Ming Fong Lin

Summary

Affiliation: University of Nebraska Medical Center
Country: USA

Publications

  1. ncbi request reprint Suppression of LNCaP prostate cancer xenograft tumors by a prostate-specific protein tyrosine phosphatase, prostatic acid phosphatase
    Tsukasa Igawa
    Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 4525, USA
    Prostate 55:247-58. 2003
  2. pmc Steroids up-regulate p66Shc longevity protein in growth regulation by inhibiting its ubiquitination
    Santosh Kumar
    Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 6:e15942. 2011
  3. pmc Androgens upregulate Cdc25C protein by inhibiting its proteasomal and lysosomal degradation pathways
    Yu Wei Chou
    Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA
    PLoS ONE 8:e61934. 2013
  4. pmc Human prostatic Acid phosphatase: structure, function and regulation
    Sakthivel Muniyan
    Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Int J Mol Sci 14:10438-64. 2013
  5. pmc Histone deacetylase inhibitor valproic acid suppresses the growth and increases the androgen responsiveness of prostate cancer cells
    Yu Wei Chou
    Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198 5870, USA
    Cancer Lett 311:177-86. 2011
  6. ncbi request reprint Differential responsiveness of prostatic acid phosphatase and prostate-specific antigen mRNA to androgen in prostate cancer cells
    M F Lin
    Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha 68198, USA
    Cell Biol Int 24:681-9. 2000
  7. ncbi request reprint Protein kinase C pathway is involved in regulating the secretion of prostatic acid phosphatase in human prostate cancer cells
    M F Lin
    Department of Biochemistry Molecular Biology, University of Nebraska Medical Center, Omaha 68198 4525, USA
    Cell Biol Int 25:1139-48. 2001
  8. ncbi request reprint Novel combination therapy against metastatic and androgen-independent prostate cancer by using gefitinib, tamoxifen and etoposide
    Murielle Mimeault
    Department of Biochemistry and Molecular Biology, University of Nebraska College of Medicine, 985870 Medical Center, Omaha, Nebraska 68198, USA
    Int J Cancer 120:160-9. 2007
  9. ncbi request reprint Androgen deprivation induces human prostate epithelial neuroendocrine differentiation of androgen-sensitive LNCaP cells
    Ta Chun Yuan
    Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, 985870 Nebraska Medical Center, Omaha, NE 68198, USA
    Endocr Relat Cancer 13:151-67. 2006
  10. pmc Reactive oxygen species induced by p66Shc longevity protein mediate nongenomic androgen action via tyrosine phosphorylation signaling to enhance tumorigenicity of prostate cancer cells
    Suresh Veeramani
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Free Radic Biol Med 53:95-108. 2012

Research Grants

  1. Signaling in Androgen-Refractory Prostate Cancer
    Ming Fong Lin; Fiscal Year: 2010
  2. Signaling in Androgen-Refractory Prostate Cancer
    Ming Fong Lin; Fiscal Year: 2006
  3. Signaling in Androgen-Refractory Prostate Cancer
    Ming Fong Lin; Fiscal Year: 2009
  4. SIGNALING IN ANDROGEN REFRACTORY PROSTATE CANCER
    Ming Fong Lin; Fiscal Year: 2003
  5. Signaling in Androgen-Refractory Prostate Cancer
    Ming Fong Lin; Fiscal Year: 2007
  6. SIGNALING IN ANDROGEN REFRACTORY PROSTATE CANCER
    Ming Fong Lin; Fiscal Year: 2002
  7. SIGNALING IN ANDROGEN REFRACTORY PROSTATE CANCER
    Ming Fong Lin; Fiscal Year: 2001
  8. SIGNALING IN ANDROGEN REFRACTORY PROSTATE CANCER
    Ming Fong Lin; Fiscal Year: 2004
  9. SIGNALING IN ANDROGEN REFRACTORY PROSTATE CANCER
    Ming Fong Lin; Fiscal Year: 2000

