Research Topics
Genomes and Genes
| Fang LinSummaryAffiliation: University of Iowa Country: USA Publications
| Collaborators
|
Detail Information
Publications
Essential roles of G{alpha}12/13 signaling in distinct cell behaviors driving zebrafish convergence and extension gastrulation movementsFang Lin
Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
J Cell Biol 169:777-87. 2005..These findings provide the first evidence that Galpha(12) and Galpha(13) have overlapping and essential roles in distinct cell behaviors that drive vertebrate gastrulation...- Galpha12/13 regulate epiboly by inhibiting E-cadherin activity and modulating the actin cytoskeletonFang Lin
Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
J Cell Biol 184:909-21. 2009..These results provide the first in vivo evidence that Galpha(12/13) regulate epiboly through two distinct mechanisms: limiting E-cadherin activity and modulating the organization of the actin cytoskeleton... - RACK1 regulates directional cell migration by acting on G betagamma at the interface with its effectors PLC beta and PI3K gammaSonghai Chen
Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA
Mol Biol Cell 19:3909-22. 2008..Taken together, these findings provide a novel mechanism of regulating cell migration, i.e., RACK1-mediated interference with G betagamma-dependent activation of key effectors critical for chemotaxis... 
RACK1 binds to a signal transfer region of G betagamma and inhibits phospholipase C beta2 activationSonghai Chen
Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 6600, USA
J Biol Chem 280:33445-52. 2005..These data thus demonstrate that RACK1 can regulate the activity of a G betagamma effector by competing for its binding to the signal transfer region of G betagamma...- The WD40 repeat protein WDR26 binds Gβγ and promotes Gβγ-dependent signal transduction and leukocyte migrationZhizeng Sun
Department of Pharmacology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
J Biol Chem 286:43902-12. 2011..Collectively, these experiments identify WDR26 as a novel Gβγ-binding protein that is required for the efficacy of Gβγ signaling and leukocyte migration... - Prostaglandin Gbetagamma signaling stimulates gastrulation movements by limiting cell adhesion through Snai1a stabilizationChristina K Speirs
Department of Biological Sciences, Vanderbilt University, Nashville, TN 37232, USA
Development 137:1327-37. 2010.... - Interaction of Gbetagamma with RACK1 and other WD40 repeat proteinsSonghai Chen
Department of Pharmacology, Vanderbilt University Medical Center, Room 442, Robinson Research Building, Nashville, TN 37232, USA
J Mol Cell Cardiol 37:399-406. 2004..Here we will describe the molecular mechanism underlying this interaction and the implications of the interaction on the signal transduction of G-protein and RACK1... 
The Gβ3 splice variant associated with the C825T gene polymorphism is an unstable and functionally inactive proteinZhizeng Sun
Department of Pharmacology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
Cell Signal 24:2349-59. 2012....- A critical role of Gbetagamma in tumorigenesis and metastasis of breast cancerXiaoyun Tang
Department of Pharmacology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
J Biol Chem 286:13244-54. 2011..Taken together, our data demonstrate a critical role of Gβγ signaling in promoting breast tumor growth and metastasis and suggest that targeting Gβγ may represent a novel therapeutic approach for breast cancer... - RACK1 regulates specific functions of GbetagammaSonghai Chen
Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 6600, USA
J Biol Chem 279:17861-8. 2004..Similarly, RACK1 does not affect signal transduction through the Galpha subunits of G(i), G(s), or G(q). Collectively, these findings suggest a role of RACK1 in regulating specific functions of Gbetagamma...