A Y Liu

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. pmc The urologic epithelial stem cell database (UESC) - a web tool for cell type-specific gene expression and immunohistochemistry images of the prostate and bladder
    Laura E Pascal
    Department of Urology, and the Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle WA 98195, USA
    BMC Urol 7:19. 2007
  2. pmc Stromal mesenchyme cell genes of the human prostate and bladder
    Young Ah Goo
    Department of Urology, University of Washington, Seattle, WA, USA
    BMC Urol 5:17. 2005
  3. pmc Molecular and cellular characterization of ABCG2 in the prostate
    Laura E Pascal
    Department of Urology, and the Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98195, USA
    BMC Urol 7:6. 2007
  4. pmc Differential expression of CD10 in prostate cancer and its clinical implication
    Marc A Dall'Era
    Department of Urology, University of Washington, Seattle, WA, USA
    BMC Urol 7:3. 2007
  5. pmc Transcriptomes of human prostate cells
    Asa J Oudes
    Urology, University of Washington, Seattle, WA 98195 6510, USA
    BMC Genomics 7:92. 2006
  6. pmc Correlation of mRNA and protein levels: cell type-specific gene expression of cluster designation antigens in the prostate
    Laura E Pascal
    Department of Urology, University of Washington, Seattle WA 98195, USA
    BMC Genomics 9:246. 2008
  7. pmc Differential expression of anterior gradient gene AGR2 in prostate cancer
    Erin L Maresh
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, 10833 Le Conte Ave, Los Angeles, CA 90095, USA
    BMC Cancer 10:680. 2010
  8. pmc Gene expression down-regulation in CD90+ prostate tumor-associated stromal cells involves potential organ-specific genes
    Laura E Pascal
    Department of Urology, University of Washington, Seattle, WA 98195, USA
    BMC Cancer 9:317. 2009
  9. pmc Application of Affymetrix array and Massively Parallel Signature Sequencing for identification of genes involved in prostate cancer progression
    Asa J Oudes
    Institute for Systems Biology, Seattle, USA
    BMC Cancer 5:86. 2005
  10. doi request reprint Stromal-epithelial interactions in early neoplasia
    Alvin Y Liu
    Department of Urology and Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA
    Cancer Biomark 9:141-55. 2010

Research Grants

  1. CD Expression in Prostate Cancer
    Alvin Liu; Fiscal Year: 2004
  2. Urologic Epithelial Stem Cells
    Alvin Liu; Fiscal Year: 2004
  3. Biomarkers for Prostate and Bladder Cancer
    Alvin Liu; Fiscal Year: 2007

