Thomas Marc Link

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Osteoporosis imaging: state of the art and advanced imaging
    Thomas M Link
    Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, CA 94143, USA
    Radiology 263:3-17. 2012
  2. pmc Comparative study of imaging at 3.0 T versus 1.5 T of the knee
    Scott Wong
    Department of Radiology, University of California, San Francisco, CA 94143 0628, USA
    Skeletal Radiol 38:761-9. 2009
  3. pmc Osteoid osteoma of the femur in a 7-month-old infant treated with radiofrequency ablation
    Warapat Virayavanich
    Department of Radiology, University of California San Francisco, San Francisco, CA, USA
    Skeletal Radiol 39:1145-9. 2010
  4. ncbi request reprint In vitro and in vivo spiral CT to determine bone mineral density: initial experience in patients at risk for osteoporosis
    Thomas M Link
    Department of Radiology, Klinikum rechts der Isar, Technische Universitaet, Munich, Germany
    Radiology 231:805-11. 2004
  5. ncbi request reprint MR imaging in osteoarthritis: hardware, coils, and sequences
    Thomas M Link
    Department of Radiology and Biomedical Imaging, University of California at San Francisco, 400 Parnassus Avenue, A 367, San Francisco, CA 94131, USA
    Radiol Clin North Am 47:617-32. 2009
  6. ncbi request reprint Radiologic assessment of osteoporotic vertebral fractures: diagnostic and prognostic implications
    Thomas M Link
    Department of Radiology, University of California, San Francisco, 400 Parnassus Ave, A 367, P O Box 0628, San Francisco, CA, 94143 0628, USA
    Eur Radiol 15:1521-32. 2005
  7. ncbi request reprint Current diagnostic techniques in the evaluation of bone architecture
    Thomas M Link
    Department of Radiology, University of California, San Francisco, 400 Parnassus Avenue A 367, Box 0628, San Francisco, CA 94143, USA
    Curr Osteoporos Rep 2:47-52. 2004
  8. pmc The Founder's Lecture 2009: advances in imaging of osteoporosis and osteoarthritis
    Thomas Marc Link
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA 94131, USA
    Skeletal Radiol 39:943-55. 2010
  9. ncbi request reprint 3.0 vs 1.5 T MRI in the detection of focal cartilage pathology--ROC analysis in an experimental model
    T M Link
    Department of Radiology, University of California, San Francisco, San Francisco, CA 94143 0628, USA
    Osteoarthritis Cartilage 14:63-70. 2006
  10. doi request reprint Bone marrow changes in osteoarthritis
    Thomas M Link
    Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, CA 94131, USA
    Semin Musculoskelet Radiol 15:238-46. 2011

Detail Information

Publications97

  1. pmc Osteoporosis imaging: state of the art and advanced imaging
    Thomas M Link
    Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, CA 94143, USA
    Radiology 263:3-17. 2012
    ....
  2. pmc Comparative study of imaging at 3.0 T versus 1.5 T of the knee
    Scott Wong
    Department of Radiology, University of California, San Francisco, CA 94143 0628, USA
    Skeletal Radiol 38:761-9. 2009
    ..5 and 3.0 T in the same patients concerning image quality and visualization of cartilage pathology and to assess diagnostic performance using arthroscopy as a standard of reference...
  3. pmc Osteoid osteoma of the femur in a 7-month-old infant treated with radiofrequency ablation
    Warapat Virayavanich
    Department of Radiology, University of California San Francisco, San Francisco, CA, USA
    Skeletal Radiol 39:1145-9. 2010
    ..In summary, this case report shows that osteoid osteoma can present in early infancy and can be successfully treated with RFA at this age, however, recurrence after the procedure can occur and close follow-up is recommended...
  4. ncbi request reprint In vitro and in vivo spiral CT to determine bone mineral density: initial experience in patients at risk for osteoporosis
    Thomas M Link
    Department of Radiology, Klinikum rechts der Isar, Technische Universitaet, Munich, Germany
    Radiology 231:805-11. 2004
    ..To evaluate, both experimentally and in vivo, if nondedicated standard spiral computed tomography (CT) may be used to obtain reliable bone mineral density (BMD) data...
  5. ncbi request reprint MR imaging in osteoarthritis: hardware, coils, and sequences
    Thomas M Link
    Department of Radiology and Biomedical Imaging, University of California at San Francisco, 400 Parnassus Avenue, A 367, San Francisco, CA 94131, USA
    Radiol Clin North Am 47:617-32. 2009
    ..Also quantitative sequences have been developed to assess cartilage volume and thickness and to analyze cartilage biochemical composition...
  6. ncbi request reprint Radiologic assessment of osteoporotic vertebral fractures: diagnostic and prognostic implications
    Thomas M Link
    Department of Radiology, University of California, San Francisco, 400 Parnassus Ave, A 367, P O Box 0628, San Francisco, CA, 94143 0628, USA
    Eur Radiol 15:1521-32. 2005
    ....
  7. ncbi request reprint Current diagnostic techniques in the evaluation of bone architecture
    Thomas M Link
    Department of Radiology, University of California, San Francisco, 400 Parnassus Avenue A 367, Box 0628, San Francisco, CA 94143, USA
    Curr Osteoporos Rep 2:47-52. 2004
    ..The methodologies described will include magnetic resonance imaging, clinical multislice spiral computed tomography, and micro-computed tomography, along with computerized analysis of radiographic patterns of trabecular bone...
  8. pmc The Founder's Lecture 2009: advances in imaging of osteoporosis and osteoarthritis
    Thomas Marc Link
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA 94131, USA
    Skeletal Radiol 39:943-55. 2010
    ..Results of pertinent studies are presented and used for illustration. In summary, novel developments have significantly impacted imaging of osteoporosis and osteoarthritis over the past three decades...
