Jim Jung Ching Lin

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc Emergence of Xin demarcates a key innovation in heart evolution
    Shaun E Grosskurth
    Department of Biology, University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 3:e2857. 2008
  2. ncbi request reprint Human tropomyosin isoforms in the regulation of cytoskeleton functions
    Jim Jung Ching Lin
    Department of Biology, University of Iowa, 340BBE, Iowa City, IA 52242 1324, USA
    Adv Exp Med Biol 644:201-22. 2008
  3. pmc Intercalated disc protein, mXinα, suppresses p120-catenin-induced branching phenotype via its interactions with p120-catenin and cortactin
    Qinchuan Wang
    Department of Biology, University of Iowa, Iowa City, IA 52242 1324, United States
    Arch Biochem Biophys 535:91-100. 2013
  4. pmc Essential roles of an intercalated disc protein, mXinbeta, in postnatal heart growth and survival
    Qinchuan Wang
    Department of Biology, University of Iowa, Iowa City, IA 52242 1324, USA
    Circ Res 106:1468-78. 2010
  5. pmc The Xin repeat-containing protein, mXinβ, initiates the maturation of the intercalated discs during postnatal heart development
    Qinchuan Wang
    Department of Biology, University of Iowa, Iowa City, IA 52242 1324, USA
    Dev Biol 374:264-80. 2013
  6. pmc Characterization of cis-regulatory elements and transcription factor binding: gel mobility shift assay
    Jim Jung Ching Lin
    Department of Biological Sciences, University of Iowa, Iowa City, USA
    Methods Mol Biol 366:183-201. 2007
  7. ncbi request reprint Opposite effects of overexpressed myosin Va or heavy meromyosin Va on vesicle distribution, cytoskeleton organization, and cell motility in nonmuscle cells
    Robbin D Eppinga
    Department of Biological Sciences, University of Iowa, Iowa City, Iowa 52242 1324, USA
    Cell Motil Cytoskeleton 65:197-215. 2008
  8. ncbi request reprint Accumulation of tropomyosin isoform 5 at the infection sites of host cells during Cryptosporidium invasion
    STEVEN P O'HARA
    Department of Biological Sciences, University of Iowa, Iowa City, IA 52242 1324, USA
    Parasitol Res 99:45-54. 2006
  9. ncbi request reprint New insights into the roles of Xin repeat-containing proteins in cardiac development, function, and disease
    Qinchuan Wang
    Department of Biology, University of Iowa, Iowa City, Iowa, USA
    Int Rev Cell Mol Biol 310:89-128. 2014
  10. pmc Requirement of TCTG(G/C) Direct Repeats and Overlapping GATA Site for Maintaining the Cardiac-Specific Expression of Cardiac troponin T in Developing and Adult Mice
    Shannon M Harlan
    Department of Biology, University of Iowa, Iowa City, Iowa 52242 1324, USA
    Anat Rec (Hoboken) 291:1574-86. 2008

Research Grants

  1. Control of Cardiac Troponin T Gene Expression
    Jim Jung Ching Lin; Fiscal Year: 2003
  2. Novel Xin Protein in Cardiac Development and Function
    Jim Jung Ching Lin; Fiscal Year: 2004
  3. Control of Cardiac Troponin T Gene Expression
    Jim Jung Ching Lin; Fiscal Year: 2004
  4. Novel Xin Protein in Cardiac Development and Function
    Jim Jung Ching Lin; Fiscal Year: 2005
  5. Control of Cardiac Troponin T Gene Expression
    Jim Jung Ching Lin; Fiscal Year: 2005
  6. Novel Xin Protein in Cardiac Development and Function
    Jim Jung Ching Lin; Fiscal Year: 2006
  7. Control of Cardiac Troponin T Gene Expression
    Jim Jung Ching Lin; Fiscal Year: 2006
  8. Novel Xin Protein in Cardiac Development and Function
    Jim Jung Ching Lin; Fiscal Year: 2007

