Adrian Liston

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. doi request reprint Unravelling the association of partial T-cell immunodeficiency and immune dysregulation
    Adrian Liston
    John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia
    Nat Rev Immunol 8:545-58. 2008
  2. ncbi request reprint Tracing the action of IL-2 in tolerance to islet-specific antigen
    Adrian Liston
    Immunogenomics Laboratory, John Curtin School of Medical Research and The Australian Phenomics Facility, The Australian National University, Canberra 2601, Australia
    Immunol Cell Biol 85:338-42. 2007
  3. pmc Differentiation of regulatory Foxp3+ T cells in the thymic cortex
    Adrian Liston
    John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory 0200, Australia
    Proc Natl Acad Sci U S A 105:11903-8. 2008
  4. pmc Impairment of organ-specific T cell negative selection by diabetes susceptibility genes: genomic analysis by mRNA profiling
    Adrian Liston
    John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2601, Australia
    Genome Biol 8:R12. 2007
  5. pmc Gene dosage--limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity
    Adrian Liston
    John Curtin School of Medical Research, The Australian Phenomics Facility, The Australian National University, Canberra 2601, Australia
    J Exp Med 200:1015-26. 2004
  6. ncbi request reprint Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim
    Adrian Liston
    Immunogenomics Laboratory, John Curtin School of Medical Research and The Australian Phenomics Facility, The Australian National University, Canberra, 2601, Australia
    Immunity 21:817-30. 2004
  7. ncbi request reprint Genetic lesions in T-cell tolerance and thresholds for autoimmunity
    Adrian Liston
    John Curtin School of Medical Research and The Australian Phenomics Facility, The Australian National University, Canberra, ACT 2601, Australia
    Immunol Rev 204:87-101. 2005
  8. ncbi request reprint Genetic lesions in thymic T cell clonal deletion and thresholds for autoimmunity
    Adrian Liston
    John Curtin School of Medical Research, The Australian Phenomics Facility, The Australian National University, Canberra, ACT 2601, Australia
    Novartis Found Symp 267:180-92; discussion 192-9. 2005
  9. pmc Decreased T-cell receptor signaling through CARD11 differentially compromises forkhead box protein 3-positive regulatory versus T(H)2 effector cells to cause allergy
    John A Altin
    Department of Immunology, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    J Allergy Clin Immunol 127:1277-85.e5. 2011
  10. pmc Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions
    Owen M Siggs
    John Curtin School of Medical Research and Australian Phenomics Facility, The Australian National University, Canberra 2601, Australia
    Immunity 27:912-26. 2007

