Joel M Linden

Summary

Affiliation: University of Virginia
Country: USA

Publications

  1. ncbi request reprint Molecular approach to adenosine receptors: receptor-mediated mechanisms of tissue protection
    J Linden
    Department of Cardiovascular Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    Annu Rev Pharmacol Toxicol 41:775-87. 2001
  2. ncbi request reprint Influence of propranolol, enalaprilat, verapamil, and caffeine on adenosine A(2A)-receptor-mediated coronary vasodilation
    Laurent M Riou
    Cardiovascular Division, University of Virginia Health System, Charlottesville, VA 22908 0500, USA
    J Am Coll Cardiol 40:1687-94. 2002
  3. ncbi request reprint A2A adenosine receptor activation improves survival in mouse models of endotoxemia and sepsis
    Gail W Sullivan
    Department of Internal Medicine, University of Virginia, Charlottesville, Virginia, USA
    J Infect Dis 189:1897-904. 2004
  4. ncbi request reprint A2A adenosine receptor induction inhibits IFN-gamma production in murine CD4+ T cells
    Courtney M Lappas
    Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 174:1073-80. 2005
  5. ncbi request reprint A2A adenosine receptors on bone marrow-derived cells protect liver from ischemia-reperfusion injury
    Yuan Ji Day
    Cardiovascular Research Center, Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 174:5040-6. 2005
  6. ncbi request reprint Characterization of human A(2B) adenosine receptors: radioligand binding, western blotting, and coupling to G(q) in human embryonic kidney 293 cells and HMC-1 mast cells
    J Linden
    Department of Internal Medicine, University of Virginia, Charlottesville, Virginia, USA
    Mol Pharmacol 56:705-13. 1999
  7. ncbi request reprint Adenosine in tissue protection and tissue regeneration
    Joel Linden
    Department of Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    Mol Pharmacol 67:1385-7. 2005
  8. ncbi request reprint Cell biology. Purinergic chemotaxis
    Joel Linden
    Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Science 314:1689-90. 2006
  9. ncbi request reprint Autoregulation of cyclic AMP in vascular smooth muscle: a role for adenosine receptors
    Joel Linden
    Department of Medicine, University of Virginia, Charlottesville 22908, USA
    Mol Pharmacol 62:969-70. 2002
  10. pmc New insights into the regulation of inflammation by adenosine
    Joel Linden
    Department of Medicine and Cardiovascular Research Center, University of Virginia, Charlottesville, Virginia 22908, USA
    J Clin Invest 116:1835-7. 2006

Collaborators

Detail Information

Publications65

  1. ncbi request reprint Molecular approach to adenosine receptors: receptor-mediated mechanisms of tissue protection
    J Linden
    Department of Cardiovascular Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    Annu Rev Pharmacol Toxicol 41:775-87. 2001
    ..These new pharmacologic tools will help investigators to sort out how adenosine protects tissues from injury and to identify new therapeutic agents that hold promise for the treatment of inflammatory and ischemic diseases...
  2. ncbi request reprint Influence of propranolol, enalaprilat, verapamil, and caffeine on adenosine A(2A)-receptor-mediated coronary vasodilation
    Laurent M Riou
    Cardiovascular Division, University of Virginia Health System, Charlottesville, VA 22908 0500, USA
    J Am Coll Cardiol 40:1687-94. 2002
    ..The study was done to determine the effects of propranolol, enalaprilat, verapamil, and caffeine on the vasodilatory properties of the adenosine A(2A)-receptor agonist ATL-146e (ATL)...
  3. ncbi request reprint A2A adenosine receptor activation improves survival in mouse models of endotoxemia and sepsis
    Gail W Sullivan
    Department of Internal Medicine, University of Virginia, Charlottesville, Virginia, USA
    J Infect Dis 189:1897-904. 2004
    ..Sepsis is currently treated with antibiotics and various adjunctive therapies that are not very effective...