  9. ncbi request reprint 3.0 vs 1.5 T MRI in the detection of focal cartilage pathology--ROC analysis in an experimental model
    T M Link
    Department of Radiology, University of California, San Francisco, San Francisco, CA 94143 0628, USA
    Osteoarthritis Cartilage 14:63-70. 2006
    ..To use receiver operator characteristics (ROC) analysis for assessing the diagnostic performance of three cartilage-specific MR sequences at 1.5 and 3 T in detecting cartilage lesions created in porcine knees...
  10. doi request reprint Bone marrow changes in osteoarthritis
    Thomas M Link
    Department of Radiology and Biomedical Imaging, University of California at San Francisco, San Francisco, CA 94131, USA
    Semin Musculoskelet Radiol 15:238-46. 2011
    ..In summary, bone marrow signal abnormalities are frequent MRI signs of osteoarthritis with different histological findings, typical associated abnormalities, and also clinical significance...
  11. ncbi request reprint Radiofrequency ablation-an alternative for definitive treatment of solitary bone metastases
    Thomas M Link
    Department of Radiology, University of California San Francisco, 400 Parnassus Ave, A 367, P O Box 0628, San Francisco, CA 94143 0628, USA
    Eur Radiol 17:3012-3. 2007
  12. ncbi request reprint Cartilage imaging: motivation, techniques, current and future significance
    Thomas M Link
    Department of Radiology, University of California, 400 Parnassus Ave, A 367, San Francisco, CA, 94143, USA
    Eur Radiol 17:1135-46. 2007
    ..There is currently substantial interest in these techniques from rheumatologists and orthopedists; radiologists therefore need to keep up with these developments...
  13. doi request reprint Correlations between joint morphology and pain and between magnetic resonance imaging, histology, and micro-computed tomography
    Thomas M Link
    Department of Radiology and Biomedical Imaging, University of California at San Francisco, 400 Parnassus Avenue, A 367, San Francisco, CA 94131, USA
    J Bone Joint Surg Am 91:30-2. 2009
    ....
  14. ncbi request reprint Normal and pathological MR findings in osteochondral autografts with longitudinal follow-up
    Thomas M Link
    Department of Radiology, Technische Universitat Munchen, Munich, Germany
    Eur Radiol 16:88-96. 2006
    ..Clinical and MR findings were not consistently associated in particular in the patients with osteochondral autograft necroses...
  15. ncbi request reprint Trabecular bone structure of the distal radius, the calcaneus, and the spine: which site predicts fracture status of the spine best?
    Thomas M Link
    Department of Diagnostic Radiology, Technische Universitaet Muenchen, Munich, Germany
    Invest Radiol 39:487-97. 2004
    ....
  16. ncbi request reprint Fuzzy logic structure analysis of trabecular bone of the calcaneus to estimate proximal femur fracture load and discriminate subjects with and without vertebral fractures using high-resolution magnetic resonance imaging at 1.5 T and 3 T
    Priyesh V Patel
    Department of Radiology, University of California, San Francisco, CA 94143 0628, USA
    Calcif Tissue Int 81:294-304. 2007
    ..Local femoral measurements are still needed to estimate femoral bone strength. Overall, parameters obtained at 3.0 T performed better than those at 1.5 T...
  17. ncbi request reprint Bone imaging: traditional techniques and their interpretation
    Holger F Boehm
    Department of Radiology, Technical University Muenchen, Ismaninger Strasse 22, 81375 Munich, Germany
    Curr Osteoporos Rep 2:41-6. 2004
    ..Quantitative ultrasound and structure analysis, based on high-resolution magnetic resonance imaging and computed tomography, are newer techniques in the diagnosis of osteoporosis that also focus on the assessment of bone structure...
  18. ncbi request reprint Analysis of trabecular bone structure with multidetector spiral computed tomography in a simulated soft-tissue environment
    Jan S Bauer
    Musculoskeletal and Quantitative Imaging Research, Department of Radiology, University of California in San Francisco, San Francisco, CA, USA
    Calcif Tissue Int 80:366-73. 2007
    ..Even though ST scatter compromises image quality substantially, the major characteristics of the trabecular network can still be appreciated and quantified...
  19. pmc Three-dimensional image registration of MR proximal femur images for the analysis of trabecular bone parameters
    Janet Blumenfeld
    Department of Radiology and UCSF UCB Joint Graduate Group in Bioengineering, University of California, San Francisco, San Francisco, California 94107, USA
    Med Phys 35:4630-9. 2008
    ....
  20. ncbi request reprint MR imaging of the ankle at 3 Tesla and 1.5 Tesla: protocol optimization and application to cartilage, ligament and tendon pathology in cadaver specimens
    Cameron Barr
    Department of Radiology, University of California San Francisco, San Francisco, CA, USA
    Eur Radiol 17:1518-28. 2007
    ..5 T and was significantly higher at 3.0 T for 2 out of 4 radiologists (p<0.05). Compared to 1.5 T, imaging of the ankle joint at 3.0 T significantly improved image quality and diagnostic performance in assessing cartilage pathology...
  21. doi request reprint Advances of 3T MR imaging in visualizing trabecular bone structure of the calcaneus are partially SNR-independent: analysis using simulated noise in relation to micro-CT, 1.5T MRI, and biomechanical strength
    Jan S Bauer
    Department of Radiology, Technische Universitat Munchen, Munich, Germany
    J Magn Reson Imaging 29:132-40. 2009
    ..5T and 3.0T and to specifically study noise effects on the visualization and quantification of trabecular architecture using conventional histomorphometric and nonlinear measures of bone structure...
