Research Topics
| STEVEN EDWARD LIPSHULTZSummaryAffiliation: University of Miami Country: USA Publications
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Publications
Continuous Versus Bolus Infusion of Doxorubicin in Children With ALL: Long-term Cardiac OutcomesSteven E Lipshultz
Department of Pediatrics, University of Miami Miller School of Medicine, Miami, FL 33101
Pediatrics 130:1003-11. 2012..Its effectiveness in reducing late cardiotoxicity in children remains uncertain. We determined continuous-infusion doxorubicin cardioprotective efficacy in long-term survivors of childhood acute lymphoblastic leukemia (ALL)...
Can the consequences of universal cholesterol screening during childhood prevent cardiovascular disease and thus reduce long-term health care costs?Steven E Lipshultz
Division of Cardiology, Department of Pediatrics, University of Miami Miller School of Medicine, Miami, FL 33101, USA
Pediatr Endocrinol Rev 9:698-705. 2012..This commentary discusses the medical, psychosocial and economic benefits and risks of universal cholesterol screening in children...
HAART to heart: highly active antiretroviral therapy and the risk of cardiovascular disease in HIV-infected or exposed children and adultsSteven E Lipshultz
Department of Pediatrics D820, University of Miami Miller School of Medicine, PO Box 16820, Miami, FL 33101, USA
Expert Rev Anti Infect Ther 10:661-74. 2012..Here, we review available research in this field and highlight the importance of understanding known complications and their mechanisms...- Cardiovascular status of childhood cancer survivors exposed and unexposed to cardiotoxic therapySteven E Lipshultz
University of Miami Miller School of Medicine, Miami, FL 33101, USA
J Clin Oncol 30:1050-7. 2012.... - Changes in cardiac biomarkers during doxorubicin treatment of pediatric patients with high-risk acute lymphoblastic leukemia: associations with long-term echocardiographic outcomesSteven E Lipshultz
University of Miami Miller School of Medicine, Miami, FL 33101, USA
J Clin Oncol 30:1042-9. 2012..Doxorubicin causes cardiac injury and cardiomyopathy in children with acute lymphoblastic leukemia (ALL). Measuring biomarkers during therapy might help individualize treatment by immediately identifying cardiac injury and cardiomyopathy... - The effect of dexrazoxane on myocardial injury in doxorubicin-treated children with acute lymphoblastic leukemiaSteven E Lipshultz
Department of Pediatrics, University of Miami School of Medicine, Holtz Children s Hospital of the University of Miami Jackson Memorial Medical Center and the Sylvester Comprehensive Cancer Center, Miami 33101, USA
N Engl J Med 351:145-53. 2004..Doxorubicin chemotherapy is very effective in children with acute lymphoblastic leukemia (ALL) but also injures myocardial cells. Dexrazoxane, a free-radical scavenger, may protect the heart from doxorubicin-associated damage... - Frequency of elevations in markers of cardiomyocyte damage in otherwise healthy newbornsSteven E Lipshultz
Department of Pediatrics, University of Miami Leonard M Miller School of Medicine, Miami, Florida, USA
Am J Cardiol 102:761-6. 2008..046), and elevated high-sensitivity C-reactive protein (r = 0.66, p = 0.005). In conclusion, clinically occult myocardial injury appears to occur in some healthy newborns, although whether it is pathologic or not remains to be determined... - Anthracycline associated cardiotoxicity in survivors of childhood cancerSteven E Lipshultz
Department of Pediatrics, Leonard M Miller School of Medicine, University of Miami, Holtz Children's Hospital of the University of Miami/Jackson Memorial Medical Center, Miami, FL 33101, USA
Heart 94:525-33. 2008 - Chronic progressive cardiac dysfunction years after doxorubicin therapy for childhood acute lymphoblastic leukemiaSteven E Lipshultz
Department of Pediatrics D820, Miller School of Medicine at the University of Miami, Miami, FL 33101, USA
J Clin Oncol 23:2629-36. 2005..Cross-sectional studies show that cardiac abnormalities are common in long-term survivors of doxorubicin-treated childhood malignancies. Longitudinal data, however, are rare... - Pathophysiology of anthracycline- and radiation-associated cardiomyopathies: implications for screening and preventionM Jacob Adams
Department of Community and Preventive Medicine, The University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