  4. ncbi request reprint A2A adenosine receptor induction inhibits IFN-gamma production in murine CD4+ T cells
    Courtney M Lappas
    Department of Pharmacology, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 174:1073-80. 2005
    ..We conclude that the rapid induction of the A(2A)AR mRNA in T cells provides a mechanism for limiting T cell activation and secondary macrophage activation in inflamed tissues...
  5. ncbi request reprint A2A adenosine receptors on bone marrow-derived cells protect liver from ischemia-reperfusion injury
    Yuan Ji Day
    Cardiovascular Research Center, Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 174:5040-6. 2005
    ..The data suggest that activation of the A(2A)R on bone marrow-derived cells is primarily responsible for protecting the liver from reperfusion injury...
  6. ncbi request reprint Characterization of human A(2B) adenosine receptors: radioligand binding, western blotting, and coupling to G(q) in human embryonic kidney 293 cells and HMC-1 mast cells
    J Linden
    Department of Internal Medicine, University of Virginia, Charlottesville, Virginia, USA
    Mol Pharmacol 56:705-13. 1999
    ..In human HMC-1 mast cells, A(2B)AR activation stimulates calcium mobilization and cAMP accumulation. We conclude that HEK-A(2B) cells and HMC-1 mast cells possess A(2B)AR glycoproteins that are coupled to both G(q/11) and G(s)...
  7. ncbi request reprint Adenosine in tissue protection and tissue regeneration
    Joel Linden
    Department of Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    Mol Pharmacol 67:1385-7. 2005
    ..Multiple cell types and all four adenosine receptors participate in these responses. Exploiting these effects of adenosine has great therapeutic potential...
  8. ncbi request reprint Cell biology. Purinergic chemotaxis
    Joel Linden
    Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    Science 314:1689-90. 2006
  9. ncbi request reprint Autoregulation of cyclic AMP in vascular smooth muscle: a role for adenosine receptors
    Joel Linden
    Department of Medicine, University of Virginia, Charlottesville 22908, USA
    Mol Pharmacol 62:969-70. 2002
  10. pmc New insights into the regulation of inflammation by adenosine
    Joel Linden
    Department of Medicine and Cardiovascular Research Center, University of Virginia, Charlottesville, Virginia 22908, USA
    J Clin Invest 116:1835-7. 2006
    ..Nevertheless, the role of the A2BAR remains enigmatic since its activation can either stimulate or inhibit the release of proinflammatory cytokines in different cells and tissues...
  11. pmc Activation of A1, A2A, or A3 adenosine receptors attenuates lung ischemia-reperfusion injury
    Leo M Gazoni
    Department of Surgery, University of Virginia Health System, Charlottesville, VA 22908, USA
    J Thorac Cardiovasc Surg 140:440-6. 2010
    ..We hypothesized that activation of A(1), A(2A), or A(3) adenosine receptors would provide protection against lung ischemia-reperfusion injury...
  12. pmc Renal protection from ischemia mediated by A2A adenosine receptors on bone marrow-derived cells
    Yuan Ji Day
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia 22908, USA
    J Clin Invest 112:883-91. 2003
    ..We conclude that protection from renal IRI by A2AR agonists or endogenous adenosine requires activation of receptors expressed on BM-derived cells...
  13. pmc Timing of adenosine 2A receptor stimulation relative to reperfusion has differential effects on infarct size and cardiac function as assessed in mice by MRI
    Zequan Yang
    Department of Surgery, University of Virginia, MR5 Bldg Rm 1219, Box 800759, 415 Lane Rd, Charlottesville, VA 22903, USA
    Am J Physiol Heart Circ Physiol 295:H2328-35. 2008
    ..The infarct size was significantly reduced by ATL when given just before reperfusion, but not 1 h postreperfusion. Either treatment window helped preserve the EF between 1 and 24 h postreperfusion...
