Irene Litvan

Summary

Affiliation: University of Louisville
Country: USA

Publications

  1. ncbi request reprint Update of atypical Parkinsonian disorders
    Irene Litvan
    Department of Neurology, University of Louisville, Louisville, Kentucky 40202, USA
    Curr Opin Neurol 20:434-7. 2007
  2. ncbi request reprint The etiopathogenesis of Parkinson disease and suggestions for future research. Part II
    Irene Litvan
    University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    J Neuropathol Exp Neurol 66:329-36. 2007
  3. doi request reprint H1/H1 genotype influences symptom severity in corticobasal syndrome
    Irene Litvan
    Division of Movement Disorders, Department of Neurology, University of Louisville, Louisville, Kentucky 40202, USA
    Mov Disord 25:760-3. 2010
  4. pmc MDS Task Force on mild cognitive impairment in Parkinson's disease: critical review of PD-MCI
    Irene Litvan
    Division of Movement Disorders, Department of Neurology, University of Louisville, Louisville, Kentucky, USA
    Mov Disord 26:1814-24. 2011
  5. ncbi request reprint The etiopathogenesis of Parkinson disease and suggestions for future research. Part I
    Irene Litvan
    University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    J Neuropathol Exp Neurol 66:251-7. 2007
  6. ncbi request reprint Update on progressive supranuclear palsy
    Irene Litvan
    Movement Disorder Program, Department of Neurology, University of Louisville School of Medicine, A Building, Room 113, 500 South Preston Street, Louisville, KY 40202, USA
    Curr Neurol Neurosci Rep 4:296-302. 2004
  7. ncbi request reprint Update on epidemiological aspects of progressive supranuclear palsy
    Irene Litvan
    Movement Disorder Program, University of Louisville School of Medicine, Louisville, Kentucky, USA
    Mov Disord 18:S43-50. 2003
  8. ncbi request reprint Movement Disorders Society Scientific Issues Committee report: SIC Task Force appraisal of clinical diagnostic criteria for Parkinsonian disorders
    Irene Litvan
    Movement Disorder Program, University of Louisville, KY 40205, USA
    Mov Disord 18:467-86. 2003
  9. pmc The Gly2019Ser mutation in LRRK2 is not fully penetrant in familial Parkinson's disease: the GenePD study
    Jeanne C Latourelle
    Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA, USA
    BMC Med 6:32. 2008
  10. pmc Diagnostic criteria for mild cognitive impairment in Parkinson's disease: Movement Disorder Society Task Force guidelines
    Irene Litvan
    Division of Movement Disorders, Department of Neurology, University of Louisville, Louisville, Kentucky, USA
    Mov Disord 27:349-56. 2012

Research Grants

  1. Genetic and Environmental Risk Factors for PSP
    Irene Litvan; Fiscal Year: 2007
  2. Genetic and Environmental Risk Factors for PSP
    Irene Litvan; Fiscal Year: 2009
  3. Genetic and Environmental Risk Factors for PSP
    Irene Litvan; Fiscal Year: 2010

