S E Lipshultz

Summary

Affiliation: University of Rochester
Country: USA

Publications

  1. ncbi request reprint Cardiovascular monitoring and therapy for HIV-infected patients
    S E Lipshultz
    Division of Pediatric Cardiology, University of Rochester Medical Center and Strong Children s Hospital, New York 14642, USA
    Ann N Y Acad Sci 946:236-73. 2001
  2. ncbi request reprint Long-term enalapril therapy for left ventricular dysfunction in doxorubicin-treated survivors of childhood cancer
    Steven E Lipshultz
    Division of Pediatric Cardiology, University of Rochester Medical Center, NY 14642, USA
    J Clin Oncol 20:4517-22. 2002
  3. ncbi request reprint Reliability of multicenter pediatric echocardiographic measurements of left ventricular structure and function: the prospective P(2)C(2) HIV study
    S E Lipshultz
    Division of Pediatric Cardiology, University of Rochester Medical Center and Children s Hospital at Strong, Rochester, NY, USA
    Circulation 104:310-6. 2001
  4. ncbi request reprint The incidence of pediatric cardiomyopathy in two regions of the United States
    Steven E Lipshultz
    Golisano Children s Hospital at Strong and University of Rochester Medical Center, and the Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    N Engl J Med 348:1647-55. 2003
  5. ncbi request reprint Cardiac dysfunction and mortality in HIV-infected children: The Prospective P2C2 HIV Multicenter Study. Pediatric Pulmonary and Cardiac Complications of Vertically Transmitted HIV Infection (P2C2 HIV) Study Group
    S E Lipshultz
    Division of Pediatric Cardiology, University of Rochester Medical Center and Children s Hospital at Strong, Rochester, NY 14642, USA
    Circulation 102:1542-8. 2000
  6. ncbi request reprint Serum cardiac troponin and subclinical cardiac status in pediatric chronic renal failure
    Steven E Lipshultz
    Department of Cardiology, Children s Hospital, Boston, Massachusetts, USA
    Pediatrics 112:79-86. 2003
  7. ncbi request reprint Absence of cardiac toxicity of zidovudine in infants. Pediatric Pulmonary and Cardiac Complications of Vertically Transmitted HIV Infection Study Group
    S E Lipshultz
    Division of Pediatric Cardiology, University of Rochester Medical Center and Children s Hospital at Strong, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    N Engl J Med 343:759-66. 2000
  8. ncbi request reprint Cardiovascular risk factors, monitoring, and therapy for HIV-infected patients
    Steven E Lipshultz
    Division of Pediatric Cardiology, University of Rochester Medical Center and Golisano Children s Hospital at Strong 14642, USA
    AIDS 17:S96-122. 2003
  9. ncbi request reprint Cardiac complications in children with human immunodeficiency virus infection. Pediatric Pulmonary and Cardiac Complications of Vertically Transmitted HIV Infection (P2C2 HIV) Study Group, National Heart, Lung, and Blood Institute
    T J Starc
    Department of Pediatrics, Division of Pediatric Cardiology, Presbyterian Hospital Columbia University School of Medicine, New York, New York 10032, USA
    Pediatrics 104:e14. 1999
  10. ncbi request reprint Left ventricular structure and function in children infected with human immunodeficiency virus: the prospective P2C2 HIV Multicenter Study. Pediatric Pulmonary and Cardiac Complications of Vertically Transmitted HIV Infection (P2C2 HIV) Study Group
    S E Lipshultz
    Department of Cardiology, Children s Hospital, Harvard Medical School, Boston, Mass, USA
    Circulation 97:1246-56. 1998

Detail Information

Publications80

  1. ncbi request reprint Cardiovascular monitoring and therapy for HIV-infected patients
    S E Lipshultz
    Division of Pediatric Cardiology, University of Rochester Medical Center and Strong Children s Hospital, New York 14642, USA
    Ann N Y Acad Sci 946:236-73. 2001
    ..We also review preventive and therapeutic cardiovascular interventions. For procedures that have not been studied in HIV+ patients, we extrapolate from evidence-based guidelines for the general population...
  2. ncbi request reprint Long-term enalapril therapy for left ventricular dysfunction in doxorubicin-treated survivors of childhood cancer
    Steven E Lipshultz
    Division of Pediatric Cardiology, University of Rochester Medical Center, NY 14642, USA
    J Clin Oncol 20:4517-22. 2002
    ..We document the long-term effects of angiotensin-converting enzyme inhibitors in doxorubicin-treated survivors of childhood cancer...