  14. ncbi request reprint Protection from ischemic liver injury by activation of A2A adenosine receptors during reperfusion: inhibition of chemokine induction
    Yuan Ji Day
    Department of Internal Medicine, Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA
    Am J Physiol Gastrointest Liver Physiol 286:G285-93. 2004
    ..We speculate that inhibition of chemokine and cytokine production limits inflammation and contributes to tissue protection by the A(2A)AR agonist ATL146e...
  15. ncbi request reprint Activation of adenosine 2A receptors attenuates allograft rejection and alloantigen recognition
    Charles P Sevigny
    Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 178:4240-9. 2007
    ..We conclude that A(2A)R agonists may represent a new class of compounds for induction therapy in organ transplantation...
  16. ncbi request reprint Therapeutic anti-inflammatory effects of myeloid cell adenosine receptor A2a stimulation in lipopolysaccharide-induced lung injury
    Jörg Reutershan
    Robert M Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 179:1254-63. 2007
    ..These findings were confirmed in A2a(flox/flox) x LysM-cre mice. ATL202 was only effective when A2a was present on BM-derived cells. A2a agonists may be effective at curbing inflammatory lung tissue damage...
  17. pmc Adenosine A2A receptor activation reduces infarct size in the isolated, perfused mouse heart by inhibiting resident cardiac mast cell degranulation
    Tyler H Rork
    Robert M Berne Cardiovascular Research Center, University of Virginia Health System, Charlottesville, VA, USA
    Am J Physiol Heart Circ Physiol 295:H1825-33. 2008
    ..In addition, our data suggest that A2AAR activation is cardioprotective in the isolated heart, at least in part by attenuating resident mast cell degranulation...
  18. pmc Adenosine A2A receptor activation on CD4+ T lymphocytes and neutrophils attenuates lung ischemia-reperfusion injury
    Ashish K Sharma
    Department of Surgery, University of Virginia Health System, Charlottesville, VA 22908, USA
    J Thorac Cardiovasc Surg 139:474-82. 2010
    ..This study tests the hypothesis that adenosine A(2A) receptor activation attenuates ischemia-reperfusion injury by inhibiting CD4+ T cell activation and subsequent neutrophil infiltration...
  19. pmc Reduction in myocardial infarct size at 48 hours after brief intravenous infusion of ATL-146e, a highly selective adenosine A2A receptor agonist
    Rajan A G Patel
    Cardiovascular Division, Department of Medicine, University of Virginia, Charlottesville, Virginia 22908, USA
    Am J Physiol Heart Circ Physiol 297:H637-42. 2009
    ..No significant further benefit was seen with a 24-h infusion...
  20. pmc Lipopolysaccharide rapidly modifies adenosine receptor transcripts in murine and human macrophages: role of NF-kappaB in A(2A) adenosine receptor induction
    Lauren J Murphree
    Department of Pharmacology, University of Virginia Health System, PO Box 801394, 1300 Jefferson Park Avenue, Charlottesville, VA 22908, USA
    Biochem J 391:575-80. 2005
    ....
  21. ncbi request reprint Renal ischemia-reperfusion injury and adenosine 2A receptor-mediated tissue protection: the role of CD4+ T cells and IFN-gamma
    Yuan Ji Day
    Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 176:3108-14. 2006
    ..These studies demonstrate that CD4+ IFN-gamma contributes to IRI and that A(2A) agonists mediate protection from IRI through action on CD4+ cells...
  22. ncbi request reprint Assessment of myocardial inflammation produced by experimental coronary occlusion and reperfusion with 99mTc-RP517, a new leukotriene B4 receptor antagonist that preferentially labels neutrophils in vivo
    Laurent M Riou
    University of Virginia Health System, Charlottesville, VA 22908 0500, USA
    Circulation 106:592-8. 2002
    ....