Pediatr Blood Cancer 44:600-6. 2005..Appropriate screening of the entire cardiovascular system should be performed because radiation and chemotherapy affect the entire system. Prevention recommendations focus on cardiomyopathy and coronary artery disease... - Clinical research directions in pediatric cardiologySteven E Lipshultz
Department of Pediatrics, Division of Pediatric Clinical Research, University of Miami, Leonard M Miller School of Medicine, Miami, Florida 33101, USA
Curr Opin Pediatr 21:585-93. 2009..Renewed interest in federally funded clinical research makes it timely to propose a comprehensive research agenda that, with its associated rationale, will attract public funds for research into child cardiovascular health and disease... - Frequency of clinically unsuspected myocardial injury at a children's hospitalSteven E Lipshultz
Department of Cardiology, Harvard Medical School, Boston, MA, USA
Am Heart J 151:916-22. 2006..Ill children are at risk but rarely screened for myocardial injury. The frequency of such injury in ill children is unknown. Elevated levels of plasma cardiac troponin I (cTnI) can detect subclinical myocardial injury... - Exposure to anthracyclines during childhood causes cardiac injurySteven E Lipshultz
Department of Pediatrics, and the Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA
Semin Oncol 33:S8-14. 2006..001). Dexrazoxane was also shown to have no effect on the event-free survival rate at 2.5 years, emphasizing that it does not detrimentally affect the efficacy of anthracycline therapy... - Cardiac effects of antiretroviral therapy in HIV-negative infants born to HIV-positive mothers: NHLBI CHAART-1 (National Heart, Lung, and Blood Institute Cardiovascular Status of HAART Therapy in HIV-Exposed Infants and Children cohort study)Steven E Lipshultz
Department of Pediatrics, University of Miami Miller School of Medicine, Miami, Florida 33101, USA
J Am Coll Cardiol 57:76-85. 2011..The aim of this study was to investigate the possible effects of antiretroviral therapy (ART) in utero on cardiac development and function in human immunodeficiency virus (HIV)-negative children... - Assessment of dexrazoxane as a cardioprotectant in doxorubicin-treated children with high-risk acute lymphoblastic leukaemia: long-term follow-up of a prospective, randomised, multicentre trialSteven E Lipshultz
University of Miami, Leonard M Miller School of Medicine, Miami, FL, USA
Lancet Oncol 11:950-61. 2010..We aimed to establish the long-term effect of dexrazoxane on the subclinical state of cardiac health in survivors of childhood high-risk ALL 5 years after completion of doxorubicin treatment... - The relevance of information generated by in vitro experimental models to clinical doxorubicin cardiotoxicitySteven E Lipshultz
Department of Pediatrics, Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine, Miami, FL, USA
Leuk Lymphoma 47:1454-8. 2006 - Cardiac changes associated with growth hormone therapy among children treated with anthracyclinesSteven E Lipshultz
Department of Pediatrics, Miller School of Medicine, University of Miami, Holtz Children s Hospital, Sylvester Comprehensive Cancer Center, Miami, Florida, USA
Pediatrics 115:1613-22. 2005..Anthracycline-treated childhood cancer survivors frequently have reduced left ventricular (LV) wall thickness and contractility, and GH therapy may affect these factors... - Anthracycline-induced cardiotoxicity: course, pathophysiology, prevention and managementElly Barry
Department of Pediatric Oncology, Dana Farber Cancer Institute Children s Hospital, Boston Harvard Medical School, 44 Binney Street, 3rd Floor, Boston, MA 02115, USA
Expert Opin Pharmacother 8:1039-58. 2007..These treatments include avoiding additional cardiotoxic regimens, controlling hypertension, lifestyle changes, medications and heart transplantation... - Associations between neurohormonal and inflammatory activation and heart failure in childrenChristopher Ratnasamy
Division of Pediatric Cardiology, Department of Pediatrics, Leonard M Miller School of Medicine, University of Miami, University of Miami Jackson Memorial Medical Center, Miami, FL 33101, USA
Am Heart J 155:527-33. 2008..We hypothesize that neuroendocrine and inflammatory activation also associate with symptom severity and echocardiographic measurements in pediatric HF... - Anthracycline cardiotoxicity in long-term survivors of childhood cancerRebecca E Scully