  22. doi request reprint Site-specific deterioration of trabecular bone architecture in men and women with advancing age
    Eva Maria Lochmüller
    Department of Gynecology I, Ludwig Maximilians Universitat Munchen, Munich, Germany
    J Bone Miner Res 23:1964-73. 2008
    ..The microstructural basis by which a loss of BV/TV occurs with age can vary between anatomical sites...
  23. pmc Meniscal measurements of T1rho and T2 at MR imaging in healthy subjects and patients with osteoarthritis
    Isabel Rauscher
    Department of Radiology, University of California, San Francisco, San Francisco, CA 94143 0628, USA
    Radiology 249:591-600. 2008
    ....
  24. doi request reprint Trabecular bone structure analysis in the osteoporotic spine using a clinical in vivo setup for 64-slice MDCT imaging: comparison to microCT imaging and microFE modeling
    Ahi S Issever
    Department of Radiology, Charite Campus Mitte, Universitaetsmedizin Berlin, Berlin, Germany
    J Bone Miner Res 24:1628-37. 2009
    ..However, when comparing with microFE-derived bone properties, BMD is superior compared with single parameters for microarchitecture, and correlations further improve when combining with texture measures...
  25. ncbi request reprint Improved performance of hip DXA using a novel region of interest in the upper part of the femoral neck: in vitro study using bone strength as a standard of reference
    Holger F Boehm
    Department of Diagnostic Radiology, LMU Muenchen, Germany
    J Clin Densitom 8:488-94. 2005
    ..Only a weak association was observed between failure load and FNAL...
  26. ncbi request reprint Volumetric quantitative CT of the spine and hip derived from contrast-enhanced MDCT: conversion factors
    Jan S Bauer
    Department of Radiology, Technische Univerität München, Klinikum rechts der Isar, Institut für Roentgendiagnostik, Ismaninger Str 22, Munchen, Germany 81675
    AJR Am J Roentgenol 188:1294-301. 2007
    ....
  27. ncbi request reprint Comparison between gadopentetate and feruglose (Clariscan)-enhanced MR-mammography: preliminary clinical experience
    Heike E Daldrup-Link
    Department of Radiology, Technical University of Munich, Germany
    Acad Radiol 9:S343-7. 2002
  28. doi request reprint Feasibility and reproducibility of relaxometry, morphometric, and geometrical measurements of the hip joint with magnetic resonance imaging at 3T
    Julio Carballido-Gamio
    Department of Radiology, University of California San Francisco, 1700 4th Street, San Francisco, CA 94158, USA
    J Magn Reson Imaging 28:227-35. 2008
    ..To test the feasibility of in vivo magnetic resonance T(1rho) relaxation time measurements of hip cartilage, and quantify the reproducibility of hip cartilage thickness, volume, T(2), T(1rho), and size of femoral head measurements...
  29. doi request reprint Proximal femur specimens: automated 3D trabecular bone mineral density analysis at multidetector CT--correlation with biomechanical strength measurement
    Markus B Huber
    Musculoskeletal and Quantitative Imaging Research, Department of Radiology, University of California, San Francisco, 185 Berry St, Suite 350, San Francisco, CA 94107, USA
    Radiology 247:472-81. 2008
    ....
  30. doi request reprint Prevalence of pathologic findings in asymptomatic knees of marathon runners before and after a competition in comparison with physically active subjects-a 3.0 T magnetic resonance imaging study
    Robert Stahl
    Musculoskeletal and Quantitative Imaging Group, Department of Radiology, University of California, San Francisco, 185 Berry Street, Suite 350, San Francisco, CA 94107 0946, USA
    Skeletal Radiol 37:627-38. 2008
    ..To compare the diagnostic performance of cartilage-dedicated magnetic resonance imaging (MRI) sequences at 3.0 T...
  31. pmc In vivo T1rho quantitative assessment of knee cartilage after anterior cruciate ligament injury using 3 Tesla magnetic resonance imaging
    Radu I Bolbos
    Musculo skeletal Quantitative Imaging Research, Department of Radiology, University of California, San Francisco, San Francisco, California 94107, USA
    Invest Radiol 43:782-8. 2008
    ....
  32. ncbi request reprint In vivo quantification of cortical bone water with ultrashort echo-time MR imaging: a new parameter to measure bone quality?
    Thomas M Link
    Department of Radiology, University of California San Francisco, 505 Parnassus Ave, Box 0628, San Francisco, CA 94143, USA
    Radiology 248:705-6. 2008
  33. pmc New techniques for cartilage magnetic resonance imaging relaxation time analysis: texture analysis of flattened cartilage and localized intra- and inter-subject comparisons
    Julio Carballido-Gamio
    Musculoskeletal and Quantitative Imaging Research Group, Department of Radiology, University of California, San Francisco, San Francisco, California 94158, USA
    Magn Reson Med 59:1472-7. 2008
    ..The results indicate that the presented techniques have potential in longitudinal and population studies of knee OA at different stages of the disease...
  34. doi request reprint T1rho, T2 and focal knee cartilage abnormalities in physically active and sedentary healthy subjects versus early OA patients--a 3.0-Tesla MRI study
    Robert Stahl
    Department of Radiology, University of California, San Francisco, CA 94107 0946, USA
    Eur Radiol 19:132-43. 2009
    ..Thus, T1rho and T2 could be a parameter suited to identify active healthy subjects at higher risk for developing cartilage pathology...
  35. pmc Variations in morphological and biomechanical indices at the distal radius in subjects with identical BMD
    Galateia J Kazakia
    Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, 185 Berry Street, San Francisco, CA, USA
    J Biomech 44:257-66. 2011
    ..Overlap of these indices among osteoporotic status groups reflects the reported incidence of osteoporotic fracture in subjects classified as osteopenic or normal...