  23. pmc Enhanced fibrinolysis protects against lung ischemia-reperfusion injury
    Christine L Lau
    Division of Thoracic and Cardiovascular Surgery, University of Virginia, Charlottesville, VA, USA
    J Thorac Cardiovasc Surg 137:1241-8. 2009
    ..This study investigates the role of the fibrinolytic cascade in lung ischemia-reperfusion injury and investigates the interplay between the fibrinolytic system and the inflammatory response...
  24. ncbi request reprint Renal ischemia-reperfusion injury and adenosine 2A receptor-mediated tissue protection: role of macrophages
    Yuan Ji Day
    Div of Nephrology, Box 133, Univ of Virginia Health System, Charlottesville, VA 22908, USA
    Am J Physiol Renal Physiol 288:F722-31. 2005
    ..We conclude that the full extent of IRI requires macrophages and that A(2A) agonist-mediated tissue protection is independent of activation of macrophage A(2A)Rs...
  25. ncbi request reprint Adenosine A2A analogue ATL-146e reduces systemic tumor necrosing factor-alpha and spinal cord capillary platelet-endothelial cell adhesion molecule-1 expression after spinal cord ischemia
    David C Cassada
    Division of Thoracic and Cardiovascular Surgery, Department of Surgery, Health Sciences Center, The University of Virginia Health System, Charlottesville, VA 22908, USA
    J Vasc Surg 35:994-8. 2002
    ..Data are expressed as mean +/- standard error of the mean, with statistical analysis with Student t test and Kruskal-Wallis nonparametric test...
  26. ncbi request reprint Activation of A2A adenosine receptor attenuates intestinal inflammation in animal models of inflammatory bowel disease
    Masaru Odashima
    Digestive Health Center of Excellence, University of Virginia Health System, Charlottesville 22908, USA
    Gastroenterology 129:26-33. 2005
    ..The aim of this study was to investigate the role of A 2A in mucosal inflammation by administering a selective A 2A agonist (ATL-146e) to experimental models of inflammatory bowel disease...
  27. pmc Adenosine receptor A2A deficiency in leukocytes increases arterial neointima formation in apolipoprotein E-deficient mice
    Huan Wang
    Department of Medicine, University of Minnesota, Minneapolis, USA
    Arterioscler Thromb Vasc Biol 30:915-22. 2010
    ....
  28. ncbi request reprint Rapid modification of the glycocalyx caused by ischemia-reperfusion is inhibited by adenosine A2A receptor activation
    Steven H Platts
    Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville 22908, USA
    Am J Physiol Heart Circ Physiol 284:H2360-7. 2003
    ..The modifications of the glycocalyx appear to be an early step in the inflammatory cascade typically associated with reperfusion injury, and adenosine A(2A) receptor activation may play a role in protection from this injury...
  29. pmc P-selectin-mediated platelet-neutrophil aggregate formation activates neutrophils in mouse and human sickle cell disease
    Renata Polanowska-Grabowska
    Department of Medicine, University of Virginia, Charlottesville, USA
    Arterioscler Thromb Vasc Biol 30:2392-9. 2010
    ..To determine the role of platelets in stimulating mouse and human neutrophil activation and pulmonary injury in sickle cell disease (SCD)...
  30. pmc Early adenosine receptor activation ameliorates spinal cord reperfusion injury
    T Brett Reece
    Department of Surgery, University of Virginia, Charlottesville, Virginia, USA
    J Cardiovasc Med (Hagerstown) 9:363-7. 2008
    ..We hypothesized that adenosine receptor activation with ATL-146e would produce similar protection from ischemic spinal cord injury, whether given at reperfusion or in a delayed fashion...
  31. pmc The A2B adenosine receptor impairs the maturation and immunogenicity of dendritic cells
    Jeffrey M Wilson
    Department of Medicine, University of Virginia, Charlottesville, VA 22908, USA
    J Immunol 182:4616-23. 2009
    ..These data indicate that engagement of A(2B)AR modifies murine BMDC maturation and suggest that adenosine regulates CD4(+) T cell responses by selecting for DC with impaired immunogencity...