  3. ncbi request reprint Reliability of multicenter pediatric echocardiographic measurements of left ventricular structure and function: the prospective P(2)C(2) HIV study
    S E Lipshultz
    Division of Pediatric Cardiology, University of Rochester Medical Center and Children s Hospital at Strong, Rochester, NY, USA
    Circulation 104:310-6. 2001
    ..To assess the reliability of pediatric echocardiographic measurements, we compared local measurements with those made at a central facility...
  4. ncbi request reprint The incidence of pediatric cardiomyopathy in two regions of the United States
    Steven E Lipshultz
    Golisano Children s Hospital at Strong and University of Rochester Medical Center, and the Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    N Engl J Med 348:1647-55. 2003
    ..Population-based data on the incidence of pediatric cardiomyopathy are rare because of the lack of large, prospective studies...
  5. ncbi request reprint Cardiac dysfunction and mortality in HIV-infected children: The Prospective P2C2 HIV Multicenter Study. Pediatric Pulmonary and Cardiac Complications of Vertically Transmitted HIV Infection (P2C2 HIV) Study Group
    S E Lipshultz
    Division of Pediatric Cardiology, University of Rochester Medical Center and Children s Hospital at Strong, Rochester, NY 14642, USA
    Circulation 102:1542-8. 2000
    ..Our objective was to determine whether abnormalities of LV structure and function independently predict all-cause mortality in HIV-infected children...
  6. ncbi request reprint Serum cardiac troponin and subclinical cardiac status in pediatric chronic renal failure
    Steven E Lipshultz
    Department of Cardiology, Children s Hospital, Boston, Massachusetts, USA
    Pediatrics 112:79-86. 2003
    ..Pediatric patients are ideal for studies of the relationship between uremia and heart disease because they are unlikely to have cardiac risk factors other than uremia...
  7. ncbi request reprint Absence of cardiac toxicity of zidovudine in infants. Pediatric Pulmonary and Cardiac Complications of Vertically Transmitted HIV Infection Study Group
    S E Lipshultz
    Division of Pediatric Cardiology, University of Rochester Medical Center and Children s Hospital at Strong, University of Rochester School of Medicine and Dentistry, NY 14642, USA
    N Engl J Med 343:759-66. 2000
    ....
  8. ncbi request reprint Cardiovascular risk factors, monitoring, and therapy for HIV-infected patients
    Steven E Lipshultz
    Division of Pediatric Cardiology, University of Rochester Medical Center and Golisano Children s Hospital at Strong 14642, USA
    AIDS 17:S96-122. 2003
    ..We also review preventive and therapeutic cardiovascular interventions. For procedures that have not been studied in HIV-infected patients, we extrapolate from evidence-based guidelines for the general population...
  9. ncbi request reprint Cardiac complications in children with human immunodeficiency virus infection. Pediatric Pulmonary and Cardiac Complications of Vertically Transmitted HIV Infection (P2C2 HIV) Study Group, National Heart, Lung, and Blood Institute
    T J Starc
    Department of Pediatrics, Division of Pediatric Cardiology, Presbyterian Hospital Columbia University School of Medicine, New York, New York 10032, USA
    Pediatrics 104:e14. 1999
    ..The objective of this report is to describe the 2-year cumulative incidence of cardiac abnormalities in HIV-infected children...
  10. ncbi request reprint Left ventricular structure and function in children infected with human immunodeficiency virus: the prospective P2C2 HIV Multicenter Study. Pediatric Pulmonary and Cardiac Complications of Vertically Transmitted HIV Infection (P2C2 HIV) Study Group
    S E Lipshultz
    Department of Cardiology, Children s Hospital, Harvard Medical School, Boston, Mass, USA
    Circulation 97:1246-56. 1998
    ..The frequency of, course of, and factors associated with cardiovascular abnormalities in pediatric HIV are incompletely understood...
  11. ncbi request reprint Non-invasive assessment of rejection in pediatric transplant patients: serologic and echocardiographic prediction of biopsy-proven myocardial rejection
    A M Moran
    Departments of Cardiology and Pediatrics, a Children s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Heart Lung Transplant 19:756-64. 2000
    ..We undertook the present study to compare rejection grade with echocardiographic and serologic estimates of transplant rejection-related myocardial damage...
  12. ncbi request reprint Cardiac, aortic, and pulmonary arteriopathy in HIV-infected children: the Prospective P2C2 HIV Multicenter Study
    A R Perez-Atayde
    Departments of Pathology and Cardiology, Children s Hospital, Harvard Medical School, 300 Longwood Avenue, Boston, MA 02115, USA
    Pediatr Dev Pathol 7:61-70. 2004
    ..Coronary and large vessel arteriopathies are common in pediatric HIV-infection and have different clinicopathologic features suggesting different pathogenesis...
