Affiliation: University of Iowa
Hu B, Gao Y, Davies L, Woo S, Topczewski J, Jessen J, et al
. Glypican 4 and Mmp14 interact in regulating the migration of anterior endodermal cells by limiting extracellular matrix deposition. Development. 2018;145: pubmed publisher
..Our results suggest that Gpc4 is crucial for generating the environment required for efficient migration of endodermal cells, uncovering a novel function of Gpc4 during development. ..
Ye D, Xie H, Hu B, Lin F. Endoderm convergence controls subduction of the myocardial precursors during heart-tube formation. Development. 2015;142:2928-40 pubmed publisher
Xie H, Ye D, Sepich D, Lin F. S1pr2/G?13 signaling regulates the migration of endocardial precursors by controlling endoderm convergence. Dev Biol. 2016;414:228-43 pubmed publisher
..The demonstration that endoderm convergence regulates the synchronized migration of endocardial and myocardial precursors reveals a new role of the endoderm in heart development. ..
Ke W, Ye D, Mersch K, Xu H, Chen S, Lin F. G?1 is required for neutrophil migration in zebrafish. Dev Biol. 2017;428:135-147 pubmed publisher
..Collectively, our data indicate that G?1 signaling controls proper neutrophil migration by activating PI3K and modulating actin dynamics. Moreover, they illustrate a role for a specific G? isoform in chemotaxis in vivo. ..
Lin F, Chen S, Sepich D, Panizzi J, Clendenon S, Marrs J, et al
. Galpha12/13 regulate epiboly by inhibiting E-cadherin activity and modulating the actin cytoskeleton. J Cell Biol. 2009;184:909-21 pubmed publisher
..These results provide the first in vivo evidence that Galpha(12/13) regulate epiboly through two distinct mechanisms: limiting E-cadherin activity and modulating the organization of the actin cytoskeleton. ..
Xu H, Ye D, Behra M, Burgess S, Chen S, Lin F. G?1 controls collective cell migration by regulating the protrusive activity of leader cells in the posterior lateral line primordium. Dev Biol. 2014;385:316-27 pubmed publisher
..Collectively, our data indicate that G?1 controls migration of the pLLP, likely by acting downstream of the Cxcl12a/Cxcr4b signaling. This study also provides compelling evidence for functional specificity among G? isoforms in vivo. ..