Research Topics
| S G LisbergerSummaryAffiliation: University of California Country: USA Publications
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Publications
Visual guidance of smooth-pursuit eye movements: sensation, action, and what happens in betweenStephen G Lisberger
Howard Hughes Medical Institute, Department of Physiology, and W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, CA 94143 0444, USA
Neuron 66:477-91. 2010..Finally, pursuit exhibits a number of voluntary characteristics that happen on short timescales. These features make pursuit an excellent exemplar for understanding the general properties of sensory-motor processing in the brain...- Internal models of eye movement in the floccular complex of the monkey cerebellumS G Lisberger
Howard Hughes Medical Institute, Department of Physiology, W M Keck Foundation Center for Integrative Neuroscience, University of California, Box 0444, 513 Parnassus Avenue, Room HSE 802, San Francisco, CA 94143 0444, USA
Neuroscience 162:763-76. 2009..Perhaps the insights from studying oculomotor control provide groundwork to guide the analysis of internal models for a wide variety of cerebellar behaviors... - Reconstruction of target speed for the guidance of pursuit eye movementsN J Priebe
Howard Hughes Medical Institute, Department of Physiology, W M Keck Foundation Center for Integrative Neuroscience, and the Neuroscience Graduate Program, University of California, San Francisco, California 94143, USA
J Neurosci 21:3196-206. 2001..We conclude that the initiation of pursuit is consistent with a reconstruction of target speed based on the speed tuning of the active population of MT cells... - Instructive signals for motor learning from visual cortical area MTMegan R Carey
Howard Hughes Medical Institute, W M Keck Foundation Center for Integrative Neuroscience, Neuroscience Graduate Program, and Department of Physiology, University of California, San Francisco, California 94143 0444, USA
Nat Neurosci 8:813-9. 2005..We conclude that MT provides instructive signals for motor learning in smooth pursuit eye movements under natural conditions, suggesting a similar role for sensory cortices in many kinds of learned behaviors... - Responses of neurons in the medial superior temporal visual area to apparent motion stimuli in macaque monkeysAnne K Churchland
Howard Hughes Medical Center, University of California San Francisco, San Francisco, CA, USA
J Neurophysiol 97:272-82. 2007..We suggest that a vector-averaging computation transforms MT's place code for target speed into the rate code of some MST neurons... - Discharge properties of MST neurons that project to the frontal pursuit area in macaque monkeysAnne K Churchland
Howard Hughes Medical Institute, Department of Physiology, W M Keck Foundation Center for Integrative Neuroscience, Neuroscience Graduate Program, University of California, San Francisco, CA 94143 0444, USA
J Neurophysiol 94:1084-90. 2005..We conclude that the population of MST neurons projecting to the FPA is highly diverse and quite similar to the general population of neurons in MST... - A population decoding framework for motion aftereffects on smooth pursuit eye movementsJustin L Gardner
Howard Hughes Medical Institute, Bioengineering Graduate Group, W M Keck Foundation Center for Integrative Neuroscience, and Department of Physiology, University of California, San Francisco, California 94143, USA
J Neurosci 24:9035-48. 2004..Our results suggest a unified framework for thinking, in terms of population decoding, about motion adaptation for both perception and action... - Relationship between adapted neural population responses in MT and motion adaptation in speed and direction of smooth-pursuit eye movementsJin Yang
Howard Hughes Medical Institute, W M Keck Foundation Center for Integrative Neuroscience, and Department of Physiology, University of California, San Francisco, San Francisco, California 94143 0444, USA
J Neurophysiol 101:2693-707. 2009..We conclude that the effects of motion adaptation on the responses of MT neurons can support behavioral adaptation in pursuit eye movements... - Relationship between extraretinal component of firing rate and eye speed in area MST of macaque monkeysAnne K Churchland
Howard Hughes Medical Institute, W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, USA
J Neurophysiol 94:2416-26. 2005..The good agreement between the eye velocity precision of the behavioral responses to perturbations of target motion and the firing of MST neurons raises regulation of the visual-motor gain of pursuit as one candidate component... - Constraints on the source of short-term motion adaptation in macaque area MT. I. the role of input and intrinsic mechanismsNicholas J Priebe
Howard Hughes Medical Institute, Department of Physiology, W M Keck Foundation, Center for Integrative Neuroscience, and the Neuroscience Graduate Program, University of California, San Francisco, California 94143, USA