Collaborators

Detail Information

Publications15

  1. pmc Emergence of Xin demarcates a key innovation in heart evolution
    Shaun E Grosskurth
    Department of Biology, University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 3:e2857. 2008
    ..We postulate that the emergence of the Xin paralogs and their functional differentiation may have played a key role in the evolutionary development of the heart...
  2. ncbi request reprint Human tropomyosin isoforms in the regulation of cytoskeleton functions
    Jim Jung Ching Lin
    Department of Biology, University of Iowa, 340BBE, Iowa City, IA 52242 1324, USA
    Adv Exp Med Biol 644:201-22. 2008
    ..We will then review tropomyosin functions in regulating cell motility and in modulating the anti-angiogenic activity of cleaved high molecular weight kininogen (HKa) and discuss future directions in this area...
  3. pmc Intercalated disc protein, mXinα, suppresses p120-catenin-induced branching phenotype via its interactions with p120-catenin and cortactin
    Qinchuan Wang
    Department of Biology, University of Iowa, Iowa City, IA 52242 1324, United States
    Arch Biochem Biophys 535:91-100. 2013
    ..It is known that p120-catenin directly regulates Rho GTPases, leading to the branching phenotype. Thus, mXinα may sequester the p120-catenin from inhibiting RhoA activity and/or from activating Rac1 activity...
  4. pmc Essential roles of an intercalated disc protein, mXinbeta, in postnatal heart growth and survival
    Qinchuan Wang
    Department of Biology, University of Iowa, Iowa City, IA 52242 1324, USA
    Circ Res 106:1468-78. 2010
    ..Ablation of mXinalpha results in adult late-onset cardiomyopathy with conduction defects. An upregulation of the mXinbeta in mXinalpha-deficient hearts suggests a partial compensation...
  5. pmc The Xin repeat-containing protein, mXinβ, initiates the maturation of the intercalated discs during postnatal heart development
    Qinchuan Wang
    Department of Biology, University of Iowa, Iowa City, IA 52242 1324, USA
    Dev Biol 374:264-80. 2013
    ..A two-step model for the development of ICD is proposed where mXinβ is essential for the redistribution of intercellular junction components from the lateral puncta to the cell termini...
  6. pmc Characterization of cis-regulatory elements and transcription factor binding: gel mobility shift assay
    Jim Jung Ching Lin
    Department of Biological Sciences, University of Iowa, Iowa City, USA
    Methods Mol Biol 366:183-201. 2007
    ..GMSA with SDS-PAGE fractionated proteins allows for the determination of the apparent molecular mass of bound trans-acting factor...
  7. ncbi request reprint Opposite effects of overexpressed myosin Va or heavy meromyosin Va on vesicle distribution, cytoskeleton organization, and cell motility in nonmuscle cells
    Robbin D Eppinga
    Department of Biological Sciences, University of Iowa, Iowa City, Iowa 52242 1324, USA
    Cell Motil Cytoskeleton 65:197-215. 2008
    ..Together, these data suggest that myosin Va overexpression induces actin bundles in vivo whereas the tailless version fails to bundle actin and disrupts cell motility...
  8. ncbi request reprint Accumulation of tropomyosin isoform 5 at the infection sites of host cells during Cryptosporidium invasion
    STEVEN P O'HARA
    Department of Biological Sciences, University of Iowa, Iowa City, IA 52242 1324, USA
    Parasitol Res 99:45-54. 2006
    ..Cryptosporidium infection appears to rearrange and recruit host TM isoforms in both culture cells and in the mouse. Localized accumulation of tropomyosin at the infection sites may facilitate parasite invasion...
  9. ncbi request reprint New insights into the roles of Xin repeat-containing proteins in cardiac development, function, and disease
    Qinchuan Wang
    Department of Biology, University of Iowa, Iowa City, Iowa, USA
    Int Rev Cell Mol Biol 310:89-128. 2014
    ..Thus, mutations in these Xin loci may lead to diverse cardiomyopathies and heart failure. ..
  10. pmc Requirement of TCTG(G/C) Direct Repeats and Overlapping GATA Site for Maintaining the Cardiac-Specific Expression of Cardiac troponin T in Developing and Adult Mice
    Shannon M Harlan
    Department of Biology, University of Iowa, Iowa City, Iowa 52242 1324, USA
    Anat Rec (Hoboken) 291:1574-86. 2008
    ..For a uniform and high level of cardiac-specific expression, the upstream element (-497 to -250 bp) is further required, possibly through the D enhancer module and the combination of Nkx2.5 and GATA sites...
  11. doi request reprint Chapter 1: roles of caldesmon in cell motility and actin cytoskeleton remodeling
    Jim Jung Ching Lin
    Department of Biology, University of Iowa, Iowa City, Iowa 52242, USA
    Int Rev Cell Mol Biol 274:1-68. 2009
    ..Regulation of CaD level and its activity may provide a novel strategy for gene therapy...
  12. ncbi request reprint A comprehensive nonredundant expressed sequence tag collection for the developing Rattus norvegicus heart
    Jennifer J S Laffin
    Department of Pediatrics and Interdepartmental Genetics Graduate Program, The University of Iowa, Iowa City, Iowa 52242, USA
    Physiol Genomics 17:245-52. 2004
    ..It is anticipated that such EST and cDNA clone resources will prove invaluable to gene expression studies aimed at the understanding of the molecular mechanisms underlying heart septation defects...
  13. ncbi request reprint A novel Cryptosporidium parvum antigen, CP2, preferentially associates with membranous structures
    STEVEN P O'HARA
    Department of Biological Sciences, University of Iowa, 138 Biology Building, Iowa City, IA 52242 1324, USA
    Parasitol Res 92:317-27. 2004
    ..The observed expression pattern suggests that CP2 may be involved in the invasion process and/or PVM integrity...
  14. pmc On the mechanisms of arrhythmias in the myocardium of mXinalpha-deficient murine left atrial-pulmonary veins
    Yu Jun Lai
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
    Life Sci 83:272-83. 2008
    ..In contrast, the non-impairment of automatic and triggered rhythms in mXinalpha-/- preparations may be due to the fact that the mechanisms underlying these rhythms do not involve cell-to-cell conduction...
  15. pmc Changes in ionic currents and reduced conduction velocity in hypertrophied ventricular myocardium of Xin alpha-deficient mice
    Yu Jun Lai
    Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, ROC
    Anadolu Kardiyol Derg 7:90-2. 2007
    ..However, changes in cationic inward currents could also contribute to the genesis of EAD and arrhythmias in mXin alpha -deficient mice...

