Jim Jung Ching Lin

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. ncbi Human tropomyosin isoforms in the regulation of cytoskeleton functions
    Jim Jung Ching Lin
    Department of Biology, University of Iowa, 340BBE, Iowa City, IA 52242 1324, USA
    Adv Exp Med Biol 644:201-22. 2008
  2. ncbi Essential roles of an intercalated disc protein, mXinbeta, in postnatal heart growth and survival
    Qinchuan Wang
    Department of Biology, University of Iowa, Iowa City, IA 52242 1324, USA
    Circ Res 106:1468-78. 2010
  3. ncbi Opposite effects of overexpressed myosin Va or heavy meromyosin Va on vesicle distribution, cytoskeleton organization, and cell motility in nonmuscle cells
    Robbin D Eppinga
    Department of Biological Sciences, University of Iowa, Iowa City, Iowa 52242 1324, USA
    Cell Motil Cytoskeleton 65:197-215. 2008
  4. ncbi Chapter 1: roles of caldesmon in cell motility and actin cytoskeleton remodeling
    Jim Jung Ching Lin
    Department of Biology, University of Iowa, Iowa City, Iowa 52242, USA
    Int Rev Cell Mol Biol 274:1-68. 2009
  5. ncbi A comprehensive nonredundant expressed sequence tag collection for the developing Rattus norvegicus heart
    Jennifer J S Laffin
    Department of Pediatrics and Interdepartmental Genetics Graduate Program, The University of Iowa, Iowa City, Iowa 52242, USA
    Physiol Genomics 17:245-52. 2004
  6. ncbi Characterization of cis-regulatory elements and transcription factor binding: gel mobility shift assay
    Jim Jung Ching Lin
    Department of Biological Sciences, University of Iowa, Iowa City, USA
    Methods Mol Biol 366:183-201. 2007
  7. ncbi Requirement of TCTG(G/C) Direct Repeats and Overlapping GATA Site for Maintaining the Cardiac-Specific Expression of Cardiac troponin T in Developing and Adult Mice
    Shannon M Harlan
    Department of Biology, University of Iowa, Iowa City, Iowa 52242 1324, USA
    Anat Rec (Hoboken) 291:1574-86. 2008
  8. ncbi Emergence of Xin demarcates a key innovation in heart evolution
    Shaun E Grosskurth
    Department of Biology, University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 3:e2857. 2008
  9. ncbi On the mechanisms of arrhythmias in the myocardium of mXinalpha-deficient murine left atrial-pulmonary veins
    Yu Jun Lai
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
    Life Sci 83:272-83. 2008
  10. ncbi Changes in ionic currents and reduced conduction velocity in hypertrophied ventricular myocardium of Xin alpha-deficient mice
    Yu Jun Lai
    Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, ROC
    Anadolu Kardiyol Derg 7:90-2. 2007

Research Grants

  1. Control of Cardiac Troponin T Gene Expression
    Jim Jung Ching Lin; Fiscal Year: 2006
  2. Novel Xin Protein in Cardiac Development and Function
    Jim Jung Ching Lin; Fiscal Year: 2007