J Neurophysiol 88:354-69. 2002..We propose that the short-term adaptation observed in area MT emerges from the intracortical circuit within MT... - Apparent motion produces multiple deficits in visually guided smooth pursuit eye movements of monkeysM M Churchland
Howard Hughes Medical Institute, Department of Physiology, W M Keck Foundation Center for Integrative Neuroscience, and Neuroscience Graduate Program, University of California, San Francisco, California 94143, USA
J Neurophysiol 84:216-35. 2000..This low gain may appear because visual inputs are so degraded that the transition from fixation to tracking is incomplete... - Context-dependent smooth eye movements evoked by stationary visual stimuli in trained monkeysM Tanaka
Howard Hughes Medical Institute, Department of Physiology and W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, California 94143, USA
J Neurophysiol 84:1748-62. 2000..We suggest that the cue-evoked smooth eye movement is related to a previously postulated on-line gain control for pursuit, and that it is a side-effect of sudden activation of the gain-controlling element... - Tuning for spatiotemporal frequency and speed in directionally selective neurons of macaque striate cortexNicholas J Priebe
Department of Physiology, Howard Hughes Medical Institute, W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, California 94143, USA
J Neurosci 26:2941-50. 2006.... - The role of the frontal pursuit area in learning in smooth pursuit eye movementsI-Han Chou
Howard Hughes Medical Institute, Department of Physiology, and W. M. Keck Foundation Center for Integrative Neuroscience, University of California San Francisco, San Francisco, California 94143-0444, USA
J Neurosci 24:4124-33. 2004..We conclude that learning occurs downstream from the FPA, possibly within the cerebellum, and that learning may be related to mechanisms that also control the gain of visual-motor responses on a rapid time scale... - Estimating target speed from the population response in visual area MTNicholas J Priebe
Howard Hughes Medical Institute, Department of Physiology, W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, California 94143, USA
J Neurosci 24:1907-16. 2004..The modification biased the speed estimation toward low target speeds when responses across the population of neurons were small... - The neural representation of speed in macaque area MT/V5Nicholas J Priebe
Howard Hughes Medical Institute, Department of Physiology, W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, California 94143, USA
J Neurosci 23:5650-61. 2003..Instead, MT neurons derive form-invariant speed tuning in a way that takes advantage of the multiple spatial frequencies that comprise moving objects in natural scenes... - Shifts in the population response in the middle temporal visual area parallel perceptual and motor illusions produced by apparent motionM M Churchland
Howard Hughes Medical Institute, Neuroscience Graduate Program, W M Keck Foundation Center for Integrative Neuroscience, University of California San Francisco, San Francisco, California 94143, USA
J Neurosci 21:9387-402. 2001.... - Linked target selection for saccadic and smooth pursuit eye movementsJ L Gardner
Howard Hughes Medical Institute, Department of Physiology, W M Keck Foundation Center for Integrative Neuroscience, and Bioengineering Graduate Group, University of California, San Francisco, California 94143, USA
J Neurosci 21:2075-84. 2001..This raises the possibility that the motor commands for saccades play a causal role, not only in enhancing visuomotor transmission for pursuit but also in choosing a target for pursuit... - Enhancement of multiple components of pursuit eye movement by microstimulation in the arcuate frontal pursuit area in monkeysMasaki Tanaka
Howard Hughes Medical Institute, Department of Physiology, University of California San Francisco, San Francisco, CA 94143, USA
J Neurophysiol 87:802-18. 2002..We conclude that the FPA plays an important role in on-line gain control for pursuit as well as possibly delivering commands for the direction and speed of smooth eye motion... - Role of arcuate frontal cortex of monkeys in smooth pursuit eye movements. I. Basic response properties to retinal image motion and positionMasaki Tanaka
Howard Hughes Medical Institute, Department of Physiology and W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, California 94143, USA
J Neurophysiol 87:2684-99. 2002..We conclude that FPA processes information in terms of image and eye velocity and that it is functionally separate from the saccadic frontal eye fields, which processes information in terms of retinal image position... - Neural substrate of modified and unmodified pathways for learning in monkey vestibuloocular reflexRamnarayan Ramachandran
Department of Physiology, Howard Hughes Medical Institute, W M Keck Center for Integrative Neuroscience, Box 0444, University of California at San Francisco, 513 Parnassus Ave, San Francisco, CA 94143 0444, USA
J Neurophysiol 100:1868-78. 2008..Other aspects of the data make predictions about how vestibular inputs are transformed as they pass through the two pathways... 
