Dan Yu Lin

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi Evaluation of population impact of candidate polymorphisms for coronary heart disease in the Framingham Heart Study Offspring Cohort
    Yu Yan
    Department of Epidemiology, University of North Carolina, 2101 McGavran Greenberg Hall, Chapel Hill, North Carolina 27599, USA
    BMC Proc 3:S118. 2009
  2. ncbi Semiparametric methods for genome-wide linkage analysis of human gene expression data
    Guoqing Diao
    Department of Statistics, George Mason University, 4400 University Drive, MS 4A7, Fairfax, Virginia 22030, USA
    BMC Proc 1:S83. 2007
  3. ncbi Longitudinal age-dependent effect on systolic blood pressure
    Bonnie R Joubert
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, 2101 McGavran Greenberg Hall, CB 7435, Chapel Hill, North Carolina 27599, USA
    BMC Proc 3:S87. 2009
  4. ncbi Nonparametric tests for the gap time distributions of serial events based on censored data
    D Y Lin
    Department of Biostatistics, University of North Carolina, Chapel Hill 27599 7400, USA
    Biometrics 57:369-75. 2001
  5. ncbi Simple and efficient analysis of disease association with missing genotype data
    D Y Lin
    Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7420, USA
    Am J Hum Genet 82:444-52. 2008
  6. ncbi Haplotype-based association analysis in cohort studies of unrelated individuals
    D Y Lin
    Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina 27599 7420, USA
    Genet Epidemiol 26:255-64. 2004
  7. ncbi Assessing genomewide statistical significance in linkage studies
    D Y Lin
    Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Genet Epidemiol 27:202-14. 2004
  8. ncbi An efficient Monte Carlo approach to assessing statistical significance in genomic studies
    D Y Lin
    Department of Biostatistics, University of North Carolina, McGavran Greenberg Hall, CB 7420, Chapel Hill, NC 27599 7420, USA
    Bioinformatics 21:781-7. 2005
  9. ncbi On the Breslow estimator
    D Y Lin
    Department of Biostatistics, University of North Carolina, CB 7420, Chapel Hill, NC 27599 7420, USA
    Lifetime Data Anal 13:471-80. 2007
  10. ncbi Evaluating statistical significance in two-stage genomewide association studies
    D Y Lin
    Department of Biostatistics, University of North Carolina, Chapel Hill, 27599 7420, USA
    Am J Hum Genet 78:505-9. 2006

Research Grants

  1. STATISTICAL METHODS IN CANCER RESEARCH
    Danyu Lin; Fiscal Year: 2010
  2. STATISTICAL METHODS IN CANCER RESEARCH
    Danyu Lin; Fiscal Year: 2009
  3. Semiparametric Regression Analysis of Censored Data
    Danyu Lin; Fiscal Year: 2007
  4. STATISTICAL METHODS IN CURRENT CANCER RESEARCH
    Danyu Lin; Fiscal Year: 2007
  5. Semiparametric Regression Analysis of Censored Data
    Danyu Lin; Fiscal Year: 2004
  6. STATISTICAL METHODS IN CURRENT CANCER RESEARCH
    Danyu Lin; Fiscal Year: 2003
  7. SEMIPARAMETRIC REGRESSION ANALYSES OF CENSORED DATA
    Danyu Lin; Fiscal Year: 2000
  8. STATISTICAL METHODS IN CANCER RESEARCH
    Danyu Lin; Fiscal Year: 2009

Detail Information

Publications50

  1. ncbi Evaluation of population impact of candidate polymorphisms for coronary heart disease in the Framingham Heart Study Offspring Cohort
    Yu Yan
    Department of Epidemiology, University of North Carolina, 2101 McGavran Greenberg Hall, Chapel Hill, North Carolina 27599, USA
    BMC Proc 3:S118. 2009
    ..The development of this novel measure of population impact creates a more comprehensive estimate of population impact over the life course of disease, which may help us to better understand genetic susceptibility at the population level...
  2. ncbi Semiparametric methods for genome-wide linkage analysis of human gene expression data
    Guoqing Diao
    Department of Statistics, George Mason University, 4400 University Drive, MS 4A7, Fairfax, Virginia 22030, USA
    BMC Proc 1:S83. 2007
    ..Particularly, we apply the SQTL mapping method and the Monte-Carlo approach to the gene expression data provided by Genetic Analysis Workshop 15...