Department of Pediatrics, Division of Pediatric Clinical Research, University of Miami Miller School of Medicine, Miami, FL 33101, USA
Cardiovasc Toxicol 7:122-8. 2007..Support and study of this population to decrease the morbidity and morality associated with anthracycline-induced cardiotoxicity is indicated in a time sensitive fashion... - Serum cardiac troponin and subclinical cardiac status in pediatric chronic renal failureSteven E Lipshultz
Department of Cardiology, Children s Hospital, Boston, Massachusetts, USA
Pediatrics 112:79-86. 2003..Pediatric patients are ideal for studies of the relationship between uremia and heart disease because they are unlikely to have cardiac risk factors other than uremia... - Cardiovascular outcomes of pediatric seroreverters perinatally exposed to HAART: design of a longitudinal clinical studyJill E Lavigne
University of Rochester, Rochester, NY, USA
Cardiovasc Toxicol 4:187-97. 2004..The cohorts are similar in terms of gender and race and the recruited subjects are representative of all eligible subjects in terms of exposure to HAART. Recruitment will continue into 2006... - Accelerated cardiovascular disease and myocardial infarction risk in patients with the human immunodeficiency virusTanvi S Sharma
University of Miami Miller School of Medicine, Miami, FL 33101, USA
J Cardiometab Syndr 3:93-7. 2008..Identifying, monitoring, and treating CVD risk factors in HIV-positive patients is vital to improving their lives and should become standard practice... - Cardiometabolic disease in human immunodeficiency virus-infected childrenTracie L Miller
Division of Pediatric Clinical Research, Department of Pediatrics, Miller School of Medicine, University of Miami, Miami, FL, USA
J Cardiometab Syndr 3:98-105. 2008..Preventive care and interventions that include surveillance of nutrition and body composition, dietary counseling, exercise programs, and drug therapy should be considered standard care for all HIV-infected children... - Relationship between body mass index and metabolic syndrome risk factors among US 8- to 14-year-olds, 1999 to 2002Sarah E Messiah
Department of Pediatrics, Division of Pediatric Clinical Research, University of Miami Leonard M Miller School of Medicine, Miami, FL 33101, USA
J Pediatr 153:215-21. 2008..To determine the prevalence of metabolic syndrome risk factors (MSRF) and examine the relationship between body mass index and the prevalence of >or=3 MSRF in 8- to 11- and 12- to 14-year-old age groups... - Risk factors for cardiovascular disease in children infected with human immunodeficiency virus-1Tracie L Miller
Division of Pediatric Clinical Research, Department of Pediatrics, Miller School of Medicine, University of Miami, Miami, FL 33101, USA
J Pediatr 153:491-7. 2008.... - Body mass index, waist circumference, and cardiovascular risk factors in adolescentsSarah E Messiah
Department of Pediatrics, Division of Pediatric Clinical Research, University of Miami Leonard M Miller School of Medicine, Miami, FL, USA
J Pediatr 153:845-50. 2008..To determine optimal threshold values for body mass index (BMI) and waist circumference (WC) for detecting cardiovascular disease (CVD) risk (as defined with >/=3 CVD risk factors [RFs]) in adolescents... - An improved estimator for the hydration of fat-free mass from in vivo measurements subject to additive technical errorsDaniel D Kinnamon
Department of Pediatrics, University of Miami Miller School of Medicine, FL 33101, USA
Physiol Meas 31:497-512. 2010.... - Biomarkers of vascular dysfunction in children infected with human immunodeficiency virus-1Tracie L Miller
Division of Pediatric Clinical Research, Department of Pediatrics, Miller School of Medicine, University of Miami, Miami, FL, USA
J Acquir Immune Defic Syndr 55:182-8. 2010..We compared biomarkers of vascular dysfunction among HIV-infected children to a demographically similar group of uninfected children and determined factors associated with these biomarkers... - Characteristics and determinants of adiposity in pediatric cancer survivorsTracie L Miller
Batchelor Children s Research Institute, Division of Pediatric Clinical Research, Department of Pediatrics D820, Miller School of Medicine, University of Miami, Miami, FL 33101, USA
Cancer Epidemiol Biomarkers Prev 19:2013-22. 2010..Direct evaluations of adiposity and comparisons to contemporary controls that can differentiate recent trends in obesity from cancer-related treatments and sequelae are limited... - Long-term effects of treatments for childhood cancersJorge A Alvarez