  13. ncbi request reprint Predictive value of cardiac troponin T in pediatric patients at risk for myocardial injury
    S E Lipshultz
    Department of Cardiology, Children s Hospital, Boston, Mass, USA
    Circulation 96:2641-8. 1997
    ..Yet, because of somatic growth and the duration of survival, a low level of myocardial damage may ultimately be of more consequence in children than in adults...
  14. ncbi request reprint Cardiac structure and function in fetuses of mothers infected with HIV: the prospective PCHIV multicenter study
    L K Hornberger
    Department of Cardiology, Children s Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA, USA
    Am Heart J 140:575-84. 2000
    ..This study was designed to determine if vertically transmitted HIV infection and maternal infection with HIV are associated with altered cardiovascular structure and function in utero...
  15. ncbi request reprint Dilation of the aortic root in children infected with human immunodeficiency virus type 1: The Prospective P2C2 HIV Multicenter Study
    W W Lai
    Department of Pediatrics, Division of Pediatric Cardiology, Box 1201, Mount Sinai School of Medicine, One Gustave L Levy Place, New York, NY 10029 6574, USA
    Am Heart J 141:661-70. 2001
    ..This study was undertaken to determine the prevalence of aortic root dilation in HIV-infected children and to evaluate some of the potential pathogenic mechanisms...
  16. ncbi request reprint Cardiac manifestations of HIV infection in infants and children
    M J Keesler
    Division of Pediatric Cardiology, University of Rochester Medical Center and Strong Children's Hospital, New York 14642, USA
    Ann N Y Acad Sci 946:169-78. 2001
    ....
  17. ncbi request reprint Incidence of cardiac abnormalities in children with human immunodeficiency virus infection: The prospective P2C2 HIV study
    Thomas J Starc
    Department of Pediatrics, Division of Pediatric Cardiology, Presbyterian Hospital Columbia University, College of Physicians and Surgeons, New York City, New York, USA
    J Pediatr 141:327-34. 2002
    ..9 years. Group II consisted of 600 HIV-exposed children enrolled prenatally or as neonates, of whom 93 were ultimately HIV-infected. The main outcome measures were echocardiographic indexes of left ventricular dysfunction...
  18. ncbi request reprint Epidemiology of cardiovascular involvement in HIV disease and AIDS
    S D Fisher
    Department of Medicine, University of Rochester Medical Center and University of Rochester School of Medicine and Dentistry, New York 14642, USA
    Ann N Y Acad Sci 946:13-22. 2001
    ....
  19. ncbi request reprint Maternal and infant factors associated with failure to thrive in children with vertically transmitted human immunodeficiency virus-1 infection: the prospective, P2C2 human immunodeficiency virus multicenter study
    T L Miller
    Division of Pediatric Gastroenterology and Nutrition, University of Rochester Medical Center, NY 14642, USA
    Pediatrics 108:1287-96. 2001
    ..Using data from the prospective, multicenter P2C2 HIV study, we evaluated the relationships between maternal and infant clinical and laboratory factors and impaired growth in this cohort...
  20. pmc Breast cancer risk 55+ years after irradiation for an enlarged thymus and its implications for early childhood medical irradiation today
    M Jacob Adams
    University of Rochester School of Medicine and Dentistry, Department of Community and Preventive Medicine, 601 Elmwood Avenue, Box 644, Rochester, New York, USA
    Cancer Epidemiol Biomarkers Prev 19:48-58. 2010
    ....
  21. ncbi request reprint Cardiovascular outcomes of pediatric seroreverters perinatally exposed to HAART: design of a longitudinal clinical study
    Jill E Lavigne
    University of Rochester, Rochester, NY, USA
    Cardiovasc Toxicol 4:187-97. 2004
    ..The cohorts are similar in terms of gender and race and the recruited subjects are representative of all eligible subjects in terms of exposure to HAART. Recruitment will continue into 2006...
  22. ncbi request reprint Pathophysiology of anthracycline- and radiation-associated cardiomyopathies: implications for screening and prevention
    M Jacob Adams
    Department of Community and Preventive Medicine, The University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Pediatr Blood Cancer 44:600-6. 2005
    ..Appropriate screening of the entire cardiovascular system should be performed because radiation and chemotherapy affect the entire system. Prevention recommendations focus on cardiomyopathy and coronary artery disease...
  23. pmc Thyroid cancer risk 40+ years after irradiation for an enlarged thymus: an update of the Hempelmann cohort
    MICHAEL JACOB ADAMS
    Department of Community and Preventive Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA
    Radiat Res 174:753-62. 2010
    ..5 years of follow-up and is dose-dependent. Although the incidence appeared to decrease after 40 years, increased risk remains a lifelong concern in those exposed to lower doses of medical radiation during early childhood...