  3. ncbi Longitudinal age-dependent effect on systolic blood pressure
    Bonnie R Joubert
    Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, 2101 McGavran Greenberg Hall, CB 7435, Chapel Hill, North Carolina 27599, USA
    BMC Proc 3:S87. 2009
    ..The value of the 2-df test for screening genetic interaction effects could not be established in this study...
  4. ncbi Nonparametric tests for the gap time distributions of serial events based on censored data
    D Y Lin
    Department of Biostatistics, University of North Carolina, Chapel Hill 27599 7400, USA
    Biometrics 57:369-75. 2001
    ..An illustration with data taken from a colon cancer study is provided. The related problem of testing the independence of two successive gap times is also studied...
  5. ncbi Simple and efficient analysis of disease association with missing genotype data
    D Y Lin
    Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7420, USA
    Am J Hum Genet 82:444-52. 2008
    ..An application to a case-control study on rheumatoid arthritis revealed several loci that deserve further investigations...
  6. ncbi Haplotype-based association analysis in cohort studies of unrelated individuals
    D Y Lin
    Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina 27599 7420, USA
    Genet Epidemiol 26:255-64. 2004
    ....
  7. ncbi Assessing genomewide statistical significance in linkage studies
    D Y Lin
    Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Genet Epidemiol 27:202-14. 2004
    ..The usefulness of the proposed approach is demonstrated through extensive simulation studies and an application to the nuclear family data from the Tenth Genetic Analysis Workshop...
  8. ncbi An efficient Monte Carlo approach to assessing statistical significance in genomic studies
    D Y Lin
    Department of Biostatistics, University of North Carolina, McGavran Greenberg Hall, CB 7420, Chapel Hill, NC 27599 7420, USA
    Bioinformatics 21:781-7. 2005
    ....
  9. ncbi On the Breslow estimator
    D Y Lin
    Department of Biostatistics, University of North Carolina, CB 7420, Chapel Hill, NC 27599 7420, USA
    Lifetime Data Anal 13:471-80. 2007
    ..The present paper describes the Breslow estimator and its tremendous impact on the theory and practice of survival analysis...
  10. ncbi Evaluating statistical significance in two-stage genomewide association studies
    D Y Lin
    Department of Biostatistics, University of North Carolina, Chapel Hill, 27599 7420, USA
    Am J Hum Genet 78:505-9. 2006
    ....
  11. ncbi Semiparametric regression analysis of longitudinal data with informative drop-outs
    D Y Lin
    Department of Biostatistics, University of North Carolina, CB 7420 McGavran Greenberg, Chapel Hill, NC 27599 7420, USA
    Biostatistics 4:385-98. 2003
    ..Extensive simulation studies demonstrate that the proposed methods are suitable for practical use. Illustrations with data taken from two AIDS clinical trials are provided...
  12. ncbi Proper analysis of secondary phenotype data in case-control association studies
    D Y Lin
    Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina 27599 7420, USA
    Genet Epidemiol 33:256-65. 2009
    ..We demonstrate the pitfalls of the standard methods and the advantages of the new methods both analytically and numerically. The relevant software is available at our website...
  13. ncbi Maximum likelihood estimation of haplotype effects and haplotype-environment interactions in association studies
    D Y Lin
    Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Genet Epidemiol 29:299-312. 2005
    ..An application to the Carolina Breast Cancer Study reveals significant haplotype effects and haplotype-smoking interactions in the development of breast cancer...
  14. ncbi Meta-analysis of genome-wide association studies with overlapping subjects
    Dan Yu Lin
    Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA
    Am J Hum Genet 85:862-72. 2009
    ..The advantages of the new approach are illustrated with empirical data from two sets of genome-wide association studies...
  15. ncbi Model-checking techniques based on cumulative residuals
    D Y Lin
    Department of Biostatistics, University of North Carolina, Chapel Hill 27599 7420, USA
    Biometrics 58:1-12. 2002
    ..The proposed techniques are particularly useful in checking the functional form of a covariate and the link function. Illustrations with several medical studies are provided...
  16. ncbi Meta-analysis of genome-wide association studies: no efficiency gain in using individual participant data
    D Y Lin
    Department of Biostatistics, University of North Carolina, McGavran Greenberg Hall, CB 7420, Chapel Hill, NC 27599 7420, USA
    Genet Epidemiol 34:60-6. 2010
    ..Collating only summary results will increase the number and representativeness of available studies, simplify data collection and analysis, reduce resource utilization, and accelerate discovery...