Collaborators

Detail Information

Publications45

  1. ncbi request reprint Suppression of LNCaP prostate cancer xenograft tumors by a prostate-specific protein tyrosine phosphatase, prostatic acid phosphatase
    Tsukasa Igawa
    Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 4525, USA
    Prostate 55:247-58. 2003
    ..To explore directly the possible therapeutic potential of cellular PAcP, we investigated the suppression effect of PAcP by utilizing cDNA direct intratumoral administration in androgen-independent LNCaP xenograft tumors...
  2. pmc Steroids up-regulate p66Shc longevity protein in growth regulation by inhibiting its ubiquitination
    Santosh Kumar
    Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 6:e15942. 2011
    ..Several lines of evidence indicate that p66Shc plays a critical role in steroid-related carcinogenesis, and steroids play a role in its elevated levels in those cells without known mechanism...
  3. pmc Androgens upregulate Cdc25C protein by inhibiting its proteasomal and lysosomal degradation pathways
    Yu Wei Chou
    Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, USA
    PLoS ONE 8:e61934. 2013
    ..These results can lead to advanced PCa therapy via up-regulating the degradation pathways of Cdc25C protein...
  4. pmc Human prostatic Acid phosphatase: structure, function and regulation
    Sakthivel Muniyan
    Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Int J Mol Sci 14:10438-64. 2013
    ..Further understanding of PAcP function and regulation of expression will have a significant impact on understanding PCa progression and therapy...
  5. pmc Histone deacetylase inhibitor valproic acid suppresses the growth and increases the androgen responsiveness of prostate cancer cells
    Yu Wei Chou
    Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198 5870, USA
    Cancer Lett 311:177-86. 2011
    ..Thus, cPAcP expression is involved in growth suppression by HDAC inhibitors in PCa cells, and VPA pre-treatments increase androgen responsiveness...
  6. ncbi request reprint Differential responsiveness of prostatic acid phosphatase and prostate-specific antigen mRNA to androgen in prostate cancer cells
    M F Lin
    Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha 68198, USA
    Cell Biol Int 24:681-9. 2000
    ..Prolonged treatment with DHT as well as TPA resulted in a similar down-regulation of protein kinase C and cellular PAcP activities. Thus, the levels of PAcP and PSA mRNA are differentially regulated by androgens in LNCaP cells...
  7. ncbi request reprint Protein kinase C pathway is involved in regulating the secretion of prostatic acid phosphatase in human prostate cancer cells
    M F Lin
    Department of Biochemistry Molecular Biology, University of Nebraska Medical Center, Omaha 68198 4525, USA
    Cell Biol Int 25:1139-48. 2001
    ..Results also showed that DHT, as well as TPA, could rapidly modulate PKC activity. Therefore, PKC can regulate PAcP secretion, and may also be involved in DHT action on PAcP secretion...
  8. ncbi request reprint Novel combination therapy against metastatic and androgen-independent prostate cancer by using gefitinib, tamoxifen and etoposide
    Murielle Mimeault
    Department of Biochemistry and Molecular Biology, University of Nebraska College of Medicine, 985870 Medical Center, Omaha, Nebraska 68198, USA
    Int J Cancer 120:160-9. 2007
    ....
  9. ncbi request reprint Androgen deprivation induces human prostate epithelial neuroendocrine differentiation of androgen-sensitive LNCaP cells
    Ta Chun Yuan
    Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, 985870 Nebraska Medical Center, Omaha, NE 68198, USA
    Endocr Relat Cancer 13:151-67. 2006
    ..These NE cells thus represent cancerous NE cells and could serve as a useful cell model system for investigating the role of cancerous NE cells in hormone-refractory proliferation of PCa cells...
  10. pmc Reactive oxygen species induced by p66Shc longevity protein mediate nongenomic androgen action via tyrosine phosphorylation signaling to enhance tumorigenicity of prostate cancer cells
    Suresh Veeramani
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Free Radic Biol Med 53:95-108. 2012
    ..Our results thus suggest that p66Shc protein functions at the critical junction point between androgens and tyrosine phosphorylation signaling in human PCa cells...
  11. pmc Human prostatic acid phosphatase, an authentic tyrosine phosphatase, dephosphorylates ErbB-2 and regulates prostate cancer cell growth
    Tsai Der Chuang
    Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA
    J Biol Chem 285:23598-606. 2010
    ..In PCa cells, decreased cPAcP expression is associated with androgen-independent cell proliferation and tumorigenicity as seen in advanced hormone-refractory prostate carcinomas...
  12. ncbi request reprint Establishment and characterization of androgen-independent human prostate cancer LNCaP cell model
    Tsukasa Igawa
    Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 4525, USA
    Prostate 50:222-35. 2002
    ..To investigate the molecular mechanism of androgen-independent growth of prostate cancer, we established a useful LNCaP cell model that resembles the clinical scenario of hormone-refractory prostate cancer...
  13. ncbi request reprint p66Shc protein is upregulated by steroid hormones in hormone-sensitive cancer cells and in primary prostate carcinomas
    Ming Shyue Lee
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Int J Cancer 108:672-8. 2004
    ..05). The data collectively indicate that p66(Shc) protein levels correlate with steroid hormone-stimulated cell growth and prostate carcinogenesis...
  14. ncbi request reprint Cytotoxic effects induced by a combination of cyclopamine and gefitinib, the selective hedgehog and epidermal growth factor receptor signaling inhibitors, in prostate cancer cells
    Murielle Mimeault
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, College of Medicine, Omaha, NE 68198 5870, USA
    Int J Cancer 118:1022-31. 2006
    ....
  15. ncbi request reprint Combined targeting of epidermal growth factor receptor and hedgehog signaling by gefitinib and cyclopamine cooperatively improves the cytotoxic effects of docetaxel on metastatic prostate cancer cells
    Murielle Mimeault
    Department of Biochemistry and Molecular Biology, 985870 Nebraska Medical Center, Eppley Cancer Institute, University of Nebraska Medical Center, Omaha, NE 68198 5870, USA
    Mol Cancer Ther 6:967-78. 2007
    ..These findings indicate that the combined use of inhibitors of EGF-EGFR and hedgehog signaling with docetaxel could represent a more promising strategy for treatment in patients with metastatic and androgen-independent prostate cancer...
  16. ncbi request reprint ErbB-2 signaling is involved in regulating PSA secretion in androgen-independent human prostate cancer LNCaP C-81 cells
    Ming Shyue Lee
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha 68198, USA
    Oncogene 22:781-96. 2003
    ....
  17. ncbi request reprint Expression of p66(Shc) protein correlates with proliferation of human prostate cancer cells
    Suresh Veeramani
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, 985870 Nebraska Medical Center, Omaha, NE 68198, USA
    Oncogene 24:7203-12. 2005
    ..Thus, our results indicate a novel role for p66(Shc) in prostate carcinogenesis, in part, promoting cell proliferation...
  18. ncbi request reprint Expression of ADAMs (a disintegrin and metalloproteases) and TIMP-3 (tissue inhibitor of metalloproteinase-3) in human prostatic adenocarcinomas
    Dev Karan
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA
    Int J Oncol 23:1365-71. 2003
    ..These results suggest that an inverse expression pattern of ADAM-17/TACE and TIMP-3, and the regulation of ADAMs with DHT might play an important role in the pathogenesis of prostate cancer...
  19. ncbi request reprint Dysregulated expression of MIC-1/PDF in human prostate tumor cells
    Dev Karan
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE, USA
    Biochem Biophys Res Commun 305:598-604. 2003
    ..33+/-0.88; n=15). Altogether, these data suggest that the serum factors (including androgens and cytokines) might contribute to the regulation of the MIC-1/PDF gene that seems to be associated with the progression of prostate cancer...
  20. ncbi request reprint ERK inhibitor PD98059 enhances docetaxel-induced apoptosis of androgen-independent human prostate cancer cells
    Stanislav Zelivianski
    Department of Biochemistry Molecular Biology, University of Nebraska Medical Center, Omaha 68198 4525, USA
    Int J Cancer 107:478-85. 2003
    ..This may lower the cytotoxicity and enhance tumor suppression in vivo. This finding of a combination effect could be of potential clinical importance in treating hormone-refractory prostate cancer...
  21. ncbi request reprint Cellular prostatic acid phosphatase: a protein tyrosine phosphatase involved in androgen-independent proliferation of prostate cancer
    Suresh Veeramani
    Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, 68198, USA
    Endocr Relat Cancer 12:805-22. 2005
    ..Results from experiments using xenograft animal models further indicate a novel role of cPAcP as a tumor suppressor. Future studies are warranted to clarify the use of cPAcP as a therapeutic agent in human prostate cancer patients...
  22. ncbi request reprint Receptor protein tyrosine phosphatase alpha signaling is involved in androgen depletion-induced neuroendocrine differentiation of androgen-sensitive LNCaP human prostate cancer cells
    Xiu Qing Zhang
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, 984525 Nebraska Medical Center, Omaha, NE 68198 4525, USA
    Oncogene 22:6704-16. 2003
    ..Our data collectively indicated that RPTPalpha signaling via ERK is involved in the NE transdifferentiation of androgen-sensitive C-33 LNCaP human prostate cancer cells in the androgen-depleted condition...
