Affiliation: University of California
- Analyses and comparisons of telomerase activity and telomere length in human T and B cells: insights for epidemiology of telomere maintenanceJue Lin
Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, CA 94143, United States
J Immunol Methods 352:71-80. 2010..55, r<0.001), indicating possible common mechanisms for telomerase activity regulation in these two cell subtypes. These data will facilitate the understanding of leukocyte aging and its relationship to human health...
- Telomeres and lifestyle factors: roles in cellular agingJue Lin
University of California, San Francisco, CA 94158, USA
Mutat Res 730:85-9. 2012..Lastly, we propose possible biochemical mechanisms that mediate these associations and discuss future directions...
- Cell aging in relation to stress arousal and cardiovascular disease risk factorsElissa S Epel
UCSF Department of Psychiatry, San Francisco, CA, USA
Psychoneuroendocrinology 31:277-87. 2006..These findings may implicate telomerase as a novel and important mediator of the effects of psychological stress on physical health and disease...
- Dynamics of telomerase activity in response to acute psychological stressElissa S Epel
Department of Psychiatry, University of California, San Francisco, 3333 Calif St, Suite 465, San Francisco, CA 94143, USA
Brain Behav Immun 24:531-9. 2010....
- Stress appraisals and cellular aging: a key role for anticipatory threat in the relationship between psychological stress and telomere lengthAoife O'Donovan
Department of Psychiatry, University of California, San Francisco, CA, USA
Brain Behav Immun 26:573-9. 2012..Exaggerated anticipatory threat appraisals may be a common and modifiable psychological mechanism of psychological stress effects on cellular aging...
- Dietary restraint and telomere length in pre- and postmenopausal womenAmy Kiefer
UCSF Department of Psychiatry, University of California, San Francisco, California, USA
Psychosom Med 70:845-9. 2008....
- Telomere length trajectory and its determinants in persons with coronary artery disease: longitudinal findings from the heart and soul studyRamin Farzaneh-Far
Division of Cardiology, San Francisco General Hospital, San Francisco, California, USA
PLoS ONE 5:e8612. 2010..We sought to investigate the longitudinal trajectory of telomere length, and to identify the independent predictors of telomere shortening, in persons with coronary artery disease...
- Childhood trauma associated with short leukocyte telomere length in posttraumatic stress disorderAoife O'Donovan
Department of Psychiatry, University of California, San Francisco, California Northern California Institute for Research and Education, San Francisco, California, USA
Biol Psychiatry 70:465-71. 2011..We also examined childhood trauma, a risk factor for both PTSD and short LTL, as a potential contributor to short LTL in PTSD...
- Changes in stress, eating, and metabolic factors are related to changes in telomerase activity in a randomized mindfulness intervention pilot studyJENNIFER DAUBENMIER
Osher Center for Integrative Medicine, Department of Medicine, University of California, San Francisco, CA, USA
Psychoneuroendocrinology 37:917-28. 2012....
- Maternal psychosocial stress during pregnancy is associated with newborn leukocyte telomere lengthSonja Entringer
Department of Pediatrics, University of California, Irvine, School of Medicine, Irvine, CA 92697, USA
Am J Obstet Gynecol 208:134.e1-7. 2013..The objective of the present study was to determine how early in life this effect of stress on LTL is apparent by quantifying the association of maternal psychosocial stress during pregnancy with newborn telomere length...
- Greater endogenous estrogen exposure is associated with longer telomeres in postmenopausal women at risk for cognitive declineJue Lin
Department of Biochemistry and Biophysics, University of California, San Francisco, CA 94118, USA
Brain Res 1379:224-31. 2011..The results suggest that the endogenous estrogens may be associated with deceleration of cellular aging. This is the first study to examine associations between endogenous estrogens, telomere length and telomerase activity...
- Association between kidney function and telomere length: the heart and soul studyNisha Bansal
Department of Medicine, University of California, San Francisco, USA
Am J Nephrol 36:405-11. 2012..Telomere attrition is a novel risk factor for cardiovascular disease. Studies of telomere length in relation to kidney function are limited. We explored the association of kidney function with telomere length and telomere shortening...
- Telomere shortening in formerly abused and never abused womenJanice Humphreys
Department of Family Health Care Nursing, School of Nursing, University of California, San Francisco, CA 94143, USA
Biol Res Nurs 14:115-23. 2012..Findings from this descriptive study suggest a link between IPV exposure, duration of IPV-related stress, and telomere length molecular mechanisms that regulate cellular aging...
- Increased telomerase activity and comprehensive lifestyle changes: a pilot studyDean Ornish
Department of Medicine, University of California, San Francisco, CA, USA
Lancet Oncol 9:1048-57. 2008..We aimed to assess whether 3 months of intensive lifestyle changes increased telomerase activity in peripheral blood mononuclear cells (PBMC)...
- The power of exercise: buffering the effect of chronic stress on telomere lengthEli Puterman
Department of Psychiatry, University of California San Francisco, San Francisco, California, USA
PLoS ONE 5:e10837. 2010..We predicted that chronic stress would be related to short telomere length (TL) in sedentary individuals, whereas in those who exercise, stress would not have measurable effects on telomere shortening...
- Association of marine omega-3 fatty acid levels with telomeric aging in patients with coronary heart diseaseRamin Farzaneh-Far
Division of Cardiology, Room 5G1, San Francisco General Hospital, 1001 Potrero Ave, San Francisco, CA 94110, USA
JAMA 303:250-7. 2010..Increased dietary intake of marine omega-3 fatty acids is associated with prolonged survival in patients with coronary heart disease. However, the mechanisms underlying this protective effect are poorly understood...
- Chronic stress elevates telomerase activity in ratsAnnaliese K Beery
Robert Wood Johnson Health and Society Scholar at University of California at San Francisco, San Francisco, CA 04143, USA
Biol Lett 8:1063-6. 2012..This significant increase suggests a potential mechanism for resilience to stress-related replicative senescence...
- Stress exposure in intrauterine life is associated with shorter telomere length in young adulthoodSonja Entringer
Department of Pediatrics, University of California, Irvine, CA 92697, USA
Proc Natl Acad Sci U S A 108:E513-8. 2011..This observation may help shed light on an important biological pathway underlying the developmental origins of adult health and disease risk...
- Shorter leukocyte telomere length in midlife women with poor sleep qualityAric A Prather
Robert Wood Johnson Foundation Health and Society Scholars Program, Center for Health and Community, University of California San Francisco, 3333 California Street, Suite 465, San Francisco, CA 94118, USA
J Aging Res 2011:721390. 2011..Conclusions. This study provides the first evidence that poor sleep quality explains significant variation in LTL, a marker of cellular aging...
- Accelerated telomere shortening in response to life stressElissa S Epel
Department of Psychiatry, University of California, 3333 California Street, Suite 465, San Francisco, CA 94143, USA
Proc Natl Acad Sci U S A 101:17312-5. 2004..These findings have implications for understanding how, at the cellular level, stress may promote earlier onset of age-related diseases...