Regulation of the gain of visually guided smooth-pursuit eye movements by frontal cortexM Tanaka
Howard Hughes Medical Institute, Department of Physiology, and W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco 94143, USA
Nature 409:191-4. 2001..Such stimulation enhances the response to a brief perturbation of target motion, regardless of the direction of motion. We postulate that the FPA sets the gain of pursuit, thereby participating in target selection for pursuit...- Role of arcuate frontal cortex of monkeys in smooth pursuit eye movements. II. Relation to vector averaging pursuitMasaki Tanaka
Howard Hughes Medical Institute, Department of Physiology and W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, California 94143, USA
J Neurophysiol 87:2700-14. 2002.... - Membrane and firing properties of avian medial vestibular nucleus neurons in vitroS Du Lac
Department of Physiology, W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco 94143 0444, USA
J Comp Physiol A 176:641-51. 1995..These properties appear identical to those of rodent MVN neurons, suggesting that the composition and distribution of ion channels in the MVN neuronal membrane has been highly conserved across vertebrate species... - Experimental and computational analysis of monkey smooth pursuit eye movementsM M Churchland
Howard Hughes Medical Institute, Department of Physiology, Neuroscience Graduate Program, and W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco 94143, USA
J Neurophysiol 86:741-59. 2001..Smooth pursuit thus illustrates that a plausible neural strategy for combating natural delays in sensory feedback is to employ information about the derivative of the sensory input... - Medial versus lateral frontal lobe contributions to voluntary saccade control as revealed by the study of patients with frontal lobe degenerationAdam L Boxer
Department of Neurology, Memory and Aging Center, University of California, San Francisco, California 94143 1207, USA
J Neurosci 26:6354-63. 2006.... - Learned timing of motor behavior in the smooth eye movement region of the frontal eye fieldsJennifer X Li
Department of Physiology, University of California, San Francisco, CA 94143, USA
Neuron 69:159-69. 2011..We suggest that the representation of time in the FEF(SEM) drives learning that is temporally linked to an instructive change in target motion, and that this may be a general function of motor areas of the cortex... - Saccades exert spatial control of motion processing for smooth pursuit eye movementsDavid Schoppik
Howard Hughes Medical Institute, Neuroscience Graduate Program, W M Keck Foundation Center for Integrative Neuroscience, and Department of Physiology, University of California, San Francisco, California 94143, USA
J Neurosci 26:7607-18. 2006..The effect of the spatial saccade plan on the pursuit response to a given retinal motion describes the dynamics of a coordinate transformation... - Directional cuing of target choice in human smooth pursuit eye movementsSiobhan Garbutt
Department of Physiology, University of California, San Francisco, San Francisco, California 94143, USA
J Neurosci 26:12479-86. 2006..We conclude that target choice for movement, like perceptual attention, can be based on the features of the chosen target and not only its location in space... - Time course of precision in smooth-pursuit eye movements of monkeysLeslie C Osborne
Sloan Swartz Center for Theoretical Neurobiology, University of California at San Francisco, San Francisco, California 94143 0444, USA
J Neurosci 27:2987-98. 2007..We conclude that noise in sensory processing of visual motion provides the major source of variation in the initiation of pursuit... - Variation, signal, and noise in cerebellar sensory-motor processing for smooth-pursuit eye movementsJavier F Medina
Howard Hughes Medical Institute, Department of Physiology, W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, California 94143 0444, USA
J Neurosci 27:6832-42. 2007..Variation in eye movement during steady-state pursuit can be attributed primarily to signal-dependent motor noise that arises downstream from PCs... - Cortical mechanisms of smooth eye movements revealed by dynamic covariations of neural and behavioral responsesDavid Schoppik
Neuroscience Graduate Program, Department of Physiology, UCSF, San Francisco, CA 94143, USA
Neuron 58:248-60. 2008.... - Doing without learning: stimulation of the frontal eye fields and floccular complex does not instruct motor learning in smooth pursuit eye movementsHilary W Heuer
Howard Hughes Medical Institute, W M Keck Foundation Center for Integrative Neuroscience, Department of Physiology, University of California, San Francisco, California 94143 0444, USA
J Neurophysiol 100:1320-31. 2008..We suggest that signals emanating from motor-related structures in the pursuit circuit do not instruct learning. Instead, instructive sensory error signals seem to be necessary... - Noise correlations in cortical area MT and their potential impact on trial-by-trial variation in the direction and speed of smooth-pursuit eye movementsXin Huang