Research Grants8

  1. Control of Cardiac Troponin T Gene Expression
    Jim Jung Ching Lin; Fiscal Year: 2003
    ..Developmental expression patterns of these DRBPs will be determined by in situ hybridization and immunohistochemical studies. ..
  2. Novel Xin Protein in Cardiac Development and Function
    Jim Jung Ching Lin; Fiscal Year: 2004
    ..Only through understanding normal development and cardiac function can intervention strategies be developed to alleviate cardiac defects. ..
  3. Control of Cardiac Troponin T Gene Expression
    Jim Jung Ching Lin; Fiscal Year: 2004
    ..Developmental expression patterns of these DRBPs will be determined by in situ hybridization and immunohistochemical studies. ..
  4. Novel Xin Protein in Cardiac Development and Function
    Jim Jung Ching Lin; Fiscal Year: 2005
    ..Only through understanding normal development and cardiac function can intervention strategies be developed to alleviate cardiac defects. ..
  5. Control of Cardiac Troponin T Gene Expression
    Jim Jung Ching Lin; Fiscal Year: 2005
    ..Developmental expression patterns of these DRBPs will be determined by in situ hybridization and immunohistochemical studies. ..
  6. Novel Xin Protein in Cardiac Development and Function
    Jim Jung Ching Lin; Fiscal Year: 2006
    ..Only through understanding normal development and cardiac function can intervention strategies be developed to alleviate cardiac defects. ..
  7. Control of Cardiac Troponin T Gene Expression
    Jim Jung Ching Lin; Fiscal Year: 2006
    ..Developmental expression patterns of these DRBPs will be determined by in situ hybridization and immunohistochemical studies. ..
  8. Novel Xin Protein in Cardiac Development and Function
    Jim Jung Ching Lin; Fiscal Year: 2007
    ..Only through understanding normal development and cardiac function can intervention strategies be developed to alleviate cardiac defects. ..