  36. ncbi request reprint MRI in degenerative arthritides: structural and clinical aspects
    Jian Zhao
    Department of Radiology, University of California San Francisco, 185 Berry Street, San Francisco, CA 94107, USA
    Ann N Y Acad Sci 1154:115-35. 2009
    ..This chapter describes advanced imaging techniques, including driven equilibrium Fourier transform (DEFT) and steady-state free precision (SSFP) imaging, direct MRI arthrography, and 3D-T1rho-relaxation mapping...
  37. pmc Quantitative assessment of bone marrow edema-like lesion and overlying cartilage in knees with osteoarthritis and anterior cruciate ligament tear using MR imaging and spectroscopic imaging at 3 Tesla
    Xiaojuan Li
    Musculo skeletal Quantitative Imaging Research MQIR, Department of Radiology, University of California, San Francisco UCSF, San Francisco, California 94107, USA
    J Magn Reson Imaging 28:453-61. 2008
    ..To quantitatively assess bone marrow edema-like lesion (BMEL) and the overlying cartilage in osteoarthritis (OA) or anterior cruciate ligament (ACL)-injured knees using magnetic resonance imaging (MRI) and spectroscopic imaging (MRSI)...
  38. doi request reprint Longitudinal evaluation of the effects of alendronate on MRI bone microarchitecture in postmenopausal osteopenic women
    Jenny Folkesson
    Musculoskeletal Quantitative Imaging Research Group MQIR, Department of Radiology and Biomedical Imaging, University of California, San Francisco, CA, USA
    Bone 48:611-21. 2011
    ..Treatment effects were observed in the distal tibia after 24 months. The BE-FCM method increased correlations to HR-pQCT-based parameters...
  39. ncbi request reprint Spatial analysis of magnetic resonance T1rho and T2 relaxation times improves classification between subjects with and without osteoarthritis
    Julio Carballido-Gamio
    Grupo Tecnológico Santa Fe, S A de C V, Mexico City 06140, Mexico
    Med Phys 36:4059-67. 2009
    ....
  40. doi request reprint Assessment of intervertebral disc degeneration with magnetic resonance single-voxel spectroscopy
    Jin Zuo
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, California, USA
    Magn Reson Med 62:1140-6. 2009
    ..0039). This study demonstrates for the first time that short-echo PRESS on a clinical 3T MR scanner can be used to noninvasively and can reproducibly quantify metabolic changes associated with degeneration of intervertebral discs...
  41. doi request reprint Advances in osteoporosis imaging
    Jan S Bauer
    Department of Radiology, UCSF, San Francisco, CA, USA
    Eur J Radiol 71:440-9. 2009
    ..MR diffusion and perfusion imaging and MR spectroscopy may provide measures of bone quality beyond trabecular micro-architecture...
  42. pmc Age- and gender-related differences in the geometric properties and biomechanical significance of intracortical porosity in the distal radius and tibia
    Andrew J Burghardt
    Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA 94158, USA
    J Bone Miner Res 25:983-93. 2010
    ..The biomechanical significance of these structural differences increases with age for men and women and provides discriminatory information for menopause-related bone quality effects...
  43. ncbi request reprint Evaluation of correction methods for coil-induced intensity inhomogeneities and their influence on trabecular bone structure parameters from MR images
    Jenny Folkesson
    Department of Radiology and Biomedical Imaging, Musculoskeletal and Quantitative Imaging Research Group MQIR, University of California, San Francisco, California 94158, USA
    Med Phys 36:1267-74. 2009
    ....
  44. pmc Patellar cartilage: T2 values and morphologic abnormalities at 3.0-T MR imaging in relation to physical activity in asymptomatic subjects from the osteoarthritis initiative
    Christoph Stehling
    Musculoskeletal and Quantitative Imaging Group, Department of Radiology, University of California San Francisco, 185 Berry St, Suite 350, San Francisco, CA 94107, USA
    Radiology 254:509-20. 2010
    ..To study the interrelationship between patella cartilage T2 relaxation time, other knee abnormalities, and physical activity levels in asymptomatic subjects from the Osteoarthritis Initiative (OAI) incidence cohort...
  45. pmc Local bone enhancement fuzzy clustering for segmentation of MR trabecular bone images
    Jenny Folkesson
    Department of Radiology and Biomedical Imaging, Musculoskeletal and Quantitative Imaging Research Group MQIR, University of California, San Francisco, California 94158, USA
    Med Phys 37:295-302. 2010
    ..This approach is meant to allow for a soft segmentation that accounts for partial volume effects while suppressing the influence of noise...
  46. pmc Assessment of cartilage-dedicated sequences at ultra-high-field MRI: comparison of imaging performance and diagnostic confidence between 3.0 and 7.0 T with respect to osteoarthritis-induced changes at the knee joint
    Robert Stahl
    Musculoskeletal and Quantitative Imaging Group, Department of Radiology, University of California, San Francisco, CA 94107 0946, USA
    Skeletal Radiol 38:771-83. 2009
    ..0 T ultra-high-field (UHF) magnetic resonance imaging (MRI) and to compare imaging performance and diagnostic confidence concerning osteoarthritis (OA)-induced changes at 7.0 and 3.0 T MRI...
  47. pmc Longitudinal assessment of bone marrow edema-like lesions and cartilage degeneration in osteoarthritis using 3 T MR T1rho quantification
    Jian Zhao
    Musculoskeletal and Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA 94107, USA
    Skeletal Radiol 39:523-31. 2010
    ..To quantitatively assess the relationship between bone marrow edema-like lesions (BMELs) and the associated cartilage in knee osteoarthritis (OA) using T(1rho) quantification at 3 T MRI...