Detail Information

Publications30

  1. pmc The urologic epithelial stem cell database (UESC) - a web tool for cell type-specific gene expression and immunohistochemistry images of the prostate and bladder
    Laura E Pascal
    Department of Urology, and the Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle WA 98195, USA
    BMC Urol 7:19. 2007
    ..Similarly, such information is available for urinary bladder cell types...
  2. pmc Stromal mesenchyme cell genes of the human prostate and bladder
    Young Ah Goo
    Department of Urology, University of Washington, Seattle, WA, USA
    BMC Urol 5:17. 2005
    ..We propose to identify the prostate stromal genes by analysis of differentially expressed genes between prostate and bladder stromal cells, and to examine their expression in prostate cancer...
  3. pmc Molecular and cellular characterization of ABCG2 in the prostate
    Laura E Pascal
    Department of Urology, and the Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA 98195, USA
    BMC Urol 7:6. 2007
    ..This phenotype is mainly mediated by the ATP-binding cassette membrane transporter ABCG2...
  4. pmc Differential expression of CD10 in prostate cancer and its clinical implication
    Marc A Dall'Era
    Department of Urology, University of Washington, Seattle, WA, USA
    BMC Urol 7:3. 2007
    ..We hypothesize that prostate tumors expressing high levels of CD10 have a more aggressive biology with an early propensity towards lymph node metastasis...
  5. pmc Transcriptomes of human prostate cells
    Asa J Oudes
    Urology, University of Washington, Seattle, WA 98195 6510, USA
    BMC Genomics 7:92. 2006
    ..To overcome the problem of heterogeneity we have developed a method to isolate individual cell types from whole tissue that are a source of RNA suitable for transcriptome profiling...
  6. pmc Correlation of mRNA and protein levels: cell type-specific gene expression of cluster designation antigens in the prostate
    Laura E Pascal
    Department of Urology, University of Washington, Seattle WA 98195, USA
    BMC Genomics 9:246. 2008
    ..Immunohistochemical stains of prostate tissues from more than 50 patients were scored for informative CD antigen expression and compared with cell-type specific transcriptomes...
  7. pmc Differential expression of anterior gradient gene AGR2 in prostate cancer
    Erin L Maresh
    Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, 10833 Le Conte Ave, Los Angeles, CA 90095, USA
    BMC Cancer 10:680. 2010
    ..In particular, AGR2 has previously been found to be one of several genes that encode secreted proteins showing increased expression in prostate cancer cells compared to normal prostatic epithelium...
  8. pmc Gene expression down-regulation in CD90+ prostate tumor-associated stromal cells involves potential organ-specific genes
    Laura E Pascal
    Department of Urology, University of Washington, Seattle, WA 98195, USA
    BMC Cancer 9:317. 2009
    ..The tumor-associated stroma is marked by increased expression of CD90/THY1. Isolation and characterization of these stromal cells could provide valuable insight into the biology of the tumor microenvironment...
  9. pmc Application of Affymetrix array and Massively Parallel Signature Sequencing for identification of genes involved in prostate cancer progression
    Asa J Oudes
    Institute for Systems Biology, Seattle, USA
    BMC Cancer 5:86. 2005
    ..In this study, two lineage-related prostate cancer cell lines, LNCaP and C4-2, were used for transcriptome analysis with the aim of identifying genes associated with prostate cancer progression...
  10. doi request reprint Stromal-epithelial interactions in early neoplasia
    Alvin Y Liu
    Department of Urology and Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA, USA
    Cancer Biomark 9:141-55. 2010
    ..In contrast, NCCIT shows minimal effect on CP stromal cells. CP stromal cells may represent a less differentiated state in the prostate stromal cell lineage...
  11. ncbi request reprint Analysis of prostate cancer by proteomics using tissue specimens
    Alvin Y Liu
    Department of Urology, University of Washington, Seattle, Washington 98195, USA
    J Urol 173:73-8. 2005
    ..We used quantitative proteomics based on glycopeptide capture followed by tandem mass spectrometry to identify differentially expressed proteins...
  12. pmc Heterogeneity in primary and metastatic prostate cancer as defined by cell surface CD profile
    Alvin Y Liu
    Department of Urology, Box 356510, University of Washington, Seattle, WA 98195, USA
    Am J Pathol 165:1543-56. 2004
    ....
  13. ncbi request reprint Lineage relationship between LNCaP and LNCaP-derived prostate cancer cell lines
    Alvin Y Liu
    Department of Urology, University of Washington, Seattle, 98195, USA
    Prostate 60:98-108. 2004
    ..Unlike LNCaP, the other cell lines show features of progressed disease such as metastatic capability and hormone independence. Analyses were done to determine if C4-2 or CL1 cells were selected from pre-existent subpopulations in LNCaP...
  14. pmc Cell-cell interaction in prostate gene regulation and cytodifferentiation
    A Y Liu
    Department of Urology, University of Washington, Seattle, WA 98195, USA
    Proc Natl Acad Sci U S A 94:10705-10. 1997
    ..Our studies show that cell-cell interaction plays an important role in prostatic cytodifferentiation and the maintenance of the differentiated state...
  15. ncbi request reprint Analysis and sorting of prostate cancer cell types by flow cytometry
    A Y Liu
    Department of Urology, University of Washington, Seattle, Washington 98195, USA
    Prostate 40:192-9. 1999
    ..Does the composition differ between primary tumor and metastasis? How can one isolate the different cancer cell types to study? What is the relationship among cancer cell types?..
  16. ncbi request reprint Differential expression of cell surface molecules in prostate cancer cells
    A Y Liu
    Department of Urology, University of Washington, Seattle 98195, USA
    Cancer Res 60:3429-34. 2000
    ..As a population, expression of these molecules appears to be heterogeneous. This heterogeneity may be an inherent property of the population...