Detail Information

Publications35

  1. ncbi request reprint Update of atypical Parkinsonian disorders
    Irene Litvan
    Department of Neurology, University of Louisville, Louisville, Kentucky 40202, USA
    Curr Opin Neurol 20:434-7. 2007
    ..This timely update discusses novel diagnostic approaches, recently identified genes, and innovative experimental symptomatic treatments for these devastating disorders...
  2. ncbi request reprint The etiopathogenesis of Parkinson disease and suggestions for future research. Part II
    Irene Litvan
    University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    J Neuropathol Exp Neurol 66:329-36. 2007
    ..Topics reviewed in Part II are genetics, animal models, and oxidative stress...
  3. doi request reprint H1/H1 genotype influences symptom severity in corticobasal syndrome
    Irene Litvan
    Division of Movement Disorders, Department of Neurology, University of Louisville, Louisville, Kentucky 40202, USA
    Mov Disord 25:760-3. 2010
    ..ApoE inheritance did not influence cognition...
  4. pmc MDS Task Force on mild cognitive impairment in Parkinson's disease: critical review of PD-MCI
    Irene Litvan
    Division of Movement Disorders, Department of Neurology, University of Louisville, Louisville, Kentucky, USA
    Mov Disord 26:1814-24. 2011
    ....
  5. ncbi request reprint The etiopathogenesis of Parkinson disease and suggestions for future research. Part I
    Irene Litvan
    University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    J Neuropathol Exp Neurol 66:251-7. 2007
  6. ncbi request reprint Update on progressive supranuclear palsy
    Irene Litvan
    Movement Disorder Program, Department of Neurology, University of Louisville School of Medicine, A Building, Room 113, 500 South Preston Street, Louisville, KY 40202, USA
    Curr Neurol Neurosci Rep 4:296-302. 2004
    ..These advances are explained in detail in this review...
  7. ncbi request reprint Update on epidemiological aspects of progressive supranuclear palsy
    Irene Litvan
    Movement Disorder Program, University of Louisville School of Medicine, Louisville, Kentucky, USA
    Mov Disord 18:S43-50. 2003
    ..The possible role of chemicals in the diet or occupation, hypertension, traumatic brain injury, coffee, and inflammation or oxidative injury are reviewed...
  8. ncbi request reprint Movement Disorders Society Scientific Issues Committee report: SIC Task Force appraisal of clinical diagnostic criteria for Parkinsonian disorders
    Irene Litvan
    Movement Disorder Program, University of Louisville, KY 40205, USA
    Mov Disord 18:467-86. 2003
    ..In each of these areas, diagnosis continues to rest on clinical findings and the judicious use of ancillary studies...
  9. pmc The Gly2019Ser mutation in LRRK2 is not fully penetrant in familial Parkinson's disease: the GenePD study
    Jeanne C Latourelle
    Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA, USA
    BMC Med 6:32. 2008
    ..Studies of the penetrance of LRRK2 mutations have produced a wide range of estimates, possibly due to differences in study design and recruitment, including in particular differences between samples of familial PD versus sporadic PD...
  10. pmc Diagnostic criteria for mild cognitive impairment in Parkinson's disease: Movement Disorder Society Task Force guidelines
    Irene Litvan
    Division of Movement Disorders, Department of Neurology, University of Louisville, Louisville, Kentucky, USA
    Mov Disord 27:349-56. 2012
    ....
  11. doi request reprint Brain-lung-thyroid disease: clinical features of a kindred with a novel thyroid transcription factor 1 mutation
    Joseph M Ferrara
    Division of Movement Disorders, Department of Neurology, University of Louisville, Louisville, Kentucky, USA
    J Child Neurol 27:68-73. 2012
    ..The unusual therapeutic response seen in our patients and others may help elucidate how disease-related migratory deficits affect neural pathways associated with motor control...
  12. pmc Executive dysfunction is the primary cognitive impairment in progressive supranuclear palsy
    Adam Gerstenecker
    Department of Psychological and Brain Sciences, University of Louisville, Louisville, KY 40292 USA
    Arch Clin Neuropsychol 28:104-13. 2013
    ..These results have important clinical implications for providers following patients with PSP...
  13. pmc Parkinsonism and frontotemporal dementia: the clinical overlap
    Alberto J Espay
    Department of Neurology, Movement Disorders Center, UC Neuroscience Institute, University of Cincinnati, Cincinnati, OH, USA
    J Mol Neurosci 45:343-9. 2011
    ..This gap is critical to bridge in order to allow testing of novel biological therapies that may slow the progression of these proteinopathies...