Howard Hughes Medical Institute, W M Keck Foundation Center for Integrative Neuroscience, and Department of Physiology, University of California, San Francisco, CA 94143, USA
J Neurophysiol 101:3012-30. 2009..A vector-averaging decoding computation revealed that the observed variation in pursuit could arise from the MT population response, without postulating other sources of motor variation... - Transformation of vestibular signals into motor commands in the vestibuloocular reflex pathways of monkeysRamnarayan Ramachandran
Howard Hughes Medical Institute, Department of Physiology and W M Keck Foundation Center for Integrative Neuroscience, University of California at San Francisco, San Francisco, CA 94143 0444, USA
J Neurophysiol 96:1061-74. 2006..5 and 9 ms. The phase shifts predicted by the model provide fingerprints for identifying brain stem neurons that participate in the modified versus unmodified VOR pathways... - A sensory source for motor variationLeslie C Osborne
Sloan Swartz Center for Theoretical Neurobiology, W M Keck Foundation Center for Integrative Neuroscience, Department of Physiology, University of California at San Francisco, San Francisco, California 94143 0444, USA
Nature 437:412-6. 2005.... - Spatial generalization of learning in smooth pursuit eye movements: implications for the coordinate frame and sites of learningI han Chou
Howard Hughes Medical Institute, W M Keck Foundation Center for Integrative Neuroscience, Department of Physiology, University of California, San Francisco, San Francisco, California 94143 0444, USA
J Neurosci 22:4728-39. 2002..Our data add the constraint that the site or sites of pursuit learning must process visual information on a fairly large spatial scale that extends across the horizontal and vertical meridians... - Serial linkage of target selection for orienting and tracking eye movementsJustin L Gardner
Howard Hughes Medical Institute, Department of Physiology, W M Keck Foundation Center for Integrative Neuroscience, and Bioengineering Graduate Group, University of California, Box 0444, San Francisco, California 94143, USA
Nat Neurosci 5:892-9. 2002..Our results imply that the neural signals responsible for saccade execution can also act as an internal command of target choice for other movement systems... - Directional anisotropies reveal a functional segregation of visual motion processing for perception and actionAnne K Churchland
Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco, San Francisco, CA 94143, USA
Neuron 37:1001-11. 2003..The directional anisotropy of perception appears to originate after the two streams have segregated and downstream from area MT... - Signals that modulate gain control for smooth pursuit eye movements in monkeysMegan R Carey
Howard Hughes Medical Institute, Department of Physiology, W M Keck Foundation Center for Integrative Neuroscience, and Neuroscience Graduate Program, University of California, San Francisco, California 94143 0444, USA
J Neurophysiol 91:623-31. 2004..Similar changes in the gaze velocity signal have been reported in the cerebellar floccular complex following adaptive modification of the VOR and could be present in other brain areas that carry putative gaze velocity signals... - Time course of information about motion direction in visual area MT of macaque monkeysLeslie C Osborne
Sloan Swartz Center for Theoretical Neurobiology, University of California at San Francisco, San Francisco, California 94143 0444, USA
J Neurosci 24:3210-22. 2004..However, neural responses still must be pooled across the population in MT to account for the direction discrimination of the pursuit behavior... - Gain control in human smooth-pursuit eye movementsAnne K Churchland
Howard Hughes Medical Institute, Department of Physiology, and W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, California 94143, USA
J Neurophysiol 87:2936-45. 2002..We conclude that on-line gain control modulates human pursuit and that it can be probed most reliably with small, brief perturbations that do not affect the on-line gain themselves... - The representation of time for motor learningJavier F Medina
Howard Hughes Medical Institute, Department of Physiology and W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, CA 94143, USA
Neuron 45:157-67. 2005..We conclude that high temporal precision in motor output relies on multiple signals whose contributions to timing vary according to task requirements... - Normal performance and expression of learning in the vestibulo-ocular reflex (VOR) at high frequenciesRamnarayan Ramachandran
Deptartment of Physiology, Howard Hughes Medical Institute and W M Keck Center for Integrative Neuroscience, University of California at San Francisco, 513 Parnassus Ave, Box 0444, San Francisco, CA 94143 0444, USA