Collaborators

Detail Information

Publications10

  1. ncbi Human tropomyosin isoforms in the regulation of cytoskeleton functions
    Jim Jung Ching Lin
    Department of Biology, University of Iowa, 340BBE, Iowa City, IA 52242 1324, USA
    Adv Exp Med Biol 644:201-22. 2008
    ..We will then review tropomyosin functions in regulating cell motility and in modulating the anti-angiogenic activity of cleaved high molecular weight kininogen (HKa) and discuss future directions in this area...
  2. ncbi Essential roles of an intercalated disc protein, mXinbeta, in postnatal heart growth and survival
    Qinchuan Wang
    Department of Biology, University of Iowa, Iowa City, IA 52242 1324, USA
    Circ Res 106:1468-78. 2010
    ..Ablation of mXinalpha results in adult late-onset cardiomyopathy with conduction defects. An upregulation of the mXinbeta in mXinalpha-deficient hearts suggests a partial compensation...
  3. ncbi Opposite effects of overexpressed myosin Va or heavy meromyosin Va on vesicle distribution, cytoskeleton organization, and cell motility in nonmuscle cells
    Robbin D Eppinga
    Department of Biological Sciences, University of Iowa, Iowa City, Iowa 52242 1324, USA
    Cell Motil Cytoskeleton 65:197-215. 2008
    ..Together, these data suggest that myosin Va overexpression induces actin bundles in vivo whereas the tailless version fails to bundle actin and disrupts cell motility...
  4. ncbi Chapter 1: roles of caldesmon in cell motility and actin cytoskeleton remodeling
    Jim Jung Ching Lin
    Department of Biology, University of Iowa, Iowa City, Iowa 52242, USA
    Int Rev Cell Mol Biol 274:1-68. 2009
    ..Regulation of CaD level and its activity may provide a novel strategy for gene therapy...
  5. ncbi A comprehensive nonredundant expressed sequence tag collection for the developing Rattus norvegicus heart
    Jennifer J S Laffin
    Department of Pediatrics and Interdepartmental Genetics Graduate Program, The University of Iowa, Iowa City, Iowa 52242, USA
    Physiol Genomics 17:245-52. 2004
    ..It is anticipated that such EST and cDNA clone resources will prove invaluable to gene expression studies aimed at the understanding of the molecular mechanisms underlying heart septation defects...
  6. ncbi Characterization of cis-regulatory elements and transcription factor binding: gel mobility shift assay
    Jim Jung Ching Lin
    Department of Biological Sciences, University of Iowa, Iowa City, USA
    Methods Mol Biol 366:183-201. 2007
    ..GMSA with SDS-PAGE fractionated proteins allows for the determination of the apparent molecular mass of bound trans-acting factor...
  7. ncbi Requirement of TCTG(G/C) Direct Repeats and Overlapping GATA Site for Maintaining the Cardiac-Specific Expression of Cardiac troponin T in Developing and Adult Mice
    Shannon M Harlan
    Department of Biology, University of Iowa, Iowa City, Iowa 52242 1324, USA
    Anat Rec (Hoboken) 291:1574-86. 2008
    ..For a uniform and high level of cardiac-specific expression, the upstream element (-497 to -250 bp) is further required, possibly through the D enhancer module and the combination of Nkx2.5 and GATA sites...
  8. ncbi Emergence of Xin demarcates a key innovation in heart evolution
    Shaun E Grosskurth
    Department of Biology, University of Iowa, Iowa City, Iowa, United States of America
    PLoS ONE 3:e2857. 2008
    ..We postulate that the emergence of the Xin paralogs and their functional differentiation may have played a key role in the evolutionary development of the heart...
  9. ncbi On the mechanisms of arrhythmias in the myocardium of mXinalpha-deficient murine left atrial-pulmonary veins
    Yu Jun Lai
    Graduate Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan
    Life Sci 83:272-83. 2008
    ..In contrast, the non-impairment of automatic and triggered rhythms in mXinalpha-/- preparations may be due to the fact that the mechanisms underlying these rhythms do not involve cell-to-cell conduction...
  10. ncbi Changes in ionic currents and reduced conduction velocity in hypertrophied ventricular myocardium of Xin alpha-deficient mice
    Yu Jun Lai
    Institute of Life Sciences, National Defense Medical Center, Taipei, Taiwan, ROC
    Anadolu Kardiyol Derg 7:90-2. 2007
    ..However, changes in cationic inward currents could also contribute to the genesis of EAD and arrhythmias in mXin alpha -deficient mice...

Research Grants8

  1. Control of Cardiac Troponin T Gene Expression
    Jim Jung Ching Lin; Fiscal Year: 2006
    ..Developmental expression patterns of these DRBPs will be determined by in situ hybridization and immunohistochemical studies. ..
  2. Novel Xin Protein in Cardiac Development and Function
    Jim Jung Ching Lin; Fiscal Year: 2007
    ..Only through understanding normal development and cardiac function can intervention strategies be developed to alleviate cardiac defects. ..