  17. ncbi Regression analysis of incomplete medical cost data
    D Y Lin
    Department of Biostatistics, University of North Carolina, CB 7420 McGavran Greenberg, Chapel Hill 27599 7420, USA
    Stat Med 22:1181-200. 2003
    ....
  18. ncbi Common genetic variation in adiponectin, leptin, and leptin receptor and association with breast cancer subtypes
    Sarah J Nyante
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
    Breast Cancer Res Treat 129:593-606. 2011
    ..Replication in additional studies where breast cancer subtypes have been defined is necessary to confirm these potential associations...
  19. ncbi Efficient semiparametric estimation of haplotype-disease associations in case-cohort and nested case-control studies
    D Zeng
    Department of Biostatistics, CB# 7420, University of North Carolina, Chapel Hill, NC 27599-7420, USA
    Biostatistics 7:486-502. 2006
    ..An application to a major cardiovascular study is provided...
  20. ncbi Estimating haplotype-disease associations with pooled genotype data
    D Zeng
    Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina 27599-7420, USA
    Genet Epidemiol 28:70-82. 2005
    ..The results show that DNA pooling is highly efficient in studying haplotype-disease associations. As a by-product, this work provides valid and efficient methods for estimating haplotype-disease associations with unpooled DNA samples...
  21. ncbi Detecting haplotype effects in genomewide association studies
    B E Huang
    Department of Biostatistics, University of North Carolina, North Carolina 27599 7420, USA
    Genet Epidemiol 31:803-12. 2007
    ..We applied the new method to a case-control study on rheumatoid arthritis and identified several loci worthy of further investigations...
  22. ncbi Efficient association mapping of quantitative trait loci with selective genotyping
    B E Huang
    Department of Biostatistics, University of North Carolina, Chapel Hill 27599 7420, USA
    Am J Hum Genet 80:567-76. 2007
    ..We demonstrate that the likelihood-based methods are highly effective in identifying causal variants and are substantially more powerful than existing methods...
  23. ncbi Semiparametric methods for mapping quantitative trait loci with censored data
    Guoqing Diao
    Department of Biostatistics, CB No. 7420, University of North Carolina, Chapel Hill, North Carolina 27599-7420, USA
    Biometrics 61:789-98. 2005
    ..Extensive simulation studies demonstrate that the proposed methods perform well in practical situations. Applications to two animal studies are provided...
  24. ncbi A general framework for detecting disease associations with rare variants in sequencing studies
    Dan Yu Lin
    Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA
    Am J Hum Genet 89:354-67. 2011
    ..An application to a deep-resequencing study of drug targets led to a discovery of rare variants associated with total cholesterol. The relevant software is freely available...
  25. ncbi Assessing the sensitivity of regression results to unmeasured confounders in observational studies
    D Y Lin
    Department of Biostatistics, University of Washington, Seattle 98195, USA
    Biometrics 54:948-63. 1998
    ..We describe applications on two major medical studies...
  26. ncbi Semiparametric analysis of recurrent events data in the presence of dependent censoring
    Debashis Ghosh
    Department of Biostatistics, University of Michigan, 1420 Washington Heights, Ann Arbor, Michigan, USA
    Biometrics 59:877-85. 2003
    ..The finite-sample behavior of the new inference procedures is evaluated through simulation studies. An application to recurrent hospitalization data taken from a study of intravenous drug users is provided...
  27. ncbi Fine-mapping and initial characterization of QT interval loci in African Americans
    Christy L Avery
    Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
    PLoS Genet 8:e1002870. 2012
    ....
  28. ncbi Goodness-of-fit methods for generalized linear mixed models
    Zhiying Pan
    Department of Biostatistics, University of North Carolina, CB 7420, McGavran-Greenberg Hall, Chapel Hill, 27599-7420, USA
    Biometrics 61:1000-9. 2005
    ..Extensive simulation studies show that the proposed goodness-of-fit tests have proper sizes and are sensitive to model misspecification. Applications to two medical studies lead to improved models...
  29. ncbi Semiparametric transformation models with random effects for joint analysis of recurrent and terminal events
    Donglin Zeng
    Department of Biostatistics, CB 7420, University of North Carolina, Chapel Hill, North Carolina 27599 7420, USA
    Biometrics 65:746-52. 2009
    ..Extensive simulation studies demonstrate that the proposed inference procedures perform well in realistic settings. Applications to two HIV/AIDS studies are presented...
