Research Topics
| R R LittleSummaryAffiliation: University of Missouri Country: USA Publications
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Detail Information
Publications
The importance of precision for hemoglobin A1c measurementRandie R Little
Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, Missouri 65212, USA
Diabetes Technol Ther 5:979-81. 2003- Effects of hemoglobin C and S traits on eight glycohemoglobin methodsWilliam L Roberts
University of Utah, Department of Pathology, Salt Lake City, UT 84132, USA
Clin Chem 48:383-5. 2002 
Measurement of Hba(1C) in patients with chronic renal failureRandie R Little
Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, One Hospital Dr, Columbia, MO 65212, United States Electronic address
Clin Chim Acta 418:73-6. 2013..There is also concern that HbA1c may give low results in these patients due to shortened erythrocyte survival...- The long and winding road to optimal HbA1c measurementRandie R Little
Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, One Hospital Dr, Columbia, MO, United States Electronic address
Clin Chim Acta 418:63-71. 2013..Here, we review the past, present and future of HbA1c standardization and describe the current status of HbA1c testing, including limitations that healthcare providers need to be aware of when interpreting HbA1c results... 
Analysis of the accuracy and precision of the Axis-Shield Afinion hemoglobin A1c measurement deviceRandie R Little
Department of Pathology and Anatomical Sciences, Columbia, Missouri 65212, USA
J Diabetes Sci Technol 6:387-8. 2012..Although they conclude that the Afinion exhibits adequate performance, they do not evaluate lot-to-lot variability. As with laboratory methods, potential assay interferences must also be considered...- Usefulness of glycated albumin assay for diabetes monitoringRandie R Little
Department of Pathology and Anatomical Sciences, Columbia School of Medicine, University of Missouri, Columbia, Missouri 65212, USA
J Diabetes Sci Technol 5:1463-5. 2011..Once the utility of glycated albumin measurement is clearly defined and its use is accepted for diabetes care, standardization may be warranted... - Validation by a mass spectrometric reference method of use of boronate affinity chromatography to measure glycohemoglobin in the presence of hemoglobin S and C traitsRandie R Little
University of Missouri-Columbia School of Medicine, Department of Pathology and Anatomical Sciences, Columbia, MO 65212, USA
Clin Chem 51:264-5. 2005 - Effects of sample storage conditions on glycated hemoglobin measurement: evaluation of five different high performance liquid chromatography methodsRandie R Little
Department of Pathology, University of Missouri School of Medicine, Columbia, Missouri 65212, USA
Diabetes Technol Ther 9:36-42. 2007..Glycated hemoglobin, reported as hemoglobin A1c (HbA1c), is widely used as a measure of long-term glycemic control in patients with diabetes. The accuracy of measurements depends in part on proper storage of the sample prior to analysis... - Standardization of C-peptide measurementsRandie R Little
Diabetes Diagnostic Laboratory, Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, MO 65212, USA
Clin Chem 54:1023-6. 2008..We assessed within- and between-laboratory imprecision of C-peptide assays and determined whether serum calibrators with values assigned by mass spectrometry could be used to harmonize C-peptide results... - Effects of hemoglobin (Hb) E and HbD traits on measurements of glycated Hb (HbA1c) by 23 methodsRandie R Little
Department of Pathology and Anatomical Sciences, University of Missouri Columbia School of Medicine, Columbia, MO 65212, USA
Clin Chem 54:1277-82. 2008..HbE and HbD are the second and fourth most common Hb variants worldwide. We investigated the accuracy of HbA(1c) measurement in the presence of HbE and/or HbD traits... - A review of variant hemoglobins interfering with hemoglobin A1c measurementRandie R Little
Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, MO 65212, USA
J Diabetes Sci Technol 3:446-51. 2009..Laboratorians should be aware of the limitations of their method with respect to these interferences... - Glycated hemoglobin standardization--National Glycohemoglobin Standardization Program (NGSP) perspectiveRandie R Little
Department of Pathology, University of Missouri School of Medicine, Columbia, MO 65212, USA
Clin Chem Lab Med 41:1191-8. 2003..8% HbA1c from the NGSP target at all HbA1c concentrations. The vast majority of laboratories in the US are now reporting results that are traceable to DCCT/UKPDS outcomes... - Analysis of point-of-care and over-the-counter testing methods for hemoglobin A1c: how good do they need to be?Randie R Little
Department of Pathology and Anatomical Sciences, University of Missouri Columbia School of Medicine, Columbia, Missouri 65212, USA
J Diabetes Sci Technol 4:1504-6. 2010.... - Status of hemoglobin A1c measurement and goals for improvement: from chaos to order for improving diabetes careRandie R Little
Diabetes Diagnostic Laboratory M767, Department of Pathology and Anatomical Sciences, University of Missouri Columbia School of Medicine, Columbia, MO 65212, USA
Clin Chem 57:205-14. 2011..The National Glycohemoglobin Standardization Program (NGSP) was implemented in 1996 to standardize Hb A(1c) results to those of the DCCT/UKPDS... - Can glycohemoglobin be used to assess glycemic control in patients with chronic renal failure?Randie R Little
Department of Child Health, University of Missouri School of Medicine, 1 Hospital Dr, Columbia, MO 65212, USA
Clin Chem 48:784-6. 2002 - The national glycohemoglobin standardization program: a five-year progress reportR R Little
Department of Child Health, University of Missouri School of Medicine, 1 Hospital Dr, Columbia, MO 65212, USA
