Shuo Lin

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Ets1-related protein is a key regulator of vasculogenesis in zebrafish
    Saulius Sumanas
    Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, USA
    PLoS Biol 4:e10. 2006
  2. pmc Wnt5 signaling in vertebrate pancreas development
    Hyon J Kim
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA
    BMC Biol 3:23. 2005
  3. pmc Etsrp/Etv2 is directly regulated by Foxc1a/b in the zebrafish angioblast
    Matthew B Veldman
    Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, 621 Charles E Young Dr South, Los Angeles, CA 90095 1606, USA
    Circ Res 110:220-9. 2012
  4. pmc Essential role of spi-1-like (spi-1l) in zebrafish myeloid cell differentiation
    Alex Bukrinsky
    Department of Biological Chemistry, University of California Los Angeles, Los Angeles, CA 90095 1606, USA
    Blood 113:2038-46. 2009
  5. pmc Identification of novel vascular endothelial-specific genes by the microarray analysis of the zebrafish cloche mutants
    Saulius Sumanas
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, 621 C Young Dr South, Los Angeles, CA 90095, USA
    Blood 106:534-41. 2005
  6. doi request reprint ff1b, the SF1 ortholog, is important for pancreatic islet cell development in zebrafish
    Jaime K Mazilu
    Department of Bioengineering, Henry Samueli School of Engineering and Applied Science, University of California Los Angeles, Los Angeles, CA 90095, USA
    Mol Genet Metab 101:391-4. 2010
  7. pmc Interplay among Etsrp/ER71, Scl, and Alk8 signaling controls endothelial and myeloid cell formation
    Saulius Sumanas
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, USA
    Blood 111:4500-10. 2008
  8. ncbi request reprint 15-zinc finger protein Bloody Fingers is required for zebrafish morphogenetic movements during neurulation
    Saulius Sumanas
    University of California, Los Angeles, Department of Molecular, Cell and Developmental Biology, CA 90095, USA
    Dev Biol 283:85-96. 2005
  9. doi request reprint Bacterial artificial chromosome transgenesis for zebrafish
    Zhongan Yang
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA, 90095 1606, USA
    Methods Mol Biol 546:103-16. 2009
  10. doi request reprint Ribosomal protein S19 deficiency in zebrafish leads to developmental abnormalities and defective erythropoiesis through activation of p53 protein family
    Nadia Danilova
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, UCLA, USA
    Blood 112:5228-37. 2008

Detail Information

Publications66

  1. pmc Ets1-related protein is a key regulator of vasculogenesis in zebrafish
    Saulius Sumanas
    Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, USA
    PLoS Biol 4:e10. 2006
    ..These results demonstrate that Etsrp is necessary and sufficient for the initiation of vasculogenesis...
  2. pmc Wnt5 signaling in vertebrate pancreas development
    Hyon J Kim
    Department of Genetics, Cell Biology, and Development, University of Minnesota, Minneapolis, MN 55455, USA
    BMC Biol 3:23. 2005
    ..Signaling by the Wnt family of secreted glycoproteins through their receptors, the frizzled (Fz) family of seven-pass transmembrane proteins, is critical for numerous cell fate and tissue polarity decisions during development...
  3. pmc Etsrp/Etv2 is directly regulated by Foxc1a/b in the zebrafish angioblast
    Matthew B Veldman
    Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, 621 Charles E Young Dr South, Los Angeles, CA 90095 1606, USA
    Circ Res 110:220-9. 2012
    ..The transcription factor etsrp/etv2 is at the top of the known genetic hierarchy for angioblast development. The transcriptional events that induce etsrp expression and angioblast specification are not well understood...
  4. pmc Essential role of spi-1-like (spi-1l) in zebrafish myeloid cell differentiation
    Alex Bukrinsky
    Department of Biological Chemistry, University of California Los Angeles, Los Angeles, CA 90095 1606, USA
    Blood 113:2038-46. 2009
    ..1 cells and its function is necessary and sufficient for macrophage and granulocyte differentiation. These results establish a critical role for spi-1l in zebrafish myeloid cell differentiation...
