S J Little

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Viral dynamics of acute HIV-1 infection
    S J Little
    Department of Medicine, University of California San Diego, San Diego, California 92103, USA
    J Exp Med 190:841-50. 1999
  2. ncbi request reprint Reduced antiretroviral drug susceptibility among patients with primary HIV infection
    S J Little
    Department of Medicine, University of California, San Diego, USA
    JAMA 282:1142-9. 1999
  3. ncbi request reprint Transmission and prevalence of HIV resistance among treatment-naive subjects
    S J Little
    Department of Medicine, University of California San Diego, USA
    Antivir Ther 5:33-40. 2000
  4. ncbi request reprint Antiretroviral-drug resistance among patients recently infected with HIV
    Susan J Little
    Antiviral Research Center, Department of Medicine, University of California San Diego, San Diego 92103, USA
    N Engl J Med 347:385-94. 2002
  5. pmc Persistence of transmitted drug resistance among subjects with primary human immunodeficiency virus infection
    Susan J Little
    Department of Medicine, University of California, San Diego, San Diego, California, USA
    J Virol 82:5510-8. 2008
  6. ncbi request reprint Transmission behaviors of recently HIV-infected men who have sex with men
    Pamina M Gorbach
    Department of Epidemiology, School of Public Health and Division of Infections Diseases, David Geffen School of Medicine, University of California, Los Angeles UCLA, Los Angeles, CA 90095 1772, USA
    J Acquir Immune Defic Syndr 42:80-5. 2006
  7. pmc Estimating selection pressures on HIV-1 using phylogenetic likelihood models
    S L Kosakovsky Pond
    Department of Pathology, University of California, San Diego, CA 92093, USA
    Stat Med 27:4779-89. 2008
  8. doi request reprint Antiretroviral drug resistance and risk behavior among recently HIV-infected men who have sex with men
    Pamina M Gorbach
    Department of Epidemiology, School of Public Health, University of California, Los Angeles, Los Angeles, CA 90095 7353, USA
    J Acquir Immune Defic Syndr 47:639-43. 2008
  9. pmc Comparison of algorithms that interpret genotypic HIV-1 drug resistance to determine the prevalence of transmitted drug resistance
    Lin Liu
    University of California San Diego, La Jolla, California 92093 0679, USA
    AIDS 22:835-9. 2008
  10. doi request reprint Dynamics of total, linear nonintegrated, and integrated HIV-1 DNA in vivo and in vitro
    Kersten K Koelsch
    University of California, San Diego, USA
    J Infect Dis 197:411-9. 2008

Detail Information

Publications41

  1. pmc Viral dynamics of acute HIV-1 infection
    S J Little
    Department of Medicine, University of California San Diego, San Diego, California 92103, USA
    J Exp Med 190:841-50. 1999
    ..These measurements provide a basis for comparison of vaccine and other strategies and support the validity of the simian immunodeficiency virus macaque model of acute HIV infection...
  2. ncbi request reprint Reduced antiretroviral drug susceptibility among patients with primary HIV infection
    S J Little
    Department of Medicine, University of California, San Diego, USA
    JAMA 282:1142-9. 1999
    ..The transmission of drug-resistant human immunodeficiency virus (HIV) has been documented, but the prevalence of such transmission is unknown...
  3. ncbi request reprint Transmission and prevalence of HIV resistance among treatment-naive subjects
    S J Little
    Department of Medicine, University of California San Diego, USA
    Antivir Ther 5:33-40. 2000
    ....
  4. ncbi request reprint Antiretroviral-drug resistance among patients recently infected with HIV
    Susan J Little
    Antiviral Research Center, Department of Medicine, University of California San Diego, San Diego 92103, USA
    N Engl J Med 347:385-94. 2002
    ..Among persons in North America who are newly infected with the human immunodeficiency virus (HIV), the prevalence of transmitted resistance to antiretroviral drugs has been estimated at 1 to 11 percent...
  5. pmc Persistence of transmitted drug resistance among subjects with primary human immunodeficiency virus infection
    Susan J Little
    Department of Medicine, University of California, San Diego, San Diego, California, USA
    J Virol 82:5510-8. 2008
    ..The prolonged persistence of transmitted drug resistance strongly supports the routine use of HIV resistance genotyping for all newly diagnosed individuals...
  6. ncbi request reprint Transmission behaviors of recently HIV-infected men who have sex with men
    Pamina M Gorbach
    Department of Epidemiology, School of Public Health and Division of Infections Diseases, David Geffen School of Medicine, University of California, Los Angeles UCLA, Los Angeles, CA 90095 1772, USA
    J Acquir Immune Defic Syndr 42:80-5. 2006
    ..Analyze postdiagnosis behaviors of recently HIV-infected men who have sex with men (MSM)...