  24. ncbi request reprint Doxorubicin administration by continuous infusion is not cardioprotective: the Dana-Farber 91-01 Acute Lymphoblastic Leukemia protocol
    Steven E Lipshultz
    Division of Pediatric Cardiology, Strong Children s Hospital and University of Rochester Medical Center, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA
    J Clin Oncol 20:1677-82. 2002
    ..We compared cardiac outcomes in children receiving bolus or continuous infusion of doxorubicin...
  25. ncbi request reprint Usefulness of the pediatric electrocardiogram in detecting left ventricular hypertrophy: results from the Prospective Pediatric Pulmonary and Cardiovascular Complications of Vertically Transmitted HIV Infection (P2C2 HIV) multicenter study
    Shannon M Rivenes
    Department of Pediatrics, Division of Pediatric Cardiology, Baylor College of Medicine Texas Children s Hospital, Houston, Tex 77030, USA
    Am Heart J 145:716-23. 2003
    ..This study prospectively assesses the usefulness of the pediatric ECG as a screening modality for LVH...
  26. ncbi request reprint Cardiomyocyte injury to transplant: pediatric management
    Gul H Dadlani
    Division of Pediatric Cardiology, Golisano Children s Hospital at Strong, University of Rochester School of Medicine and Dentistry, New York 14642, USA
    Curr Opin Cardiol 18:91-7. 2003
    ..This article reviews the current recommendations and evidence-based medicine, where available, for the medical management of myopathic dysfunction and transplantation in pediatric patients...
  27. ncbi request reprint Mediators in HIV-associated cardiovascular disease: a focus on cytokines and genes
    Stacy D Fisher
    Department of Medicine, Cardiology Unit, University of Rochester Medical Center, Rochester, New York 14642, USA
    AIDS 17:S29-35. 2003
    ..In the present review, we discuss possible cytokine and gene-mediated effects on HIV-associated cardiovascular illness that may play a role in diagnosis, management, and therapy of HIV-associated heart failure...
  28. ncbi request reprint Anthracycline-induced cardiotoxicity: course, pathophysiology, prevention and management
    Elly Barry
    Department of Pediatric Oncology, Dana Farber Cancer Institute Children s Hospital, Boston Harvard Medical School, 44 Binney Street, 3rd Floor, Boston, MA 02115, USA
    Expert Opin Pharmacother 8:1039-58. 2007
    ..These treatments include avoiding additional cardiotoxic regimens, controlling hypertension, lifestyle changes, medications and heart transplantation...
  29. ncbi request reprint Factors associated with establishing a causal diagnosis for children with cardiomyopathy
    Gerald F Cox
    Division of Genetics, Department of Medicine, Children s Hospital, Boston, Massachusetts, USA
    Pediatrics 118:1519-31. 2006
    ..The goal was to identify the clinical variables associated with establishing a cause of cardiomyopathy in children...
  30. ncbi request reprint Cardiotoxicity of cancer chemotherapy: implications for children
    Valeriano C Simbre
    Division of Pediatric Cardiology, University of Rochester Medical Center and Golisano Children s Hospital at Strong, Rochester, New York, USA
    Paediatr Drugs 7:187-202. 2005
    ..Treatments include diuresis, afterload reduction, beta-adrenoceptor antagonists, and improving myocardial contractility...
  31. ncbi request reprint Radiation-associated cardiovascular disease
    M Jacob Adams
    Department of Pediatrics, Division of Pediatric Cardiology, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box 631, Rochester, NY 14642, USA
    Crit Rev Oncol Hematol 45:55-75. 2003
    ..Long-term cardiac follow-up of these patients is therefore essential, and the range of appropriate cardiac screening is discussed, although no specific, evidence-based screening regimen was found in the literature...
  32. ncbi request reprint Changes in clinical measures of autonomic nervous system function related to cancer chemotherapy-induced nausea
    G R Morrow
    Behavioral Medicine Unit, University of Rochester Cancer Center, NY 14642, USA
    J Auton Nerv Syst 78:57-63. 1999
    ..Further investigation of ANS involvement in chemotherapy-induced nausea could increase understanding of nausea etiology and potentially lead to the prediction of susceptible patients...
  33. ncbi request reprint Maternal age and other predictors of newborn blood pressure
    Matthew W Gillman
    Department of Ambulatory Care and Prevention, Harvard Medical School Harvard Pilgrim Health Care, Department of Obstetrics and Gynecology, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts, USA
    J Pediatr 144:240-5. 2004
    ..To investigate perinatal predictors of newborn blood pressure...