  5. pmc Identification of novel vascular endothelial-specific genes by the microarray analysis of the zebrafish cloche mutants
    Saulius Sumanas
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, 621 C Young Dr South, Los Angeles, CA 90095, USA
    Blood 106:534-41. 2005
    ..Further functional studies of these novel genes should help to elucidate critical early steps leading to the formation of vertebrate blood vessels...
  6. doi request reprint ff1b, the SF1 ortholog, is important for pancreatic islet cell development in zebrafish
    Jaime K Mazilu
    Department of Bioengineering, Henry Samueli School of Engineering and Applied Science, University of California Los Angeles, Los Angeles, CA 90095, USA
    Mol Genet Metab 101:391-4. 2010
    ....
  7. pmc Interplay among Etsrp/ER71, Scl, and Alk8 signaling controls endothelial and myeloid cell formation
    Saulius Sumanas
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, USA
    Blood 111:4500-10. 2008
    ..We further demonstrate that the choice of endothelial versus myeloid fate depends on a combinatorial effect of etsrp, scl, and alk8 genes...
  8. ncbi request reprint 15-zinc finger protein Bloody Fingers is required for zebrafish morphogenetic movements during neurulation
    Saulius Sumanas
    University of California, Los Angeles, Department of Molecular, Cell and Developmental Biology, CA 90095, USA
    Dev Biol 283:85-96. 2005
    ..We conclude that blf plays an important role in regulating morphogenetic movements during gastrulation and neurulation while its role in hematopoiesis may be redundant...
  9. doi request reprint Bacterial artificial chromosome transgenesis for zebrafish
    Zhongan Yang
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA, 90095 1606, USA
    Methods Mol Biol 546:103-16. 2009
    ..In this chapter, experimental procedures for BAC DNA preparation and generation of transgenic zebrafish lines by microinjection are described...
  10. doi request reprint Ribosomal protein S19 deficiency in zebrafish leads to developmental abnormalities and defective erythropoiesis through activation of p53 protein family
    Nadia Danilova
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, UCLA, USA
    Blood 112:5228-37. 2008
    ..Ribosomal stress syndromes represent a broader spectrum of human congenital diseases caused by genotoxic stress; therefore, imbalance of p53 family members may become a new target for therapeutics...
  11. pmc In vivo time-lapse imaging delineates the zebrafish pituitary proopiomelanocortin lineage boundary regulated by FGF3 signal
    Ning Ai Liu
    Department of Medicine, Cedars Sinai Research Institute, University of California Los Angeles, Los Angeles, California 90048, USA
    Dev Biol 319:192-200. 2008
    ....
  12. pmc Discovery and characterization of novel vascular and hematopoietic genes downstream of etsrp in zebrafish
    Gustavo A Gomez
    Department of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS ONE 4:e4994. 2009
    ..The results described here identify a group of genes downstream of etsrp likely to be critical for vascular and/or myeloid development...
  13. pmc Targeting zebrafish and murine pituitary corticotroph tumors with a cyclin-dependent kinase (CDK) inhibitor
    Ning Ai Liu
    Department of Medicine, Cedars Sinai Medical Center, Los Angeles, CA 90048, USA
    Proc Natl Acad Sci U S A 108:8414-9. 2011
    ..The results suggest that use of selective CDK inhibitors could effectively target corticotroph tumor growth and hormone secretion...
  14. doi request reprint Zebrafish as a developmental model organism for pediatric research
    Matthew B Veldman
    Department of Molecular, Cellular, and Developmental Biology, University of California, Los Angeles, California 90095, USA
    Pediatr Res 64:470-6. 2008
    ..With novel technologies being regularly developed, the zebrafish is poised to significantly improve our understanding of vertebrate development under normal and pathologic conditions...
