Su Ju Lin
Affiliation: University of California
James Theoga Raj C, Croft T, Venkatakrishnan P, Groth B, Dhugga G, Cater T, et al
. The copper-sensing transcription factor Mac1, the histone deacetylase Hst1, and nicotinic acid regulate de novo NAD+ biosynthesis in budding yeast. J Biol Chem. 2019;294:5562-5575 pubmed publisher
..In summary, we have identified and characterized novel NAD+ homeostasis factors. These findings will expand our understanding of the molecular basis and regulation of NAD+ metabolism. ..
Lin S, Ford E, Haigis M, Liszt G, Guarente L. Calorie restriction extends yeast life span by lowering the level of NADH. Genes Dev. 2004;18:12-6 pubmed
..A genetic intervention that specifically decreases NADH levels increases life span, validating the model that NADH regulates yeast longevity in response to CR. ..
Kato M, Lin S. YCL047C/POF1 is a novel nicotinamide mononucleotide adenylyltransferase (NMNAT) in Saccharomyces cerevisiae. J Biol Chem. 2014;289:15577-87 pubmed publisher
..Our findings may contribute to the understanding of the molecular basis and regulation of NAD(+) metabolism in higher eukaryotes. ..
Tsang F, James C, Kato M, Myers V, Ilyas I, Tsang M, et al
. Reduced Ssy1-Ptr3-Ssy5 (SPS) signaling extends replicative life span by enhancing NAD+ homeostasis in Saccharomyces cerevisiae. J Biol Chem. 2015;290:12753-64 pubmed publisher
..Our findings may contribute to understanding the molecular basis of NAD(+) metabolism, cellular life span, and diseases associated with NAD(+) deficiency and aging. ..
Croft T, James Theoga Raj C, Salemi M, Phinney B, Lin S. A functional link between NAD+ homeostasis and N-terminal protein acetylation in Saccharomyces cerevisiae. J Biol Chem. 2018;293:2927-2938 pubmed publisher
..In summary, our results support a connection between NatB-mediated protein acetylation and NAD+ homeostasis. Our findings may contribute to understanding the molecular basis and regulation of NAD+ metabolism. ..