D Y Lin

Summary

Affiliation: University of Washington
Country: USA

Publications

  1. ncbi request reprint Assessing the sensitivity of regression results to unmeasured confounders in observational studies
    D Y Lin
    Department of Biostatistics, University of Washington, Seattle 98195, USA
    Biometrics 54:948-63. 1998
  2. ncbi request reprint Proportional means regression for censored medical costs
    D Y Lin
    Department of Biostatistics, University of Washington, Seattle 98195, USA
    Biometrics 56:775-8. 2000
  3. ncbi request reprint Poisson regression with missing durations of exposure
    D Y Lin
    Department of Biostatistics, University of Washington, Seattle 98195, USA
    Biometrics 55:252-7. 1999
  4. pmc A general framework for studying genetic effects and gene-environment interactions with missing data
    Y J Hu
    Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599 7420, USA
    Biostatistics 11:583-98. 2010
  5. ncbi request reprint Efficient semiparametric estimation of haplotype-disease associations in case-cohort and nested case-control studies
    D Zeng
    Department of Biostatistics, CB 7420, University of North Carolina, Chapel Hill, NC 27599 7420, USA
    Biostatistics 7:486-502. 2006
  6. ncbi request reprint Detecting haplotype effects in genomewide association studies
    B E Huang
    Department of Biostatistics, University of North Carolina, North Carolina 27599 7420, USA
    Genet Epidemiol 31:803-12. 2007
  7. pmc Simple and efficient analysis of disease association with missing genotype data
    D Y Lin
    Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7420, USA
    Am J Hum Genet 82:444-52. 2008
  8. pmc Analysis of untyped SNPs: maximum likelihood and imputation methods
    Y J Hu
    Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina 27599 7420, USA
    Genet Epidemiol 34:803-15. 2010
  9. pmc Semiparametric transformation models with random effects for joint analysis of recurrent and terminal events
    Donglin Zeng
    Department of Biostatistics, CB 7420, University of North Carolina, Chapel Hill, North Carolina 27599 7420, USA
    Biometrics 65:746-52. 2009
  10. ncbi request reprint Semiparametric methods for mapping quantitative trait loci with censored data
    Guoqing Diao
    Department of Biostatistics, CB No 7420, University of North Carolina, Chapel Hill, North Carolina 27599 7420, USA
    Biometrics 61:789-98. 2005