  15. pmc Antagonistic interactions of hedgehog, Bmp and retinoic acid signals control zebrafish endocrine pancreas development
    Zahra Tehrani
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095 1606, USA
    Development 138:631-40. 2011
    ..These results identify multiple sequential roles for Hh in pancreas development and highlight an unexpected antagonistic relationship between Hh and other signaling pathways to control pancreatic specification and differentiation...
  16. doi request reprint High content screening in zebrafish speeds up hazard ranking of transition metal oxide nanoparticles
    Sijie Lin
    Center for Environmental Implications of Nanotechnology, California NanoSystems Institute, Los Angeles, California 90095, USA
    ACS Nano 5:7284-95. 2011
    ....
  17. ncbi request reprint Vhnf1 acts downstream of Bmp, Fgf, and RA signals to regulate endocrine beta cell development in zebrafish
    Jianbo Song
    Department of Molecular, Cell and Developmental Biology, University of California Los Angeles, CA 90095, USA
    Dev Biol 303:561-75. 2007
    ..Taken together, our data establish that vhnf1 acts downstream of the signaling pathways of RA, Bmp, and Fgf to regulate pancreas development in zebrafish...
  18. pmc Ribosomal protein L11 mutation in zebrafish leads to haematopoietic and metabolic defects
    Nadia Danilova
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, 90095, USA
    Br J Haematol 152:217-28. 2011
    ..Our results provide new insights into the pathogenesis of DBA and point to the potential avenues for therapeutic intervention...
  19. doi request reprint p53 family in development
    Nadia Danilova
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, 615 Charles E Young Drive South, BSRB 454, Los Angeles, CA 90095 1606, USA
    Mech Dev 125:919-31. 2008
    ..Members of the p53 protein family with opposing activity perform coordination of these processes. Imbalance of p53 protein family may contribute to a significant proportion of congenital developmental abnormalities in humans...
  20. doi request reprint Use of a high-throughput screening approach coupled with in vivo zebrafish embryo screening to develop hazard ranking for engineered nanomaterials
    Saji George
    Department of Medicine, Division of NanoMedicine, Center for Environmental Implications of Nanotechnology, California NanoSystems Institute, Los Angeles, CA 90095, USA
    ACS Nano 5:1805-17. 2011
    ..In conclusion, the use of a high-throughput screening, in silico data handling and zebrafish testing may constitute a paradigm for rapid and integrated ENM toxicological screening...
  21. pmc A highly conserved regulatory element controls hematopoietic expression of GATA-2 in zebrafish
    Zhongan Yang
    Department of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, California 90095 1606, USA
    BMC Dev Biol 7:97. 2007
    ..Identification and characterization of these elements should help elucidating transcription regulatory mechanisms of GATA-2 expression in hematopoietic lineage...
  22. ncbi request reprint Modified bacterial artificial chromosomes for zebrafish transgenesis
    Zhongan Yang
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, CA 90095 1606, USA
    Methods 39:183-8. 2006
    ..Experimental procedures for BAC DNA preparation, microinjection of zebrafish embryos and screening of transgenic zebrafish carrying GFP/RFP modified BAC clones are detailed...
  23. pmc Zebrafish usp39 mutation leads to rb1 mRNA splicing defect and pituitary lineage expansion
    YESENIA RIOS
    Department of Molecular, Cell, and Developmental Biology, University of California Los Angeles, Los Angeles, California, United States of America
    PLoS Genet 7:e1001271. 2011
    ..These results provide a mechanism for dysregulated rb1 and e2f4 pathways that may result in pituitary tumorigenesis...
  24. pmc The expression of nr0b1, the earliest gene in zebrafish tooth development, is a marker for human tooth and ameloblastoma formation
    Jamie Powers
    Department of Pediatrics, David Geffen School of Medicine, UCLA, MDCC B2 375, Los Angeles, CA 90095, USA
    Dev Genes Evol 219:419-25. 2009
    ..The association of NR0B1 and its protein product DAX1 with primary tooth development and ameloblastoma tumorigenesis is an association not previously described...