Clin Chem 47:1985-92. 2001..For most certified methods in 2000, between-laboratory CVs were <5%. For all certified methods in 2000, the mean percent HbA(1c) was within 0.8% HbA(1c) of the NGSP target at all HbA(1c) concentrations... - Analysis: point-of-care testing for glycated hemoglobin (GHB)Randie R Little
Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, Missouri 65212, USA
Diabetes Technol Ther 7:913-5. 2005 - Use of GHb (HbA1c) in screening for undiagnosed diabetes in the U.S. populationC L Rohlfing
Department of Child Health, University of Missouri School of Medicine, Columbia 65203, USA
Diabetes Care 23:187-91. 2000..To evaluate the use of GHb as a screening test for undiagnosed diabetes (fasting plasma glucose > or =7.0 mmol/l) in a representative sample of the U.S. population... - Defining the relationship between plasma glucose and HbA(1c): analysis of glucose profiles and HbA(1c) in the Diabetes Control and Complications TrialCurt L Rohlfing
Department of Child Health, University of Missouri School of Medicine, 1 Hospital Drive M772, Columbia, MO 65203, USA
Diabetes Care 25:275-8. 2002..To define the relationship between HbA(1c) and plasma glucose (PG) levels in patients with type 1 diabetes using data from the Diabetes Control and Complications Trial (DCCT)... - Effects of hemoglobin C and S traits on glycohemoglobin measurements by eleven methodsWilliam L Roberts
Department of Pathology, ARUP Institute for Clinical and Experimental Pathology, University of Utah, Salt Lake City, UT 84108, USA
Clin Chem 51:776-8. 2005 - HbA1c: how do we measure it and what does it mean?Randie R Little
Department of Pathology and Anatomical Sciences, University of Missouri School of Medicine, Columbia, Missouri, USA
Curr Opin Endocrinol Diabetes Obes 16:113-8. 2009..Description of recent developments in the standardization of HbA1c measurement and interpretation of HbA1c results... - Effects of hemoglobin C and S traits on the results of 14 commercial glycated hemoglobin assaysShella K Mongia
Department of Pathology, University of Utah, Salt Lake City, UT, USA
Am J Clin Pathol 130:136-40. 2008..6% at 6% HbA1c). One immunoassay method exhibited clinically significant differences owing to the presence of HbC and HbS traits... - Tests of glycemia in diabetesDavid E Goldstein
Department of Child Health, University of Missouri School of Medicine, Columbia, MO 65212, USA
Diabetes Care 27:1761-73. 2004 - The effect of elevated fetal hemoglobin on hemoglobin A1c results: five common hemoglobin A1c methods compared with the IFCC reference methodCurt L Rohlfing
Departments of Pathology and Anatomical Sciences, Child Health and Medicine, University of Missouri, Columbia School of Medicine, Columbia, MO 65212, USA
Am J Clin Pathol 129:811-4. 2008..Physicians and laboratory professionals need to be aware of potential interference from elevated HbF levels that could affect HbA1c results, including those from boronate-affinity methods... - Effects of beta thalassemia minor on results of six glycated hemoglobin methodsChristopher Polage
Department of Pathology, University of Utah, Salt Lake City, UT 84132, USA
Clin Chim Acta 350:123-8. 2004..However, the Synchron methods yielded higher results for samples with lower hemoglobin concentrations, like those that can be seen in BTM. The Synchron method was improved at the end of 2003, which minimized this problem... - International comparison of C-peptide measurementsHsiao Mei Wiedmeyer
Department of Pathology and Anatomical Sciences, University of Missouri Columbia School of Medicine, Columbia, MO 65212, USA
Clin Chem 53:784-7. 2007..We assessed the comparability of C-peptide results obtained with different methods and by different laboratories and determined whether C-peptide results could be harmonized by normalization with a WHO reference reagent or with plasma... - Determination of glycated hemoglobin in clinically silent hemoglobin variantsWolfgang J Schnedl
Department of Internal Medicine, Medical University, School of Medicine, Graz, Austria
Diabetes Metab Res Rev 20:460-5. 2004..Evaluation of glycated hemoglobin determination methods in patients with clinically silent hemoglobin variants... - Trends in A1C concentrations among U.S. adults with diagnosed diabetes from 1999 to 2004Earl S Ford
Division of Adult and Community Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA
Diabetes Care 31:102-4. 2008 - Tests of glycemia in diabetesDavid E Goldstein
Diabetes Care 26:S106-8. 2003 - Laboratory testing for glycated hemoglobin in the general community: are we following the clinical recommendations?Todd S Harwell
Diabetes Technol Ther 4:859-61. 2002 - Testing for microalbuminuria in 2002: barriers to implementing current guidelinesTodd S Harwell
Montana Department of Public Health and Human Services, Helena, MT 59620 2951, USA
Am J Kidney Dis 42:245-8. 2003..Testing for microalbuminuria is recommended to detect early kidney damage in patients with diabetes or other diseases. However, few studies have examined laboratory practices for microalbuminuria testing in the general community... - Tests of glycemia in diabetesDavid E Goldstein
Diabetes Care 27:S91-3. 2004 - Global standardization of glycated hemoglobin measurement: the position of the IFCC Working GroupAndrea Mosca
Centre for Metrological Traceability in Laboratory Medicine CIRME, Dept Science and Biomedical Technology, University of Milano, Italy
Clin Chem Lab Med 45:1077-80. 2007..The IFCC WG-HbA1c recommends maintaining the use of the name HbA1c in clinical practice... - Trends in hyperinsulinemia among nondiabetic adults in the U.SChaoyang Li
Centers for Disease Control and Prevention, 4770 Buford Hwy, MS K66, Atlanta, GA 30341, USA
Diabetes Care 29:2396-402. 2006..Our aim was to assess the trends in the mean concentrations of fasting serum insulin and the prevalence of hyperinsulinemia among nondiabetic adults during the periods of 1988-1994 and 1999-2002 in the U.S...