Research Topics
| Jack J LinSummaryAffiliation: University of California Country: USA Publications
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Detail Information
Publications
Striatal hypertrophy and its cognitive effects in new-onset benign epilepsy with centrotemporal spikesJack J Lin
Department of Neurology, University of California, Irvine, California 92697, USA
Epilepsia 53:677-85. 2012..Given the motor manifestations of seizures in BECTS, we hypothesize that anatomic networks in BECTS involve a distributed corticostriatal circuit...
Three-dimensional preoperative maps of hippocampal atrophy predict surgical outcomes in temporal lobe epilepsyJ J Lin
Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA
Neurology 65:1094-7. 2005..These atrophic regions may indicate areas of increased epileptogenicity, contributing to poorer surgical outcomes...
Reduced neocortical thickness and complexity mapped in mesial temporal lobe epilepsy with hippocampal sclerosisJack J Lin
Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA
Cereb Cortex 17:2007-18. 2007..The pervasive extrahippocampal structural deficits may result from chronic seizure propagation or may reflect other causes such as initial precipitating factors leading to MTLE...
Vulnerability of the frontal-temporal connections in temporal lobe epilepsyJack J Lin
Department of Neurology, University of California, Irvine, CA, USA
Epilepsy Res 82:162-70. 2008..We therefore investigated the integrity of two major frontal-temporal white matter association tracts, uncinate fasciculus (UF) and arcuate fasciculus (AF), and their clinical correlates...
Three-dimensional surface maps link local atrophy and fast ripples in human epileptic hippocampusJennifer A Ogren
Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 7169, USA
Ann Neurol 66:783-91. 2009..It is hypothesized that morphological changes associated with hippocampal atrophy (HA) contribute to the generation of FR, yet there is limited evidence that hippocampal FR-generating sites correspond with local areas of atrophy...
Altered white matter integrity in temporal lobe epilepsy: association with cognitive and clinical profilesJeffrey D Riley
Department of Neurology, University of California, Irvine, CA 92868, USA
Epilepsia 51:536-45. 2010..However, limited data exist regarding the extent of white matter tract abnormalities, cognitive effects of these abnormalities, and relationship to clinical factors. The current study examined these issues in subjects with chronic TLE...
Three-dimensional hippocampal atrophy maps distinguish two common temporal lobe seizure-onset patternsJennifer A Ogren
Department of Neurobiology, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 7169, USA
Epilepsia 50:1361-70. 2009..We used three-dimensional (3D) hippocampal mapping to quantify HA and determine whether each onset group exhibited a unique distribution of atrophy consistent with the functional differences that distinguish the two onset morphologies...
Caudate atrophy and impaired frontostriatal connections are linked to executive dysfunction in temporal lobe epilepsyJeffrey D Riley
Department of Neurology, University of California, Irvine, Irvine, CA, USA
Epilepsy Behav 21:80-7. 2011..The results suggest that atrophy in the dorsal head of the caudate might disrupt frontostriatal networks that are critical for executive functioning in TLE...
Ventricular enlargement in new-onset pediatric epilepsiesDaren C Jackson
Department of Neurology, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin 53792 0001, USA
Epilepsia 52:2225-32. 2011..To examine baseline and prospective (2-year) changes in third, fourth, and lateral ventricle volumes in children with new-onset idiopathic epilepsies and controls (age 8-18 years)...
The emerging architecture of neuropsychological impairment in epilepsyBruce P Hermann
Department of Neurology, University of Wisconsin School of Medicine and Public Health, 600 North Highland Avenue, Madison, WI 53792, USA
Neurol Clin 27:881-907. 2009....
The neurobiology of cognitive disorders in temporal lobe epilepsyBrian Bell
Department of Neurology, University of Wisconsin School of Medicine and Public Health, 600 North Highland Avenue, Madison, WI 53792, USA
Nat Rev Neurol 7:154-64. 2011..Clarifying the origin of these cognitive and anatomical abnormalities, their progression over time and, most importantly, methods for protecting cognitive and brain health in epilepsy, present a challenge to neurologists...
Uncovering the neurobehavioural comorbidities of epilepsy over the lifespanJack J Lin
Department of Neurology, University of California at Irvine, Irvine, CA, USA
Lancet 380:1180-92. 2012....
MRI analysis in temporal lobe epilepsy: cortical thinning and white matter disruptions are related to side of seizure onsetNobuko Kemmotsu
Department of Psychiatry, University of California, San Diego, California, USA
Epilepsia 52:2257-66. 2011..This study investigated the relationship between cortical thinning, white matter compromise, epilepsy variables, and the side of seizure onset, in patients with TLE...