  25. ncbi request reprint Genetic analysis of early endocrine pancreas formation in zebrafish
    Hyon J Kim
    Department of Molecular Cellular and Developmental Biology University of California, Los Angeles, California 90095, USA
    Mol Endocrinol 20:194-203. 2006
    ..Further study on these mutants will reveal important information on novel genes involved in pancreatic islet cell specification and morphogenesis...
  26. doi request reprint Role of p53 family in birth defects: lessons from zebrafish
    Nadia Danilova
    Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, California 90095 1606, USA
    Birth Defects Res C Embryo Today 84:215-27. 2008
    ..Understanding of p53 family developmental functions may lead to new therapeutic approaches for treatment and prevention of birth defects. Zebrafish is becoming the vertebrate system of choice for studying p53 family role in development...
  27. ncbi request reprint Prolactin receptor signaling mediates the osmotic response of embryonic zebrafish lactotrophs
    Ning Ai Liu
    Department of Medicine, Cedars Sinai Research Institute, University of California, Los Angeles, California 90048, USA
    Mol Endocrinol 20:871-80. 2006
    ....
  28. pmc NXT2 is required for embryonic heart development in zebrafish
    Haigen Huang
    Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, California 90095, USA
    BMC Dev Biol 5:7. 2005
    ..NXT2 is a member of NXT family proteins that are generally involved in exporting nuclear RNA in eukaryotic cells. It is not known if NXT2 has any function in specific biological processes...
  29. ncbi request reprint Cloning zebrafish by nuclear transfer
    Bensheng Ju
    Department of Molecular, Cellular, and Developmental Biology, University of California Los Angeles, Los Angeles, California 90095, USA
    Methods Cell Biol 77:403-11. 2004
  30. doi request reprint The effects of hyperglycemia on adrenal cortex function and steroidogenesis in the zebrafish
    Jamie W Powers
    Division of Neonatology, Mattel Children s Hospital, University of California Los Angeles, Los Angeles, CA 90095, USA
    Mol Genet Metab 101:421-2. 2010
    ..By inducing hyperglycemia in a zebrafish animal model, we show a direct correlation between glucose and cortisol levels...
  31. ncbi request reprint Induction of reversible hemolytic anemia in living zebrafish using a novel small molecule
    Ebrahim Shafizadeh
    Department of Molecular, Cell, and Developmental Biology, University of California at Los Angeles, 621 Charles E Young Drive, South Life Sciences Building, LS4325, Los Angeles, CA 90095, USA
    Comp Biochem Physiol C Toxicol Pharmacol 138:245-9. 2004
    ..The induced anemia is reversible and treated fish recover in about 4 days. This study shows the feasibility of using zebrafish to screen for small molecules that can modulate the specific process of erythropoiesis...
  32. ncbi request reprint Pur alpha and Sp8 as opposing regulators of neural gata2 expression
    William Todd Penberthy
    Department of Molecular, Cell, and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095 1606, USA
    Dev Biol 275:225-34. 2004
    ....
  33. doi request reprint Decreased dissolution of ZnO by iron doping yields nanoparticles with reduced toxicity in the rodent lung and zebrafish embryos
    Tian Xia
    Division of NanoMedicine, Department of Medicine, University of California, Los Angeles, California 90095, USA
    ACS Nano 5:1223-35. 2011
    ..All considered, the above data show that Fe doping is a possible safe design strategy for preventing ZnO toxicity in animals and the environment...
  34. doi request reprint C1q-like inhibits p53-mediated apoptosis and controls normal hematopoiesis during zebrafish embryogenesis
    Jie Mei
    State Key Laboratory of Freshwater Ecology and Biotechnology, Center for Developmental Biology, Institute of Hydrobiology, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Wuhan 430072, China
    Dev Biol 319:273-84. 2008
    ....