  23. ncbi request reprint Downregulation of PTEN/MMAC/TEP1 expression in human prostate cancer cell line DU145 by growth stimuli
    Dhundy R Bastola
    Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha 68198 4525, USA
    Mol Cell Biochem 236:75-81. 2002
    ..Thus, PTEN may play a critical role in regulating cellular signaling in prostate cancer cells...
  24. ncbi request reprint Aberrant expression of transmembrane mucins, MUC1 and MUC4, in human prostate carcinomas
    Ajay P Singh
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska 68198 5870, USA
    Prostate 66:421-9. 2006
    ..Recent findings have provided substantial evidence for the involvement of transmembrane mucins, MUC1 and MUC4, in altered cell signaling, tumor growth, and metastasis...
  25. ncbi request reprint Tyrosine-317 of p52(Shc) mediates androgen-stimulated proliferation signals in human prostate cancer cells
    Ming Shyue Lee
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, 984525 Nebraska Medical Center, Omaha, NE 68198 4525, USA
    Oncogene 23:3048-58. 2004
    ..Thus, Y317 of p52(Shc) serves as an important regulatory site that allows tyrosine phosphorylation pathways to moderate androgen sensitivity in human prostate cancer cells...
  26. pmc Epigenetic repression of regulator of G-protein signaling 2 promotes androgen-independent prostate cancer cell growth
    Dennis W Wolff
    Department of Pharmacology, Creighton University School of Medicine, Omaha, NE 68178, USA
    Int J Cancer 130:1521-31. 2012
    ..Targeting this reversible process may provide a new strategy for suppressing prostate cancer progression by reestablishing its androgen sensitivity...
  27. pmc p66Shc--a longevity redox protein in human prostate cancer progression and metastasis : p66Shc in cancer progression and metastasis
    Mythilypriya Rajendran
    Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, 985870 Nebraska Medical Center, Omaha, NE, 68198 5870, USA
    Cancer Metastasis Rev 29:207-22. 2010
    ..The data together indicate that p66Shc might be a useful biomarker for the prognosis of prostate cancer and serve as an effective target for its cancer treatment...
  28. ncbi request reprint Expression profile of differentially-regulated genes during progression of androgen-independent growth in human prostate cancer cells
    Dev Karan
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198 4525, USA
    Carcinogenesis 23:967-75. 2002
    ....
  29. doi request reprint Improvement of cytotoxic effects induced by mitoxantrone on hormone-refractory metastatic prostate cancer cells by co-targeting epidermal growth factor receptor and hedgehog signaling cascades
    Murielle Mimeault
    Department of Biochemistry and Molecular Biology, College of Medicine, Eppley Institute of Cancer and Allied Diseases, 985870 University of Nebraska Medical Center, Omaha, NE 68198 5870, USA
    Growth Factors 25:400-16. 2007
    ....
  30. ncbi request reprint Current status of the molecular genetics of human prostatic adenocarcinomas
    Dev Karan
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha 68198, USA
    Int J Cancer 103:285-93. 2003
    ..In this review we summarize the ongoing molecular genetic events associated with the sporadic and hereditary prostate cancer development and progression...
  31. ncbi request reprint Prostate-derived factor as a paracrine and autocrine factor for the proliferation of androgen receptor-positive human prostate cancer cells
    Siu Ju Chen
    Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198, USA
    Prostate 67:557-71. 2007
    ..The expression of prostate-derived factor (PDF) is significantly elevated in human prostate tumors. We investigate the functional role and signaling of PDF in androgen receptor (AR)-positive human prostate cancer cells...
  32. pmc Suppression of ErbB-2 in androgen-independent human prostate cancer cells enhances cytotoxic effect by gemcitabine in an androgen-reduced environment
    Li Zhang
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, 68198 5870, USA
    Cancer Lett 285:58-65. 2009
    ..This finding has significant implications in the choice of drugs for combination therapy as well as the order of administration for treating cancer patients...
  33. pmc TNF╬▒ enhances the motility and invasiveness of prostatic cancer cells by stimulating the expression of selective glycosyl- and sulfotransferase genes involved in the synthesis of selectin ligands
    Prakash Radhakrishnan
    Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Biochem Biophys Res Commun 409:436-41. 2011
    ..These results support the hypothesis that inflammation contributes to cancer metastasis...
  34. ncbi request reprint Identification and characterization of regulatory elements of the human prostatic acid phosphatase promoter
    Stanislav Zelivianski
    Department of Biochemistry Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198 4525, USA
    Oncogene 21:3696-705. 2002