  48. doi request reprint Isotropic 3-dimensional fast spin echo imaging versus standard 2-dimensional imaging at 3.0 T of the knee: artificial cartilage and meniscal lesions in a porcine model
    Oliver Ristow
    Department of Radiology, University of California San Francisco, San Francisco, CA, USA
    J Comput Assist Tomogr 34:260-9. 2010
    ....
  49. pmc In vivo 3.0-tesla magnetic resonance T1rho and T2 relaxation mapping in subjects with intervertebral disc degeneration and clinical symptoms
    Gabrielle Blumenkrantz
    Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, California 94158, USA
    Magn Reson Med 63:1193-200. 2010
    ..This study suggests that T(1rho) may be sensitive to early degenerative changes (corroborating previous studies) and clinical symptoms in intervertebral disc degeneration...
  50. pmc A longitudinal HR-pQCT study of alendronate treatment in postmenopausal women with low bone density: Relations among density, cortical and trabecular microarchitecture, biomechanics, and bone turnover
    Andrew J Burghardt
    Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, San Francisco, CA, USA
    J Bone Miner Res 25:2558-71. 2010
    ..48, p < .05). These findings suggest a more pronounced response to ALN in the tibia than in the radius, driven by trabecular and endocortical changes...
  51. pmc High-resolution imaging techniques for the assessment of osteoporosis
    Roland Krug
    MQIR, Department of Radiology and Biomedical Imaging, University of California San Francisco, UCSF China Basin Landing, 185 Berry Street, San Francisco, CA 94107, USA
    Radiol Clin North Am 48:601-21. 2010
    ..Details regarding imaging protocols as well as image postprocessing methods for bone structure quantification are discussed...
  52. pmc High-resolution peripheral quantitative computed tomographic imaging of cortical and trabecular bone microarchitecture in patients with type 2 diabetes mellitus
    Andrew J Burghardt
    Musculoskeletal Quantitative Imaging Research Group, Department of Radiology and Biomedical Imaging, University of California, San Francisco, QB3 Building, Suite 203, San Francisco, California 94158, USA
    J Clin Endocrinol Metab 95:5045-55. 2010
    ..Cross-sectional epidemiological studies have found that patients with type 2 diabetes mellitus (T2DM) have a higher incidence of certain fragility fractures despite normal or elevated bone mineral density (BMD)...
  53. doi request reprint Geodesic topological analysis of trabecular bone microarchitecture from high-spatial resolution magnetic resonance images
    Julio Carballido-Gamio
    Musculoskeletal and Quantitative Imaging Research Group, Department of Radiology, University of California, San Francisco, San Francisco, California 94158, USA
    Magn Reson Med 61:448-56. 2009
    ..95; p < 0.001). Results indicate that GTA can substantially contribute in studies of osteoporosis involving imaging of the trabecular bone microarchitecture...
  54. doi request reprint Significance of sagittal reformations in routine thoracic and abdominal multislice CT studies for detecting osteoporotic fractures and other spine abnormalities
    Dirk Müller
    Department of Radiology, Klinikum rechts der Isar, TU Munchen, Ismaninger Str 22, 81675, Munchen, Germany
    Eur Radiol 18:1696-702. 2008
    ..Sagittal reformations of standard MDCT images provide important additional information on spinal abnormalities; in particular, osteoporotic vertebral deformities are substantially better detected...
  55. pmc Relationship between trabecular bone structure and articular cartilage morphology and relaxation times in early OA of the knee joint using parallel MRI at 3 T
    R I Bolbos
    Musculoskeletal Quantitative Imaging Research, Department of Radiology, University of California San Francisco, San Francisco, CA 94107, USA
    Osteoarthritis Cartilage 16:1150-9. 2008
    ..To evaluate trabecular bone structure in relationship with cartilage parameters in distal femur and proximal tibia of the human knee at 3Tesla (3T) using high-resolution magnetic resonance imaging (MRI) with parallel imaging...
  56. doi request reprint In vivo ultra-high-field magnetic resonance imaging of trabecular bone microarchitecture at 7 T
    Roland Krug
    Department of Radiology and Biomedical Imaging, University of California, San Francisco, California, USA
    J Magn Reson Imaging 27:854-9. 2008
    ....
  57. ncbi request reprint A pilot, two-year longitudinal study of the interrelationship between trabecular bone and articular cartilage in the osteoarthritic knee
    Gabrielle Blumenkrantz
    Musculoskeletal and Quantitative Imaging Research Group, Department of Radiology, University of California, San Francisco, CA 94107, USA
    Osteoarthritis Cartilage 12:997-1005. 2004
    ..To examine the relationship between structural changes of trabecular bone and cartilage, in patients with varying degrees of osteoarthritis (OA) over 2 years, using magnetic resonance imaging...
  58. ncbi request reprint Migration of iron oxide-labeled human hematopoietic progenitor cells in a mouse model: in vivo monitoring with 1.5-T MR imaging equipment
    Heike E Daldrup-Link
    Department of Radiology, Technical University, Munich, Germany
    Radiology 234:197-205. 2005
    ..To evaluate the use of clinical 1.5-T magnetic resonance (MR) imaging equipment to depict the in vivo distribution of iron oxide-labeled human hematopoietic progenitor cells in athymic mice...
  59. pmc Regional variations of gender-specific and age-related differences in trabecular bone structure of the distal radius and tibia
    Miki Sode
    Joint Graduate Group in Bioengineering, University of California, San Francisco, CA, USA
    Bone 46:1652-60. 2010
    ..Therefore, a combined approach of investigating the entire region, each subregion, and the cortical compartment may offer more complete information...