  35. doi request reprint Gfi1.1 regulates hematopoietic lineage differentiation during zebrafish embryogenesis
    Wei Wei
    Key Laboratory of Cell Proliferation and Differentiation, Center of Developmental Biology and Genetics, College of Life Sciences, Peking University, Ministry of Education, Beijing 100871, China
    Cell Res 18:677-85. 2008
    ..1 plays a critical role in regulating the balance of embryonic erythroid and myeloid lineage determination, and is also required for the differentiation of lymphocytes and granulocytes during zebrafish embryogenesis...
  36. doi request reprint Visualization of monoaminergic neurons and neurotoxicity of MPTP in live transgenic zebrafish
    Lu Wen
    Key Laboratory of Cell Proliferation and Differentiation, Center of Developmental Biology and Genetics, College of Life Sciences, Peking University, Ministry of Education, Beijing, 100871, PR China
    Dev Biol 314:84-92. 2008
    ..This enhancer trap line should be useful for genetic and pharmacological analyses of monoaminergic neuron development and processes underlying Parkinson's disease...
  37. pmc Vertebrate MAX-1 is required for vascular patterning in zebrafish
    Hanbing Zhong
    College of Life Science, Peking University, Beijing 100871, China
    Proc Natl Acad Sci U S A 103:16800-5. 2006
    ..Our findings therefore suggest that max-1, acting upstream of the ephrin pathway, is critically required in vascular patterning in vertebrate species...
  38. ncbi request reprint Zebrafish yolk-specific not really started (nrs) gene is a vertebrate homolog of the Drosophila spinster gene and is essential for embryogenesis
    Rodrigo M Young
    Millennium Nucleus in Developmental Biology and Departamento de Biologia, Facultad de Ciencias, Universidad de Chile Santiago, Chile
    Dev Dyn 223:298-305. 2002
    ..These results suggest that the nrs mutation affects an essential gene encoding a putative membrane-bound protein expressed specifically in the yolk cell during zebrafish embryogenesis...
  39. pmc The LTR enhancer of ERV-9 human endogenous retrovirus is active in oocytes and progenitor cells in transgenic zebrafish and humans
    Wenhu Pi
    Department of Biochemistry and Molecular Biology and Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA
    Proc Natl Acad Sci U S A 101:805-10. 2004
    ....
  40. ncbi request reprint Microarray analysis of zebrafish cloche mutant using amplified cDNA and identification of potential downstream target genes
    Feng Qian
    Laboratory of Molecular and Developmental Immunology, Institute of Molecular and Cell Biology, Proteos, Singapore
    Dev Dyn 233:1163-72. 2005
    ..Our study provides valuable information for studying hematopoiesis and vessel formation. The method described here offers a powerful tool for gene expression profiling of zebrafish mutants in general...
  41. ncbi request reprint Regulation of primitive hematopoiesis in zebrafish embryos by the death receptor gene
    Tommy T Kwan
    Department of Medicine, University of Hong Kong, Hong Kong
    Exp Hematol 34:27-34. 2006
    ..We investigated the regulatory mechanism of primitive hematopoiesis in zebrafish (Danio rerio) embryos with particular reference to the role of a death receptor (zDR) gene, based on a morpholino (MO) knockdown approach...
  42. ncbi request reprint Pituitary corticotroph ontogeny and regulation in transgenic zebrafish
    Ning Ai Liu
    Department of Medicine, Cedars Sinai Research Institute, University of California Los Angeles School of Medicine, 90048, USA
    Mol Endocrinol 17:959-66. 2003
    ..Transgenic zebrafish with specific POMC-GFP expression in pituitary corticotrophs offers a powerful genetic system for in vivo study of vertebrate corticotroph lineage development...
