G S Lipshutz

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc AAV-based gene therapy prevents neuropathology and results in normal cognitive development in the hyperargininemic mouse
    E K Lee
    Department of Surgery, David Geffen School of Medicine at University of California, Los Angeles UCLA, Los Angeles, CA 90095 7054, USA
    Gene Ther 20:785-96. 2013
  2. pmc AAV-based neonatal gene therapy for hemophilia A: long-term correction and avoidance of immune responses in mice
    C Hu
    Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Gene Ther 19:1166-76. 2012
  3. ncbi request reprint Pancreas-kidney and pancreas transplantation for the treatment of diabetes mellitus
    Gerald S Lipshutz
    Kidney and Pancreas Transplant Program, Department of Surgery, 77 120 CHS, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Endocrinol Metab Clin North Am 36:1015-38; x. 2007
  4. doi request reprint Death from metastatic donor-derived ovarian cancer in a male kidney transplant recipient
    G S Lipshutz
    Department of Surgery and Department of Urology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Am J Transplant 9:428-32. 2009
  5. doi request reprint ABO blood type-incompatible kidney transplantation and access to organs
    Gerald S Lipshutz
    Department of Surgery, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095 7054, USA
    Arch Surg 146:453-8. 2011
  6. ncbi request reprint In utero delivery of adeno-associated viral vectors: intraperitoneal gene transfer produces long-term expression
    G S Lipshutz
    Department of Surgery, University of California, San Francisco, San Francisco, California 94143-0793, USA
    Mol Ther 3:284-92. 2001
  7. pmc The evolving role of alemtuzumab (Campath-1H) in renal transplantation
    Phuong Thu T Pham
    Division of Nephrology, Department of Medicine, Kidney and Pancreas Transplant Program, David Geffen School of Medicine at UCLA, University of California Los Angeles, 200 UCLA Medical Plaza, Los Angeles, CA 90095, USA
    Drug Des Devel Ther 3:41-9. 2009
  8. pmc Analysis of long-term outcomes of 3200 liver transplantations over two decades: a single-center experience
    Ronald W Busuttil
    Dumont UCLA Liver Transplant Center, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Ann Surg 241:905-16; discussion 916-8. 2005
  9. pmc Optimal utilization of donor grafts with extended criteria: a single-center experience in over 1000 liver transplants
    Andrew M Cameron
    Dumont UCLA Liver Transplant Center, and Department of Surgery, David Geffen School of Medicine at UCLA, 10833 LeConte Avenue, Los Angeles, CA 90095, USA
    Ann Surg 243:748-53; discussion 753-5. 2006
  10. ncbi request reprint Polyomavirus-associated nephropathy in simultaneous kidney-pancreas transplant recipients: a single-center experience
    G S Lipshutz
    Department of Surgery, University of California, San Francisco, 94143, USA
    Transplant Proc 36:1097-8. 2004

