Kersti Linask

Summary

Affiliation: University of South Florida
Country: USA

Publications

  1. ncbi request reprint Directionality of heart looping: effects of Pitx2c misexpression on flectin asymmetry and midline structures
    Kersti K Linask
    Department of Cell Biology, University of Medicine and Dentistry of New Jersey School of Osteopathic Medicine, Stratford, New Jersey 08084, USA
    Dev Biol 246:407-17. 2002
  2. pmc The heart-placenta axis in the first month of pregnancy: induction and prevention of cardiovascular birth defects
    Kersti K Linask
    USF Children s Research Institute, Department of Pediatrics, 140 7th Avenue South, St Petersburg, FL 33701, USA
    J Pregnancy 2013:320413. 2013
  3. pmc Blood flow dynamics of one cardiac cycle and relationship to mechanotransduction and trabeculation during heart looping
    Barbara Garita
    Department of Pediatrics, The Children s Research Institute, University of South Florida and All Children s Hospital, St Petersburg, USA
    Am J Physiol Heart Circ Physiol 300:H879-91. 2011
  4. ncbi request reprint A role for the cytoskeleton in heart looping
    Kersti K Linask
    University of South Florida and All Children s Hospital, Department of Pediatrics, The Children s Research Institute, St Petersburg, FL 33701, USA
    ScientificWorldJournal 7:280-98. 2007
  5. doi request reprint Molecular effects of lithium exposure during mouse and chick gastrulation and subsequent valve dysmorphogenesis
    Jizhen Chen
    USF Pediatric Cardiology, Department of Pediatrics, Children s Research Institute, St Petersburg, Florida 33701, USA
    Birth Defects Res A Clin Mol Teratol 82:508-18. 2008
  6. ncbi request reprint Effects of antisense misexpression of CFC on downstream flectin protein expression during heart looping
    Kersti K Linask
    Department of Cell Biology, University of Medicine and Dentistry of New Jersey SOM, Stratford, New Jersey, USA
    Dev Dyn 228:217-30. 2003
  7. ncbi request reprint Cardiac morphogenesis: matrix metalloproteinase coordination of cellular mechanisms underlying heart tube formation and directionality of looping
    Kersti K Linask
    University of South Florida, Department of Pediatrics, The Children s Research Institute, St Petersburg, Florida 33701, USA
    Dev Dyn 233:739-53. 2005
  8. ncbi request reprint Cross talk between cell-cell and cell-matrix adhesion signaling pathways during heart organogenesis: implications for cardiac birth defects
    Kersti K Linask
    Department of Pediatrics, University of South Florida, College of Medicine, The Children s Research Institute, St Petersburg, FL 33701, USA
    Microsc Microanal 11:200-8. 2005
  9. ncbi request reprint Early temporal-specific responses and differential sensitivity to lithium and Wnt-3A exposure during heart development
    Shyam M Manisastry
    University of South Florida Children s Research Institute, Department of Pediatrics, St Petersburg, Florida 33701, USA
    Dev Dyn 235:2160-74. 2006
  10. doi request reprint Cellular nonmuscle myosins NMHC-IIA and NMHC-IIB and vertebrate heart looping
    Wenge Lu
    Department of Pediatrics, USF ACH Children s Research Institute, St Petersburg, Florida 33701, USA
    Dev Dyn 237:3577-90. 2008

