Robert J Lipinski

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi Ethanol-induced face-brain dysmorphology patterns are correlative and exposure-stage dependent
    Robert J Lipinski
    The Bowles Center For Alcohol Studies, University of North Carolina, Chapel Hill, North Carolina, United States of America
    PLoS ONE 7:e43067. 2012
  2. ncbi Identification of Hedgehog signaling inhibitors with relevant human exposure by small molecule screening
    Robert J Lipinski
    Molecular and Environmental Toxicology Center, School of Medicine and Public Health, University of Wisconsin Madison, Madison, WI 27599, USA
    Toxicol In Vitro 24:1404-9. 2010
  3. ncbi Cleft lip and palate results from Hedgehog signaling antagonism in the mouse: Phenotypic characterization and clinical implications
    Robert J Lipinski
    Molecular and Environmental Toxicology Center, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA
    Birth Defects Res A Clin Mol Teratol 88:232-40. 2010
  4. ncbi Unique and complimentary activities of the Gli transcription factors in Hedgehog signaling
    Robert J Lipinski
    Molecular and Environmental Toxicology Center, Madison, WI 53705 222, USA
    Exp Cell Res 312:1925-38. 2006
  5. ncbi Identification and characterization of several dietary alkaloids as weak inhibitors of hedgehog signaling
    Robert J Lipinski
    Molecular and Environmental Toxicology Center, University of Wisconsin Madison, Madison, WI 53703, USA
    Toxicol Sci 100:456-63. 2007
  6. ncbi Dose- and route-dependent teratogenicity, toxicity, and pharmacokinetic profiles of the hedgehog signaling antagonist cyclopamine in the mouse
    Robert J Lipinski
    Molecular and Environmental Toxicology Center, School of Medicine and Public Health, University of Wisconsin, Madison WI 53703, USA
    Toxicol Sci 104:189-97. 2008
  7. ncbi Magnetic resonance-based imaging in animal models of fetal alcohol spectrum disorder
    Shonagh K O'Leary-Moore
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Neuropsychol Rev 21:167-85. 2011
  8. ncbi Sonic hedgehog signaling regulates the expression of insulin-like growth factor binding protein-6 during fetal prostate development
    Robert J Lipinski
    Division of Urology, Department of Surgery, University of Wisconsin Madison, Madison, Wisconsin 53792, USA
    Dev Dyn 233:829-36. 2005
  9. ncbi Establishment and characterization of immortalized Gli-null mouse embryonic fibroblast cell lines
    Robert J Lipinski
    Department of Surgery, School of Medicine and Public Health, University of Wisconsin Madison, Madison, WI, USA
    BMC Cell Biol 9:49. 2008
  10. ncbi Hedgehog pathway responsiveness correlates with the presence of primary cilia on prostate stromal cells
    Jingxian Zhang
    Department of Urology, University of Wisconsin Madison, Madison, WI, USA
    BMC Dev Biol 9:50. 2009

Detail Information

Publications10

  1. ncbi Ethanol-induced face-brain dysmorphology patterns are correlative and exposure-stage dependent
    Robert J Lipinski
    The Bowles Center For Alcohol Studies, University of North Carolina, Chapel Hill, North Carolina, United States of America
    PLoS ONE 7:e43067. 2012
    ....
  2. ncbi Identification of Hedgehog signaling inhibitors with relevant human exposure by small molecule screening
    Robert J Lipinski
    Molecular and Environmental Toxicology Center, School of Medicine and Public Health, University of Wisconsin Madison, Madison, WI 27599, USA
    Toxicol In Vitro 24:1404-9. 2010
    ....
  3. ncbi Cleft lip and palate results from Hedgehog signaling antagonism in the mouse: Phenotypic characterization and clinical implications
    Robert J Lipinski
    Molecular and Environmental Toxicology Center, School of Medicine and Public Health, University of Wisconsin, Madison, WI, USA
    Birth Defects Res A Clin Mol Teratol 88:232-40. 2010
    ..In humans and in animal models interference with this pathway yields birth defects, among the most well-studied of which fall within the holoprosencephaly (HPE) spectrum...
  4. ncbi Unique and complimentary activities of the Gli transcription factors in Hedgehog signaling
    Robert J Lipinski
    Molecular and Environmental Toxicology Center, Madison, WI 53705 222, USA
    Exp Cell Res 312:1925-38. 2006
    ....
  5. ncbi Identification and characterization of several dietary alkaloids as weak inhibitors of hedgehog signaling
    Robert J Lipinski
    Molecular and Environmental Toxicology Center, University of Wisconsin Madison, Madison, WI 53703, USA
    Toxicol Sci 100:456-63. 2007
    ..Using an embryonic zebra fish developmental assay, we found that while cyclopamine exposure caused HPE-like defects, exposure to one of these dietary compounds, solanidine, did not...
  6. ncbi Dose- and route-dependent teratogenicity, toxicity, and pharmacokinetic profiles of the hedgehog signaling antagonist cyclopamine in the mouse
    Robert J Lipinski
    Molecular and Environmental Toxicology Center, School of Medicine and Public Health, University of Wisconsin, Madison WI 53703, USA
    Toxicol Sci 104:189-97. 2008
    ....
  7. ncbi Magnetic resonance-based imaging in animal models of fetal alcohol spectrum disorder
    Shonagh K O'Leary-Moore
    Bowles Center for Alcohol Studies, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Neuropsychol Rev 21:167-85. 2011
    ..Consideration is also given to the promise of methodological advances to allow in vivo studies of aberrant brain and behavior relationships in model animals and to the translational nature of this work...
  8. ncbi Sonic hedgehog signaling regulates the expression of insulin-like growth factor binding protein-6 during fetal prostate development
    Robert J Lipinski
    Division of Urology, Department of Surgery, University of Wisconsin Madison, Madison, Wisconsin 53792, USA
    Dev Dyn 233:829-36. 2005
    ..These studies show that Igfbp-6 is an actual target of Shh signaling in the urogenital sinus and provide the first evidence for a linkage between the Hedgehog and IGF signaling pathways in prostate development...
  9. ncbi Establishment and characterization of immortalized Gli-null mouse embryonic fibroblast cell lines
    Robert J Lipinski
    Department of Surgery, School of Medicine and Public Health, University of Wisconsin Madison, Madison, WI, USA
    BMC Cell Biol 9:49. 2008
    ..We previously characterized the individual and cooperative roles of the Gli proteins in Hh target gene regulation using a battery of primary embryonic fibroblasts from Gli null mice...
  10. ncbi Hedgehog pathway responsiveness correlates with the presence of primary cilia on prostate stromal cells
    Jingxian Zhang
    Department of Urology, University of Wisconsin Madison, Madison, WI, USA
    BMC Dev Biol 9:50. 2009
    ..The primary cilium, a feature of most interphase vertebrate cell types, serves as a required localization domain for Hh signaling transducing proteins...