  32. pmc The allosteric enhancer PD81,723 increases chimaeric A1/A2A adenosine receptor coupling with Gs
    Samita Bhattacharya
    Department of Internal Medicine, Cardiovascular Division, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    Biochem J 396:139-46. 2006
    ..The results suggest that the recognition site for PD81,723 is on the A1 receptor and that the enhancer acts to directly stabilize the receptor to a conformational state capable of coupling with G(i) or G(s)...
  33. ncbi request reprint Adenosine A2A receptor activation attenuates inflammation and injury in diabetic nephropathy
    Alaa S Awad
    Department of Medicine, University of Virginia, Charlottesville, USA
    Am J Physiol Renal Physiol 290:F828-37. 2006
    ..These results demonstrate that chronic A(2A)R activation in diabetic rats 1) ameliorates histological and functional changes in kidneys induced by diabetes and 2) causes reduced inflammation associated with diabetic nephropathy...
  34. ncbi request reprint Optimization of a mouse locomotor rating system to evaluate compression-induced spinal cord injury: correlation of locomotor and morphological injury indices
    Yuesheng Li
    Department of Medicine, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    J Neurosurg Spine 4:165-73. 2006
    ..The authors describe an improved locomotor scoring system for evaluating SCI. The modified Basso-Beattie-Bresnahan (mBBB) scoring system for mice is compared with existing procedures as well as histological SCI criteria...
  35. pmc Activation of adenosine 2A receptors preserves structure and function of podocytes
    Alaa S Awad
    Division of Nephrology, Box 133, University of Virginia Health System, Charlottesville, VA 22908, USA
    J Am Soc Nephrol 19:59-68. 2008
    ..It was concluded that A(2A)R activation reduces glomerular proteinuria, at least in part, by preserving the normal structure of podocyte foot processes, slit diaphragms, and actin cytoskeleton...
  36. pmc Adenosine A2A receptor activation reduces hepatic ischemia reperfusion injury by inhibiting CD1d-dependent NKT cell activation
    Courtney M Lappas
    Department of Pharmacology, University of Virginia, Charlottesville, VA 2290, USA
    J Exp Med 203:2639-48. 2006
    ..These findings suggest that hepatic reperfusion injury is initiated by the CD1d-dependent activation of NKT cells, and the activation of these cells is inhibited by A2AR activation...
  37. ncbi request reprint Comparison of systemic and retrograde delivery of adenosine A2A agonist for attenuation of spinal cord injury after thoracic aortic cross-clamping
    T Brett Reece
    Department of Surgery, University of Virginia, Charlottesville, Virginia, USA
    Ann Thorac Surg 81:902-9. 2006
    ..We hypothesized that despite retrograde spinal perfusion of an adenosine A2A agonist (ATL-146e), systemic therapy produces superior spinal cord protection with reduced inflammation...
  38. pmc CD73 is expressed by human regulatory T helper cells and suppresses proinflammatory cytokine production and Helicobacter felis-induced gastritis in mice
    Mohammad S Alam
    Digestive Health Center, Division of Gastroenterology and Hepatology, Department of Medicine, University of Virginia, Charlottesville, VA 22908 0708, USA
    J Infect Dis 199:494-504. 2009
    ..We investigated the expression of CD39 and CD73 on human T helper (Th) cells and the role of CD73 in regulating Helicobacter felis-induced gastritis and colonization...
  39. pmc Compartmentalization of neutrophils in the kidney and lung following acute ischemic kidney injury
    Alaa S Awad
    Division of Nephrology, Department of Medicine, University of Virginia Health System, Charlottesville, VA 22908, USA
    Kidney Int 75:689-98. 2009
    ..Our findings suggest there is a sequential recruitment and transmigration of neutrophils from the vasculature into the kidney interstitium at the site of tissue injury following renal ischemia-reperfusion...
