Fang Lin

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc Essential roles of G{alpha}12/13 signaling in distinct cell behaviors driving zebrafish convergence and extension gastrulation movements
    Fang Lin
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Cell Biol 169:777-87. 2005
  2. pmc Galpha12/13 regulate epiboly by inhibiting E-cadherin activity and modulating the actin cytoskeleton
    Fang Lin
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Cell Biol 184:909-21. 2009
  3. pmc RACK1 regulates directional cell migration by acting on G betagamma at the interface with its effectors PLC beta and PI3K gamma
    Songhai Chen
    Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA
    Mol Biol Cell 19:3909-22. 2008
  4. ncbi request reprint RACK1 binds to a signal transfer region of G betagamma and inhibits phospholipase C beta2 activation
    Songhai Chen
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 6600, USA
    J Biol Chem 280:33445-52. 2005
  5. pmc The WD40 repeat protein WDR26 binds Gβγ and promotes Gβγ-dependent signal transduction and leukocyte migration
    Zhizeng Sun
    Department of Pharmacology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Biol Chem 286:43902-12. 2011
  6. pmc Prostaglandin Gbetagamma signaling stimulates gastrulation movements by limiting cell adhesion through Snai1a stabilization
    Christina K Speirs
    Department of Biological Sciences, Vanderbilt University, Nashville, TN 37232, USA
    Development 137:1327-37. 2010
  7. pmc The Gβ3 splice variant associated with the C825T gene polymorphism is an unstable and functionally inactive protein
    Zhizeng Sun
    Department of Pharmacology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Cell Signal 24:2349-59. 2012
  8. ncbi request reprint Interaction of Gbetagamma with RACK1 and other WD40 repeat proteins
    Songhai Chen
    Department of Pharmacology, Vanderbilt University Medical Center, Room 442, Robinson Research Building, Nashville, TN 37232, USA
    J Mol Cell Cardiol 37:399-406. 2004
  9. pmc A critical role of Gbetagamma in tumorigenesis and metastasis of breast cancer
    Xiaoyun Tang
    Department of Pharmacology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 286:13244-54. 2011
  10. ncbi request reprint RACK1 regulates specific functions of Gbetagamma
    Songhai Chen
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 6600, USA
    J Biol Chem 279:17861-8. 2004

Collaborators

Detail Information

Publications10

  1. pmc Essential roles of G{alpha}12/13 signaling in distinct cell behaviors driving zebrafish convergence and extension gastrulation movements
    Fang Lin
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Cell Biol 169:777-87. 2005
    ..These findings provide the first evidence that Galpha(12) and Galpha(13) have overlapping and essential roles in distinct cell behaviors that drive vertebrate gastrulation...
  2. pmc Galpha12/13 regulate epiboly by inhibiting E-cadherin activity and modulating the actin cytoskeleton
    Fang Lin
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    J Cell Biol 184:909-21. 2009
    ..These results provide the first in vivo evidence that Galpha(12/13) regulate epiboly through two distinct mechanisms: limiting E-cadherin activity and modulating the organization of the actin cytoskeleton...
  3. pmc RACK1 regulates directional cell migration by acting on G betagamma at the interface with its effectors PLC beta and PI3K gamma
    Songhai Chen
    Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA
    Mol Biol Cell 19:3909-22. 2008
    ..Taken together, these findings provide a novel mechanism of regulating cell migration, i.e., RACK1-mediated interference with G betagamma-dependent activation of key effectors critical for chemotaxis...
  4. ncbi request reprint RACK1 binds to a signal transfer region of G betagamma and inhibits phospholipase C beta2 activation
    Songhai Chen
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 6600, USA
    J Biol Chem 280:33445-52. 2005
    ..These data thus demonstrate that RACK1 can regulate the activity of a G betagamma effector by competing for its binding to the signal transfer region of G betagamma...
  5. pmc The WD40 repeat protein WDR26 binds Gβγ and promotes Gβγ-dependent signal transduction and leukocyte migration
    Zhizeng Sun
    Department of Pharmacology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    J Biol Chem 286:43902-12. 2011
    ..Collectively, these experiments identify WDR26 as a novel Gβγ-binding protein that is required for the efficacy of Gβγ signaling and leukocyte migration...
  6. pmc Prostaglandin Gbetagamma signaling stimulates gastrulation movements by limiting cell adhesion through Snai1a stabilization
    Christina K Speirs
    Department of Biological Sciences, Vanderbilt University, Nashville, TN 37232, USA
    Development 137:1327-37. 2010
    ....
  7. pmc The Gβ3 splice variant associated with the C825T gene polymorphism is an unstable and functionally inactive protein
    Zhizeng Sun
    Department of Pharmacology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, IA 52242, USA
    Cell Signal 24:2349-59. 2012
    ....
  8. ncbi request reprint Interaction of Gbetagamma with RACK1 and other WD40 repeat proteins
    Songhai Chen
    Department of Pharmacology, Vanderbilt University Medical Center, Room 442, Robinson Research Building, Nashville, TN 37232, USA
    J Mol Cell Cardiol 37:399-406. 2004
    ..Here we will describe the molecular mechanism underlying this interaction and the implications of the interaction on the signal transduction of G-protein and RACK1...
  9. pmc A critical role of Gbetagamma in tumorigenesis and metastasis of breast cancer
    Xiaoyun Tang
    Department of Pharmacology, Roy J and Lucille A Carver College of Medicine, University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 286:13244-54. 2011
    ..Taken together, our data demonstrate a critical role of Gβγ signaling in promoting breast tumor growth and metastasis and suggest that targeting Gβγ may represent a novel therapeutic approach for breast cancer...
  10. ncbi request reprint RACK1 regulates specific functions of Gbetagamma
    Songhai Chen
    Department of Pharmacology, Vanderbilt University Medical Center, Nashville, Tennessee 37232 6600, USA
    J Biol Chem 279:17861-8. 2004
    ..Similarly, RACK1 does not affect signal transduction through the Galpha subunits of G(i), G(s), or G(q). Collectively, these findings suggest a role of RACK1 in regulating specific functions of Gbetagamma...