  60. ncbi request reprint Optimization of gadodiamide concentration for MR arthrography at 3 T
    Jeffrey N Masi
    Department of Radiology, University of California, San Francisco, 400 Parnassus Ave, A 367, Box 0628, San Francisco, CA 94143 0628, USA
    AJR Am J Roentgenol 184:1754-61. 2005
    ..5 T, although a slightly greater dilution may be useful at 3 T. Signal-to-noise ratio peak levels are significantly reduced by adding an iodinated contrast agent, relatively significantly more at 3 T than at 1.5 T...
  61. ncbi request reprint In vivo 3T spiral imaging based multi-slice T(1rho) mapping of knee cartilage in osteoarthritis
    Xiaojuan Li
    Musculo skeletal Quantitative Imaging Research MQIR, Department of Radiology, University of California, San Francisco UCSF, 94107, USA
    Magn Reson Med 54:929-36. 2005
    ..The results suggest that T(1rho) relaxation times may be a promising clinical tool for osteoarthritis detection and treatment monitoring...
  62. ncbi request reprint MR imaging findings in the follow-up of patients with different stages of knee osteoarthritis and the correlation with clinical symptoms
    Catherine M Phan
    Department of Radiology, University of California San Francisco, 185 Berry Street, Suite 350, Box 0628, San Francisco, CA 94143 0946, USA
    Eur Radiol 16:608-18. 2006
    ..5-T MRI in patients with knee osteoarthritis and to correlate these findings with the clinical Western Ontario and McMaster University Osteoarthitis (WOMAC) score...
  63. ncbi request reprint A feasibility study of in vivo T1rho imaging of the intervertebral disc
    Gabrielle Blumenkrantz
    Department of Radiology, University of California San Francisco, QB3 Building, Box 2520, San Francisco, CA 94158, USA
    Magn Reson Imaging 24:1001-7. 2006
    ..The purpose of this study was to test the feasibility of quantifying T1rho relaxation time in phantoms and intervertebral discs of healthy volunteers using in vivo MR imaging at 3 T...
  64. pmc MR imaging of therapy-induced changes of bone marrow
    Heike E Daldrup-Link
    Department of Radiology, University of California San Francisco, 505 Parnassus Ave, San Francisco, CA, 94143 0628, USA
    Eur Radiol 17:743-61. 2007
    ..Future developments are directed to yield comprehensive information about bone marrow structure, function and microenvironment...
  65. doi request reprint Lactic acid and proteoglycans as metabolic markers for discogenic back pain
    Kayvan R Keshari
    Department of Radiology, University of California, San Francisco, CA 94158 2330, USA
    Spine (Phila Pa 1976) 33:312-7. 2008
    ..These samples were then analyzed using ex vivo proton high resolution magic angle spinning (HR-MAS) NMR spectroscopy to produce metabolic profiles for comparison between the 2 patient groups...
  66. ncbi request reprint Iron-oxide-enhanced MR imaging of bone marrow in patients with non-Hodgkin's lymphoma: differentiation between tumor infiltration and hypercellular bone marrow
    Heike E Daldrup-Link
    Department of Radiology, Technical University of Munich, Ismaninger Strasse 22, 81675 Munich, Germany
    Eur Radiol 12:1557-66. 2002
    ....
  67. ncbi request reprint Characterization of trabecular bone structure from high-resolution magnetic resonance images using fuzzy logic
    Julio Carballido-Gamio
    MQIR, Department of Radiology, University of California, San Francisco, San Francisco, CA 94158, USA
    Magn Reson Imaging 24:1023-9. 2006
    ..85; P<.001) and good agreements based on Bland-Altman analysis, suggesting that the level of fuzziness in high-resolution magnetic resonance images could be related to the trabecular bone structure...
  68. ncbi request reprint The effects of geometric and threshold definitions on cortical bone metrics assessed by in vivo high-resolution peripheral quantitative computed tomography
    Kevin A Davis
    Department of Mechanical Engineering, University of California Berkeley, Berkeley, CA, USA
    Calcif Tissue Int 81:364-71. 2007
    ..Furthermore, while the direct 3D Ct.Th method is less sensitive to threshold effects, both methods are moderate predictors of mechanical strength, with the annular method being the stronger correlate...
  69. ncbi request reprint Imaging of trabecular bone structure
    Thomas M Link
    Department of Radiology, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Strasse 22, D 81675 Munich, Germany
    Semin Musculoskelet Radiol 6:253-61. 2002
    ..With the advances in magnetic resonance hardware and software and new CT techniques (i.e., multislice spiral CT and clinical micro-CT), noninvasive imaging of trabecular bone is becoming more feasible...
  70. ncbi request reprint Magnetic resonance imaging of normal and osteoarthritic trabecular bone structure in the human knee
    Olivier Beuf
    University of California San Francisco, 1 Irving Street, San Francisco, CA 94143 1290, USA
    Arthritis Rheum 46:385-93. 2002
    ..To use high-resolution magnetic resonance imaging (MRI) to evaluate the trabecular bone structure in the distal femur and the proximal tibia and its to correlate the findings with different stages of osteoarthritis (OA) of the human knee...
  71. ncbi request reprint Macromolecular contrast medium (feruglose) versus small molecular contrast medium (gadopentetate) enhanced magnetic resonance imaging: differentiation of benign and malignant breast lesions
    Heike E Daldrup-Link
    Department of Radiology, Technical University of Munich, Insmaningerstr 22, 81675 Munich, Germany
    Acad Radiol 10:1237-46. 2003
    ..To compare the diagnostic performance of the blood pool agent feruglose and the standard extracellular contrast agent gadopentetate in their abilities to differentiate benign and malignant breast tumors...
