STEVEN MONROE LIPKIN

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Kinetics of cancer: a method to test hypotheses of genetic causation
    Steven A Frank
    Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697 2525, USA
    BMC Cancer 5:163. 2005
  2. ncbi request reprint Meiotic arrest and aneuploidy in MLH3-deficient mice
    Steven M Lipkin
    Division of Hematology Oncology, Department of Medicine, University of California, Irvine, California 92697, USA
    Nat Genet 31:385-90. 2002
  3. ncbi request reprint Familial colorectal cancer syndrome X
    Steven M Lipkin
    Cancer Genetics Clinic, Chao Family NCI Designated Comprehensive Cancer Center, University of California, Irvine, CA 92697 4038, USA
    Semin Oncol 34:425-7. 2007
  4. ncbi request reprint The MLH1 D132H variant is associated with susceptibility to sporadic colorectal cancer
    Steven M Lipkin
    Division of Oncology, Department of Medicine, University of California, Irvine, Irvine, California 92697, USA
    Nat Genet 36:694-9. 2004
  5. ncbi request reprint Contributions by MutL homologues Mlh3 and Pms2 to DNA mismatch repair and tumor suppression in the mouse
    Peng Chieh Chen
    Department of Medicine and Biological Chemistry, University of California, Irvine, California, USA
    Cancer Res 65:8662-70. 2005
  6. pmc Localization of MMR proteins on meiotic chromosomes in mice indicates distinct functions during prophase I
    Nadine K Kolas
    Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Cell Biol 171:447-58. 2005
  7. pmc Novel roles for MLH3 deficiency and TLE6-like amplification in DNA mismatch repair-deficient gastrointestinal tumorigenesis and progression
    Peng Chieh Chen
    Department of Biological Chemistry, University of California Irvine, Irvine, California, USA
    PLoS Genet 4:e1000092. 2008
  8. doi request reprint Effects of socioeconomic status and treatment disparities in colorectal cancer survival
    Hoa Le
    Chao Family Comprehensive Cancer Center, Division of Hematology Oncology, School of Medicine, University of California at Irvine, Irvine, CA 92697, USA
    Cancer Epidemiol Biomarkers Prev 17:1950-62. 2008
  9. ncbi request reprint Genetic testing to identify high-risk populations for chemoprevention studies
    Jonathan L Velasquez
    Department of Medicine, Division of Hematology Oncology, University of California, Irvine, CA 92697, USA
    Cancer Biomark 3:163-8. 2007
  10. pmc Epigenetic repression of DNA mismatch repair by inflammation and hypoxia in inflammatory bowel disease-associated colorectal cancer
    Robert A Edwards
    Department of Pathology, University of California Irvine, Irvine, California 92697 4800, USA
    Cancer Res 69:6423-9. 2009