  30. ncbi An efficient resampling method for assessing genome-wide statistical significance in mapping quantitative trait Loci
    Fei Zou
    Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina 27599 7420, USA
    Genetics 168:2307-16. 2004
    ..The usefulness of the proposed method is demonstrated through simulation studies and an application to a Drosophila backcross...
  31. ncbi A powerful and robust method for mapping quantitative trait loci in general pedigrees
    G Diao
    Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599-7420, USA
    Am J Hum Genet 77:97-111. 2005
    ..The computer program that implements the new method is freely available...
  32. ncbi Improving the power of association tests for quantitative traits in family studies
    G Diao
    Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina 27599-7420, USA
    Genet Epidemiol 30:301-13. 2006
    ..We have implemented the new methods in a freely available computer program...
  33. ncbi Poisson regression with missing durations of exposure
    D Y Lin
    Department of Biostatistics, University of Washington, Seattle 98195, USA
    Biometrics 55:252-7. 1999
    ..We describe an application to a population-based case-control study assessing the transient increase in the risk of primary cardiac arrest during leisure-time physical activity...
  34. ncbi Proportional means regression for censored medical costs
    D Y Lin
    Department of Biostatistics, University of Washington, Seattle 98195, USA
    Biometrics 56:775-8. 2000
    ..The estimator is consistent and asymptotically normal with an easily estimable covariance matrix. Simulation studies show that the proposed methodology is appropriate for practical use. An application to AIDS is provided...
  35. ncbi Semiparametric variance-component models for linkage and association analyses of censored trait data
    G Diao
    Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA
    Genet Epidemiol 30:570-81. 2006
    ..We provide an application to the age at onset of alcohol dependence data from the Collaborative Study on the Genetics of Alcoholism. A computer program is freely available...
  36. ncbi Efficient resampling methods for nonsmooth estimating functions
    Donglin Zeng
    Department of Biostatistics, CB 7420, University of North Carolina, Chapel Hill, NC 27599 7420, USA
    Biostatistics 9:355-63. 2008
    ..Its usefulness is illustrated with heteroscedastic quantile regression and censored data rank regression. Numerical results based on simulated and real data are provided...
  37. ncbi Model-checking techniques for stratified case-control studies
    Patrick G Arbogast
    Department of Biostatistics, Vanderbilt University, S 2323 Medical Center North, Nashville, TN 37232 2158, USA
    Stat Med 24:229-47. 2005
    ..Simulation studies demonstrate that the proposed methods perform well in practical settings. Illustration with an oesophageal cancer study is provided...
  38. ncbi Mapping quantitative trait loci with censored observations
    Guoqing Diao
    Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina 27599-7420, USA
    Genetics 168:1689-98. 2004
    ..In addition, we show how to assess genome-wide statistical significance. The performance of the proposed methods is evaluated through extensive simulation studies. An application to a mouse cross is provided...
  39. ncbi A variable selection method for genome-wide association studies
    Qianchuan He
    Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA
    Bioinformatics 27:1-8. 2011
    ..Existing methods for joint analysis of GWAS data tend to miss causal SNPs that are marginally uncorrelated with disease and have high false discovery rates (FDRs)...
  40. ncbi Methods for analyzing health care utilization and costs
    P Diehr
    Department of Biostatistics, University of Washington, Seattle 98195, USA
    Annu Rev Public Health 20:125-44. 1999
    ..We also address issues of study design and new methods for dealing with censored data. Examples are presented...
  41. ncbi Survival analysis in clinical trials: past developments and future directions
    T R Fleming
    Department of Biostatistics, Box 357232, University of Washington, Seattle, Washington 98195, USA
    Biometrics 56:971-83. 2000
    ....
  42. ncbi Association of genetic variants and incident coronary heart disease in multiethnic cohorts: the PAGE study
    Nora Franceschini
    Gillings School of Global Public Health, University of North Carolina, Chapel Hill, NC, USA
    Circ Cardiovasc Genet 4:661-72. 2011
    ..The association of 13 published CHD SNPs was examined in 5 ancestry groups of 4 large US prospective cohorts...
