Su Ju Lin

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Effects of calorie restriction on life span of microorganisms
    Craig Skinner
    Department of Microbiology, College of Biological Sciences, University of California, 323 Briggs Hall One Shields Ave, Davis, CA 95616, USA
    Appl Microbiol Biotechnol 88:817-28. 2010
  2. pmc Calorie restriction extends yeast life span by lowering the level of NADH
    Su Ju Lin
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genes Dev 18:12-6. 2004
  3. pmc Tissue-specific regulation of SIRT1 by calorie restriction
    Danica Chen
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genes Dev 22:1753-7. 2008
  4. pmc The dihydrolipoamide acetyltransferase is a novel metabolic longevity factor and is required for calorie restriction-mediated life span extension
    Erin Easlon
    Section of Microbiology, University of California, Davis, California 95616, USA
    J Biol Chem 282:6161-71. 2007
  5. pmc The malate-aspartate NADH shuttle components are novel metabolic longevity regulators required for calorie restriction-mediated life span extension in yeast
    Erin Easlon
    Section of Microbiology, College of Biological Sciences, University of California at Davis, Davis, California 95616, USA
    Genes Dev 22:931-44. 2008
  6. pmc Deleting the 14-3-3 protein Bmh1 extends life span in Saccharomyces cerevisiae by increasing stress response
    Chen Wang
    Department of Microbiology, College of Biological Sciences, University of California, Davis, California 95616, USA
    Genetics 183:1373-84. 2009
  7. ncbi request reprint Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration
    Su Ju Lin
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nature 418:344-8. 2002
  8. pmc Phosphate-responsive signaling pathway is a novel component of NAD+ metabolism in Saccharomyces cerevisiae
    Shu Ping Lu
    Department of Microbiology, College of Biological Sciences, University of California, Davis, California 95616, USA
    J Biol Chem 286:14271-81. 2011
  9. pmc Regulation of yeast sirtuins by NAD(+) metabolism and calorie restriction
    Shu Ping Lu
    Department of Microbiology, College of Biological Sciences, University of California, Davis, CA 95616, USA
    Biochim Biophys Acta 1804:1567-75. 2010
  10. ncbi request reprint Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease
    Su Ju Lin
    Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, MA 02139, USA
    Curr Opin Cell Biol 15:241-6. 2003