  43. ncbi request reprint Analyses of pancreas development by generation of gfp transgenic zebrafish using an exocrine pancreas-specific elastaseA gene promoter
    Haiyan Wan
    Department of Biological Sciences, National University of Singapore, Singapore
    Exp Cell Res 312:1526-39. 2006
    ..Thus, our works demonstrated the new transgenic line provided a useful experimental tool in analyzing exocrine pancreas development...
  44. ncbi request reprint Characterization of embryonic globin genes of the zebrafish
    Alison Brownlie
    Division of Hematology Oncology, Children s Hospital, Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA
    Dev Biol 255:48-61. 2003
    ..Our studies are the first to systematically evaluate the embryonic globins in the zebrafish and will ultimately be useful in evaluating zebrafish mutants with defects in hemoglobin production and switching...
  45. pmc The zebrafish moonshine gene encodes transcriptional intermediary factor 1gamma, an essential regulator of hematopoiesis
    David G Ransom
    Division of Hematology Oncology, Children s Hospital and Harvard Medical School, Boston, Massachusetts, USA
    PLoS Biol 2:E237. 2004
    ..Our results establish a major role for this transcriptional intermediary factor in the differentiation of hematopoietic cells in vertebrates...
  46. ncbi request reprint Isolation and expression of zebrafish zinc-finger transcription factor gene tsh1
    Han Wang
    Department of Zoology and Stephenson Research and Technology Center, University of Oklahoma, Norman, OK 73019, USA
    Gene Expr Patterns 7:318-22. 2007
    ..Furthermore, tsh1 expression was down-regulated in the spinal cord in the zebrafish neckless mutant in which RA signaling is disrupted due to a missense mutation in the gene encoding retinaldehyde dehydrogenase type 2...
  47. ncbi request reprint Cloned zebrafish by nuclear transfer from long-term-cultured cells
    Ki Young Lee
    Department of Molecular, Cellular, and Developmental Biology, University of California Los Angeles, Los Angeles, CA 90095 1606, USA
    Nat Biotechnol 20:795-9. 2002
    ..This finding demonstrates that slowly dividing nuclei from cultured cells can be reprogrammed to support rapid embryonic development and sets up a foundation for targeted genetic manipulation in zebrafish...
  48. ncbi request reprint Transgenic zebrafish expressing green fluorescent protein
    Ebrahim Shafizadeh
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, Georgia, USA
    Methods Mol Biol 183:225-33. 2002
  49. ncbi request reprint Rapid analysis of angiogenesis drugs in a live fluorescent zebrafish assay
    Laura M Cross
    Arterioscler Thromb Vasc Biol 23:911-2. 2003
  50. ncbi request reprint Characterization of zebrafish merlot/chablis as non-mammalian vertebrate models for severe congenital anemia due to protein 4.1 deficiency
    Ebrahim Shafizadeh
    Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912 USA
    Development 129:4359-70. 2002
    ..This work presents merlot/chablis as the first characterized non-mammalian vertebrate models of hereditary anemia due to a defect in protein 4.1R integrity...
  51. ncbi request reprint Mycophenolic acid is a potent inhibitor of angiogenesis
    Xinrong Wu
    Arterioscler Thromb Vasc Biol 26:2414-6. 2006
  52. ncbi request reprint Transplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutants
    David Traver
    Children s Hospital Boston and the Howard Hughes Medical Institute, 320 Longwood Avenue, Enders 720, Boston, Massachusetts 02115, USA
    Nat Immunol 4:1238-46. 2003
    ..Direct visualization of fluorescent donor cells in embryonic recipients allows engraftment and homing events to be imaged in real time. These results provide a cellular context in which to study the genetics of hematopoiesis...
  53. ncbi request reprint Migration of zebrafish spinal motor nerves into the periphery requires multiple myotome-derived cues
    Jörg Zeller
    RIKEN Brain Science Institute, Saitama, Japan
    Dev Biol 252:241-56. 2002
    ..In summary, we provide compelling evidence that myotomal cells produce multiple signals to initiate and control the migration of spinal nerve axons into the somites...
