Lawrence Litt

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint Temperature control of respiring rat brain slices during high field NMR spectroscopy
    Lawrence Litt
    Department of Anesthesia, University of California, San Francisco, CA 94143, USA
    Brain Res Brain Res Protoc 10:191-8. 2003
  2. ncbi request reprint Pyruvate improves recovery after PARP-1-associated energy failure induced by oxidative stress in neonatal rat cerebrocortical slices
    Jianying Zeng
    Department of Anesthesia, University of California at San Francisco, 94143 0648, USA
    J Cereb Blood Flow Metab 27:304-15. 2007
  3. ncbi request reprint Exogenous ethyl pyruvate versus pyruvate during metabolic recovery after oxidative stress in neonatal rat cerebrocortical slices
    Jianying Zeng
    Department of Anesthesia and Perioperative Care, The University of California, San Francisco, CA, USA
    Anesthesiology 107:630-40. 2007
  4. pmc Outcome-related metabolomic patterns from 1H/31P NMR after mild hypothermia treatments of oxygen-glucose deprivation in a neonatal brain slice model of asphyxia
    Jia Liu
    Department of Anesthesia, University of California, San Francisco, California 94143 0648, USA
    J Cereb Blood Flow Metab 31:547-59. 2011
  5. pmc Fructose-1,6-bisphosphate does not preserve ATP in hypoxic-ischemic neonatal cerebrocortical slices
    Jia Liu
    Department of Anesthesia and Perioperative Medicine, The University of California San Francisco, San Francisco, CA 94143, USA
    Brain Res 1238:230-8. 2008
  6. ncbi request reprint PI3K inhibition in neonatal rat brain slices during and after hypoxia reduces phospho-Akt and increases cytosolic cytochrome c and apoptosis
    Kiyoshi Hirai
    Department of Anesthesia, University of California, San Francisco, 521 Parnassus Avenue, Room C455, San Francisco, CA 94143 0648, USA
    Brain Res Mol Brain Res 124:51-61. 2004
  7. pmc 1H nuclear magnetic resonance brain metabolomics in neonatal mice after hypoxia-ischemia distinguished normothermic recovery from mild hypothermia recoveries
    Jia Liu
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, California, USA
    Pediatr Res 74:170-9. 2013
  8. ncbi request reprint Using 31P NMR spectroscopy at 14.1 Tesla to investigate PARP-1 associated energy failure and metabolic rescue in cerebrocortical slices
    Jianying Zeng
    Department of Anesthesia, University of California at San Francisco, San Francisco, California 94143 0648, USA
    J Bioenerg Biomembr 36:415-9. 2004
  9. ncbi request reprint Cytochrome c associated apoptosis during ATP recovery after hypoxia in neonatal rat cerebrocortical slices
    Kiyoshi Hirai
    Department of Anesthesia, University of California, San Francisco, San Francisco, California 94143 0648, USA
    J Neurochem 83:309-19. 2002
  10. pmc Metabolomics of oxidative stress in recent studies of endogenous and exogenously administered intermediate metabolites
    Jia Liu
    Department of Anesthesia, University of California, San Francisco, CA 94143, USA E Mails J L M K
    Int J Mol Sci 12:6469-501. 2011