  7. pmc Estimating selection pressures on HIV-1 using phylogenetic likelihood models
    S L Kosakovsky Pond
    Department of Pathology, University of California, San Diego, CA 92093, USA
    Stat Med 27:4779-89. 2008
    ..To illustrate our methods, we present an analysis of compartment-specific evolution of HIV-1 env in blood and cerebrospinal fluid and of site-to-site variation in the gag gene of subtype C HIV-1...
  8. doi request reprint Antiretroviral drug resistance and risk behavior among recently HIV-infected men who have sex with men
    Pamina M Gorbach
    Department of Epidemiology, School of Public Health, University of California, Los Angeles, Los Angeles, CA 90095 7353, USA
    J Acquir Immune Defic Syndr 47:639-43. 2008
    ..Examine associations among behaviors including substance use during sexual encounters, and transmitted HIV drug resistance in recently HIV-infected men who have sex with men (MSM)...
  9. pmc Comparison of algorithms that interpret genotypic HIV-1 drug resistance to determine the prevalence of transmitted drug resistance
    Lin Liu
    University of California San Diego, La Jolla, California 92093 0679, USA
    AIDS 22:835-9. 2008
    ..We compared eight genotypic interpretation methods to determine whether the method used would affect the rates of reported transmitted drug resistance...
  10. doi request reprint Dynamics of total, linear nonintegrated, and integrated HIV-1 DNA in vivo and in vitro
    Kersten K Koelsch
    University of California, San Diego, USA
    J Infect Dis 197:411-9. 2008
    ..Recent studies report an association between HIV-1 DNA levels, disease progression, and treatment outcome. However, HIV-1 DNA exists as distinct molecular forms that are not distinguished by conventional assays...
  11. pmc The origins of sexually transmitted HIV among men who have sex with men
    David M Butler
    University of California, San Diego, La Jolla, CA 92093, USA
    Sci Transl Med 2:18re1. 2010
    ....
  12. ncbi request reprint Clade B HIV-1 superinfection with wild-type virus after primary infection with drug-resistant clade B virus
    Kersten K Koelsch
    University of California San Diego, La Jolla, CA 92093, USA
    AIDS 17:F11-6. 2003
    ....
  13. ncbi request reprint Greater CD4 T-cell gains after one year of antiretroviral therapy are associated with lower HIV-1 pol replication capacity
    Jason D Barbour
    Positive Health Program, Department of Medicine, San Francisco General Hospital, University of California, San Francisco, California, USA
    AIDS 20:2123-5. 2006
    ..Viral polRC was measured before starting ART in all subjects. We examined 243 individuals for a median 260 days after initiating ART. Low baseline polRC was associated with greater CD4 T-cell gains independent of virological responses...
  14. ncbi request reprint Transmission fitness of drug-resistant human immunodeficiency virus and the prevalence of resistance in the antiretroviral-treated population
    Andrew J Leigh Brown
    Department of Pathology, University of California, San Diego, California, USA
    J Infect Dis 187:683-6. 2003
    ..It revealed that resistant virus was transmitted only approximately 20% as frequently as expected from these patients. Individuals with primary resistance may become a significant source of resistant strains...
  15. ncbi request reprint Associations between substance use, erectile dysfunction medication and recent HIV infection among men who have sex with men
    Lydia N Drumright
    Division of International Health and Cross Cultural Medicine, Department of Family and Preventive Medicine, School of Medicine, University of California, San Diego, 9500 Gilman Drive, Mail code 0622, La Jolla, CA 92093, USA
    AIDS Behav 13:328-36. 2009
    ..Use of nitrites and amphetamine may increase HIV risk among MSM...
  16. pmc Herpes simplex virus type 2 acquisition during recent HIV infection does not influence plasma HIV levels
    Edward R Cachay
    University of California, San Diego, La Jolla, CA 92103 8681, USA
    J Acquir Immune Defic Syndr 47:592-6. 2008
    ..5 log10 copies/mL over 11 days). The HSV-2 incidence rate was high in our cohort of recently HIV-infected individuals; however, HSV-2 acquisition did not significantly change the plasma HIV dynamics and CD4 cell levels...
  17. ncbi request reprint Long-term persistence of transmitted HIV drug resistance in male genital tract secretions: implications for secondary transmission
    Davey M Smith
    University of California, San Diego, La Jolla, CA 92093 0679, USA
    J Infect Dis 196:356-60. 2007
    ..Transmitted drug-resistant HIV slowly reverts in the blood to drug-sensitive virus. The environment of the male genital tract (MGT) may result in even slower rates of reversion to drug susceptibility...