  72. ncbi request reprint Quantification of breast tumor microvascular permeability with feruglose-enhanced MR imaging: initial phase II multicenter trial
    Heike E Daldrup-Link
    Dept of Radiology, Univ Hosp, Technical Univ of Munich, Ismaningerstr 22, 81675 Munich, Germany
    Radiology 229:885-92. 2003
    ..To investigate use of the macromolecular contrast agent feruglose for differentiating and grading of human benign and malignant breast tumors on the basis of their microvascular characteristics...
  73. ncbi request reprint Bone structure of the distal radius and the calcaneus vs BMD of the spine and proximal femur in the prediction of osteoporotic spine fractures
    Thomas M Link
    Department of Clinical Radiology, University of Muenster, Muenster, Germany
    Eur Radiol 12:401-8. 2002
    ..A combination of BMD and structure measures did not yield any additional information on fracture status...
  74. ncbi request reprint Osteoporosis imaging
    Thomas M Link
    Department of Radiology, Technische Universitat Munchen, Ismaninger Strasse 22, Munich D 81675, Germany
    Radiol Clin North Am 41:813-39. 2003
    ..In this article the authors presented these standard techniques and newer diagnostic techniques that provide insights in the structure of trabecular bone...
  75. ncbi request reprint Analysis of vertebral morphology in idiopathic scoliosis with use of magnetic resonance imaging and multiplanar reconstruction
    Ulf R Liljenqvist
    Department of Orthopaedics, Universitatsklinikum Munster, Germany
    J Bone Joint Surg Am 84:359-68. 2002
    ..Several studies have provided data on the vertebral morphology of normal spines, but there is a paucity of data on the vertebral morphology in patients with idiopathic scoliosis...
  76. ncbi request reprint Targeting of hematopoietic progenitor cells with MR contrast agents
    Heike E Daldrup-Link
    Department of Radiology, Technical University, Ismaninger Str 22, 81675 Munich, Germany
    Radiology 228:760-7. 2003
    ..To label human hematopoietic progenitor cells with various magnetic resonance (MR) imaging contrast agents and to obtain 1.5-T MR images of them...
  77. ncbi request reprint High-resolution magnetic resonance imaging to assess trabecular bone structure in patients after transplantation: a review
    Thomas M Link
    Department of Radiology, Technische Universitat Munchen, Ismaninger Strasse 22, D 81675 Munich, Germany
    Top Magn Reson Imaging 13:365-75. 2002
    ..In conclusion, structure measures determined in high-resolution magnetic resonance images may be useful in assessing changes of trabecular bone after organ transplantation and may improve the prediction of fracture risk...
  78. ncbi request reprint Detection and quantification of breast tumor necrosis with MR imaging: value of the necrosis-avid contrast agent Gadophrin-3
    Stephan Metz
    Department of Radiology, Technical University, Ismaninger Strasse 22, 81675 Munich, Germany
    Acad Radiol 10:484-90. 2003
    ..The authors evaluated the use of T1-weighted magnetic resonance (MR) imaging with Gadophrin-3 enhancement and of plain T2-weighted MR imaging to detect and quantify breast tumor necrosis...
  79. ncbi request reprint High-resolution MRI vs multislice spiral CT: which technique depicts the trabecular bone structure best?
    Thomas M Link
    Department of Clinical Radiology, University of Munster, Munster, Germany
    Eur Radiol 13:663-71. 2003
    ..01). High-resolution MR-derived structure parameters, however, performed better in the prediction of trabecular bone structure...
  80. ncbi request reprint Local differences in the trabecular bone structure of the proximal femur depicted with high-spatial-resolution MR imaging and multisection CT
    Ahi Sema Issever
    Magnetic Resonance Science Center, Department of Radiology, University of California, San Francisco, USA
    Acad Radiol 9:1395-406. 2002
    ..The authors performed this study to investigate structural variations in the trabecular bone of the proximal femur at high-resolution magnetic resonance (MR) imaging and high-resolution multisection computed tomography (CT)...
  81. ncbi request reprint Reproducibility and side differences of mechanical tests for determining the structural strength of the proximal femur
    Felix Eckstein
    Musculoskeletal Research Group, Institute of Anatomy, Ludwig Maximilians Universitat, Munchen, Germany
    J Bone Miner Res 19:379-85. 2004
    ..Based on side differences in femoral failure loads in 55 pairs of femora, we estimated the upper limit of the precision error to be 15% for the side impact test, whereas the intersubject variability was >40%...
  82. ncbi request reprint Assessment of vascular invasion in pancreatic head cancer with multislice spiral CT: value of multiplanar reconstructions
    Melanie Brügel
    Department of Radiology, Klinikum rechts der Isar, Technische Universitat Munchen, Ismaninger Strasse 22, 81675 Munich, Germany
    Eur Radiol 14:1188-95. 2004
    ..Thin-slice MPRs oriented perpendicularly to a possibly invaded vessel exactly depict the grade of circumferential involvement and thus have the capability to improve the assessment of vascular invasion in pancreatic cancer...
  83. ncbi request reprint Determinants and heterogeneity of mechanical competence throughout the thoracolumbar spine of elderly women and men
    Felix Eckstein
    Department of Diagnostic Radiology, TU, Munchen, Germany
    Bone 35:364-74. 2004
    ..However, total density predicts functional segment failure stress with higher accuracy than (sub)cortical or trabecular density and is thus recommended for predicting fracture strength clinically...
  84. ncbi request reprint In vivo bone and cartilage MRI using fully-balanced steady-state free-precession at 7 tesla
    Roland Krug
    Department of Radiology, University of California, San Francisco, San Francisco, California, USA
    Magn Reson Med 58:1294-8. 2007
    ..3) compared with 3T (21.3 +/- 3.3). Bone SNR increased from 11.8 +/- 2.0 to 13.2 +/- 2.5 at the higher field strength. We concluded that there is SNR benefit and great potential for bone and cartilage imaging at higher field strength...