  34. doi request reprint Associations between neurohormonal and inflammatory activation and heart failure in children
    Christopher Ratnasamy
    Division of Pediatric Cardiology, Department of Pediatrics, Leonard M Miller School of Medicine, University of Miami, University of Miami Jackson Memorial Medical Center, Miami, FL 33101, USA
    Am Heart J 155:527-33. 2008
    ..We hypothesize that neuroendocrine and inflammatory activation also associate with symptom severity and echocardiographic measurements in pediatric HF...
  35. doi request reprint Absence of secondary malignant neoplasms in children with high-risk acute lymphoblastic leukemia treated with dexrazoxane
    Elly V Barry
    Departments of Pediatric Oncology, Dana Farber Cancer Institute, 44 Binney St, Boston, MA 02115, USA
    J Clin Oncol 26:1106-11. 2008
    ..We report the absence of an association of SMNs in children with acute lymphoblastic leukemia (ALL) treated on Dana-Farber Cancer Institute ALL Consortium Protocol 95-01...
  36. ncbi request reprint Cardiac management by pediatricians versus pediatric cardiologists in an inpatient academic center
    Jacques Benun
    Department of Pediatrics, Boston Medical Center, Boston, Mass, USA
    Am Heart J 145:424-9. 2003
    ..To study this strategy, we compared the management decisions of pediatricians with the recommendations of pediatric cardiologists who reviewed the records of the same patients...
  37. ncbi request reprint Epidemiology and cause-specific outcome of hypertrophic cardiomyopathy in children: findings from the Pediatric Cardiomyopathy Registry
    Steven D Colan
    Department of Cardiology, Children s Hospital, Harvard Medical School, Boston, Mass 02115, USA
    Circulation 115:773-81. 2007
    ..Current information on the epidemiology and outcomes of hypertrophic cardiomyopathy (HCM) in children is limited by disease diversity and small case series...
  38. ncbi request reprint Frequency of clinically unsuspected myocardial injury at a children's hospital
    Steven E Lipshultz
    Department of Cardiology, Harvard Medical School, Boston, MA, USA
    Am Heart J 151:916-22. 2006
    ..Ill children are at risk but rarely screened for myocardial injury. The frequency of such injury in ill children is unknown. Elevated levels of plasma cardiac troponin I (cTnI) can detect subclinical myocardial injury...
  39. ncbi request reprint Wise up: do not do it without protection!
    Stephen E Sallan
    Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, USA
    Pediatr Blood Cancer 45:872-3. 2005
  40. ncbi request reprint Cardiovascular disease and toxicities related to HIV infection and its therapies
    Karolina M Zareba
    University of Rochester, School of Medicine and Dentistry, Rochester, NY 14642, USA
    Expert Opin Drug Saf 4:1017-25. 2005
    ..Exercise, a nonpharmacological approach to treating HAART-associated metabolic syndrome, is also discussed...
  41. ncbi request reprint Cardiovascular status of infants and children of women infected with HIV-1 (P(2)C(2) HIV): a cohort study
    Steven E Lipshultz
    Division of Pediatric Cardiology, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Lancet 360:368-73. 2002
    ..Data from cross-sectional and short-term longitudinal studies have suggested that children infected with HIV-1 might have cardiovascular abnormalities. We aimed to investigate this hypothesis in a long-term cohort study...
  42. pmc Maternal calcium intake and offspring blood pressure
    Matthew W Gillman
    Department of Ambulatory Care and Prevention, Harvard Medical School Harvard Pilgrim Health Care, Boston, Mass 02215, USA
    Circulation 110:1990-5. 2004
    ..Few data exist on the intergenerational influence of calcium intake during pregnancy on offspring blood pressure...
  43. ncbi request reprint Cardiovascular effects of HAART in infants and children of HIV-infected mothers
    Karolina M Zareba
    University of Rochester School of Medicine and Dentistry, Rochester, NY, USA
    Cardiovasc Toxicol 4:271-9. 2004
    ..Further studies are needed to explore the long-term effects and possible toxicities of prophylactic antiretroviral therapy on infants born to HIV-infected mothers...
  44. ncbi request reprint Effects of environmental exposures on the cardiovascular system: prenatal period through adolescence
    Suzanne M Mone
    Division of Pediatric Cardiology, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    Pediatrics 113:1058-69. 2004
    ..Where evidence about environmental exposures is limited, we have included models of disease and other exposures that are suggestive of the potential impact of environmental exposures...