Department of Pediatrics, University of Miami Jackson Memorial Medical Center, Miami, Florida, USA
Curr Opin Pediatr 19:23-31. 2007..We selectively review the negative late cardiac, endocrine, and neurological effects of childhood cancer and its treatments and comment on current research and recommendations for the care of long-term survivors of childhood cancer... - Incidence of cardiac abnormalities in children with human immunodeficiency virus infection: The prospective P2C2 HIV studyThomas J Starc
Department of Pediatrics, Division of Pediatric Cardiology, Presbyterian Hospital/Columbia University, College of Physicians and Surgeons, New York City, New York, USA
J Pediatr 141:327-34. 2002..We recommend that HIV-infected children undergo routine echocardiographic surveillance for cardiac abnormalities... - Serial measurements of serum NT-proBNP as markers of left ventricular systolic function and remodeling in children with heart failurePaolo G Rusconi
Divisions of Pediatric Cardiology, Miami, FL, USA
Am Heart J 160:776-83. 2010..We determined whether changes in NT-proBNP level are associated with changes in symptoms and left ventricular (LV) systolic function and remodeling in children with HF secondary to dilated cardiomyopathy... - Usefulness of the pediatric electrocardiogram in detecting left ventricular hypertrophy: results from the Prospective Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted HIV Infection (P2C2 HIV) multicenter studyShannon M Rivenes
Department of Pediatrics, Division of Pediatric Cardiology, Baylor College of Medicine Texas Children s Hospital, Houston, Tex 77030, USA
Am Heart J 145:716-23. 2003..This study prospectively assesses the usefulness of the pediatric ECG as a screening modality for LVH... - Doxorubicin administration by continuous infusion is not cardioprotective: the Dana-Farber 91-01 Acute Lymphoblastic Leukemia protocolSteven E Lipshultz
Division of Pediatric Cardiology, Strong Children s Hospital and University of Rochester Medical Center, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
J Clin Oncol 20:1677-82. 2002..We compared cardiac outcomes in children receiving bolus or continuous infusion of doxorubicin... - Cardiac management by pediatricians versus pediatric cardiologists in an inpatient academic centerJacques Benun
Department of Pediatrics, Boston Medical Center, Boston, Mass, USA
Am Heart J 145:424-9. 2003..CONCLUSIONS: Pediatricians have different management styles than pediatric cardiologists for patients with suspected cardiac disease. The effect of these differences on outcome is unknown, and further investigation is warranted... - Radiation-associated cardiovascular diseaseM Jacob Adams
Department of Pediatrics, Division of Pediatric Cardiology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 631, Rochester, NY 14642, USA
Crit Rev Oncol Hematol 45:55-75. 2003..Long-term cardiac follow-up of these patients is therefore essential, and the range of appropriate cardiac screening is discussed, although no specific, evidence-based screening regimen was found in the literature... - Maternal age and other predictors of newborn blood pressureMatthew W Gillman
Department of Ambulatory Care and Prevention, Harvard Medical School Harvard Pilgrim Health Care, Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
J Pediatr 144:240-5. 2004..To investigate perinatal predictors of newborn blood pressure... - Cardiovascular effects of HAART in infants and children of HIV-infected mothersKarolina M Zareba
University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
Cardiovasc Toxicol 4:271-9. 2004..Further studies are needed to explore the long-term effects and possible toxicities of prophylactic antiretroviral therapy on infants born to HIV-infected mothers... - Cardiotoxicity of cancer chemotherapy: implications for childrenValeriano C Simbre
Division of Pediatric Cardiology, University of Rochester Medical Center and Golisano Children's Hospital at Strong, Rochester, New York, USA
Paediatr Drugs 7:187-202. 2005..Treatments include diuresis, afterload reduction, beta-adrenoceptor antagonists, and improving myocardial contractility... - Absence of secondary malignant neoplasms in children with high-risk acute lymphoblastic leukemia treated with dexrazoxaneElly V Barry
Departments of Pediatric Oncology, Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
