Jonathan H Lin

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc IRE1 signaling affects cell fate during the unfolded protein response
    Jonathan H Lin
    Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, CA 94158, USA
    Science 318:944-9. 2007
  2. pmc Endoplasmic reticulum stress in disease pathogenesis
    Jonathan H Lin
    Department of Biochemistry, University of California, San Francisco, CA 94143, USA
    Annu Rev Pathol 3:399-425. 2008
  3. pmc Divergent effects of PERK and IRE1 signaling on cell viability
    Jonathan H Lin
    Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA, USA
    PLoS ONE 4:e4170. 2009
  4. pmc Induction of endoplasmic reticulum stress genes, BiP and chop, in genetic and environmental models of retinal degeneration
    Heike Kroeger
    Department of Pathology, University of California, San Diego, La Jolla, California, USA
    Invest Ophthalmol Vis Sci 53:7590-9. 2012
  5. pmc IRE1 directs proteasomal and lysosomal degradation of misfolded rhodopsin
    Wei Chieh Chiang
    Department of Pathology, University of California, San Diego, La Jolla, CA 92093, USA
    Mol Biol Cell 23:758-70. 2012
  6. pmc Translational and posttranslational regulation of XIAP by eIF2α and ATF4 promotes ER stress-induced cell death during the unfolded protein response
    Nobuhiko Hiramatsu
    Department of Pathology, University of California at San Diego, La Jolla, CA 92093 Center for Neuroscience, Aging, and Stem Cell Research, Sanford Burnham Medical Research Institute, La Jolla, CA 92037 Departments of Anatomy and Ophthalmology, University of California at San Francisco, San Francisco, CA 94143
    Mol Biol Cell 25:1411-20. 2014
  7. pmc Misfolded proteins and retinal dystrophies
    Jonathan H Lin
    Department of Pathology, University of California, San Diego, CA 92093 0612, USA
    Adv Exp Med Biol 664:115-21. 2010
  8. ncbi request reprint Endoplasmic reticulum stress in vertebrate mutant rhodopsin models of retinal degeneration
    Heike Kroeger
    Department of Pathology, University of California, San Diego, USA
    Adv Exp Med Biol 801:585-92. 2014
  9. pmc De novo prion aggregates trigger autophagy in skeletal muscle
    Shivanjali Joshi-Barr
    Department of Pathology, School of Medicine, University of California, San Diego, La Jolla, California, USA
    J Virol 88:2071-82. 2014
  10. pmc The unfolded protein response is a major mechanism by which LRP1 regulates Schwann cell survival after injury
    Elisabetta Mantuano
    Department of Anesthesiology, University of California, San Diego, La Jolla, California 92093 0629, USA
    J Neurosci 31:13376-85. 2011

Collaborators

Detail Information

Publications11

  1. pmc IRE1 signaling affects cell fate during the unfolded protein response
    Jonathan H Lin
    Howard Hughes Medical Institute, University of California at San Francisco, San Francisco, CA 94158, USA
    Science 318:944-9. 2007
    ..Key findings from our studies in cell culture were recapitulated in photoreceptors expressing mutant rhodopsin in animal models of retinitis pigmentosa...
  2. pmc Endoplasmic reticulum stress in disease pathogenesis
    Jonathan H Lin
    Department of Biochemistry, University of California, San Francisco, CA 94143, USA
    Annu Rev Pathol 3:399-425. 2008
    ..This review provides background information on the unfolded protein response and discusses a selection of diseases whose pathogenesis involves ER stress...
  3. pmc Divergent effects of PERK and IRE1 signaling on cell viability
    Jonathan H Lin
    Howard Hughes Medical Institute, University of California San Francisco, San Francisco, CA, USA
    PLoS ONE 4:e4170. 2009
    ..These results demonstrate that extended PERK and IRE1 signaling have opposite effects on cell viability. Differential activation of PERK and IRE1 may determine life or death decisions after ER protein misfolding...
  4. pmc Induction of endoplasmic reticulum stress genes, BiP and chop, in genetic and environmental models of retinal degeneration
    Heike Kroeger
    Department of Pathology, University of California, San Diego, La Jolla, California, USA
    Invest Ophthalmol Vis Sci 53:7590-9. 2012
    ....
  5. pmc IRE1 directs proteasomal and lysosomal degradation of misfolded rhodopsin
    Wei Chieh Chiang
    Department of Pathology, University of California, San Diego, La Jolla, CA 92093, USA
    Mol Biol Cell 23:758-70. 2012
    ..Our findings reveal the diversity of proteolytic mechanisms used by IRE1 to eliminate misfolded rhodopsin...
  6. pmc Translational and posttranslational regulation of XIAP by eIF2α and ATF4 promotes ER stress-induced cell death during the unfolded protein response
    Nobuhiko Hiramatsu
    Department of Pathology, University of California at San Diego, La Jolla, CA 92093 Center for Neuroscience, Aging, and Stem Cell Research, Sanford Burnham Medical Research Institute, La Jolla, CA 92037 Departments of Anatomy and Ophthalmology, University of California at San Francisco, San Francisco, CA 94143
    Mol Biol Cell 25:1411-20. 2014
    ..We propose a "two-hit" model of ER stress-induced cell death involving concomitant CHOP up-regulation and XIAP down-regulation both induced by PERK. ..
  7. pmc Misfolded proteins and retinal dystrophies
    Jonathan H Lin
    Department of Pathology, University of California, San Diego, CA 92093 0612, USA
    Adv Exp Med Biol 664:115-21. 2010
    ..Last, we review new therapies for these diseases based on preventing protein misfolding in the retina...
  8. ncbi request reprint Endoplasmic reticulum stress in vertebrate mutant rhodopsin models of retinal degeneration
    Heike Kroeger
    Department of Pathology, University of California, San Diego, USA
    Adv Exp Med Biol 801:585-92. 2014
    ..Here, we examine and compare the contribution of endoplasmic reticulum stress to retinal degeneration in several vertebrate models of RP generated through expression of mutant rhodopsins. ..
  9. pmc De novo prion aggregates trigger autophagy in skeletal muscle
    Shivanjali Joshi-Barr
    Department of Pathology, School of Medicine, University of California, San Diego, La Jolla, California, USA
    J Virol 88:2071-82. 2014
    ..Blocking of autophagic degradation in cell culture models led to an accumulation of aggregated prion protein. Collectively, these findings suggest that autophagy has an instrumental role in prion protein clearance. ..
  10. pmc The unfolded protein response is a major mechanism by which LRP1 regulates Schwann cell survival after injury
    Elisabetta Mantuano
    Department of Anesthesiology, University of California, San Diego, La Jolla, California 92093 0629, USA
    J Neurosci 31:13376-85. 2011
    ..LRP1 functions as a potent activator of PI3K in SCs and, by this mechanism, limits SC apoptosis resulting from increased CHOP expression in nerve injury...
  11. pmc Monitoring and manipulating mammalian unfolded protein response
    Nobuhiko Hiramatsu
    Department of Pathology, School of Medicine, University of California, San Diego, La Jolla, California, USA
    Methods Enzymol 491:183-98. 2011
    ....