  45. ncbi request reprint Association between congenital cardiovascular malformations and neuroblastoma
    Rani E George
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA
    J Pediatr 144:444-8. 2004
    ..We explored the association between neuroblastoma and congenital cardiovascular malformations (CCM), previously described in case reports...
  46. ncbi request reprint Radiation-associated cardiovascular disease: manifestations and management
    M Jacob Adams
    Department of Pediatrics, University of Rochester School of Medicine, Rochester, NY 14642, USA
    Semin Radiat Oncol 13:346-56. 2003
    ..The broad range of radiation-associated cardiovascular disease makes it necessary for survivors to be examined with multiple screening modalities, although data do not exist to support definitive recommendations on test frequency...
  47. ncbi request reprint Cardiovascular status in long-term survivors of Hodgkin's disease treated with chest radiotherapy
    M Jacob Adams
    Department of Community and Preventive Medicine, University of Rochester School of Medicine and Dentistry, NY, USA
    J Clin Oncol 22:3139-48. 2004
    ..Cardiovascular status was assessed in 48 Hodgkin's disease (HD) survivors at a median of 14.3 years (range, 5.9 to 27.5 years) after diagnosis because they may be at increased risk for cardiovascular abnormalities...
  48. ncbi request reprint Predictors of cardiac morbidity and related mortality in children with acquired immunodeficiency syndrome
    Inas Al-Attar
    Department of Cardiology, Children s Hospital, Boston, Massachusetts, USA
    J Am Coll Cardiol 41:1598-605. 2003
    ..The aim of this study was to determine the prevalence of cardiovascular dysfunction and its predictors in children with acquired immunodeficiency syndrome (AIDS)...
  49. ncbi request reprint Anthracycline cardiotoxicity in long-term survivors of childhood cancer
    Rebecca E Scully
    Department of Pediatrics, Division of Pediatric Clinical Research, University of Miami Miller School of Medicine, Miami, FL 33101, USA
    Cardiovasc Toxicol 7:122-8. 2007
    ..Support and study of this population to decrease the morbidity and morality associated with anthracycline-induced cardiotoxicity is indicated in a time sensitive fashion...
  50. ncbi request reprint Incidence, causes, and outcomes of dilated cardiomyopathy in children
    Jeffrey A Towbin
    Texas Children s Hospital, Baylor College of Medicine, Houston, USA
    JAMA 296:1867-76. 2006
    ..Dilated cardiomyopathy (DCM) is the most common form of cardiomyopathy and cause of cardiac transplantation in children. However, the epidemiology and clinical course of DCM in children are not well established...
  51. ncbi request reprint Long-term effects of treatments for childhood cancers
    Jorge A Alvarez
    Department of Pediatrics, University of Miami Jackson Memorial Medical Center, Miami, Florida, USA
    Curr Opin Pediatr 19:23-31. 2007
    ..We selectively review the negative late cardiac, endocrine, and neurological effects of childhood cancer and its treatments and comment on current research and recommendations for the care of long-term survivors of childhood cancer...
  52. doi request reprint Anthracycline associated cardiotoxicity in survivors of childhood cancer
    Steven E Lipshultz
    Department of Pediatrics, Leonard M Miller School of Medicine, University of Miami, Holtz Children s Hospital of the University of Miami Jackson Memorial Medical Center, Miami, FL 33101, USA
    Heart 94:525-33. 2008
  53. pmc Anthracycline cardiotoxicity: from bench to bedside
    Luca Gianni
    Division of Medical Oncology, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico, Instituto Nazionale Tumori, Milan, Italy
    J Clin Oncol 26:3777-84. 2008
    ..Here, we incorporate these discussions into the framework of a broader review of preclinical and clinical issues...
  54. doi request reprint Effects of HIV infection and antiretroviral therapy on the heart and vasculature
    Michael P Dube
    Circulation 118:e36-40. 2008
  55. pmc State of the science conference: Initiative to decrease cardiovascular risk and increase quality of care for patients living with HIV/AIDS: executive summary
    Steven K Grinspoon
    Circulation 118:198-210. 2008
  56. ncbi request reprint Exposure to anthracyclines during childhood causes cardiac injury
    Steven E Lipshultz
    Department of Pediatrics, and the Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Semin Oncol 33:S8-14. 2006
    ..001). Dexrazoxane was also shown to have no effect on the event-free survival rate at 2.5 years, emphasizing that it does not detrimentally affect the efficacy of anthracycline therapy...
  57. ncbi request reprint Mild dilated cardiomyopathy and increased left ventricular mass predict mortality: the prospective P2C2 HIV Multicenter Study
    Stacy D Fisher
    Midatlantic Cardiology Associates, Baltimore, MD, USA
    Am Heart J 150:439-47. 2005
    ..Many HIV-infected children die with cardiac abnormalities. We sought to understand the course of these HIV-associated abnormalities and their impact on all-cause mortality...