  17. ncbi request reprint Changes in cell surface molecules associated with in vitro culture of prostatic stromal cells
    A Y Liu
    Department of Urology, University of Washington, Seattle 98195, USA
    Prostate 44:303-12. 2000
    ....
  18. ncbi request reprint Characterization of cultured human prostatic epithelial cells by cluster designation antigen expression
    A Y Liu
    Department of Urology, University of Washington, Seattle, WA 98195, USA
    Cell Tissue Res 305:389-97. 2001
    ..We conclude that cells in culture retain expression of certain lineage-characteristic CD antigens. Furthermore, CD antigens can define subpopulations of cells with differential gene expression...
  19. ncbi request reprint Human prostate epithelial cell-type cDNA libraries and prostate expression patterns
    Alvin Y Liu
    Department of Urology, University of Washington, Seattle, Washington 98195, USA
    Prostate 50:92-103. 2002
    ..Transcriptome analysis is a powerful approach to uncovering genes responsible for diseases such as prostate cancer. Ideally, one would like to compare the transcriptomes of a cancer cell and its normal counterpart for differences...
  20. ncbi request reprint An expressed-sequence-tag database of the human prostate: sequence analysis of 1168 cDNA clones
    P S Nelson
    Department of Molecular Biotechnology, University of Washington, Seattle 98195, USA
    Genomics 47:12-25. 1998
    ..No novel transcripts were represented by more than one EST and thus are expressed at levels much lower than the known prostate-specific genes...
  21. pmc Gene expression relationship between prostate cancer cells of Gleason 3, 4 and normal epithelial cells as revealed by cell type-specific transcriptomes
    Laura E Pascal
    Department of Urology, University of Washington, Seattle, WA 98195, USA
    BMC Cancer 9:452. 2009
    ..This CD phenotype suggests a lineage relationship between cancer cells and luminal cells. The Gleason grade of tumors is a descriptive of tumor glandular differentiation. Higher Gleason scores are associated with treatment failure...
  22. ncbi request reprint Improved reverse transcriptase-polymerase chain reaction protocol with exogenous internal competitive control for prostate-specific antigen mRNA in blood and bone marrow
    E Corey
    Department of Urology, School of Medicine, University of Washington, Seattle 98195, USA
    Clin Chem 43:443-52. 1997
    ..Because PCR procedures frequently exhibit tube-to-tube variability, we have incorporated a set of internal and external controls into the protocol-a significant advance in assuring assay reliability...
  23. ncbi request reprint Loss of CD10 (neutral endopeptidase) is a frequent and early event in human prostate cancer
    Stephen J Freedland
    Department of Urology, UCLA School of Medicine, Los Angeles, CA 90095 1738, USA
    Prostate 55:71-80. 2003
    ....
  24. doi request reprint Temporal expression profiling of the effects of secreted factors from prostate stromal cells on embryonal carcinoma stem cells
    Laura E Pascal
    Department of Urology, Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, Washington, USA
    Prostate 69:1353-65. 2009
    ....
  25. doi request reprint Identification of secreted glycoproteins of human prostate and bladder stromal cells by comparative quantitative proteomics
    Young Ah Goo
    Department of Urology, University of Washington, Seattle, Washington 98195 7610, USA
    Prostate 69:49-61. 2009
    ..One approach to gain a molecular understanding of stromal cells is to identify, as a first step, secreted stromal signaling factors. We proposed to do this by comparative analysis between bladder and prostate...
  26. ncbi request reprint HSP27 and HSP70 interact with CD10 in C4-2 prostate cancer cells
    Marc A Dall'Era
    Department of Urology, University of Washington, Seattle, Washington, USA
    Prostate 67:714-21. 2007
    ..In this study, we compared CD10 mRNA and protein expression between benign and malignant prostate cells and employed proteomic analysis to identify proteins that interact with CD10 in C4-2 prostate cancer cells...
  27. pmc Characterization of prostate cell types by CD cell surface molecules
    Alvin Y Liu
    Department of Urology, University of Washington, Seattle, Washington 98195, USA
    Am J Pathol 160:37-43. 2002
    ..The cell-type specificity of CD molecules increases the prospect of isolating specific cell populations, using such techniques as laser capture microdissection and flow cytometry, for cell-specific molecular studies...
  28. ncbi request reprint Mass spectrometric detection of tissue proteins in plasma
    Hui Zhang
    Institute for Systems Biology, Seattle, Washington 98103, USA
    Mol Cell Proteomics 6:64-71. 2007
    ....
  29. doi request reprint Minimum information specification for in situ hybridization and immunohistochemistry experiments (MISFISHIE)
    Eric W Deutsch
    Institute for Systems Biology, 1441 N 34th Street, Seattle, Washington 98103, USA
    Nat Biotechnol 26:305-12. 2008
    ..This specification has benefited the consortium within which it was developed and is expected to benefit the wider research community. We welcome feedback from the scientific community to help improve our proposal...
  30. ncbi request reprint A challenge for the diagnostic immunohistopathologist. Adding the CD phenotypes to our diagnostic toolbox
    Lawrence D True
    Am J Clin Pathol 120:13-5. 2003

Research Grants4

  1. CD Expression in Prostate Cancer
    Alvin Liu; Fiscal Year: 2004
    ..CD10 and CD13 are both peptidases and are likely involved in the processing of bioactive signaling peptides. Their absence might lead to the aberrant cellular differentiation and development of cancer. ..
  2. Urologic Epithelial Stem Cells
    Alvin Liu; Fiscal Year: 2004
    ....
  3. Biomarkers for Prostate and Bladder Cancer
    Alvin Liu; Fiscal Year: 2007
    ..Urine samples will be obtained from cancer patients and age-matched volunteers. The goal is to develop an assay for cancer associated protein markers that can be detected in voided urine for the diagnosis of prostate and bladder cancer. ..