Michael Z Lin

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc A drug-controllable tag for visualizing newly synthesized proteins in cells and whole animals
    Michael Z Lin
    Department of Pharmacology and Howard Hughes Medical Institute, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0647, USA
    Proc Natl Acad Sci U S A 105:7744-9. 2008
  2. pmc Fluorescent and photo-oxidizing TimeSTAMP tags track protein fates in light and electron microscopy
    Margaret T Butko
    Department of Pharmacology and Howard Hughes Medical Institute, University of California San Diego, La Jolla, California, USA
    Nat Neurosci 15:1742-51. 2012
  3. pmc Characterization of engineered channelrhodopsin variants with improved properties and kinetics
    John Y Lin
    Department of Pharmacology, University of California, San Diego, California, USA
    Biophys J 96:1803-14. 2009
  4. pmc Autofluorescent proteins with excitation in the optical window for intravital imaging in mammals
    Michael Z Lin
    Department of Pharmacology, University of California, San Diego, La Jolla, 92093, USA
    Chem Biol 16:1169-79. 2009
  5. pmc Neuroligin trafficking deficiencies arising from mutations in the alpha/beta-hydrolase fold protein family
    Antonella De Jaco
    Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 285:28674-82. 2010
  6. pmc Mammalian expression of infrared fluorescent proteins engineered from a bacterial phytochrome
    Xiaokun Shu
    Howard Hughes Medical Institute, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0647, USA
    Science 324:804-7. 2009
  7. ncbi Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis
    Sandeep Robert Datta
    Division of Neuroscience, Children s Hospital and Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Dev Cell 3:631-43. 2002

Collaborators

Detail Information

Publications7

  1. pmc A drug-controllable tag for visualizing newly synthesized proteins in cells and whole animals
    Michael Z Lin
    Department of Pharmacology and Howard Hughes Medical Institute, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0647, USA
    Proc Natl Acad Sci U S A 105:7744-9. 2008
    ..We demonstrate applications of TimeSTAMP in retrospectively identifying growing synapses in cultured neurons and in visualizing the distribution of recently synthesized proteins in intact fly brains...
  2. pmc Fluorescent and photo-oxidizing TimeSTAMP tags track protein fates in light and electron microscopy
    Margaret T Butko
    Department of Pharmacology and Howard Hughes Medical Institute, University of California San Diego, La Jolla, California, USA
    Nat Neurosci 15:1742-51. 2012
    ..These results demonstrate the versatility of the TimeSTAMP approach for visualizing newly synthesized proteins in neurons...
  3. pmc Characterization of engineered channelrhodopsin variants with improved properties and kinetics
    John Y Lin
    Department of Pharmacology, University of California, San Diego, California, USA
    Biophys J 96:1803-14. 2009
    ..ChEF and ChIEF allow more precise temporal control of depolarization, and can induce action potential trains that more closely resemble natural spiking patterns...
  4. pmc Autofluorescent proteins with excitation in the optical window for intravital imaging in mammals
    Michael Z Lin
    Department of Pharmacology, University of California, San Diego, La Jolla, 92093, USA
    Chem Biol 16:1169-79. 2009
    ..The crystal structure of Neptune reveals a novel mechanism for red-shifting involving the acquisition of a new hydrogen bond with the acylimine region of the chromophore...
  5. pmc Neuroligin trafficking deficiencies arising from mutations in the alpha/beta-hydrolase fold protein family
    Antonella De Jaco
    Department of Pharmacology, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California 92093, USA
    J Biol Chem 285:28674-82. 2010
    ..Our results suggest that disease-related mutations in the alpha/beta-hydrolase fold domain share common trafficking deficiencies yet lead to discrete congenital disorders of differing severity in the endocrine and nervous systems...
  6. pmc Mammalian expression of infrared fluorescent proteins engineered from a bacterial phytochrome
    Xiaokun Shu
    Howard Hughes Medical Institute, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0647, USA
    Science 324:804-7. 2009
    ..Because their wavelengths penetrate tissue well, IFPs are suitable for whole-body imaging. The IFPs developed here provide a scaffold for further engineering...
  7. ncbi Survival factor-mediated BAD phosphorylation raises the mitochondrial threshold for apoptosis
    Sandeep Robert Datta
    Division of Neuroscience, Children s Hospital and Department of Neurobiology, Harvard Medical School, Boston, MA 02115, USA
    Dev Cell 3:631-43. 2002
    ..These findings establish a function for endogenous BAD phosphorylation, and elucidate a mechanism by which survival kinases block apoptosis in vivo...