  18. pmc Herpes simplex virus 2 serostatus and viral loads of HIV-1 in blood and semen as risk factors for HIV transmission among men who have sex with men
    David M Butler
    University of California, San Diego, California, USA
    AIDS 22:1667-71. 2008
    ..We compared the relationships of HIV-1 transmission risk with blood plasma viral load, seminal plasma viral load, herpes simplex virus 2 serostatus and other factors...
  19. pmc A public health model for the molecular surveillance of HIV transmission in San Diego, California
    Davey M Smith
    University of California San Diego, La Jolla, CA 92093 0679, USA
    AIDS 23:225-32. 2009
    ..Here, we investigate how molecular epidemiology can be used to identify highly related HIV networks within a population and how voluntary contact tracing of sexual partners can be used to selectively target these networks...
  20. pmc The use of pooled viral load testing to identify antiretroviral treatment failure
    Davey M Smith
    University of California San Diego, La Jolla, CA 92093 0679, USA
    AIDS 23:2151-8. 2009
    ....
  21. pmc Gene expression before HAART initiation predicts HIV-infected individuals at risk of poor CD4+ T-cell recovery
    Christopher H Woelk
    Department of Medicine, University of California, San Diego, La Jolla, USA
    AIDS 24:217-22. 2010
    ..To identify a pre-HAART gene expression signature in peripheral blood mononuclear cells (PBMCs) predictive of CD4 T-cell recovery during HAART in HIV-infected individuals...
  22. pmc Evaluation of an HIV nucleic acid testing program with automated Internet and voicemail systems to deliver results
    Sheldon R Morris
    Antiviral Research Center, University of California San Diego, 200 Arbor Drive, San Diego, CA 92103, USA
    Ann Intern Med 152:778-85. 2010
    ..Nucleic acid testing (NAT) in routine HIV testing programs can increase the detection of infected individuals, but the most effective implementation of NAT remains unclear...
  23. ncbi request reprint Herpes simplex virus type 2 infection does not influence viral dynamics during early HIV-1 infection
    Edward R Cachay
    University of California, San Diego, La Jolla, CA 92103, USA
    J Infect Dis 195:1270-7. 2007
    ..We sought to compare baseline and longitudinal plasma HIV-1 loads between herpes simplex virus type 2 (HSV-2)-seropositive and -seronegative individuals who are enrolled in a primary HIV-1 infection cohort in San Diego, California...
  24. ncbi request reprint Unprotected anal intercourse and substance use before and after HIV diagnosis among recently HIV-infected men who have sex with men
    Lydia N Drumright
    Antiviral Research Center, Department of Medicine, University of California, San Diego, California, USA
    Sex Transm Dis 34:401-7. 2007
    ..The objective of this study was to assess associations between unprotected anal intercourse (UAI) and substance use before and after HIV diagnosis among recently HIV-infected MSM...
  25. pmc Neutralizing antibody responses drive the evolution of human immunodeficiency virus type 1 envelope during recent HIV infection
    Simon D W Frost
    Department of Pathology, University of California at San Diego, La Jolla, CA 92093 0679, USA
    Proc Natl Acad Sci U S A 102:18514-9. 2005
    ..Our results suggest that autologous neutralizing antibody responses may play a pivotal role in the diversification of HIV-1 envelope during the early stages of infection...
  26. pmc HIV evolution and escape
    Douglas D Richman
    Veterans Affairs San Diego Healthcare System, San Diego, CA 92161 0679, USA
    Trans Am Clin Climatol Assoc 115:289-303. 2004
    ..Certain selective pressures that drive the evolution of HIV include chemotherapy, anatomic compartmentalization and the immune response. Examples of these selective forces on HIV evolution are described...
  27. ncbi request reprint Characteristics of recently HIV-infected men who use the Internet to find male sex partners and sexual practices with those partners
    Davey M Smith
    University of California San Diego, 9500 Gilman Drive 0679, La Jolla, CA 92093, USA
    J Acquir Immune Defic Syndr 43:582-7. 2006
    ....
  28. ncbi request reprint Unprotected anal intercourse and substance use among men who have sex with men with recent HIV infection
    Lydia N Drumright
    Department of Medicine, Antiviral Research Center, University of California, San Diego, CA 92093, USA
    J Acquir Immune Defic Syndr 43:344-50. 2006
    ..To examine within-subjects and combined between- and within-subjects associations between substance use and unprotected anal intercourse (UAI) among men who have sex with men (MSM) with recent HIV infection...