J Clin Oncol 26:1106-11. 2008..We report the absence of an association of SMNs in children with acute lymphoblastic leukemia (ALL) treated on Dana-Farber Cancer Institute ALL Consortium Protocol 95-01... - Cardiovascular disease and toxicities related to HIV infection and its therapiesKarolina M Zareba
University of Rochester, School of Medicine and Dentistry, Rochester, NY 14642, USA
Expert Opin Drug Saf 4:1017-25. 2005..Exercise, a nonpharmacological approach to treating HAART-associated metabolic syndrome, is also discussed... - Evaluation of coxsackievirus infection in children with human immunodeficiency virus type 1-associated cardiomyopathyHal B Jenson
Department of Pediatrics, MC 7811, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
J Infect Dis 185:1798-802. 2002..These results do not identify a causal role for coxsackieviruses for cardiomyopathy in HIV-1-infected children... - Wise up: do not do it without protection!Stephen E Sallan
Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA
Pediatr Blood Cancer 45:872-3. 2005 - Association between congenital cardiovascular malformations and neuroblastomaRani E George
Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA
J Pediatr 144:444-8. 2004..We explored the association between neuroblastoma and congenital cardiovascular malformations (CCM), previously described in case reports... - Body mass index as a function of length of United States residency among Haitian immigrant childrenNancy Strickman-Stein
Department of Epidemiology and Public Health, University of Miami, Leonard M Miller School of Medicine, Miami, Florida 33130, USA
Ethn Dis 20:22-8. 2010.... - Radiation-associated cardiovascular disease: manifestations and managementM Jacob Adams
Department of Pediatrics, University of Rochester School of Medicine, Rochester, NY 14642, USA
Semin Radiat Oncol 13:346-56. 2003..The broad range of radiation-associated cardiovascular disease makes it necessary for survivors to be examined with multiple screening modalities, although data do not exist to support definitive recommendations on test frequency... - Mediators in HIV-associated cardiovascular disease: a focus on cytokines and genesStacy D Fisher
Department of Medicine, Cardiology Unit, University of Rochester Medical Center, Rochester, New York 14642, USA
AIDS 17:S29-35. 2003..In the present review, we discuss possible cytokine and gene-mediated effects on HIV-associated cardiovascular illness that may play a role in diagnosis, management, and therapy of HIV-associated heart failure... - Treating children with idiopathic dilated cardiomyopathy (from the Pediatric Cardiomyopathy Registry)William G Harmon
Department of Pediatrics, University of Miami, Leonard M Miller School of Medicine, Miami, Florida, USA
Am J Cardiol 104:281-6. 2009..In conclusion, therapeutic clinical trials are strongly indicated because practice variation is substantial and medical outcomes in these children have not improved in the previous several decades... - Factors associated with establishing a causal diagnosis for children with cardiomyopathyGerald F Cox
Division of Genetics, Department of Medicine, Children's Hospital, Boston, Massachusetts, USA
Pediatrics 118:1519-31. 2006..Although not widely used, skeletal muscle biopsy may yield a cause for some patients with hypertrophic cardiomyopathy and for patients suspected of having a mitochondrial disorder... - Coronary artery calcifications in the long-term follow-up of Kawasaki diseaseGul H Dadlani
Congenital Heart Institute of Florida, All Children s Hospital, St Petersburg, Florida, USA
Am Heart J 150:1016. 2005..To determine if detection of coronary artery calcifications in patients with Kawasaki disease may serve as a noninvasive predictor of future coronary artery events... - Maternal calcium intake and offspring blood pressureMatthew W Gillman
Department of Ambulatory Care and Prevention, Harvard Medical School Harvard Pilgrim Health Care, Boston, Mass 02215, USA
Circulation 110:1990-5. 2004..Few data exist on the intergenerational influence of calcium intake during pregnancy on offspring blood pressure... - Health effects of energy drinks on children, adolescents, and young adultsSara M Seifert
Department of Pediatrics and Pediatric Integrative Medicine Program, University of Miami, Leonard M Miller School of Medicine, Miami, Florida 33101, USA