  58. ncbi request reprint Cardiovascular trials in long-term survivors of childhood cancer
    Steven E Lipshultz
    J Clin Oncol 22:769-73. 2004
  59. ncbi request reprint The effect of dexrazoxane on myocardial injury in doxorubicin-treated children with acute lymphoblastic leukemia
    Steven E Lipshultz
    Department of Pediatrics, University of Miami School of Medicine, Holtz Children s Hospital of the University of Miami Jackson Memorial Medical Center and the Sylvester Comprehensive Cancer Center, Miami 33101, USA
    N Engl J Med 351:145-53. 2004
    ..Doxorubicin chemotherapy is very effective in children with acute lymphoblastic leukemia (ALL) but also injures myocardial cells. Dexrazoxane, a free-radical scavenger, may protect the heart from doxorubicin-associated damage...
  60. pmc Risk factors for cardiovascular disease in children infected with human immunodeficiency virus-1
    Tracie L Miller
    Division of Pediatric Clinical Research, Department of Pediatrics, Miller School of Medicine, University of Miami, Miami, FL 33101, USA
    J Pediatr 153:491-7. 2008
    ....
  61. ncbi request reprint Postmortem cardiomegaly and echocardiographic measurements of left ventricular size and function in children infected with the human immunodeficiency virus. The Prospective P2C2 HIV Multicenter Study
    Debra L Kearney
    Department of Pathology, Baylor College of Medicine, Houston, TX 77030, USA
    Cardiovasc Pathol 12:140-8. 2003
    ..We sought to determine the postmortem prevalence, clinicopathologic relationships and importance of cardiomegaly in HIV-infected children...
  62. ncbi request reprint HIV-related cardiovascular disease and drug interactions
    Kinjal A Nanavati
    Sinai Hospital of Baltimore, Baltimore, Maryland, USA
    Am J Cardiovasc Drugs 4:315-24. 2004
    ..In summary, cardiovascular complications are important contributors to morbidity and mortality in HIV-infected patients that can be detected early in many cases and treated effectively...
  63. ncbi request reprint CDC/AHA Workshop on Markers of Inflammation and Cardiovascular Disease: Application to Clinical and Public Health Practice: report from the clinical practice discussion group
    Sidney C Smith
    Circulation 110:e550-3. 2004
  64. ncbi request reprint Chronic progressive cardiac dysfunction years after doxorubicin therapy for childhood acute lymphoblastic leukemia
    Steven E Lipshultz
    Department of Pediatrics D820, Miller School of Medicine at the University of Miami, Miami, FL 33101, USA
    J Clin Oncol 23:2629-36. 2005
    ..Cross-sectional studies show that cardiac abnormalities are common in long-term survivors of doxorubicin-treated childhood malignancies. Longitudinal data, however, are rare...
  65. ncbi request reprint Cardiac changes associated with growth hormone therapy among children treated with anthracyclines
    Steven E Lipshultz
    Department of Pediatrics, Miller School of Medicine, University of Miami, Holtz Children s Hospital, Sylvester Comprehensive Cancer Center, Miami, Florida, USA
    Pediatrics 115:1613-22. 2005
    ..Anthracycline-treated childhood cancer survivors frequently have reduced left ventricular (LV) wall thickness and contractility, and GH therapy may affect these factors...
  66. ncbi request reprint Establishing norms for echocardiographic measurements of cardiovascular structures and function in children
    Steven E Lipshultz
    J Appl Physiol 99:386-8. 2005
  67. ncbi request reprint Protecting against anthracycline-induced myocardial damage: a review of the most promising strategies
    Karlijn A Wouters
    Division of Paediatrics, Vrije Universiteit Medical Centre, Amsterdam, The Netherlands
    Br J Haematol 131:561-78. 2005
    ..We summarise the most promising current strategies to limit or prevent anthracycline-induced cardiotoxicity, as well as possible strategies to prevent existing cardiomyopathy from worsening...
  68. ncbi request reprint Dexrazoxane-associated risk for secondary malignancies in pediatric Hodgkin's disease: a claim without compelling evidence
    Steven E Lipshultz
    J Clin Oncol 25:3179; author reply 3180. 2007
  69. ncbi request reprint The relevance of information generated by in vitro experimental models to clinical doxorubicin cardiotoxicity
    Steven E Lipshultz
    Department of Pediatrics, Sylvester Comprehensive Cancer Center, University of Miami, Miller School of Medicine, Miami, FL, USA
    Leuk Lymphoma 47:1454-8. 2006
  70. pmc Frequency of elevations in markers of cardiomyocyte damage in otherwise healthy newborns
    Steven E Lipshultz
    Department of Pediatrics, University of Miami Leonard M Miller School of Medicine, Miami, Florida, USA
    Am J Cardiol 102:761-6. 2008
    ..046), and elevated high-sensitivity C-reactive protein (r = 0.66, p = 0.005). In conclusion, clinically occult myocardial injury appears to occur in some healthy newborns, although whether it is pathologic or not remains to be determined...