Research Grants

Collaborators

Detail Information

Publications17

  1. pmc Effects of calorie restriction on life span of microorganisms
    Craig Skinner
    Department of Microbiology, College of Biological Sciences, University of California, 323 Briggs Hall One Shields Ave, Davis, CA 95616, USA
    Appl Microbiol Biotechnol 88:817-28. 2010
    ..Here, we discuss the contributions of microorganisms to our knowledge of CR and longevity at the level of both the cell and the organism...
  2. pmc Calorie restriction extends yeast life span by lowering the level of NADH
    Su Ju Lin
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genes Dev 18:12-6. 2004
    ..A genetic intervention that specifically decreases NADH levels increases life span, validating the model that NADH regulates yeast longevity in response to CR...
  3. pmc Tissue-specific regulation of SIRT1 by calorie restriction
    Danica Chen
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Genes Dev 22:1753-7. 2008
    ..Our findings suggest that designing CR mimetics that target SIRT1 to provide uniform systemic benefits may be more complex than currently imagined...
  4. pmc The dihydrolipoamide acetyltransferase is a novel metabolic longevity factor and is required for calorie restriction-mediated life span extension
    Erin Easlon
    Section of Microbiology, University of California, Davis, California 95616, USA
    J Biol Chem 282:6161-71. 2007
    ..CR may therefore also extend life span and ameliorate age-associated diseases by increasing metabolic fitness through regulating central metabolic enzymes...
  5. pmc The malate-aspartate NADH shuttle components are novel metabolic longevity regulators required for calorie restriction-mediated life span extension in yeast
    Erin Easlon
    Section of Microbiology, College of Biological Sciences, University of California at Davis, Davis, California 95616, USA
    Genes Dev 22:931-44. 2008
    ..Together, these data suggest that CR may extend life span and ameliorate age-associated metabolic diseases by activating components of the NADH shuttles...
  6. pmc Deleting the 14-3-3 protein Bmh1 extends life span in Saccharomyces cerevisiae by increasing stress response
    Chen Wang
    Department of Microbiology, College of Biological Sciences, University of California, Davis, California 95616, USA
    Genetics 183:1373-84. 2009
    ..Deleting Bmh1 may eliminate the inhibitory effects of Bmh1 on these longevity factors and therefore extends life span...
  7. ncbi request reprint Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration
    Su Ju Lin
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
    Nature 418:344-8. 2002
    ..We discuss how this metabolic strategy may apply to CR in animals...
  8. pmc Phosphate-responsive signaling pathway is a novel component of NAD+ metabolism in Saccharomyces cerevisiae
    Shu Ping Lu
    Department of Microbiology, College of Biological Sciences, University of California, Davis, California 95616, USA
    J Biol Chem 286:14271-81. 2011
    ..Therefore, NaMN is a putative molecular link connecting the PHO signaling and NAD(+) metabolic pathways. Our findings may contribute to the understanding of the molecular basis and regulation of NAD(+) metabolism in higher eukaryotes...
  9. pmc Regulation of yeast sirtuins by NAD(+) metabolism and calorie restriction
    Shu Ping Lu
    Department of Microbiology, College of Biological Sciences, University of California, Davis, CA 95616, USA
    Biochim Biophys Acta 1804:1567-75. 2010
    ..Therefore, these findings will help elucidate the mechanisms underlying age-associated metabolic disease and perhaps human aging...
  10. ncbi request reprint Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease
    Su Ju Lin
    Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, MA 02139, USA
    Curr Opin Cell Biol 15:241-6. 2003
    ..Many human diseases are associated with changes in NAD level and/or the NAD : NADH ratio, raising the possibility that the Sir2p family might play a role in these diseases...
  11. pmc Identification of potential calorie restriction-mimicking yeast mutants with increased mitochondrial respiratory chain and nitric oxide levels
    Bin Li
    Department of Microbiology, College of Biological Sciences, University of California at Davis, Davis, CA 95616, USA
    J Aging Res 2011:673185. 2011
    ..Our results suggest that CR may derepress some hypoxic genes for mitochondrial proteins that function to promote the production of NO and the extension of lifespan...
  12. pmc Assimilation of endogenous nicotinamide riboside is essential for calorie restriction-mediated life span extension in Saccharomyces cerevisiae
    Shu Ping Lu
    Department of Microbiology, University of California, Davis, California 95616, USA
    J Biol Chem 284:17110-9. 2009
    ..Conversion to NmR may thus represent a strategy for the transport and assimilation of large nonpermeable NAD(+) precursors. Together, our studies provide a molecular basis for how NAD(+) homeostasis factors confer metabolic flexibility...
  13. pmc Sirt1 regulates insulin secretion by repressing UCP2 in pancreatic beta cells
    Laura Bordone
    Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    PLoS Biol 4:e31. 2006
    ..Sirt1 knockout mice display constitutively high UCP2 expression. Our findings show that Sirt1 regulates UCP2 in beta cells to affect insulin secretion...
  14. pmc The role of calorie restriction and SIRT1 in prion-mediated neurodegeneration
    Danica Chen
    Department of Biology, MIT, Cambridge, MA 02139, USA
    Exp Gerontol 43:1086-93. 2008
    ..Taken together, our results suggest a more complex interplay between CR, SIRT1, and neurodegenerative diseases than previously appreciated...
  15. ncbi request reprint HST2 mediates SIR2-independent life-span extension by calorie restriction
    Dudley W Lamming
    Paul F Glenn Laboratories for the Biological Mechanisms of Aging, Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, MA 02115, USA
    Science 309:1861-4. 2005
    ..These findings demonstrate that the maintenance of DNA stability is critical for yeast life-span extension by CR and suggest that, in higher organisms, multiple members of the Sir2 family may regulate life span in response to diet...
  16. pmc Increased life span due to calorie restriction in respiratory-deficient yeast
    Su Ju Lin
    PLoS Genet 2:e33; author reply e34. 2006
  17. ncbi request reprint Life-span extension in yeast
    David A Sinclair
    Science 312:195-7; author reply 195-7. 2006

Research Grants6

  1. The Role of Metabolic Signaling in Longevity Regulation
    Su Ju Lin; Fiscal Year: 2010
    ..Many cellular pathways are conserved in yeast and mammals. Therefore, insight into these molecular processes in yeast will also provide clues to the molecular basis of human aging and age-associated diseases. ..