  85. pmc Inter-subject comparison of MRI knee cartilage thickness
    Julio Carballido-Gamio
    MQIR, Department of Radiology, University of California, QB3 Building, 2nd Floor, 201, 1700 4th Street, San Francisco, CA 94158, USA
    Med Image Anal 12:120-35. 2008
    ..Results showed that the proposed technique is robust, accurate, and reproducible to perform point to point inter-subject comparison of knee cartilage thickness values...
  86. ncbi request reprint Magnetic resonance imaging of the ankle at 3.0 Tesla and 1.5 Tesla in human cadaver specimens with artificially created lesions of cartilage and ligaments
    Jan S Bauer
    Department of Radiology, Technical University, Munich, Germany
    Invest Radiol 43:604-11. 2008
    ..To compare magnetic resonance imaging of the ankle joint at 1.5 Tesla (T) and 3.0 T in the assessment of cartilage and ligament pathology in fresh human cadaver specimens...
  87. ncbi request reprint Fast high-spatial-resolution MRI of the ankle with parallel imaging using GRAPPA at 3 T
    Jan Stefan Bauer
    Department of Radiology, University of California at San Francisco, San Francisco, CA, USA
    AJR Am J Roentgenol 189:240-5. 2007
    ..The purpose of our study was to compare an autocalibrating parallel imaging technique at 3 T with standard acquisitions at 3 and 1.5 T for small-field-of-view imaging of the ankle...
  88. ncbi request reprint Sex differences of human trabecular bone microstructure in aging are site-dependent
    Felix Eckstein
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Medical University, Salzburg, Austria
    J Bone Miner Res 22:817-24. 2007
    ..Significant sex differences are observed at the distal radius, femoral neck, and femoral trochanter, but not at the iliac crest, calcaneus, and lumbar vertebral body. Correlations in BV/TV between sites ranged from r = 0.13 to 0.56...
  89. ncbi request reprint Quantitative MRI of cartilage and bone: degenerative changes in osteoarthritis
    Felix Eckstein
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Private Medical University PMU, A 5020 Salzburg, Austria
    NMR Biomed 19:822-54. 2006
    ....
  90. ncbi request reprint Volumetric cartilage measurements of porcine knee at 1.5-T and 3.0-T MR imaging: evaluation of precision and accuracy
    Jan S Bauer
    Musculoskeletal and Quantitative Imaging Research, Department of Radiology, University of California, San Francisco, Calif, USA
    Radiology 241:399-406. 2006
    ..To compare the precision and accuracy of 3.0-T and 1.5-T magnetic resonance (MR) imaging in the quantification of cartilage volume by using direct volumetric measurements as a reference standard...
  91. ncbi request reprint Trabecular bone structure of the calcaneus: comparison of MR imaging at 3.0 and 1.5 T with micro-CT as the standard of reference
    Catherine M Phan
    Department of Radiology, University of California, San Francisco, 400 Parnassus Ave, A 367, Box 0628, San Francisco, CA 94143 0628, USA
    Radiology 239:488-96. 2006
    ..0-T MR imaging with that of 1.5-T MR imaging in differentiating donors with spinal fractures from those without spinal fractures...
  92. ncbi request reprint Cartilage MR imaging at 3.0 versus that at 1.5 T: preliminary results in a porcine model
    Jeffrey N Masi
    Department of Radiology, University of California, San Francisco, 400 Parnassus Ave, A 367, Box 0628, San Francisco, CA 94143 0628, USA
    Radiology 236:140-50. 2005
    ..To compare 1.5- and 3.0-T magnetic resonance (MR) images of porcine knee specimens containing artificial cartilage lesions in terms of accuracy of lesion depiction, image quality, and signal-to-noise ratio (SNR)...
  93. ncbi request reprint Computer-aided quantification of focal cartilage lesions using MRI: accuracy and initial arthroscopic comparison
    Keh Yang Lee
    University of California at San Francisco, San Francisco, CA 94143, USA
    Osteoarthritis Cartilage 13:728-37. 2005
    ..The GPM using magnetic resonance imaging (MRI) was previously proposed to quantitatively assess the morphology of focal cartilage lesions, and its feasibility was demonstrated...
  94. ncbi request reprint Trabecular bone structure obtained from multislice spiral computed tomography of the calcaneus predicts osteoporotic vertebral deformities
    Priyesh V Patel
    Chicago Medical School, North Chicago, IL, USA
    J Comput Assist Tomogr 29:246-53. 2005
    ....
  95. ncbi request reprint Chest radiography with a digital flat-panel detector: experimental receiver operating characteristic analysis
    Stephan Metz
    Department of Diagnostic Radiology and Institute of Medical Statistics and Epidemiology, Technische Universitat Munchen, Ismaninger Str 22, 81675 Munich, Germany
    Radiology 234:776-84. 2005
    ....
  96. ncbi request reprint In vivo determination of bone structure in postmenopausal women: a comparison of HR-pQCT and high-field MR imaging
    Galateia J Kazakia
    Musculoskeletal and Quantitative Imaging Research Group, Department of Radiology, University of California, San Francisco, California 94158, USA
    J Bone Miner Res 23:463-74. 2008
    ..Significant but moderate correlations and 2- to 4-fold discrepancies in parameter values were detected, suggesting that differences in acquisition and analysis must be considered when interpreting data from these imaging modalities...
  97. doi request reprint MRI and CT of insufficiency fractures of the pelvis and the proximal femur
    Miguel C Cabarrus
    Department of Radiology, University of California, San Francisco, 400 Parnassus Ave, A 367, San Francisco, CA 94143, USA
    AJR Am J Roentgenol 191:995-1001. 2008
    ....