  40. pmc An A2A adenosine receptor agonist, ATL313, reduces inflammation and improves survival in murine sepsis models
    CHRISTOPHER C MOORE
    Division of Infectious Diseases and International Health, Department of Medicine, University of Virginia, Box 801342, Charlottesville, VA 22908, USA
    BMC Infect Dis 8:141. 2008
    ..Here we describe molecular and cellular responses, as well as survival, in A 2A adenosine receptor (AR) agonist treated and untreated animals during experimental sepsis...
  41. ncbi request reprint Adenosine A2A analogue reduces long-term neurologic injury after blunt spinal trauma
    T Brett Reece
    Department of Surgery, University of Virginia, Charlottesville, VA 22908, USA
    J Surg Res 121:130-4. 2004
    ..In the current study, we extended the treatment paradigm and tested neurobehavioral functioning out to 1 week after injury to assess if early neurological improvement is sustained long term by an adenosine analogue...
  42. ncbi request reprint Anatomy of adenosine A2A receptors in brain: morphological substrates for integration of striatal function
    Diane L Rosin
    Department of Pharmacology, University of Virginia Health Sciences Center, Charlottesville, VA 22908 0735, USA
    Neurology 61:S12-8. 2003
    ..These ultrastructural findings suggest several pathways through which A2A receptor blockade may act to dampen the elevated striatopallidal GABAergic signaling that occurs in PD...
  43. ncbi request reprint A comparison of adenosine A2A agonism and methylprednisolone in attenuating neuronal damage and improving functional outcome after experimental traumatic spinal cord injury in rabbits
    David O Okonkwo
    Department of Neurological Surgery, University of Virginia Health System, Charlottesville 22908 0212, USA
    J Neurosurg Spine 4:64-70. 2006
    ..The authors of this study evaluated ATL-146e and methylprednisolone for their ability to preserve neuronal viability and motor function in experimental SCI...
  44. ncbi request reprint Lidocaine enhances Galphai protein function
    Claudia Benkwitz
    Department of Anesthesiology, University of Virginia, Charlottesville, Virginia, 22908 0710, USA
    Anesthesiology 99:1093-101. 2003
    ..A1Rs are widely expressed and abundant in the spinal cord, brain, and heart. Interactions of LAs with the hA1R-coupled transduction cascade therefore might produce a broad range of clinically relevant effects...
  45. pmc Protection from pulmonary ischemia-reperfusion injury by adenosine A2A receptor activation
    Ashish K Sharma
    Department of Surgery, University of Virginia Health System, Charlottesville, Virginia, USA
    Respir Res 10:58. 2009
    ..In the present study, we investigated the effects of adenosine A2A receptor (A2AAR) activation on resident lung cells after IR injury using an isolated, buffer-perfused murine lung model...
  46. pmc The role of adenosine A2A receptor signaling in bronchiolitis obliterans
    Christine L Lau
    Department of Surgery, University of Virginia Health System, Charlottesville, Virginia, USA
    Ann Thorac Surg 88:1071-8. 2009
    ....
  47. ncbi request reprint Activation of A2A adenosine receptors inhibits expression of alpha 4/beta 1 integrin (very late antigen-4) on stimulated human neutrophils
    Gail W Sullivan
    Department of Internal Medicine, University of Virginia, Charlottesville, VA 22908, USA
    J Leukoc Biol 75:127-34. 2004
    ..We conclude that adenosine binding to A(2A)AR counteracts stimulation of neutrophil CD49d integrin expression and neutrophil binding to VCAM-1 via a cAMP/PKA-mediated pathway...
  48. ncbi request reprint Adenosine A2A receptor activation decreases reperfusion injury associated with high-flow reperfusion
    Steven M Fiser
    Department of Thoracic and Cardiovascular Surgery, University of Virginia Health Sciences Center, Charlottesville, VA 22908, USA
    J Thorac Cardiovasc Surg 124:973-8. 2002
    ..Our hypothesis was that selective activation of the adenosine A(2A) receptor with a highly specific analog (ATL-146e) would inhibit leukocyte activation and decrease reperfusion injury after high-flow reperfusion...