Detail Information

Publications19

  1. doi request reprint Unravelling the association of partial T-cell immunodeficiency and immune dysregulation
    Adrian Liston
    John Curtin School of Medical Research, Australian National University, Canberra, ACT 0200, Australia
    Nat Rev Immunol 8:545-58. 2008
    ....
  2. ncbi request reprint Tracing the action of IL-2 in tolerance to islet-specific antigen
    Adrian Liston
    Immunogenomics Laboratory, John Curtin School of Medical Research and The Australian Phenomics Facility, The Australian National University, Canberra 2601, Australia
    Immunol Cell Biol 85:338-42. 2007
    ....
  3. pmc Differentiation of regulatory Foxp3+ T cells in the thymic cortex
    Adrian Liston
    John Curtin School of Medical Research, Australian National University, Canberra, Australian Capital Territory 0200, Australia
    Proc Natl Acad Sci U S A 105:11903-8. 2008
    ..Instead, multiple accessory cell types probably contribute to the thymic generation of regulatory Foxp3(+) T cells...
  4. pmc Impairment of organ-specific T cell negative selection by diabetes susceptibility genes: genomic analysis by mRNA profiling
    Adrian Liston
    John Curtin School of Medical Research, The Australian National University, Canberra, ACT 2601, Australia
    Genome Biol 8:R12. 2007
    ..negative from positive selection is poorly understood, despite the fact that inherited defects in negative selection underlie organ-specific autoimmune disease in AIRE-deficient people and the non-obese diabetic (NOD) mouse strain..
  5. pmc Gene dosage--limiting role of Aire in thymic expression, clonal deletion, and organ-specific autoimmunity
    Adrian Liston
    John Curtin School of Medical Research, The Australian Phenomics Facility, The Australian National University, Canberra 2601, Australia
    J Exp Med 200:1015-26. 2004
    ....
  6. ncbi request reprint Generalized resistance to thymic deletion in the NOD mouse; a polygenic trait characterized by defective induction of Bim
    Adrian Liston
    Immunogenomics Laboratory, John Curtin School of Medical Research and The Australian Phenomics Facility, The Australian National University, Canberra, 2601, Australia
    Immunity 21:817-30. 2004
    ..These findings establish defects in thymic deletion and Bim induction as a key mechanism in the pathogenesis of autoimmunity...
  7. ncbi request reprint Genetic lesions in T-cell tolerance and thresholds for autoimmunity
    Adrian Liston
    John Curtin School of Medical Research and The Australian Phenomics Facility, The Australian National University, Canberra, ACT 2601, Australia
    Immunol Rev 204:87-101. 2005
    ..These data allow us to propose a model relating efficiency of thymic deletion to T-cell tolerance and susceptibility to autoimmunity...
  8. ncbi request reprint Genetic lesions in thymic T cell clonal deletion and thresholds for autoimmunity
    Adrian Liston
    John Curtin School of Medical Research, The Australian Phenomics Facility, The Australian National University, Canberra, ACT 2601, Australia
    Novartis Found Symp 267:180-92; discussion 192-9. 2005
    ....
  9. pmc Decreased T-cell receptor signaling through CARD11 differentially compromises forkhead box protein 3-positive regulatory versus T(H)2 effector cells to cause allergy
    John A Altin
    Department of Immunology, John Curtin School of Medical Research, Australian National University, Canberra, Australia
    J Allergy Clin Immunol 127:1277-85.e5. 2011
    ....
  10. pmc Opposing functions of the T cell receptor kinase ZAP-70 in immunity and tolerance differentially titrate in response to nucleotide substitutions
    Owen M Siggs
    John Curtin School of Medical Research and Australian Phenomics Facility, The Australian National University, Canberra 2601, Australia
    Immunity 27:912-26. 2007
    ..The pleiotropic functions of ZAP-70 and their differential response to graded variation provide a paradigm for understanding the complex outcomes of human genetic variation...
  11. ncbi request reprint Aire regulates negative selection of organ-specific T cells
    Adrian Liston
    ACRF Genetics Lab, Medical Genome Centre, John Curtin School of Medical Research, The Australian National University, ACT 2601 Australia
    Nat Immunol 4:350-4. 2003
    ..These results indicate that autoimmune polyendocrinopathy syndrome 1 is caused by failure of a specialized mechanism for deleting forbidden T cell clones, establishing a central role for this tolerance mechanism...
  12. ncbi request reprint The why and how of thymocyte negative selection
    Owen Marc Siggs
    John Curtin School of Medical Research and School of Biochemistry and Molecular Biology, The Australian National University, Canberra 2601, Australia
    Curr Opin Immunol 18:175-83. 2006
    ..Negative selection also ensures that T cells emerge with receptors that are focussed on the peptide moiety of MHC-peptide complexes...
  13. doi request reprint Understanding the genetic regulation of IgE production
    John Altin
    John Curtin School of Medical Research, Australian National University, Canberra 0200, Australia
    Blood Rev 24:163-9. 2010
    ..These genetic data demonstrate the mechanisms of control over IgE production and the manner in which they can be circumvented...
  14. doi request reprint T-follicular helper cell differentiation and the co-option of this pathway by non-helper cells
    Michelle A Linterman
    Cambridge Institute for Medical Research and the Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke s Hospital, Cambridge, UK
    Immunol Rev 247:143-59. 2012
    ....
  15. pmc Dicer-dependent microRNA pathway safeguards regulatory T cell function
    Adrian Liston
    Department of Immunology and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98195, USA
    J Exp Med 205:1993-2004. 2008
    ..However, in diseased mice, Dicer-deficient T reg cells completely lost suppressor capacity. Thus, miRNA preserve the T reg cell functional program under inflammatory conditions...
  16. ncbi request reprint Developmental kinetics, turnover, and stimulatory capacity of thymic epithelial cells
    Daniel H D Gray
    Monash Immunology and Stem Cell Laboratories MISCL, Level 3, STRIP, Building 75, Monash University, Wellington Road, Clayton, Victoria, 3800, Australia
    Blood 108:3777-85. 2006
    ..Overall, these studies show that the thymic stroma is a surprisingly dynamic population and may have a more direct role in negative selection than previously thought...
  17. pmc Lack of Foxp3 function and expression in the thymic epithelium
    Adrian Liston
    Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA
    J Exp Med 204:475-80. 2007
    ..Therefore, in mice the only known role for Foxp3 remains promotion of T reg cell differentiation within the T cell lineage, whereas there is no role for Foxp3 in thymic epithelial cells...
  18. doi request reprint Autoimmunity: beyond the immune system
    Adrian Liston
    Immunol Cell Biol 86:295-6. 2008
  19. ncbi request reprint Thymic development and peripheral homeostasis of regulatory T cells
    Adrian Liston
    Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA
    Curr Opin Immunol 19:176-85. 2007
    ..These factors are also needed to maintain the T-reg cell subset in the periphery...