    ..The data collectively indicate that region between -1258 and -779 is involved in governing the cell type-specific expression of the PAcP gene...
  35. pmc Transcriptional activation of the human prostatic acid phosphatase gene by NF-kappaB via a novel hexanucleotide-binding site
    Stanislav Zelivianski
    Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha NE 68198, USA
    Nucleic Acids Res 32:3566-80. 2004
    ..The data collectively indicate that NF-kappaB up-regulates PAcP promoter activity via its binding to the AGGTGT motif, a novel binding sequence located inside the cis-active enhancer element in human prostate cancer cells...
  36. ncbi request reprint Neuroendocrine-like prostate cancer cells: neuroendocrine transdifferentiation of prostate adenocarcinoma cells
    Ta Chun Yuan
    Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, 985870 Nebraska Medical Center, Omaha, Nebraska 68198 5870, USA
    Endocr Relat Cancer 14:531-47. 2007
    ..Knowledge of understanding NE-like PCa cells will help us to explore new therapeutic strategies for treating PCa...
  37. pmc Genome-wide expression profiling reveals transcriptomic variation and perturbed gene networks in androgen-dependent and androgen-independent prostate cancer cells
    Ajay P Singh
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, 985870 Nebraska Medical Center, Omaha, NE 68198 5870, USA
    Cancer Lett 259:28-38. 2008
    ....
  38. pmc Epigenetic regulation of phosphatidylinositol 3,4,5-triphosphate-dependent Rac exchanger 1 gene expression in prostate cancer cells
    Chuu Yun A Wong
    Department of Pharmacology, Creighton University School of Medicine, Omaha, Nebraska 68178, USA
    J Biol Chem 286:25813-22. 2011
    ..Disassociation of HDACs from Sp1 on the P-Rex1 promoter may contribute to aberrant up-regulation of P-Rex1 in cancer...
  39. ncbi request reprint Protease-activated receptor 1: a role in prostate cancer metastasis
    Ta Chun Yuan
    Department of Biochemistry, University of Nebraska Medical Center, Omaha, NE 68198 5870, USA
    Clin Prostate Cancer 3:189-91. 2004
    ....
  40. ncbi request reprint Opposing roles for the insulin-like growth factor (IGF)-II and mannose 6-phosphate (Man-6-P) binding activities of the IGF-II/Man-6-P receptor in the growth of prostate cancer cells
    Beverly S Schaffer
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska 68198 4525, USA
    Endocrinology 144:955-66. 2003
    ..The magnitude of each activity in a given cell type seems to determine whether the net effect of the IGF2R on cell growth is inhibitory or stimulatory...
  41. pmc A novel role of Shc adaptor proteins in steroid hormone-regulated cancers
    Syed Mahfuzul Alam
    Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, Nebraska 68198 5870, USA
    Endocr Relat Cancer 16:1-16. 2009
    ..The p66(Shc) protein may serve as an effective biomarker for predicting cancer prognosis as well as a useful target for treatment...
  42. ncbi request reprint Vasoactive intestinal peptide transactivates the androgen receptor through a protein kinase A-dependent extracellular signal-regulated kinase pathway in prostate cancer LNCaP cells
    Yan Xie
    Department of Pharmacology, Creighton University School of Medicine, Omaha, NE 68178, USA
    Mol Pharmacol 72:73-85. 2007
    ....
  43. pmc Elevated expression of L-selectin ligand in lymph node-derived human prostate cancer cells correlates with increased tumorigenicity
    Prakash Radhakrishnan
    Department of Biochemistry and Molecular Biology, College of Medicine, 985870, Nebraska Medical Center, University of Nebraska Medical Center, Omaha, NE 68198, USA
    Glycoconj J 26:75-81. 2009
    ..These results suggest that modulated expression of selective glycogenes correlates with altered tumorigenicity of cancer cells...
  44. pmc Antischistosomal versus antiandrogenic properties of aryl hydantoin Ro 13-3978
    Chunkai Wang
    College of Pharmacy, University of Nebraska Medical Center, Omaha, Nebraska Department of Chemical Biology and Therapeutics, St Jude Children s Research Hospital, Memphis, Tennessee Department of Biochemistry and Molecular Biology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, and University of Basel, Basel, Switzerland
    Am J Trop Med Hyg 90:1156-8. 2014
    ..For AH01, nilutamide, and three closely related aryl hydantoin derivatives, there was no correlation between antischistosomal activity and androgen receptor interaction. ..
  45. ncbi request reprint Vitamin D receptor agonists induce prostatic acid phosphatase to reduce cell growth and HER-2 signaling in LNCaP-derived human prostate cancer cells
    Lamonica V Stewart
    Department of Molecular and Cellular Biology, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA
    J Steroid Biochem Mol Biol 97:37-46. 2005
    ..These data therefore suggest that 1,25D-mediated decreases in LNCaP and C81 LN cell growth are in part due to decreases in tyrosine kinase signaling that result from up-regulation of PAcP...