  49. ncbi request reprint 2-Aminothiazoles: a new class of agonist allosteric enhancers of A(1) adenosine receptors
    Mahendra D Chordia
    Department of Chemistry, University of Virginia, Charlottesville, VA 22901, USA
    Bioorg Med Chem Lett 12:1563-6. 2002
    ..The EC(50) of compounds 6a, 6b, 7, and 8 were 0.3, 4.5, 3.8, and 1.2 microM, substantially lower than that of the 'Gold Standard' 2-amino-3-benzoyl thiophene (PD 81,723), which has an EC(50) of 38 microM...
  50. ncbi request reprint The evolution of ischemic spinal cord injury in function, cytoarchitecture, and inflammation and the effects of adenosine A2A receptor activation
    T Brett Reece
    Department of Surgery, University of Virginia Health System, PO Box 801359, Charlottesville, VA 22908, USA
    J Thorac Cardiovasc Surg 128:925-32. 2004
    ..This study defines injury progression in terms of function, cytoarchitecture, and inflammation and assesses whether adenosine A 2A receptor activation by ATL-146e limits injury progression...
  51. ncbi request reprint Reduction of infarct size and postischemic inflammation from ATL-146e, a highly selective adenosine A2A receptor agonist, in reperfused canine myocardium
    David K Glover
    Department of Internal Medicine, Division of Cardiology, University of Virginia, PO Box 800500, UVA Health System, Cobb Hall, Rm 1010, Hospital Drive, Charlottesville, VA 22908 0500, USA
    Am J Physiol Heart Circ Physiol 288:H1851-8. 2005
    ..Such combination therapy may be beneficial clinically by potentiating cardioprotection after coronary reperfusion at doses far below those producing vasodilatation or side effects...
  52. ncbi request reprint Adenosine A2A receptor activation reduces inflammation and preserves pulmonary function in an in vivo model of lung transplantation
    T Brett Reece
    Department of Surgery, University of Virginia Health System, PO Box 801359, Charlottesville, VA 22908, USA
    J Thorac Cardiovasc Surg 129:1137-43. 2005
    ..We hypothesized that adenosine A 2A receptor activation by ATL-146e during the initial reperfusion period preserves pulmonary function and attenuates inflammation in a porcine model of lung transplantation...
  53. ncbi request reprint Functional and cytoarchitectural spinal cord protection by ATL-146e after ischemia/reperfusion is mediated by adenosine receptor agonism
    T Brett Reece
    Department of Surgery, University of Virginia, Charlottesville, VA 22908, USA
    J Vasc Surg 44:392-7. 2006
    ....
  54. ncbi request reprint Influence of differential stability of G protein βγ dimers containing the γ11 subunit on functional activity at the M1 muscarinic receptor, A1 adenosine receptor, and phospholipase C-β
    William E McIntire
    Department of Pharmacology, University of Virginia Health System, Post Office Box 800735, 1300 Jefferson Park Avenue, Charlottesville, Virginia 22908, USA
    Biochemistry 45:11616-31. 2006
    ..These results suggest that the stability of the beta4gamma11 dimer can modulate G protein activity at the receptor and effector...
  55. ncbi request reprint Myocardial infarct-sparing effect of adenosine A2A receptor activation is due to its action on CD4+ T lymphocytes
    Zequan Yang
    Department of Biomedical Engineering, University of Virginia Health System, Box 800759, Charlottesville, VA 22903, USA
    Circulation 114:2056-64. 2006
    ..In this study we show that CD4+ but not CD8+ T lymphocytes contribute to myocardial ischemia/reperfusion injury...