Collaborators

Detail Information

Publications27

  1. pmc AAV-based gene therapy prevents neuropathology and results in normal cognitive development in the hyperargininemic mouse
    E K Lee
    Department of Surgery, David Geffen School of Medicine at University of California, Los Angeles UCLA, Los Angeles, CA 90095 7054, USA
    Gene Ther 20:785-96. 2013
    ....
  2. pmc AAV-based neonatal gene therapy for hemophilia A: long-term correction and avoidance of immune responses in mice
    C Hu
    Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Gene Ther 19:1166-76. 2012
    ..These studies support the consideration of gene replacement therapy for diseases that are diagnosed in utero or in the early neonatal period...
  3. ncbi request reprint Pancreas-kidney and pancreas transplantation for the treatment of diabetes mellitus
    Gerald S Lipshutz
    Kidney and Pancreas Transplant Program, Department of Surgery, 77 120 CHS, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Endocrinol Metab Clin North Am 36:1015-38; x. 2007
    ..These documented benefits of a simultaneous kidney and pancreas transplant are the basis for its acceptance as an appropriate therapy for patients who have type 1 diabetes mellitus and end-stage renal disease...
  4. doi request reprint Death from metastatic donor-derived ovarian cancer in a male kidney transplant recipient
    G S Lipshutz
    Department of Surgery and Department of Urology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
    Am J Transplant 9:428-32. 2009
    ..We report a male patient who developed metastatic ovarian malignancy secondary to donor transmission...
  5. doi request reprint ABO blood type-incompatible kidney transplantation and access to organs
    Gerald S Lipshutz
    Department of Surgery, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095 7054, USA
    Arch Surg 146:453-8. 2011
    ..To determine whether ABO-incompatible (ABOi) kidney transplantation can be performed safely and result in acceptable posttransplantation outcomes...
  6. ncbi request reprint In utero delivery of adeno-associated viral vectors: intraperitoneal gene transfer produces long-term expression
    G S Lipshutz
    Department of Surgery, University of California, San Francisco, San Francisco, California 94143-0793, USA
    Mol Ther 3:284-92. 2001
    ....
  7. pmc The evolving role of alemtuzumab (Campath-1H) in renal transplantation
    Phuong Thu T Pham
    Division of Nephrology, Department of Medicine, Kidney and Pancreas Transplant Program, David Geffen School of Medicine at UCLA, University of California Los Angeles, 200 UCLA Medical Plaza, Los Angeles, CA 90095, USA
    Drug Des Devel Ther 3:41-9. 2009
    ..This article provides an overview of the literature on the evolving role of alemtuzumab in renal transplantation...
  8. pmc Analysis of long-term outcomes of 3200 liver transplantations over two decades: a single-center experience
    Ronald W Busuttil
    Dumont UCLA Liver Transplant Center, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California 90095, USA
    Ann Surg 241:905-16; discussion 916-8. 2005
    ..This work analyzes the experience of nearly 2 decades by the same team in a single center. Outcomes of OLT and factors affecting survival were analyzed...
  9. pmc Optimal utilization of donor grafts with extended criteria: a single-center experience in over 1000 liver transplants
    Andrew M Cameron
    Dumont UCLA Liver Transplant Center, and Department of Surgery, David Geffen School of Medicine at UCLA, 10833 LeConte Avenue, Los Angeles, CA 90095, USA
    Ann Surg 243:748-53; discussion 753-5. 2006
    ..This work aimed to identify factors that impact survival outcomes for extended criteria donors (ECD) and developed an ECD scoring system to facilitate graft-recipient matching and optimize utilization of ECDs...
  10. ncbi request reprint Polyomavirus-associated nephropathy in simultaneous kidney-pancreas transplant recipients: a single-center experience
    G S Lipshutz
    Department of Surgery, University of California, San Francisco, 94143, USA
    Transplant Proc 36:1097-8. 2004
    ..The purpose of this article is to outline the clinical course of SPK patients who developed documented polyoma infection in the transplanted kidney...
  11. ncbi request reprint Outcome of liver transplantation in septuagenarians: a single-center experience
    Gerald S Lipshutz
    Center for Surgical Outcomes and Quality, Department of Surgery, David Geffen School of Medicine at UCLA, Room 77 120 CHS, Los Angeles, CA 90095, USA
    Arch Surg 142:775-81; discussion 781-4. 2007
    ..This work compares post-liver transplant survival in septuagenarians with that of patients aged 50 to 59 years...
  12. pmc Short-term correction of factor VIII deficiency in a murine model of hemophilia A after delivery of adenovirus murine factor VIII in utero
    G S Lipshutz
    Department of Surgery, Third and Parnassus Avenues, University of California, San Francisco, CA 94143 0793, USA
    Proc Natl Acad Sci U S A 96:13324-9. 1999
    ..The future development of efficient and persisting vectors that produce long-term gene expression may allow for in utero correction of genetic diseases originating in the fetal liver, hematopoietic stem cells, as well as other tissues...
  13. ncbi request reprint Obesity and outcome following renal transplantation
    J L Gore
    Department of Urology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Am J Transplant 6:357-63. 2006
    ..001). Donor BMI did not affect overall graft survival (p > or = 0.07). Recipient obesity is associated with an increased risk of DGF and decreased graft survival following renal transplantation...
  14. ncbi request reprint Death from donor-transmitted malignancy despite emergency liver retransplantation
    Gerald S Lipshutz