Research Grants10

  1. Signaling in Androgen-Refractory Prostate Cancer
    Ming Fong Lin; Fiscal Year: 2010
    ..The intensity and the extent of staining will be semi-quantified for calculating a composite score, which will be correlated with clinico-pathological progression of PCa, including HR PCa. ..
  2. Signaling in Androgen-Refractory Prostate Cancer
    Ming Fong Lin; Fiscal Year: 2006
    ..The intensity and the extent of staining will be semi-quantified for calculating a composite score, which will be correlated with clinico-pathological progression of PCa, including HR PCa. ..
  3. Signaling in Androgen-Refractory Prostate Cancer
    Ming Fong Lin; Fiscal Year: 2009
    ..The intensity and the extent of staining will be semi-quantified for calculating a composite score, which will be correlated with clinico-pathological progression of PCa, including HR PCa. ..
  4. SIGNALING IN ANDROGEN REFRACTORY PROSTATE CANCER
    Ming Fong Lin; Fiscal Year: 2003
    ..The in vitro findings will be correlated with the morphological progression of clinical tumors. ..
  5. Signaling in Androgen-Refractory Prostate Cancer
    Ming Fong Lin; Fiscal Year: 2007
    ..The intensity and the extent of staining will be semi-quantified for calculating a composite score, which will be correlated with clinico-pathological progression of PCa, including HR PCa. ..
  6. SIGNALING IN ANDROGEN REFRACTORY PROSTATE CANCER
    Ming Fong Lin; Fiscal Year: 2002
    ..The in vitro findings will be correlated with the morphological progression of clinical tumors. ..
  7. SIGNALING IN ANDROGEN REFRACTORY PROSTATE CANCER
    Ming Fong Lin; Fiscal Year: 2001
    ..The in vitro findings will be correlated with the morphological progression of clinical tumors. ..
  8. SIGNALING IN ANDROGEN REFRACTORY PROSTATE CANCER
    Ming Fong Lin; Fiscal Year: 2004
    ..The in vitro findings will be correlated with the morphological progression of clinical tumors. ..
  9. SIGNALING IN ANDROGEN REFRACTORY PROSTATE CANCER
    Ming Fong Lin; Fiscal Year: 2000
    ..The in vitro findings will be correlated with the morphological progression of clinical tumors. ..