  56. ncbi request reprint Infarct-sparing effect of A2A-adenosine receptor activation is due primarily to its action on lymphocytes
    Zequan Yang
    Department of Biomedical Engineering, of Virginia Health System, Charlottesville 22903, USA
    Circulation 111:2190-7. 2005
    ..A2A-adenosine receptor (A2AAR) activation on reperfusion after ischemia reduces the size of myocardial infarction, but the mechanism of action has not been fully defined...
  57. ncbi request reprint Cardioprotection by adenosine A2A agonists in a canine model of myocardial stunning produced by multiple episodes of transient ischemia
    David K Glover
    Cardiovascular Division, Department of Medicine, University of Virginia Health System, Charlottesville, VA 22908 0500, USA
    Am J Physiol Heart Circ Physiol 292:H3164-71. 2007
    ....
  58. ncbi request reprint Adenosine A2A receptor agonist improves cardiac dysfunction from pulmonary ischemia-reperfusion injury
    T Brett Reece
    Department of Surgery, University of Virginia Health System, Charlottesville, Virginia, USA
    Ann Thorac Surg 79:1189-95. 2005
    ..We hypothesized that pulmonary ischemia-reperfusion causes secondary heart dysfunction and ATL-146e will improve this dysfunction...
  59. pmc Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression
    Silvia Deaglio
    Department of Medicine, Harvard Medical School, Transplantation Research Center, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
    J Exp Med 204:1257-65. 2007
    ..We conclude that CD39 and CD73 are surface markers of T reg cells that impart a specific biochemical signature characterized by adenosine generation that has functional relevance for cellular immunoregulation...
  60. ncbi request reprint Adenosine A2A activation attenuates nontransplantation lung reperfusion injury
    Peter I Ellman
    Department of Surgery, University of Virginia, Charlottesville, Virginia 22908, USA
    J Surg Res 149:3-8. 2008
    ..There has been little work, however, examining its effects in the setting of nontransplant ischemia reperfusion. Our hypothesis was that an A(2A) agonist would attenuate lung reperfusion injury in a warm ischemia hilar clamping model...
  61. doi request reprint Additive protection against lung ischemia-reperfusion injury by adenosine A2A receptor activation before procurement and during reperfusion
    Leo M Gazoni
    Department of Surgery, University of Virginia, Charlottesville 22908, USA
    J Thorac Cardiovasc Surg 135:156-65. 2008
    ....
  62. pmc Inactivation of the adenosine A2A receptor protects apolipoprotein E-deficient mice from atherosclerosis
    Huan Wang
    Department of Medicine, University of Minnesota, Minneapolis, MN 55455, USA
    Arterioscler Thromb Vasc Biol 29:1046-52. 2009
    ..Atherosclerosis is a chronic inflammatory disease of the arterial vessel wall. The A(2A) receptor (A(2A)R) plays a central role in many antiinflammatory effects of adenosine. However, the role of A(2A)R in atherosclerosis is not clear...
  63. pmc Adenosine A2B receptors are highly expressed on murine type II alveolar epithelial cells
    Rebecca E Cagnina
    Robert M Berne Cardiovascular Research Center, University of Virginia, Charlottesville, VA 22908, USA
    Am J Physiol Lung Cell Mol Physiol 297:L467-74. 2009
    ..6 nM), and selective (>900 fold over other adenosine receptor subtypes) antagonist of the mouse A(2B)R...
  64. ncbi request reprint 6-aryl-8H-indeno[1,2-d]thiazol-2-ylamines: A1 adenosine receptor agonist allosteric enhancers having improved potency
    Mahendra D Chordia
    Department of Chemistry, University of Virginia, Charlottesville, VA 22901, USA
    J Med Chem 48:5131-9. 2005
    ..The new compounds also have substantially higher maximal AE activity. These compounds had no AE activity at the A(2A)AR and only minimal activity at the A(3)AR...
  65. ncbi request reprint Pharmacologic characterization of novel adenosine A2A receptor agonists in equine neutrophils
    Wan chun Sun
    Department of Large Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA
    Am J Vet Res 68:981-7. 2007
    ....