KARLEY LITTLE

Summary

Affiliation: University of Michigan
Country: USA

Publications

  1. ncbi Lack of dopamine receptor agonists effect on striatal dopamine transporter binding sites
    K Y Little
    Department of Psychiatry, University of Michigan, Ann Arbor 48109, USA
    Brain Res 742:313-6. 1996
  2. ncbi Loss of striatal vesicular monoamine transporter protein (VMAT2) in human cocaine users
    Karley Y Little
    Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA
    Am J Psychiatry 160:47-55. 2003
  3. ncbi Cocaine induction of dopamine transporter trafficking to the plasma membrane
    Karley Y Little
    Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA
    Mol Pharmacol 61:436-45. 2002
  4. ncbi Striatal dopaminergic abnormalities in human cocaine users
    K Y Little
    Department of Psychiatry, University of Michigan, Ann Arbor VA Medical Center 48105, USA
    Am J Psychiatry 156:238-45. 1999
  5. ncbi Brain dopamine transporter messenger RNA and binding sites in cocaine users: a postmortem study
    K Y Little
    Department of Psychiatry, University of Michigan, and Ann Arbor Veterans Affairs Medical Center, 48105, USA
    Arch Gen Psychiatry 55:793-9. 1998
  6. ncbi Striatal [125I]RTI-55 binding sites in cocaine-abusing humans
    K Y Little
    Department of Psychiatry, University of Michigan, Ann Arbor, USA
    Prog Neuropsychopharmacol Biol Psychiatry 22:455-66. 1998
  7. ncbi Cocaine, ethanol, and genotype effects on human midbrain serotonin transporter binding sites and mRNA levels
    K Y Little
    Department of Psychiatry, University of Michigan, Ann Arbor, USA
    Am J Psychiatry 155:207-13. 1998
  8. ncbi Lack of pineal beta-adrenergic receptor alterations in suicide victims with major depression
    K Y Little
    Department of Psychiatry, University of Michigan School of Medicine, Ann Arbor, USA
    Psychoneuroendocrinology 22:53-62. 1997
  9. ncbi Fluoxetine-induced alterations in human platelet serotonin transporter expression: serotonin transporter polymorphism effects
    Karley Y Little
    Department of Psychiatry, University of Michigan and Ann Arbor VAMC, Ann Arbor, MI 48105, USA
    J Psychiatry Neurosci 31:333-9. 2006
  10. ncbi Serotonin transporter promoter polymorphism, peripheral indexes of serotonin function, and personality measures in families with alcoholism
    Scott F Stoltenberg
    University of Michigan Addiction Research Center and Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48108, USA
    Am J Med Genet 114:230-4. 2002

Research Grants

  1. Brain dopamine alterations in human cocaine users
    KARLEY LITTLE; Fiscal Year: 2006

Detail Information

Publications10

  1. ncbi Lack of dopamine receptor agonists effect on striatal dopamine transporter binding sites
    K Y Little
    Department of Psychiatry, University of Michigan, Ann Arbor 48109, USA
    Brain Res 742:313-6. 1996
    ..Analysis of the results indicated that quinpirole and apomorphine administration did not alter DAT cocaine binding sites...
  2. ncbi Loss of striatal vesicular monoamine transporter protein (VMAT2) in human cocaine users
    Karley Y Little
    Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA
    Am J Psychiatry 160:47-55. 2003
    ..The hypothesis that human cocaine users lose vesicular monoamine transporter (VMAT2) protein was tested in striatal samples from cocaine users and age-, sex-, and postmortem interval-matched comparison subjects...
  3. ncbi Cocaine induction of dopamine transporter trafficking to the plasma membrane
    Karley Y Little
    Department of Psychiatry, University of Michigan, Ann Arbor, Michigan, USA
    Mol Pharmacol 61:436-45. 2002
    ..The present model system may further our understanding of regulatory alterations in DAT radioligand binding and function caused by cocaine exposure...
  4. ncbi Striatal dopaminergic abnormalities in human cocaine users
    K Y Little
    Department of Psychiatry, University of Michigan, Ann Arbor VA Medical Center 48105, USA
    Am J Psychiatry 156:238-45. 1999
    ..Previous inconsistencies in results were perhaps related to selective radioligand affinity changes or a coexisting loss of dopamine neurons...
  5. ncbi Brain dopamine transporter messenger RNA and binding sites in cocaine users: a postmortem study
    K Y Little
    Department of Psychiatry, University of Michigan, and Ann Arbor Veterans Affairs Medical Center, 48105, USA
    Arch Gen Psychiatry 55:793-9. 1998
    ..The present experiment tested the hypothesis in cocaine-using humans that synthesis of midbrain DAT messenger RNA increases parallel with increased striatal DAT binding sites...
  6. ncbi Striatal [125I]RTI-55 binding sites in cocaine-abusing humans
    K Y Little
    Department of Psychiatry, University of Michigan, Ann Arbor, USA
    Prog Neuropsychopharmacol Biol Psychiatry 22:455-66. 1998
    ..4. Evidence from the present and earlier experiments suggests that cocaine exposure may induce conformational changes in the dopamine transporter...
  7. ncbi Cocaine, ethanol, and genotype effects on human midbrain serotonin transporter binding sites and mRNA levels
    K Y Little
    Department of Psychiatry, University of Michigan, Ann Arbor, USA
    Am J Psychiatry 155:207-13. 1998
    ..The present investigation tested the hypothesis that brain serotonin transporter function is altered in chronic users of ethanol and cocaine, which might be related to a common serotonin transporter promoter polymorphism...
  8. ncbi Lack of pineal beta-adrenergic receptor alterations in suicide victims with major depression
    K Y Little
    Department of Psychiatry, University of Michigan School of Medicine, Ann Arbor, USA
    Psychoneuroendocrinology 22:53-62. 1997
    ..No differences in beta-adrenergic receptors were detected between subjects with major depression compared to the matched controls...
  9. ncbi Fluoxetine-induced alterations in human platelet serotonin transporter expression: serotonin transporter polymorphism effects
    Karley Y Little
    Department of Psychiatry, University of Michigan and Ann Arbor VAMC, Ann Arbor, MI 48105, USA
    J Psychiatry Neurosci 31:333-9. 2006
    ..This effect could be related to an individual's genotype for an SERT promoter polymorphism (human serotonin transporter coding [5-HTTLPR]). We aimed to determine the effects of fluoxetine exposure on human platelet SERT levels...
  10. ncbi Serotonin transporter promoter polymorphism, peripheral indexes of serotonin function, and personality measures in families with alcoholism
    Scott F Stoltenberg
    University of Michigan Addiction Research Center and Department of Psychiatry, University of Michigan, Ann Arbor, Michigan 48108, USA
    Am J Med Genet 114:230-4. 2002
    ..The results of this pilot study suggest that further work should examine the mediation of the genetic effects on personality traits by biochemical measures and their moderation by gender...

Research Grants4

  1. Brain dopamine alterations in human cocaine users
    KARLEY LITTLE; Fiscal Year: 2006
    ..Goal #4 is to confirm these increases and determine if induction of related genes occurs in human cocaine users. Specific Aim # 4 is to test the hypotheses that COX-1, NHE-1 and related mRNA's are increased in dopamine neurons. ..