J Neurophysiol 93:2028-38. 2005..We were able to reproduce the main features of our data with a two-pathway model of the VOR, where the two pathways had different relationships between phase shift and frequency... - Oculomotor function in frontotemporal lobar degeneration, related disorders and Alzheimer's diseaseSiobhan Garbutt
Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA 94143 1207, USA
Brain 131:1268-81. 2008..These data suggest that oculomotor assessment may aid in the diagnosis of FTLD and related disorders... - Evidence for object permanence in the smooth-pursuit eye movements of monkeysMark M Churchland
Howard Hughes Medical Institute, San Francisco, California 94143, USA
J Neurophysiol 90:2205-18. 2003..Computer simulations show that these results are best understood by assuming that a mechanism of eye-velocity memory remains engaged during target occlusion but is disengaged during target blinks... - The neural basis for combinatorial coding in a cortical population responseLeslie C Osborne
Sloan Swartz Center for Theoretical Neurobiology, W M Keck Foundation Center for Integrative Neuroscience, University of California at San Francisco, San Francisco, California 94143, USA
J Neurosci 28:13522-31. 2008..Our findings suggest that combinatorial codes are advantageous for representing stimulus information on short time scales, even when neurons have no complicated, stimulus-dependent correlation structure... - Constraints on the source of short-term motion adaptation in macaque area MT. II. tuning of neural circuit mechanismsNicholas J Priebe
Howard Hughes Medical Institute, Department of Physiology, W M Keck Foundation, Center for Integrative Neuroscience and the Neuroscience Graduate Program, University of California, San Francisco, California 94143, USA
J Neurophysiol 88:370-82. 2002..The circuit responsible for adaptation is tuned for both speed and direction and has the same direction tuning as the circuit responsible for the initial response of MT neurons... - Eye movements and brainstem neuronal responses evoked by cerebellar and vestibular stimulation in chicksS Du Lac
Department of Physiology, W M Keck Foundation Center for Integrative Neuroscience, University of California, San Francisco 94143
J Comp Physiol A 171:629-38. 1992..Similarities between these findings and those of similar studies in mammals indicate that the chick will provide a good model system for cellular studies of adaptive changes in the vestibulo-ocular reflex... - Behavioral analysis of gain control for smooth pursuit eye movementsMegan R Carey
Keck Center for Integrative Neuroscience, University of California, San Francisco, California 94122-2747, USA
Ann N Y Acad Sci 978:507. 2002 - Sensory versus motor loci for integration of multiple motion signals in smooth pursuit eye movements and human motion perceptionYu Qiong Niu
Department of Physiology, Howard Hughes Medical Institute, University of California, San Francisco, California, USA
J Neurophysiol 106:741-53. 2011..A second locus resides deeper in sensory-motor processing and may be more closely related to action selection than to stimulus selection... - Links from complex spikes to local plasticity and motor learning in the cerebellum of awake-behaving monkeysJavier F Medina
Department of Psychology, University of Pennsylvania, 3720 Walnut Street, Philadelphia, Pennsylvania 19104, USA
Nat Neurosci 11:1185-92. 2008..We found that the presence of a complex spike on one learning trial was linked to a substantial depression of simple-spike responses on the subsequent trial, at a time when behavioral learning was expressed... - Comparison of the spatial limits on direction selectivity in visual areas MT and V1Mark M Churchland
Neuroscience Graduate Program and Department of Physiology, Stanford University, 330 Serra Mall, CISX 312, Stanford, CA 94305 4075, USA
J Neurophysiol 93:1235-45. 2005....
Research Grants
- CORTICAL PLASTICITY SYSTEMSStephen Lisberger; Fiscal Year: 2006..abstract_text> ..
- NEURAL CONTROL OF EYE MOVEMENTStephen Lisberger; Fiscal Year: 2007....
- Core C: Electrical and machine shopsStephen Lisberger; Fiscal Year: 2007..The machine shop also plays an important role in maintaining and repairing existing implants and equipment. ..
- Collaborative research: CRCNS: Precision and coding in smooth pursuitStephen G Lisberger; Fiscal Year: 2010..abstract_text> ..
- NEURAL CONTROL OF EYE MOVEMENTStephen Lisberger; Fiscal Year: 2003..Thus, this proposal also has the potential to reveal neural bases for common motor neurological deficits. ..
- NEURAL CONTROL OF EYE MOVEMENTStephen G Lisberger; Fiscal Year: 2010..It will be especially important for relieving the double vision caused by misalignments of the eyes and the poor vision that results from eye movement disorders that make it difficult to track moving objects. ..