Collaborators

Detail Information

Publications24

  1. pmc Kinetics of cancer: a method to test hypotheses of genetic causation
    Steven A Frank
    Department of Ecology and Evolutionary Biology, University of California, Irvine, CA 92697 2525, USA
    BMC Cancer 5:163. 2005
    ..We use our method to demonstrate a clear association between somatic mutation rates of different DNA mismatch repair (MMR) genotypes and the kinetics of cancer progression...
  2. ncbi request reprint Meiotic arrest and aneuploidy in MLH3-deficient mice
    Steven M Lipkin
    Division of Hematology Oncology, Department of Medicine, University of California, Irvine, California 92697, USA
    Nat Genet 31:385-90. 2002
    ..Mlh3(-/-) spermatocytes reach metaphase before succumbing to apoptosis, but oocytes fail to complete meiosis I after fertilization. Our results show that Mlh3 has an essential and distinct role in mammalian meiosis...
  3. ncbi request reprint Familial colorectal cancer syndrome X
    Steven M Lipkin
    Cancer Genetics Clinic, Chao Family NCI Designated Comprehensive Cancer Center, University of California, Irvine, CA 92697 4038, USA
    Semin Oncol 34:425-7. 2007
    ....
  4. ncbi request reprint The MLH1 D132H variant is associated with susceptibility to sporadic colorectal cancer
    Steven M Lipkin
    Division of Oncology, Department of Medicine, University of California, Irvine, Irvine, California 92697, USA
    Nat Genet 36:694-9. 2004
    ..These studies suggest that variants of mismatch repair proteins with attenuated function may account for a higher proportion of susceptibility to sporadic microsatellite-stable CRC than previously assumed...
  5. ncbi request reprint Contributions by MutL homologues Mlh3 and Pms2 to DNA mismatch repair and tumor suppression in the mouse
    Peng Chieh Chen
    Department of Medicine and Biological Chemistry, University of California, Irvine, California, USA
    Cancer Res 65:8662-70. 2005
    ....
  6. pmc Localization of MMR proteins on meiotic chromosomes in mice indicates distinct functions during prophase I
    Nadine K Kolas
    Department of Molecular Genetics, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    J Cell Biol 171:447-58. 2005
    ....
  7. pmc Novel roles for MLH3 deficiency and TLE6-like amplification in DNA mismatch repair-deficient gastrointestinal tumorigenesis and progression
    Peng Chieh Chen
    Department of Biological Chemistry, University of California Irvine, Irvine, California, USA
    PLoS Genet 4:e1000092. 2008
    ....
  8. doi request reprint Effects of socioeconomic status and treatment disparities in colorectal cancer survival
    Hoa Le
    Chao Family Comprehensive Cancer Center, Division of Hematology Oncology, School of Medicine, University of California at Irvine, Irvine, CA 92697, USA
    Cancer Epidemiol Biomarkers Prev 17:1950-62. 2008
    ..We set out to determine this using data from the large, population-based California Cancer Registry database...
  9. ncbi request reprint Genetic testing to identify high-risk populations for chemoprevention studies
    Jonathan L Velasquez
    Department of Medicine, Division of Hematology Oncology, University of California, Irvine, CA 92697, USA
    Cancer Biomark 3:163-8. 2007
    ....
  10. pmc Epigenetic repression of DNA mismatch repair by inflammation and hypoxia in inflammatory bowel disease-associated colorectal cancer
    Robert A Edwards
    Department of Pathology, University of California Irvine, Irvine, California 92697 4800, USA
    Cancer Res 69:6423-9. 2009
    ..These data link chronic hypoxic inflammation, epigenetic MMR protein down-regulation, development of MMR-deficient colorectal cancer, and the firstmouse model of somatically acquired MMR-deficient colorectal cancer...
  11. ncbi request reprint Race, socioeconomic status, treatment, and survival time among pancreatic cancer cases in California
    Jason A Zell
    Chao Family Comprehensive Cancer Center, Division of Hematology Oncology, University of California, Irvine Medical Center, 101 The City Drive South, Orange, CA 92868, USA
    Cancer Epidemiol Biomarkers Prev 16:546-52. 2007
    ..We set out to determine this using the large, population-based California Cancer Registry (CCR) database as a model...
  12. pmc Molecular models for the tissue specificity of DNA mismatch repair-deficient carcinogenesis
    Elizabeth C Chao
    Department of Medicine, Division of Hematology Oncology, University of California Irvine, CA 92697 4038, USA
    Nucleic Acids Res 34:840-52. 2006
    ....
  13. ncbi request reprint CDX2 polymorphisms, RNA expression, and risk of colorectal cancer
    Laura S Rozek
    Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, Michigan 48109 0638, USA
    Cancer Res 65:5488-92. 2005
    ....
  14. doi request reprint A population-based, descriptive analysis of malignant intraductal papillary mucinous neoplasms of the pancreas
    Hoa Le
    Chao Family Comprehensive Cancer Center, Division of Hematology Oncology, School of Medicine, University of California, Irvine, CA 92697, USA
    Cancer Epidemiol Biomarkers Prev 17:2737-41. 2008
    ..We set out to do a population-based analysis of malignant IPMNs compared with other pancreatic subtypes to better delineate its characteristics and explore implications for prevention and management...
  15. doi request reprint Genetic variation in 3-hydroxy-3-methylglutaryl CoA reductase modifies the chemopreventive activity of statins for colorectal cancer
    Steven M Lipkin
    Department of Medicine, Weill Cornell School of Medicine, New York, New York 10021, USA
    Cancer Prev Res (Phila) 3:597-603. 2010
    ..We anticipate that these data may advance the development of personalized statin use for reducing the risk of cancer as well as cardiovascular disease among the approximately 25 million people currently using statins worldwide...
  16. ncbi request reprint What are SNPs and haplotypes and how will they help us manage the prevention of adult cancer?
    Jonathan L Velasquez
    Department of Medicine, Division of Hematology Oncology, University of California, Irvine, 839 Medical Sciences Court, 2nd Floor, Sprague Hall Lab 250, Irvine, CA 92697, USA
    Curr Oncol Rep 7:475-9. 2005
    ....
  17. ncbi request reprint Expression of the MutL homologue hMLH3 in human cells and its role in DNA mismatch repair
    Elda Cannavo
    Institute of Molecular Cancer Research, University of Zurich, Zurich, Switzerland
    Cancer Res 65:10759-66. 2005
    ..If hMLH3 participates in MMR in vivo, its partial redundancy with hPMS2, coupled with the fluctuating expression levels of hMLH3, may help explain the low penetrance of hPMS2 mutations in hereditary nonpolyposis colon cancer families...
  18. doi request reprint Accurate classification of MLH1/MSH2 missense variants with multivariate analysis of protein polymorphisms-mismatch repair (MAPP-MMR)
    Elizabeth C Chao
    Genetic Epidemiology Research Institute, University of California, Irvine, Irvine, California, USA
    Hum Mutat 29:852-60. 2008
    ..MAPP-MMR is an effective bioinformatic tool for missense variant interpretation that accurately distinguishes MLH1/MSH2 deleterious variants from neutral variants...
  19. doi request reprint Survival of distinct Asian groups among colorectal cancer cases in California
    Hoa Le
    Division of Hematology Oncology, Chao Family Comprehensive Cancer Center, University of California at Irvine, Irvine, California, USA
    Cancer 115:259-70. 2009
    ..In the current study, the authors attempted to determine differences using data from the large, population-based California Cancer Registry (CCR)...
  20. pmc Disruption of Paneth and goblet cell homeostasis and increased endoplasmic reticulum stress in Agr2-/- mice
    Fang Zhao
    Department of Medicine and Biological Chemistry, University of California, Irvine, CA, USA
    Dev Biol 338:270-9. 2010
    ..These studies implicate Agr2 in intestinal homeostasis and ER stress and suggest a role in the etiology of inflammatory bowel disease...
  21. doi request reprint NOTCH signaling is required for formation and self-renewal of tumor-initiating cells and for repression of secretory cell differentiation in colon cancer
    Shaheen S Sikandar
    Department of Biological Chemistry, School of Medicine, University of California, Irvine, California, USA
    Cancer Res 70:1469-78. 2010
    ..Our findings describe a novel human cell system to study NOTCH signaling in CRC tumor initiation and suggest that inhibition of NOTCH signaling may improve CRC chemoprevention and chemotherapy...
  22. ncbi request reprint Identification and characterization of Grainyhead-like epithelial transactivator (GET-1), a novel mammalian Grainyhead-like factor
    Elena I Kudryavtseva
    Department of Medicine, Divisions of Endocrinology and Metabolism, University of California, Irvine, California 92697, USA
    Dev Dyn 226:604-17. 2003
    ..These data suggest that GET-1 is a transcriptional regulator that may perform important functions in epithelial tissues of mammals...
  23. ncbi request reprint Family with acute myelocytic leukemia, breast, ovarian, and gastrointestinal cancer
    Henry T Lynch
    Department of Preventive Medicine and Public Health, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA
    Cancer Genet Cytogenet 137:8-14. 2002
    ..However, two family members affected with AML exhibited abnormal acquired clones in their bone marrow specimens by both G-band studies and interphase FISH, both with a deletion of 5q...
  24. doi request reprint Impaired placental trophoblast lineage differentiation in Alkbh1(-/-) mice
    Zishu Pan
    Department of Medicine, University of California, Irvine, Irvine, California 92697, USA
    Dev Dyn 237:316-27. 2008
    ..Our study demonstrates Alkbh1 performs important functions in placental trophoblast lineage differentiation and participates in mechanisms of transcriptional regulation...

