Su Ju Lin

Summary

Affiliation: University of California
Country: USA

Publications

  1. James Theoga Raj C, Croft T, Venkatakrishnan P, Groth B, Dhugga G, Cater T, et al. The copper-sensing transcription factor Mac1, the histone deacetylase Hst1, and nicotinic acid regulate de novo NAD+ biosynthesis in budding yeast. J Biol Chem. 2019;294:5562-5575 pubmed publisher
    ..In summary, we have identified and characterized novel NAD+ homeostasis factors. These findings will expand our understanding of the molecular basis and regulation of NAD+ metabolism. ..
  2. Lin S, Ford E, Haigis M, Liszt G, Guarente L. Calorie restriction extends yeast life span by lowering the level of NADH. Genes Dev. 2004;18:12-6 pubmed
    ..A genetic intervention that specifically decreases NADH levels increases life span, validating the model that NADH regulates yeast longevity in response to CR. ..
  3. Kato M, Lin S. YCL047C/POF1 is a novel nicotinamide mononucleotide adenylyltransferase (NMNAT) in Saccharomyces cerevisiae. J Biol Chem. 2014;289:15577-87 pubmed publisher
    ..Our findings may contribute to the understanding of the molecular basis and regulation of NAD(+) metabolism in higher eukaryotes. ..
  4. Tsang F, James C, Kato M, Myers V, Ilyas I, Tsang M, et al. Reduced Ssy1-Ptr3-Ssy5 (SPS) signaling extends replicative life span by enhancing NAD+ homeostasis in Saccharomyces cerevisiae. J Biol Chem. 2015;290:12753-64 pubmed publisher
    ..Our findings may contribute to understanding the molecular basis of NAD(+) metabolism, cellular life span, and diseases associated with NAD(+) deficiency and aging. ..
  5. Croft T, James Theoga Raj C, Salemi M, Phinney B, Lin S. A functional link between NAD+ homeostasis and N-terminal protein acetylation in Saccharomyces cerevisiae. J Biol Chem. 2018;293:2927-2938 pubmed publisher
    ..In summary, our results support a connection between NatB-mediated protein acetylation and NAD+ homeostasis. Our findings may contribute to understanding the molecular basis and regulation of NAD+ metabolism. ..