  54. ncbi request reprint Myc-induced T cell leukemia in transgenic zebrafish
    David M Langenau
    Department of Pediatric Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Science 299:887-90. 2003
    ..This transgenic model provides a platform for drug screens and for genetic screens aimed at identifying mutations that suppress or enhance c-myc- induced carcinogenesis...
  55. ncbi request reprint Protocol for nuclear transfer in zebrafish
    Haigen Huang
    Department of Molecular, Cellular, and Developmental Biology, University of California, Los Angeles, California 90095 1606, USA
    Cloning Stem Cells 5:333-7. 2003
  56. ncbi request reprint [Development of retrovirus-mediated insertional mutagenesis in zebrafish and its application in saturation mutagenesis and gene screening]
    Fei Qi
    College of Life Science, Peking University, Beijing 100871, China
    Yi Chuan Xue Bao 31:750-7. 2004
    ..Gene trap elements are also used in the construction of retrovirus vectors. The whole system is likely to make zebrafish the first vertebrate to achieve saturation mutagenesis and gene screening...
  57. ncbi request reprint A critical role of vascular endothelial growth factor D in zebrafish embryonic vasculogenesis and angiogenesis
    Min Song
    State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, and School of Life Science, Sichuan University, Chengdu 610041, China
    Biochem Biophys Res Commun 357:924-30. 2007
    ....
  58. pmc Efficient genome-wide mutagenesis of zebrafish genes by retroviral insertions
    Dongmei Wang
    Key Laboratory of Cell Proliferation and Differentiation, Center of Developmental Biology and Genetics, College of Life Sciences, Peking University, Ministry of Education, Beijing 100871, China
    Proc Natl Acad Sci U S A 104:12428-33. 2007
    ..Combining this increase in efficiency with cryopreservation of sperm samples from the F(1) fish, it is now possible to create a stable resource that contains mutations in every known zebrafish gene...
  59. ncbi request reprint Src-family kinases stabilize the neuromuscular synapse in vivo via protein interactions, phosphorylation, and cytoskeletal linkage of acetylcholine receptors
    Gayathri Sadasivam
    Department of Neurochemistry, Brain Research Institute, University of Zurich, CH 8057 Zurich, Switzerland
    J Neurosci 25:10479-93. 2005
    ..SFKs hold the postsynaptic apparatus together through stabilization of AChR-rapsyn interaction and AChR phosphorylation. In addition, SFKs control rapsyn levels and AChR-cytoskeletal linkage...
  60. pmc Initiation of V(D)J recombination in zebrafish (Danio rerio) ovaries
    Hanbing Zhong
    Center of Developmental Biology and Genetics, College of Life Sciences, Peking University, Beijing 100871, PR China
    Mol Immunol 44:1784-92. 2007
    ..Our data, therefore, substantiate the speculation that RAG might have been derived from a transposase, invading germ cells of ancient species, and later become a dedicated recombinase only expressed in developing lymphocytes...
  61. doi request reprint The role of nerve- versus muscle-derived factors in mammalian neuromuscular junction formation
    Shuo Lin
    Biozentrum, University of Basel, CH 4056 Basel, Switzerland
    J Neurosci 28:3333-40. 2008
    ..A model is proposed that explains either the neurocentric or the myocentric mode of NMJ formation depending on a balance between the levels of MuSK expression and the availability of nerve-released agrin...
  62. ncbi request reprint Fluorescent tagged analysis of neural gene function using mosaics in zebrafish and Xenopus laevis
    Greg Conway
    NASA Ames Research Center, Moffett Field, CA 94035, USA
    Brain Res 1070:150-9. 2006
    ..These methods should prove useful for the analysis of neural gene function in two important model organisms, the zebrafish and Xenopus laevis...
