGDCRADcox-2R, Ad5VEGFE1, Ad5/3VEGFE1, Ad5-Delta24RGD, and Ad5/3-Delta24...
  40. pmc Implications of an antiparallel dimeric structure of nonphosphorylated STAT1 for the activation-inactivation cycle
    Minghao Zhong
    Laboratory of Molecular Cell Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 102:3966-71. 2005
    ..We conclude that a parallel STAT1 phosphodimer not bound to DNA most likely undergoes a conformational rearrangement (parallel to antiparallel) to present the phosphotyrosine efficiently for dephosphorylation...
  41. ncbi request reprint [The mechanisms of p21WAF1/Cip-1 expression in MOLT-4 cell line induced by TSA]
    Yi Song
    Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China
    Zhongguo Shi Yan Xue Ye Xue Za Zhi 13:174-81. 2005
    ..It is concluded that p21(WAF1/Cip-1) plays a significant role in G(2)/M arrest and apoptosis signaling induced by TSA in MOLT-4 cells...
  42. ncbi request reprint The crystal structure of the plexin-semaphorin-integrin domain/hybrid domain/I-EGF1 segment from the human integrin beta2 subunit at 1.8-A resolution
    MinLong Shi
    School of Biological Sciences, Nanyang Technological University, 60 Nanyang Drive, Singapore 637551, Singapore
    J Biol Chem 280:30586-93. 2005
    ....
  43. ncbi request reprint Characterization and neural differentiation of fetal lung mesenchymal stem cells
    Cun Gang Fan
    National Research Center for Stem Cell Engineering and Technology, State Key Laboratory of Experimental Hematology, Institute of Hematology, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin, People s Republic of China
    Cell Transplant 14:311-21. 2005
    ..Our data suggest that the fetal lung MSC population is an alternative source of stem cells for cell-based therapy of neurological defects or mesenchymal-originating diseases...
  44. ncbi request reprint [Production of transgenic mice by in vivo spermatogonia-mediated gene transfer]
    Jun Zhao
    Military Veterinary Institute, Quartermaster University of PLA, Changchun 130062
    Shi Yan Sheng Wu Xue Bao 36:197-201. 2003
    ..Seven out of 45 F1 mice were proven to be transgenic by PCR. It is concluded that transfecting spermatogonia in vivo can produce transgenic mice...
  45. ncbi request reprint Modulation by bradykinin of angiotensin type 1 receptor-evoked RhoA activation of connective tissue growth factor expression in human lung fibroblasts
    Zhenhua Huang
    Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA
    Am J Physiol Lung Cell Mol Physiol 290:L1291-9. 2006
    ..These data demonstrate that, in human lung fibroblasts, BK modulates the action of AngII through the small G protein RhoA, but in a Galphai/Galphaq-independent manner...
  46. ncbi request reprint IL-5 up-regulates the expression of TGF-beta1 in human blood eosinophils in vitro
    Yabing Huang
    Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College, Huzhong University of Science and Technology, Key Laboratory of Organ Transplantation, Ministry of Education and Health, Wuhan 430030, China
    J Huazhong Univ Sci Technolog Med Sci 25:665-7. 2005
    ..42, 1.70, 1.76-folds higher than that of the non-stimulated controls. It is concluded that IL-5 can up-regulate the expression of TGF-beta1 in eosinophils in vitro, which might have effect in eosinophil-associated chronic rejection...
  47. ncbi request reprint Hemangiopoietin, a novel human growth factor for the primitive cells of both hematopoietic and endothelial cell lineages
    Yong Jun Liu
    State Key Laboratory of Experimental Hematology, Chinese Academy of Medical Sciences and Peking Union of Medical College, 288 Nanjing Road, Tianjin 300020, P R China
    Blood 103:4449-56. 2004
    ....
  48. ncbi request reprint Quantitative intracellular molecular profiling using a one-dimensional flow system
    Leiji Zhou
    Biomedical Engineering Center, State Key Lab of Chemo Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China
    Anal Chem 78:6246-51. 2006
    ..This ability to quantitatively analyze normal and diseased cells raises new possibilities in studying cancer heterogeneity and circulating tumor cells...
  49. ncbi request reprint The effect of conjugation to gold nanoparticles on the ability of low molecular weight chitosan to transfer DNA vaccine
    Xianfeng Zhou
    College of Life Science, Jilin University, Changchun 130012, PR China
    Biomaterials 29:111-7. 2008
    ..Additionally, in contrast to naked DNA, the Chito6-GNPs conjugates induced potent cytotoxic T lymphocyte responses at a low dose...

Research Grants2

  1. The role of PIAS1 in inflammation and immune disorders
    Bin Liu; Fiscal Year: 2007
    ..These studies will provide further understanding of the role of PIAS1 in inflammation and immune diseases and may identify novel targets for therapeutic interventions. ..