Collaborators

Detail Information

Publications15

  1. ncbi request reprint Temperature control of respiring rat brain slices during high field NMR spectroscopy
    Lawrence Litt
    Department of Anesthesia, University of California, San Francisco, CA 94143, USA
    Brain Res Brain Res Protoc 10:191-8. 2003
    ..All brain slices have an 'injury layer' approximately 50-microm thick from mechanical shear. In our protocol the injury layer is confined to one side of the slice, and appears to contribute minimally to NMR spectra...
  2. ncbi request reprint Pyruvate improves recovery after PARP-1-associated energy failure induced by oxidative stress in neonatal rat cerebrocortical slices
    Jianying Zeng
    Department of Anesthesia, University of California at San Francisco, 94143 0648, USA
    J Cereb Blood Flow Metab 27:304-15. 2007
    ..Pyruvate superfusion of PARP-injured brain slices helps replenish NAD(+) while providing metabolic fuel. Although this augments recovery, a strong antioxidant role for pyruvate has not been ruled out...
  3. ncbi request reprint Exogenous ethyl pyruvate versus pyruvate during metabolic recovery after oxidative stress in neonatal rat cerebrocortical slices
    Jianying Zeng
    Department of Anesthesia and Perioperative Care, The University of California, San Francisco, CA, USA
    Anesthesiology 107:630-40. 2007
    ..The authors used an acute rat brain slice preparation to compare EP and pyruvate rescue after H(2)O(2) oxidative stress, asking whether EP was again better and whether its actions were exclusively metabolic...
  4. pmc Outcome-related metabolomic patterns from 1H/31P NMR after mild hypothermia treatments of oxygen-glucose deprivation in a neonatal brain slice model of asphyxia
    Jia Liu
    Department of Anesthesia, University of California, San Francisco, California 94143 0648, USA
    J Cereb Blood Flow Metab 31:547-59. 2011
    ..The findings suggest a potential role for metabolomic monitoring during therapeutic hypothermia...
  5. pmc Fructose-1,6-bisphosphate does not preserve ATP in hypoxic-ischemic neonatal cerebrocortical slices
    Jia Liu
    Department of Anesthesia and Perioperative Medicine, The University of California San Francisco, San Francisco, CA 94143, USA
    Brain Res 1238:230-8. 2008
    ..Exogenous FBP did not provide protection or enter glycolysis. Its use as an antioxidant might be worth studying at higher FBP concentrations...
  6. ncbi request reprint PI3K inhibition in neonatal rat brain slices during and after hypoxia reduces phospho-Akt and increases cytosolic cytochrome c and apoptosis
    Kiyoshi Hirai
    Department of Anesthesia, University of California, San Francisco, 521 Parnassus Avenue, Room C455, San Francisco, CA 94143 0648, USA
    Brain Res Mol Brain Res 124:51-61. 2004
    ..The data support prominent roles for Bad phosphorylation in phospho-Akt's reduction of cyt c apoptosis, and possible apoptotic roles at mitochondrial targets of Bad...
  7. pmc 1H nuclear magnetic resonance brain metabolomics in neonatal mice after hypoxia-ischemia distinguished normothermic recovery from mild hypothermia recoveries
    Jia Liu
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, California, USA
    Pediatr Res 74:170-9. 2013
    ....
  8. ncbi request reprint Using 31P NMR spectroscopy at 14.1 Tesla to investigate PARP-1 associated energy failure and metabolic rescue in cerebrocortical slices
    Jianying Zeng
    Department of Anesthesia, University of California at San Francisco, San Francisco, California 94143 0648, USA
    J Bioenerg Biomembr 36:415-9. 2004
    ..It appears possible to use brain slices to quantitatively study PARP-related, NAD-associated energy failure, and rescue with TCA metabolites...
  9. ncbi request reprint Cytochrome c associated apoptosis during ATP recovery after hypoxia in neonatal rat cerebrocortical slices
    Kiyoshi Hirai
    Department of Anesthesia, University of California, San Francisco, San Francisco, California 94143 0648, USA
    J Neurochem 83:309-19. 2002
    ..At all time points after hypoxia the primary injury was cytochrome c associated apoptosis...
  10. pmc Metabolomics of oxidative stress in recent studies of endogenous and exogenously administered intermediate metabolites
    Jia Liu
    Department of Anesthesia, University of California, San Francisco, CA 94143, USA E Mails J L M K
    Int J Mol Sci 12:6469-501. 2011
    ..All, however, shared the common goal of ultimately developing "omics"-based, diagnostic tests to help influence therapies...
  11. ncbi request reprint Awareness without recall during anesthesia for electroconvulsive therapy
    Lawrence Litt
    Anesthesia Department, University of California, San Francisco, California 94143 0648, USA
    Anesthesiology 106:871-2. 2007
  12. ncbi request reprint Arterial catheter pressure cable corrosion leading to artifactual diagnosis of hypotension
    Kimberly Skidmore
    Department of Anesthesia and Perioperative Care, University of California San Francisco, Box 0427, 513 Parnassus Avenue, San Francisco, CA 94143 0427, USA
    Anesth Analg 95:1192-5, table of contents. 2002
    ..Arterial pressure cable corrosion leads to artifactual hypotension despite a normally appearing waveform...
  13. ncbi request reprint Physiologic monitoring and anesthesia considerations in acute ischemic stroke
    Chanhung Z Lee
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, San Francisco, California 94110, USA
    J Vasc Interv Radiol 15:S13-9. 2004
    ..Issues specific to anesthesia monitoring and management in the radiology suite are emphasized...
  14. doi request reprint Anesthetic concerns in patients with known cerebrovascular insufficiency
    Anna V Logvinova
    Department of Anesthesia and Perioperative Care, University of California, San Francisco, 1001 Potrero Avenue, San Francisco, CA 94110, USA
    Anesthesiol Clin 28:1-12. 2010
    ..Planning the anesthetic and perioperative management is predicated on understanding the goals of the therapeutic intervention and anticipating potential problems...
  15. ncbi request reprint Comparison of the effects of cyclosporin a on the metabolism of perfused rat brain slices during normoxia and hypoxia
    Natalie Serkova
    Department of Biology and Chemistry, University of Bremen, Bremen, Germany
    J Cereb Blood Flow Metab 22:342-52. 2002
    ..Whether the overall effect was a reduction or protection of cell energy metabolism depended on the concentrations of both oxygen and cyclosporin A in the buffer solution...