  63. ncbi request reprint Uses of GFP in transgenic vertebrates
    Sean Megason
    Beckman Institute of Biological Imaging, California Institute of Technology, Pasadena, CA 91125, USA
    Methods Biochem Anal 47:285-303. 2006
  64. ncbi request reprint Overexpression of mini-agrin in skeletal muscle increases muscle integrity and regenerative capacity in laminin-alpha2-deficient mice
    C Florian Bentzinger
    Biozentrum, University of Basel, Basel, Switzerland
    FASEB J 19:934-42. 2005
    ..Our findings thus suggest that treatment with mini-agrin might be beneficial over the entire spectrum of the MDC1A disease, whose severity inversely correlates with expression levels and the size of the truncation in laminin-alpha2...
  65. pmc The neurite outgrowth inhibitor Nogo-A promotes denervation in an amyotrophic lateral sclerosis model
    Natasa Jokic
    INSERM, U692, Laboratoire de Signalisations Moléculaires et Neurodégénérescence, 11 rue Humann, F 67085 Strasbourg, France
    EMBO Rep 7:1162-7. 2006
    ..This suggests that the expression of Nogo-A occurring early in ALS skeletal muscle could cause repulsion and destabilization of the motor nerve terminals, and subsequent dying back of the axons and motor neurons...
  66. ncbi request reprint The zebrafish as a model for human disease
    William T Penberthy
    Molecular, Cell, and Developmental Biology, UCLA, 621 Charles E Young Dr South, Los Angeles, CA 90095 1606, USA
    Front Biosci 7:d1439-53. 2002
    ..Additionally a survey of current and future zebrafish models of human disease is presented...

Research Grants36

  1. Environmental biosensor of transgenic zebrafish
    Shuo Lin; Fiscal Year: 2005
    ....
  2. TARGETED MUTAGENESIS IN ZEBRAFISH BY ANIMAL CLONING
    Shuo Lin; Fiscal Year: 2006
    ..The two systems will then truly complement each other to advance our understanding of vertebrate developmental biology. ..
  3. GENETIC ANALYSIS OF HEMATOPOIETIC DEVELOPMENT
    Shuo Lin; Fiscal Year: 2007
    ..We believe that studies from zebrafish should ultimately help us understand how hematopoietic development is controlled in human being. ..
  4. TRANSGENIC TECHNOLOGY AND RESOURCES OF ZEBRAFISH
    Shuo Lin; Fiscal Year: 2007
    ..With these sophisticated technologies established in zebrafish, our ability to analyze gene expression and function in vivo will be greatly enhanced. ..
  5. GENETIC ANALYSIS OF HEMATOPOIETIC DEVELOPMENT
    Shuo Lin; Fiscal Year: 2010
    ..Since these genes are highly conserved between fish and human our studies will provide valuable information for understanding human hematopoietic and vascular diseases and assisting design of novel therapeutic approaches. ..
  6. High-throughput gene disruption in zebrafish using retroviral integration
    Shuo Lin; Fiscal Year: 2010
    ..Since these genes are highly conserved our studies will provide valuable information for understanding human diseases and assisting design of novel therapeutic approaches. ..
  7. EMBRYONIC NEURONAL CDNA LIBRARIES: TRANSGENIC ZEBRAFISH
    Shuo Lin; Fiscal Year: 2002
    ..abstract_text> ..
  8. GENETIC ANALYSIS OF HEMATOPOIETIC DEVELOPMENT
    Shuo Lin; Fiscal Year: 2002
    ....
  9. TRANSGENIC TECHNOLOGY AND RESOURCES OF ZEBRAFISH
    Shuo Lin; Fiscal Year: 2003
    ..These transgenic fish will be available for use by anyone in the zebrafish community. ..
  10. GENETIC ANALYSIS OF HEMATOPOIETIC DEVELOPMENT
    Shuo Lin; Fiscal Year: 2010
    ..Since these genes are highly conserved between fish and human our studies will provide valuable information for understanding human hematopoietic and vascular diseases and assisting design of novel therapeutic approaches. ..