  14. doi request reprint Cognitive and neuropsychiatric effects of subthalamotomy for Parkinson's disease
    Scott Bickel
    Division of Movement Disorders, Department of Neurology, University of Louisville School of Medicine, Frazier Rehab Neuroscience Institute, 220 Abraham Flexner Way, Ste 1503, Louisville, KY 40202, USA
    Parkinsonism Relat Disord 16:535-9. 2010
    ..The results of this proof-of-concept pilot study suggest the need for larger, long-term, randomized controlled studies to assess motor, neuropsychiatric, behavioral and radiologic correlations after subthalamotomies...
  15. pmc Functional impairment in progressive supranuclear palsy
    Kevin Duff
    Department of Neurology, University of Utah, Salt Lake City, USA
    Neurology 80:380-4. 2013
    ..The current study sought to describe the functional profiles of patients with early-stage progressive supranuclear palsy (PSP) in a large prospective, multisite study...
  16. pmc Polymorphic genes of detoxification and mitochondrial enzymes and risk for progressive supranuclear palsy: a case control study
    Lisa F Potts
    Department of Anatomical Sciences and Neurobiology, University of Louisville, KY, USA
    BMC Med Genet 13:16. 2012
    ....
  17. ncbi request reprint Alzheimer's disease presenting as corticobasal syndrome
    Pratap Chand
    Department of Neurology, University of Louisville School of Medicine, Louisville, Kentucky 40202, USA
    Mov Disord 21:2018-22. 2006
    ..The videotaped clinical features, neuropsychological aspects, and neuropathological correlates are presented and discussed...
  18. pmc Huntington CAG repeat size does not modify onset age in familial Parkinson's disease: the GenePD study
    Christopher F McNicoll
    Department of Neurology, Boston University School of Medicine, Boston University, Boston, Massachusetts 02118, USA
    Mov Disord 23:1596-601. 2008
    ..No relation between the HD CAG repeat size and the age at onset for PD was found in this sample of familial PD...
  19. doi request reprint Unraveling progressive supranuclear palsy: from the bedside back to the bench
    David J Houghton
    Division of Movement Disorders, Department of Neurology, University of Louisville, Louisville, KY, USA
    Parkinsonism Relat Disord 13:S341-6. 2007
    ..31 to be associated with PSP, while the H2 haplotype seems protective. With greater knowledge of the molecular and genetic aspects of PSP, we can expect future diagnostic and therapeutic challenges to be more effectively met...
  20. ncbi request reprint Corticobasal degeneration and its relationship to progressive supranuclear palsy and frontotemporal dementia
    Bradley F Boeve
    Division of Behavioral Neurology, Department of Neurology, and Alzheimer s Disease Research Center, Mayo Clinic, Rochester, MN 55905, USA
    Ann Neurol 54:S15-9. 2003
  21. doi request reprint Rapidly progressive atypical parkinsonism associated with frontotemporal lobar degeneration and motor neuron disease
    Alberto J Espay
    Department of Neurology, Movement Disorders Center, The Neuroscience Institute, University of Cincinnati, Cincinnati, Ohio, USA
    J Neurol Neurosurg Psychiatry 82:751-3. 2011
    ..To report the rare but distinct clinical and neuropathological phenotype of non-familial, rapidly progressive parkinsonism and dementia associated with frontotemporal lobar degeneration with motor neuron disease (FTLD-MND)...
  22. pmc A recommended scale for cognitive screening in clinical trials of Parkinson's disease
    Kelvin L Chou
    Department of Neurology, University of Michigan, Ann Arbor, Michigan 48109 5316, USA
    Mov Disord 25:2501-7. 2010
    ..Widespread adoption of a single instrument such as the MoCA in clinical trials can improve comparability between research studies on PD...
  23. pmc Cytokine expression and microglial activation in progressive supranuclear palsy
    Rafael Fernandez-Botran
    Department of Pathology and Laboratory Medicine, School of Medicine, University of Louisville, Louisville, KY 40292, USA
    Parkinsonism Relat Disord 17:683-8. 2011
    ..If so, the use of cytokine-inhibitors and/or other anti-inflammatory agents may be able to slow disease progression in PSP...
  24. ncbi request reprint Increased tau burden in the cortices of progressive supranuclear palsy presenting with corticobasal syndrome
    Yoshio Tsuboi
    Department of Neurology, Fukoka University, Fukoka, Japan
    Mov Disord 20:982-8. 2005
    ....
  25. ncbi request reprint Magnetic resonance imaging-based volumetry differentiates progressive supranuclear palsy from corticobasal degeneration
    Klaus Gröschel
    Department of General Neurology, and Hertie Institute for Clinical Brain Research, University of Tuebingen, Germany
    Neuroimage 21:714-24. 2004