  71. pmc Results of the Dana-Farber Cancer Institute ALL Consortium Protocol 95-01 for children with acute lymphoblastic leukemia
    Albert Moghrabi
    Division of Hematology and Oncology, Sainte Justine Hospital, University of Montreal, Quebec, Canada
    Blood 109:896-904. 2007
    ....
  72. ncbi request reprint Impact of HIV and highly active antiretroviral therapy on leukocyte adhesion molecules, arterial inflammation, dyslipidemia, and atherosclerosis
    Stacy D Fisher
    Mid Atlantic Cardiovascular Associates, Baltimore, MD, USA
    Atherosclerosis 185:1-11. 2006
    ....
  73. ncbi request reprint Improved outcomes of pediatric dilated cardiomyopathy with utilization of heart transplantation
    Anna E Tsirka
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri, USA
    J Am Coll Cardiol 44:391-7. 2004
    ..We studied the outcomes of pediatric patients diagnosed with dilated cardiomyopathy (DCM) and their relation to epidemiologic and echocardiographic variables at the time of presentation...
  74. pmc Characteristics and outcomes of cardiomyopathy in children with Duchenne or Becker muscular dystrophy: a comparative study from the Pediatric Cardiomyopathy Registry
    David M Connuck
    Janet Weis Children s Hospital, Geisinger Medical Center, Danville, PA, USA
    Am Heart J 155:998-1005. 2008
    ..The aim of this study was to determine in pediatric Duchenne (DMD) and Becker muscular dystrophy (BMD) or other dilated cardiomyopathies (ODCM) whether outcomes differ by diagnosis...
  75. doi request reprint Isoproterenol-induced cardiotoxicity in sprague-dawley rats: correlation of reversible and irreversible myocardial injury with release of cardiac troponin T and roles of iNOS in myocardial injury
    Jun Zhang
    Division of Applied Pharmacology Research, Center for Drug Evaluation and Research, United States Food and Drug Administration, Silver Spring, Maryland 20993 0002, USA
    Toxicol Pathol 36:277-8. 2008
    ..These findings suggest that low doses of Iso exert complex effects on the myocardium and that the generation of NO through increased expression of iNOS could be an important factor in the pathogenesis of myocyte injury...
  76. ncbi request reprint Coronary artery calcifications in the long-term follow-up of Kawasaki disease
    Gul H Dadlani
    Congenital Heart Institute of Florida, All Children s Hospital, St Petersburg, Florida, USA
    Am Heart J 150:1016. 2005
    ..To determine if detection of coronary artery calcifications in patients with Kawasaki disease may serve as a noninvasive predictor of future coronary artery events...
  77. pmc Maternal protein intake is not associated with infant blood pressure
    Susanna Y Huh
    Department of Ambulatory Care and Prevention, Harvard Medical School Harvard Pilgrim Health Care, MA 02215, USA
    Int J Epidemiol 34:378-84. 2005
    ..We examined the associations of first and second trimester maternal protein intake with offspring blood pressure (BP) at the age of six months...
  78. ncbi request reprint Serum cardiac troponin T as a biomarker for acute myocardial injury induced by low doses of isoproterenol in rats
    Eugene Herman
    Division of Applied Pharmacology Research, Center for Drug Evaluation and Research, FDA, Silver Spring, MD 20993, USA
    Cardiovasc Toxicol 6:211-22. 2006
    ....
  79. ncbi request reprint Evaluation of coxsackievirus infection in children with human immunodeficiency virus type 1-associated cardiomyopathy
    Hal B Jenson
    Department of Pediatrics, MC 7811, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, TX 78229 3900, USA
    J Infect Dis 185:1798-802. 2002
    ..These results do not identify a causal role for coxsackieviruses for cardiomyopathy in HIV-1-infected children...
  80. doi request reprint Radiation-induced cardiovascular injury
    Jolyon H Hendry
    Applied Radiation Biology and Radiotherapy Section, Division of Human Health, Department of Nuclear Sciences and Applications, International Atomic Energy Agency, Wagramer Strasse 5, Vienna, Austria
    Radiat Environ Biophys 47:189-93. 2008