    Division of Transplantation, Department of Surgery, University of California, San Francisco, CA 94143, USA
    Liver Transpl 9:1102-7. 2003
    ..This case of donor-transmitted malignancy underscores the need for vigilance by the procuring surgeon in identifying potential malignancy during organ retrieval and use of a full autopsy on selected donors after organ procurement...
  15. ncbi request reprint BKV in simultaneous pancreas-kidney transplant recipients: a leading cause of renal graft loss in first 2 years post-transplant
    Gerald S Lipshutz
    University of California, Los Angeles, Department of Surgery, Los Angeles, CA, USA
    Am J Transplant 5:366-73. 2005
    ..The pancreas, however, is spared from evidence of infection, and no pancreatic rejection occurred when immunosuppression was decreased...
  16. doi request reprint rPSGL-Ig for improvement of early liver allograft function: a double-blind, placebo-controlled, single-center phase II study
    R W Busuttil
    Dumont UCLA Transplant Center, Los Angeles, CA, USA
    Am J Transplant 11:786-97. 2011
    ..05). This is the first clinical trial of an adhesion molecule antagonist to demonstrate a beneficial effect on liver transplantation IRI and supported by therapeutic modulation of two hepatic IRI biomarkers...
  17. ncbi request reprint Portocaval hemitransposition in pediatric liver transplant recipients: a single-center experience
    Gerald S Lipshutz
    Dumont UCLA Liver Transplant Center, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Liver Transpl 12:1097-103. 2006
    ..Appropriate selection of recipient and type of donor graft are essential for good outcomes. Portocaval hemitransposition should be used cautiously and as a last resort to establish portovenous inflow...
  18. ncbi request reprint Thorotrast-induced liver neoplasia: a collective review
    Gerald S Lipshutz
    Department of Surgery, University of California, San Francisco 94143, USA
    J Am Coll Surg 195:713-8. 2002
  19. doi request reprint Thrombotic microangiopathy following pancreas after kidney transplants
    Gerald S Lipshutz
    Department of Surgery and Department of Urology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Clin Transplant 22:236-41. 2008
    ..Whether PAK transplantation pre-disposes a subset of patients to the development of post-transplant TMA is not known. Diagnostic kidney biopsies should be considered in PAK transplant recipients with worsening kidney allograft function...
  20. ncbi request reprint Gene therapy in liver ischemia and reperfusion injury
    Bibo Ke
    The Dumont UCLA Transplant Center, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
    Curr Pharm Des 12:2969-75. 2006
    ..Future advances in gene therapy technology should result in fewer side effects, and thus more acceptable for clinical application, and more successful for organ transplantation...
  21. ncbi request reprint BK nephropathy in kidney transplant recipients treated with a calcineurin inhibitor-free immunosuppression regimen
    Gerald S Lipshutz
    Department of Surgery, University of California San Francisco, San Francisco, California, USA
    Am J Transplant 4:2132-4. 2004
    ..These cases demonstrate that, unlike reports linking tacrolimus and PVAN, polyomavirus infection may develop in patients maintained on CNI-free immunosuppressive regimens and have not had episodes of rejection...
  22. pmc Evaluation of gene promoters for liver expression by hydrodynamic gene transfer
    Andrew T Nguyen
    Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, California 90095 7054, USA
    J Surg Res 148:60-6. 2008
    ..The purpose of the present study was to evaluate promoters for efficient gene expression in hepatocytes in vivo by hydrodynamic delivery and to test the findings in a model of hemophilia A...
  23. ncbi request reprint New onset diabetes mellitus after solid organ transplantation
    Phuong Thu T Pham
    Kidney and Pancreas Transplantation, Department of Medicine, University of California, Los Angeles, CA 90095 1693, USA
    Endocrinol Metab Clin North Am 36:873-90; vii. 2007
    ..Suggested guidelines for early identification and management of NODAT are also discussed...
  24. ncbi request reprint Liver transplantation for HELLP syndrome
    Ali Zarrinpar
    Dumont UCLA Transplant Center, Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, California, USA
    Am Surg 73:1013-6. 2007
    ..This is the largest single-center report of LT for HELLP. Early recognition and transfer to a transplant center will yield best results with this challenging complication of pregnancy...
  25. ncbi request reprint Liver transplantation in those of advancing age: the case for transplantation
    Gerald S Lipshutz
    Liver Transpl 13:1355-7. 2007
  26. doi request reprint CMV otitis: a rare presentation in an adult transplant recipient
    Gerald S Lipshutz
    Transplantation 85:1870-71. 2008
  27. ncbi request reprint Catheter-directed therapy for DVT after pancreas transplantation
    Harish D Mahanty
    Department of Transplantation, California Pacific Medical Center, San Francisco, CA 94115, USA
    Clin Transplant 21:748-54. 2007
    ..Iliac vein deep venous thrombosis (DVT) ipsilateral to the pancreas transplant can lead to severe leg edema and compromise graft function. Treatment modalities for iliac vein DVT in the pancreas transplant recipient are limited...

Research Grants3

  1. The Immune Response to Viral Vector and Transgenes in the Fetus
    Gerald Lipshutz; Fiscal Year: 2007
    ..These studies will utilize a gene therapy vector in a fetal mouse model to determine if tolerance can be induced to 'non-self proteins important in therapy. ..
  2. Pathophysiology and Gene Replacement Strategies for Arginase Deficiency
    Gerald S Lipshutz; Fiscal Year: 2010
    ....