  29. ncbi request reprint Lack of neutralizing antibody response to HIV-1 predisposes to superinfection
    Davey M Smith
    University of California San Diego, La Jolla, CA 92093 0679, USA
    Virology 355:1-5. 2006
    ..These data have considerable implications for vaccine development...
  30. pmc Characterization of human immunodeficiency virus type 1 (HIV-1) envelope variation and neutralizing antibody responses during transmission of HIV-1 subtype B
    Simon D W Frost
    UCSD Antiviral Research Center, 150 W Washington St, Suite 100, San Diego, CA 92103, USA
    J Virol 79:6523-7. 2005
    ..We suggest that limited genetic variation within the infecting host reduces the likelihood of selective transmission of neutralization-sensitive HIV...
  31. ncbi request reprint HIV drug resistance acquired through superinfection
    Davey M Smith
    University of California San Diego, USA
    AIDS 19:1251-6. 2005
    ..We report an individual initially infected with a drug-sensitive clade B strain of HIV who was superinfected with another clade B strain resistant to two classes of antiretroviral drugs...
  32. ncbi request reprint HIV superinfection
    Davey M Smith
    University of California, San Diego, 92093, USA
    J Infect Dis 192:438-44. 2005
    ..Here, we review the current understanding of HIV superinfection...
  33. pmc Rapid evolution of the neutralizing antibody response to HIV type 1 infection
    Douglas D Richman
    Department of Pathology, Veterans Affairs San Diego Healthcare System and the University of California at San Diego, La Jolla, CA 92093 0679, USA
    Proc Natl Acad Sci U S A 100:4144-9. 2003
    ..These data argue that neutralizing antibody responses account for the extensive variation in the envelope gene that is observed in the early months after primary HIV infection...
  34. pmc Maintenance of Nef-mediated modulation of major histocompatibility complex class I and CD4 after sexual transmission of human immunodeficiency virus type 1
    C M Noviello
    Biomedical Sciences Graduate Program, Department of Medicine, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093, USA
    J Virol 81:4776-86. 2007
    ..These data suggest that both functions are important for the successful establishment of infection in a new host...
  35. ncbi request reprint The prostate as a reservoir for HIV-1
    Davey M Smith
    Department of Medicine, University of California, San Diego, CA, USA
    AIDS 18:1600-2. 2004
    ..Six of the nine participants had undetectable seminal plasma(SP) HIV RNA in all samples without previous PM, but had detectable SP HIV RNA (> 25 copies/ml) in one to three samples collected after PM...
  36. doi request reprint A case cluster demonstrating the relationship between HLA concordance and virologic and disease outcomes in human immunodeficiency virus infection
    A Chaillon
    University of California, San Diego, La Jolla, CA, USA Inserm UMR U966, Tours, France Electronic address
    Virology 449:104-8. 2014
    ..We suggest that non-viral factors, which might be related to differences in the HLA profile, played a role in determining different CD4+ T-cells dynamics for these two recipients. ..
  37. ncbi request reprint Effect of treatment, during primary infection, on establishment and clearance of cellular reservoirs of HIV-1
    Matthew C Strain
    Department of Physics, University of California at San Diego, La Jolla, California, USA
    J Infect Dis 191:1410-8. 2005
    ..1 IUPM; P<.0005). These results suggest that treatment <6 months after seroconversion may facilitate long-term control of cellular reservoirs that maintain HIV-1 infection during treatment...
  38. pmc Human immunodeficiency virus type 1 clade B superinfection: evidence for differential immune containment of distinct clade B strains
    Otto O Yang
    37 121 Center for Health Sciences, Division of Infectious Diseases, 10833 LeConte Ave, UCLA Medical Center, Los Angeles, CA 90095, USA
    J Virol 79:860-8. 2005
    ..In conclusion, the rapid overgrowth of a superinfecting strain of HIV-1 of the same subtype raises major concerns for effective vaccine development...
  39. ncbi request reprint Incidence of HIV superinfection following primary infection
    Davey M Smith
    JAMA 292:1177-8. 2004
  40. pmc Genetic basis of hypersusceptibility to protease inhibitors and low replicative capacity of human immunodeficiency virus type 1 strains in primary infection
    Andrew J Leigh Brown
    University of Edinburgh, Edinburgh, Scotland
    J Virol 78:2242-6. 2004
    ..This supports the view that variation in PR function is directly responsible for variation in fitness among strains in primary infection...
  41. ncbi request reprint HIV treatment decisions and transmitted drug resistance
    Susan J Little
    Clin Infect Dis 41:233-5. 2005