Detail Information

Publications38

  1. ncbi request reprint Assessing the sensitivity of regression results to unmeasured confounders in observational studies
    D Y Lin
    Department of Biostatistics, University of Washington, Seattle 98195, USA
    Biometrics 54:948-63. 1998
    ..We describe applications on two major medical studies...
  2. ncbi request reprint Proportional means regression for censored medical costs
    D Y Lin
    Department of Biostatistics, University of Washington, Seattle 98195, USA
    Biometrics 56:775-8. 2000
    ..The estimator is consistent and asymptotically normal with an easily estimable covariance matrix. Simulation studies show that the proposed methodology is appropriate for practical use. An application to AIDS is provided...
  3. ncbi request reprint Poisson regression with missing durations of exposure
    D Y Lin
    Department of Biostatistics, University of Washington, Seattle 98195, USA
    Biometrics 55:252-7. 1999
    ..We describe an application to a population-based case-control study assessing the transient increase in the risk of primary cardiac arrest during leisure-time physical activity...
  4. pmc A general framework for studying genetic effects and gene-environment interactions with missing data
    Y J Hu
    Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599 7420, USA
    Biostatistics 11:583-98. 2010
    ..Extensive simulation studies demonstrate that the proposed inferential and numerical methods perform well in practical settings. Illustration with a genome-wide association study of lung cancer is provided...
  5. ncbi request reprint Efficient semiparametric estimation of haplotype-disease associations in case-cohort and nested case-control studies
    D Zeng
    Department of Biostatistics, CB 7420, University of North Carolina, Chapel Hill, NC 27599 7420, USA
    Biostatistics 7:486-502. 2006
    ..An application to a major cardiovascular study is provided...
  6. ncbi request reprint Detecting haplotype effects in genomewide association studies
    B E Huang
    Department of Biostatistics, University of North Carolina, North Carolina 27599 7420, USA
    Genet Epidemiol 31:803-12. 2007
    ..We applied the new method to a case-control study on rheumatoid arthritis and identified several loci worthy of further investigations...
  7. pmc Simple and efficient analysis of disease association with missing genotype data
    D Y Lin
    Department of Biostatistics, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7420, USA
    Am J Hum Genet 82:444-52. 2008
    ..An application to a case-control study on rheumatoid arthritis revealed several loci that deserve further investigations...
  8. pmc Analysis of untyped SNPs: maximum likelihood and imputation methods
    Y J Hu
    Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina 27599 7420, USA
    Genet Epidemiol 34:803-15. 2010
    ..In addition, we provide an illustration with genome-wide data from the Wellcome Trust Case-Control Consortium (WTCCC) [2007]...
  9. pmc Semiparametric transformation models with random effects for joint analysis of recurrent and terminal events
    Donglin Zeng
    Department of Biostatistics, CB 7420, University of North Carolina, Chapel Hill, North Carolina 27599 7420, USA
    Biometrics 65:746-52. 2009
    ..Extensive simulation studies demonstrate that the proposed inference procedures perform well in realistic settings. Applications to two HIV/AIDS studies are presented...
  10. ncbi request reprint Semiparametric methods for mapping quantitative trait loci with censored data
    Guoqing Diao
    Department of Biostatistics, CB No 7420, University of North Carolina, Chapel Hill, North Carolina 27599 7420, USA
    Biometrics 61:789-98. 2005
    ..Extensive simulation studies demonstrate that the proposed methods perform well in practical situations. Applications to two animal studies are provided...
  11. pmc Efficient association mapping of quantitative trait loci with selective genotyping
    B E Huang
    Department of Biostatistics, University of North Carolina, Chapel Hill 27599 7420, USA
    Am J Hum Genet 80:567-76. 2007
    ..We demonstrate that the likelihood-based methods are highly effective in identifying causal variants and are substantially more powerful than existing methods...
  12. ncbi request reprint Semiparametric variance-component models for linkage and association analyses of censored trait data
    G Diao
    Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA
    Genet Epidemiol 30:570-81. 2006
    ..We provide an application to the age at onset of alcohol dependence data from the Collaborative Study on the Genetics of Alcoholism. A computer program is freely available...
  13. ncbi request reprint Maximum likelihood estimation of haplotype effects and haplotype-environment interactions in association studies
    D Y Lin
    Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Genet Epidemiol 29:299-312. 2005
    ..An application to the Carolina Breast Cancer Study reveals significant haplotype effects and haplotype-smoking interactions in the development of breast cancer...
  14. ncbi request reprint Estimating haplotype-disease associations with pooled genotype data
    D Zeng
    Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina 27599 7420, USA
    Genet Epidemiol 28:70-82. 2005
    ..The results show that DNA pooling is highly efficient in studying haplotype-disease associations. As a by-product, this work provides valid and efficient methods for estimating haplotype-disease associations with unpooled DNA samples...
  15. pmc Proper analysis of secondary phenotype data in case-control association studies
    D Y Lin
    Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina 27599 7420, USA
    Genet Epidemiol 33:256-65. 2009
    ..We demonstrate the pitfalls of the standard methods and the advantages of the new methods both analytically and numerically. The relevant software is available at our website...
  16. doi request reprint Meta-analysis of genome-wide association studies: no efficiency gain in using individual participant data
    D Y Lin
    Department of Biostatistics, University of North Carolina, McGavran Greenberg Hall, CB 7420, Chapel Hill, NC 27599 7420, USA
    Genet Epidemiol 34:60-6. 2010
    ..Collating only summary results will increase the number and representativeness of available studies, simplify data collection and analysis, reduce resource utilization, and accelerate discovery...
  17. pmc Efficient resampling methods for nonsmooth estimating functions
    Donglin Zeng
    Department of Biostatistics, CB 7420, University of North Carolina, Chapel Hill, NC 27599 7420, USA
    Biostatistics 9:355-63. 2008
    ..Its usefulness is illustrated with heteroscedastic quantile regression and censored data rank regression. Numerical results based on simulated and real data are provided...