  43. ncbi Time-dependent covariates in the Cox proportional-hazards regression model
    L D Fisher
    Department of Biostatistics, University of Washington, Seattle 98195 7232, USA
    Annu Rev Public Health 20:145-57. 1999
    ..The estimated probability of an event over time is not related to the hazard function in the usual fashion. An appendix summarizes the mathematics of time-dependent covariates...
  44. ncbi Electrocardiographic QT interval prolongation and risk of primary cardiac arrest in diabetic patients
    Eric A Whitsel
    Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA
    Diabetes Care 28:2045-7. 2005
  45. ncbi Association of polymorphisms in the CRP gene with circulating C-reactive protein levels and cardiovascular events
    Leslie A Lange
    Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 7264, USA
    JAMA 296:2703-11. 2006
    ..C-reactive protein (CRP) is an inflammation protein that may play a role in the pathogenesis of cardiovascular disease (CVD)...
  46. ncbi Digoxin therapy and the risk of primary cardiac arrest in patients with congestive heart failure: effect of mild-moderate renal impairment
    Thomas D Rea
    Cardiovascular Health Research Unit, University of Washington, Department of Medicine, Metropolitan Park, 1730 Minor Avenue, East Tower, Seattle, WA 98101, USA
    J Clin Epidemiol 56:646-50. 2003
    ..The cardiac safety of digoxin therapy for congestive heart failure (CHF) is a source of concern, especially among those with renal impairment...
  47. ncbi Prolonged follow-up of patients in the U.S. multicenter trial of ursodeoxycholic acid for primary biliary cirrhosis
    Burton Combes
    University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75390-9151, USA
    Am J Gastroenterol 99:264-8. 2004
    ....
  48. ncbi Multistage sampling for genetic studies
    Robert C Elston
    Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio 44106, USA
    Annu Rev Genomics Hum Genet 8:327-42. 2007
    ..Finally, we note that the sampling of family data for linkage analysis is not a practice that should be automatically discontinued...
  49. ncbi Inhaled beta-2 adrenergic receptor agonists and primary cardiac arrest
    Rozenn N Lemaitre
    Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington 98101, USA
    Am J Med 113:711-6. 2002
    ..We sought to investigate if short-acting, inhaled beta2-adrenergic receptor agonists were associated with higher risk of primary cardiac arrest in patients with asthma or chronic obstructive pulmonary disease (COPD)...

Research Grants19

  1. STATISTICAL METHODS IN CANCER RESEARCH
    Danyu Lin; Fiscal Year: 2010
    ..This research will not only significantly advance the fields of survival analysis, longitudinal data analysis and statistical genetics, but will also provide valuable new tools to cancer researchers. ..
  2. STATISTICAL METHODS IN CANCER RESEARCH
    Danyu Lin; Fiscal Year: 2009
    ..abstract_text> ..
  3. Semiparametric Regression Analysis of Censored Data
    Danyu Lin; Fiscal Year: 2007
    ..This research will not only significantly advances the fields of survival analysis and longitudinal data analysis, but will also provide valuable new tools to biomedical researchers. ..
  4. STATISTICAL METHODS IN CURRENT CANCER RESEARCH
    Danyu Lin; Fiscal Year: 2007
    ..This research will not only advance the fields of longitudinal data analysis, survival analysis and statistical genetics, but will also provide valuable new tools to cancer researchers. ..
  5. Semiparametric Regression Analysis of Censored Data
    Danyu Lin; Fiscal Year: 2004
    ..Applications to real medical studies will be provided. The research results will be disseminated to practicing statisticians and medical investigators via publications, lectures and software distributions. ..
  6. STATISTICAL METHODS IN CURRENT CANCER RESEARCH
    Danyu Lin; Fiscal Year: 2003
    ..The usefulness of the proposed methods will be illustrated with real cancer studies. The research results will be disseminated to practicing statisticians and medical investigators via publications, lectures and software distributions. ..
  7. SEMIPARAMETRIC REGRESSION ANALYSES OF CENSORED DATA
    Danyu Lin; Fiscal Year: 2000
    ..All the proposed methods will be implemented in computer programs for public use and applied to real biomedical studies. ..
  8. STATISTICAL METHODS IN CANCER RESEARCH
    Danyu Lin; Fiscal Year: 2009
    ..PUBLIC HEALTH RELEVANCE: The broad, long-term objectives of this research are the developments of statistical methods for the designs and analysis of clinical and epidemiological cancer studies, with or without genetic components. ..