Research Grants

  1. Cardiac Teratogenicity of Lithium
    Kersti Linask; Fiscal Year: 2004

Collaborators

  • J C Huhta
  • Philip R Brauer
  • Thomas Brand
  • Mingda Han
  • Barbara Garita
  • Jizhen Chen
  • Shyam M Manisastry
  • Maria C Serrano
  • Wenge Lu
  • Jushuo Wang
  • Patrizia Trotta
  • Jacquelyn Gerhart
  • Jean M Sanger
  • Joseph W Sanger
  • Aiping Du
  • Chao Zhou
  • Michael VanAuker
  • J G Fujimoto
  • Michiko Watanabe
  • Michael W Jenkins
  • Andrew M Rollins
  • Pilar Brinez
  • Ganesh Acharya
  • Ren Chen
  • Rosana Lastra-Vicente
  • Cassandra Farthing
  • Anne Sophie Arnold
  • Steven H Seeholzer
  • Peter Steele
  • Dipak K Dube
  • Robert W Zajdel
  • Harold Thurston
  • Eugene Essandoh
  • Nancy J Philp
  • Arun Rajan
  • Maria Serrano
  • Mary Otoo
  • Syamalima Dube
  • Karen Knudsen
  • Jordanna Perlman
  • Justin Elder
  • Luis Narciso
  • Christine Neely
  • Jessica Pfautz
  • Mindy George-Weinstein
  • Carl Coleman