Pediatrics 127:511-28. 2011..To review the effects, adverse consequences, and extent of energy drink consumption among children, adolescents, and young adults... - Cardiovascular status of infants and children of women infected with HIV-1 (P(2)C(2) HIV): a cohort studySteven E Lipshultz
Division of Pediatric Cardiology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
Lancet 360:368-73. 2002.... - Cardiovascular status in long-term survivors of Hodgkin's disease treated with chest radiotherapyM Jacob Adams
Department of Community and Preventive Medicine, University of Rochester School of Medicine and Dentistry, NY, USA
J Clin Oncol 22:3139-48. 2004..We recommend serial, comprehensive cardiac screening of HD survivors who fit this profile... - Improved outcomes of pediatric dilated cardiomyopathy with utilization of heart transplantationAnna E Tsirka
Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri, USA
J Am Coll Cardiol 44:391-7. 2004..Utilization of heart transplantation has led to improved survival after the diagnosis of pediatric DCM... - The incidence of pediatric cardiomyopathy in two regions of the United StatesSteven E Lipshultz
Golisano Children s Hospital at Strong and University of Rochester Medical Center, and the Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
N Engl J Med 348:1647-55. 2003..Population-based data on the incidence of pediatric cardiomyopathy are rare because of the lack of large, prospective studies... - Predictors of cardiac morbidity and related mortality in children with acquired immunodeficiency syndromeInas Al-Attar
Department of Cardiology, Children's Hospital, Boston, Massachusetts, USA
J Am Coll Cardiol 41:1598-605. 2003..Factors such as recurrent bacterial infections, wasting, encephalopathy, male gender, low CD4 and IgG levels, and an earlier year at AIDS diagnosis may identify high-risk patients...
Research Grants
- CARDIAC RISK FACTORS IN PEDIATRIC CANCER SURVIVORSSteven Lipshultz; Fiscal Year: 2002..If the hypotheses are true, this should enable more rational recommendations for preventive cardiology in long-term survivors to be made and to standardize care and management for this population. ..
- Cardiovascular Status of HAART-Exposed Infants/ChildrenSteven Lipshultz; Fiscal Year: 2006..This study will determine the cardiovascular effects of HAART in seroreverters and the need for future cardiovascular follow-up and cardiovascular preventive and therapeutic trials in this rapidly expanding population. ..
- Primary Cardiomyopathies in Children: Research Directions & StrategiesSteven Lipshultz; Fiscal Year: 2007..It is anticipated that this exchange of knowledge will identify future research directions and new approaches and technologies that will lead to a better understanding of this disease and improved treatment and prevention strategies. ..
- PEDIATRIC CARDIOMYOPATHY REGISTRYSteven Lipshultz; Fiscal Year: 2007..These studies will dramatically increase our understanding of pediatric cardiomyopathy, suggest new areas of research and improved patient management. ..
- HAART Associated Cardiotoxicity in HIV-Infected ChildrenSteven Lipshultz; Fiscal Year: 2007..The findings will help determine the need for cardiovascular follow-up, prevention and therapeutic trials. ..
- Genetic Mechanisms of Anthracycline Cardiotoxicity in Pediatric Cancer SurvivorsSteven Lipshultz; Fiscal Year: 2007..If the HFE mutations are related to increased cardiotoxicity of anthracyclines. This study will elucidate the molecular mechanisms of anthracycline cardiotoxicity in pediatric ALL cancer survivors. ..
- PEDIATRIC CARDIOMYOPATHY REGISTRYSteven Lipshultz; Fiscal Year: 2009..These studies will dramatically increase our understanding of pediatric cardiomyopathy, suggest new areas of research and improved patient management. ..
- PEDIATRIC CARDIOMYOPATHY REGISTRYSteven Lipshultz; Fiscal Year: 2000..The registry should lead to definitive understanding of the pathogenesis of these disorders and offer the hope to have a major clinical impact on the clinical practice of medicine in this area. ..
- PEDIATRIC CARDIOMYOPATHY REGISTRYSteven Lipshultz; Fiscal Year: 2003..abstract_text> ..
- Genetic Mechanisms of Anthracycline Cardiotoxicity in Pediatric Cancer SurvivorsSteven Lipshultz; Fiscal Year: 2009..If the HFE mutations are related to increased cardiotoxicity of anthracyclines. This study will elucidate the molecular mechanisms of anthracycline cardiotoxicity in pediatric ALL cancer survivors. ..