Research Grants17

  1. MOLECULAR ANALYSES OF MLH3 NULL MICE
    Steven Lipkin; Fiscal Year: 2003
    ....
  2. DNA Mismatch Repair and associated genes in suppression of GI adenomas and carcin
    STEVEN MONROE LIPKIN; Fiscal Year: 2010
    ..This study's goal to help define more precisely which MLH1 domains are critical for the DNA damage response has important implications for deciding which chemotherapy regimen patients carrying MLH1 missense mutations are given. ..
  3. Cancer Susceptibility and MSI Analyses of Mlh3 Null Mice
    Steven Lipkin; Fiscal Year: 2007
    ..The aim tests two hypotheses: (1) Mlh3 mutations cause MSI and (2) Mlh3 mutations disrupt single-basepair mismatch repair. ..
  4. Hypomorphic Mismatch Repair Gene Mutations and Single Molecular MSI Analyses
    Steven Lipkin; Fiscal Year: 2007
    ..SPECIFIC AIM 2: To Test Single-Molecule MSI as a Validation Assay for Additional Predicted MLH1/MSH2 deleterious alleles in MSS CRCs. ..
  5. Cancer Susceptibility and MSI Analyses of Mlh3 Null Mice
    Steven Lipkin; Fiscal Year: 2007
    ..The aim tests two hypotheses: (1) Mlh3 mutations cause MSI and (2) Mlh3 mutations disrupt single-basepair mismatch repair. ..
  6. Cancer Susceptibility and MSI Analyses of Mlh3 Null Mice
    Steven Lipkin; Fiscal Year: 2005
    ..The RESUME AND SUMMARY OF DISCUSSION section documents the final outcome of the evaluation by reviewers and is the basis for the assigned priority score ..