Detail Information

Publications16

  1. ncbi request reprint Directionality of heart looping: effects of Pitx2c misexpression on flectin asymmetry and midline structures
    Kersti K Linask
    Department of Cell Biology, University of Medicine and Dentistry of New Jersey School of Osteopathic Medicine, Stratford, New Jersey 08084, USA
    Dev Biol 246:407-17. 2002
    ..The position of the heart with respect to the embryo midline is defined by the position of the foregut. Incubating embryos in the presence of flectin antibody caused randomization of heart looping or no looping...
  2. pmc The heart-placenta axis in the first month of pregnancy: induction and prevention of cardiovascular birth defects
    Kersti K Linask
    USF Children s Research Institute, Department of Pediatrics, 140 7th Avenue South, St Petersburg, FL 33701, USA
    J Pregnancy 2013:320413. 2013
    ..Our studies demonstrate pathways and cell processes that are involved with protection of one-carbon metabolism during heart development...
  3. pmc Blood flow dynamics of one cardiac cycle and relationship to mechanotransduction and trabeculation during heart looping
    Barbara Garita
    Department of Pediatrics, The Children s Research Institute, University of South Florida and All Children s Hospital, St Petersburg, USA
    Am J Physiol Heart Circ Physiol 300:H879-91. 2011
    ....
  4. ncbi request reprint A role for the cytoskeleton in heart looping
    Kersti K Linask
    University of South Florida and All Children s Hospital, Department of Pediatrics, The Children s Research Institute, St Petersburg, FL 33701, USA
    ScientificWorldJournal 7:280-98. 2007
    ..In recent years, the steps involved in this central and complex process of heart development that is the basis of numerous congenital heart defects are being unraveled...
  5. doi request reprint Molecular effects of lithium exposure during mouse and chick gastrulation and subsequent valve dysmorphogenesis
    Jizhen Chen
    USF Pediatric Cardiology, Department of Pediatrics, Children s Research Institute, St Petersburg, Florida 33701, USA
    Birth Defects Res A Clin Mol Teratol 82:508-18. 2008
    ..The objective of this study was to define whether Li mimicry of canonical Wnt/beta-catenin signaling induces cardiac valve defects...
  6. ncbi request reprint Effects of antisense misexpression of CFC on downstream flectin protein expression during heart looping
    Kersti K Linask
    Department of Cell Biology, University of Medicine and Dentistry of New Jersey SOM, Stratford, New Jersey, USA
    Dev Dyn 228:217-30. 2003
    ..Thus, Pitx2 can be experimentally uncoupled from heart looping. The flectin asymmetry continues to be maintained in the secondary heart field during looping...
  7. ncbi request reprint Cardiac morphogenesis: matrix metalloproteinase coordination of cellular mechanisms underlying heart tube formation and directionality of looping
    Kersti K Linask
    University of South Florida, Department of Pediatrics, The Children s Research Institute, St Petersburg, Florida 33701, USA
    Dev Dyn 233:739-53. 2005
    ....
  8. ncbi request reprint Cross talk between cell-cell and cell-matrix adhesion signaling pathways during heart organogenesis: implications for cardiac birth defects
    Kersti K Linask
    Department of Pediatrics, University of South Florida, College of Medicine, The Children s Research Institute, St Petersburg, FL 33701, USA
    Microsc Microanal 11:200-8. 2005
    ..Lithium exposure results in an anterior-posterior progression of severe cardiac defects...
  9. ncbi request reprint Early temporal-specific responses and differential sensitivity to lithium and Wnt-3A exposure during heart development
    Shyam M Manisastry
    University of South Florida Children s Research Institute, Department of Pediatrics, St Petersburg, Florida 33701, USA
    Dev Dyn 235:2160-74. 2006
    ..Taken together, our results demonstrate that there are temporal-specific responses and differential sensitivities to lithium/Wnt-3A exposure during early heart development...
  10. doi request reprint Cellular nonmuscle myosins NMHC-IIA and NMHC-IIB and vertebrate heart looping
    Wenge Lu
    Department of Pediatrics, USF ACH Children s Research Institute, St Petersburg, Florida 33701, USA
    Dev Dyn 237:3577-90. 2008
    ..These results document the characterization of flectin and extend the importance of NMHC-II and the cytoskeletal actomyosin complex to the mammalian heart and cardiac looping...
  11. pmc Folate rescues lithium-, homocysteine- and Wnt3A-induced vertebrate cardiac anomalies
    Mingda Han
    Division of Pediatric Cardiology, Department of Pediatrics, USF ACH Children s Research Institute, St Petersburg, FL 33701, USA
    Dis Model Mech 2:467-78. 2009
    ....
  12. ncbi request reprint MCT-4, A511/Basigin and EF5 expression patterns during early chick cardiomyogenesis indicate cardiac cell differentiation occurs in a hypoxic environment
    Mingda Han
    Department of Pediatrics, USF Children s Research Institute, St Petersburg, Florida 33701, USA
    Dev Dyn 235:124-31. 2006
    ..These results indicate that cardiac precursor cells are equipped for differentiating in a hypoxic environment using anaerobic metabolism for energy production...
  13. ncbi request reprint Myofibrillogenesis in the first cardiomyocytes formed from isolated quail precardiac mesoderm
    Aiping Du
    Department of Cell and Developmental Biology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 6058, USA
    Dev Biol 257:382-94. 2003
    ....
  14. ncbi request reprint Regulation of heart morphology: current molecular and cellular perspectives on the coordinated emergence of cardiac form and function
    Kersti K Linask
    Department of Cell Biology, University of Medicine and Dentistry of New Jersey SOM Stratford, NJ 08084, USA
    Birth Defects Res C Embryo Today 69:14-24. 2003
    ..During early heart development, in addition to cells being induced to differentiate into cardiomyocytes, pathways are activated that lead to cardiac morphogenesis or the development of form...
  15. doi request reprint Tropomyosin expression and dynamics in developing avian embryonic muscles
    Jushuo Wang
    Department of Cell and Developmental Biology, SUNY Upstate Medical University, Syracuse, New York 13210, USA
    Cell Motil Cytoskeleton 65:379-92. 2008
    ..We speculate that the differences in the two muscles is due to the appearance of nebulin in the skeletal myocytes premyofibrils transform into mature myofibrils...
  16. pmc Cells that express MyoD mRNA in the epiblast are stably committed to the skeletal muscle lineage
    Jacquelyn Gerhart
    Center for Chronic Disorders of Aging, Philadelphia College of Osteopathic Medicine, Philadelphia, PA 19131, USA
    J Cell Biol 178:649-60. 2007
    ..Stable programming in the epiblast may ensure that MyoDpos cells express similar signaling molecules in a variety of environments...

Research Grants4

  1. Cardiac Teratogenicity of Lithium
    Kersti Linask; Fiscal Year: 2004
    ..Until the safety of lithium is conclusively proven, one must assume teratogenic potential and harm to the fetus. ..