    ..3D-MR imaging-based volumetry may help to differentiate PSP from CBD ante mortem...
  26. ncbi request reprint Freezing of gait in postmortem-confirmed atypical parkinsonism
    Jörg Müller
    Department of Neurology, University Hospital Innsbruck, Austria
    Mov Disord 17:1041-5. 2002
    ..Whether FoG and urinary incontinence share similar neuropathological substrates remains to be determined by future studies...
  27. ncbi request reprint High-density SNP haplotyping suggests altered regulation of tau gene expression in progressive supranuclear palsy
    Rosa Rademakers
    Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology, University of Antwerp, Belgium
    Hum Mol Genet 14:3281-92. 2005
    ..Thus, risk variants on different H1 htSNP haplotypes and protective variants on H2 contribute to population risk for PSP...
  28. ncbi request reprint Progression of gait, speech and swallowing deficits in progressive supranuclear palsy
    Christopher G Goetz
    Department of Neurological Sciences, Rush University Rush Presbyterian St Luke s Medical Center, Chicago, IL, USA
    Neurology 60:917-22. 2003
    ..To identify outcome measures for clinical trials in progressive supranuclear palsy (PSP), the authors determined the time to key motor impairments in a well-defined patient cohort...
  29. ncbi request reprint Lrrk2 and Lewy body disease
    Owen A Ross
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    Ann Neurol 59:388-93. 2006
    ..The Lrrk2 kinase domain G2019S substitution is the most common genetic basis of familial and sporadic parkinsonism. Patients harboring the G2019S substitution usually present with clinical Parkinson's disease...
  30. ncbi request reprint Penguins and hummingbirds: midbrain atrophy in progressive supranuclear palsy
    Klaus Gröschel
    Department of Neurology, University of Jena, Gottingen, Germany
    Neurology 66:949-50. 2006
  31. ncbi request reprint Influence of heterozygosity for parkin mutation on onset age in familial Parkinson disease: the GenePD study
    Mei Sun
    Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Arch Neurol 63:826-32. 2006
    ..The PARK2 gene at 6q26 encodes parkin, whose inactivation is implicated in an early-onset autosomal recessive form of Parkinson disease (PD)...
  32. pmc Replication of association between ELAVL4 and Parkinson disease: the GenePD study
    Anita L Destefano
    Department of Biostatistics, Boston University School of Public Health, 715 Albany Street, Crosstown Center, 3rd Floor, Boston, MA 02118, USA
    Hum Genet 124:95-9. 2008
    ..This replication of association with rs967582 in a third cohort further implicates ELAVL4 as a PD susceptibility gene...
  33. ncbi request reprint Diagnostic procedures for Parkinson's disease dementia: recommendations from the movement disorder society task force
    Bruno Dubois
    INSERM UPMC UMRS 610, Federation of Neurology, AP HP, Salpêtrière Hospital Université Paris6, Paris, France
    Mov Disord 22:2314-24. 2007
    ..We accept, however, that further validation of certain tests and modifications in the recommended cut off values will be required through future studies...
  34. ncbi request reprint Clinical diagnostic criteria for dementia associated with Parkinson's disease
    Murat Emre
    Department of Neurology, Behavioral Neurology and Movement Disorders Unit, Istanbul Faculty of Medicine, Istanbul University, Istanbul, Turkey
    Mov Disord 22:1689-707; quiz 1837. 2007
    ..Based on the characteristic features associated with this condition, clinical diagnostic criteria for probable and possible PD-D are proposed...
  35. pmc Identification of a novel risk locus for progressive supranuclear palsy by a pooled genomewide scan of 500,288 single-nucleotide polymorphisms
    Stacey Melquist
    Department of Neuroscience, Mayo Clinic College of Medicine, Jacksonville, FL 32224, USA
    Am J Hum Genet 80:769-78. 2007
    ..Since DNA damage and lysosomal dysfunction have been implicated in aging and neurodegenerative processes, both genes are viable candidates for conferring risk of disease...

Research Grants6

  1. Genetic and Environmental Risk Factors for PSP
    Irene Litvan; Fiscal Year: 2007
    ..The use of the NINDS cell repository for genetic banking will also allow DNA sample sharing with other investigators. ..
  2. Genetic and Environmental Risk Factors for PSP
    Irene Litvan; Fiscal Year: 2009
    ..The use of the NINDS cell repository for genetic banking will also allow DNA sample sharing with other investigators. ..
  3. Genetic and Environmental Risk Factors for PSP
    Irene Litvan; Fiscal Year: 2010
    ..The use of the NINDS cell repository for genetic banking will also allow DNA sample sharing with other investigators. ..