  18. ncbi request reprint Improving the power of association tests for quantitative traits in family studies
    G Diao
    Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina 27599 7420, USA
    Genet Epidemiol 30:301-13. 2006
    ..We have implemented the new methods in a freely available computer program...
  19. ncbi request reprint Goodness-of-fit methods for generalized linear mixed models
    Zhiying Pan
    Department of Biostatistics, University of North Carolina, CB 7420, McGavran Greenberg Hall, Chapel Hill, 27599 7420, USA
    Biometrics 61:1000-9. 2005
    ..Extensive simulation studies show that the proposed goodness-of-fit tests have proper sizes and are sensitive to model misspecification. Applications to two medical studies lead to improved models...
  20. pmc Evaluating statistical significance in two-stage genomewide association studies
    D Y Lin
    Department of Biostatistics, University of North Carolina, Chapel Hill, 27599 7420, USA
    Am J Hum Genet 78:505-9. 2006
    ....
  21. pmc An efficient resampling method for assessing genome-wide statistical significance in mapping quantitative trait Loci
    Fei Zou
    Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina 27599 7420, USA
    Genetics 168:2307-16. 2004
    ..The usefulness of the proposed method is demonstrated through simulation studies and an application to a Drosophila backcross...
  22. pmc A powerful and robust method for mapping quantitative trait loci in general pedigrees
    G Diao
    Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599 7420, USA
    Am J Hum Genet 77:97-111. 2005
    ..The computer program that implements the new method is freely available...
  23. ncbi request reprint Nonparametric tests for the gap time distributions of serial events based on censored data
    D Y Lin
    Department of Biostatistics, University of North Carolina, Chapel Hill 27599 7400, USA
    Biometrics 57:369-75. 2001
    ..An illustration with data taken from a colon cancer study is provided. The related problem of testing the independence of two successive gap times is also studied...
  24. ncbi request reprint On the Breslow estimator
    D Y Lin
    Department of Biostatistics, University of North Carolina, CB 7420, Chapel Hill, NC 27599 7420, USA
    Lifetime Data Anal 13:471-80. 2007
    ..The present paper describes the Breslow estimator and its tremendous impact on the theory and practice of survival analysis...
  25. ncbi request reprint GOFCOX: a computer program for the goodness-of-fit analysis of the Cox proportional hazards model
    D Y Lin
    Department of Biostatistics, University of Washington, Seattle 98195
    Comput Methods Programs Biomed 38:101-5. 1992
    ..The program runs on both mainframe computers and microcomputers. The running time is minimal even for large data sets. A simple example is provided to illustrate the features of the program...
  26. ncbi request reprint Semiparametric analysis of recurrent events data in the presence of dependent censoring
    Debashis Ghosh
    Department of Biostatistics, University of Michigan, 1420 Washington Heights, Ann Arbor, Michigan, USA
    Biometrics 59:877-85. 2003
    ..The finite-sample behavior of the new inference procedures is evaluated through simulation studies. An application to recurrent hospitalization data taken from a study of intravenous drug users is provided...
  27. pmc Mapping quantitative trait loci with censored observations
    Guoqing Diao
    Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina 27599 7420, USA
    Genetics 168:1689-98. 2004
    ..In addition, we show how to assess genome-wide statistical significance. The performance of the proposed methods is evaluated through extensive simulation studies. An application to a mouse cross is provided...
  28. ncbi request reprint An efficient Monte Carlo approach to assessing statistical significance in genomic studies
    D Y Lin
    Department of Biostatistics, University of North Carolina, McGavran Greenberg Hall, CB 7420, Chapel Hill, NC 27599 7420, USA
    Bioinformatics 21:781-7. 2005
    ..The Bonferroni correction and Holm's step-down procedure are overly conservative, whereas the permutation test is time-consuming and is restricted to simple problems...
  29. ncbi request reprint Model-checking techniques for stratified case-control studies
    Patrick G Arbogast
    Department of Biostatistics, Vanderbilt University, S 2323 Medical Center North, Nashville, TN 37232 2158, USA
    Stat Med 24:229-47. 2005
    ..Simulation studies demonstrate that the proposed methods perform well in practical settings. Illustration with an oesophageal cancer study is provided...
  30. ncbi request reprint Evaluating the role of CD4-lymphocyte counts as surrogate endpoints in human immunodeficiency virus clinical trials
    D Y Lin
    Department of Biostatistics, University of Washington, Seattle 98195
    Stat Med 12:835-42. 1993
    ..The results indicate that the CD4-lymphocyte count captures part of the relationship between zidovudine and time to a first critical event but does not fulfil the Prentice criterion...
  31. ncbi request reprint Methods for analyzing health care utilization and costs
    P Diehr
    Department of Biostatistics, University of Washington, Seattle 98195, USA
    Annu Rev Public Health 20:125-44. 1999
    ..We also address issues of study design and new methods for dealing with censored data. Examples are presented...
  32. ncbi request reprint Survival analysis in clinical trials: past developments and future directions
    T R Fleming
    Department of Biostatistics, Box 357232, University of Washington, Seattle, Washington 98195, USA
    Biometrics 56:971-83. 2000
    ....
  33. ncbi request reprint Haplotype-based association analysis in cohort studies of unrelated individuals
    D Y Lin
    Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina 27599 7420, USA
    Genet Epidemiol 26:255-64. 2004
    ....
  34. ncbi request reprint Semiparametric regression analysis of longitudinal data with informative drop-outs
    D Y Lin
    Department of Biostatistics, University of North Carolina, CB 7420 McGavran Greenberg, Chapel Hill, NC 27599 7420, USA
    Biostatistics 4:385-98. 2003
    ..Extensive simulation studies demonstrate that the proposed methods are suitable for practical use. Illustrations with data taken from two AIDS clinical trials are provided...
  35. ncbi request reprint Assessing genomewide statistical significance in linkage studies
    D Y Lin
    Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina 27599, USA
    Genet Epidemiol 27:202-14. 2004
    ..The usefulness of the proposed approach is demonstrated through extensive simulation studies and an application to the nuclear family data from the Tenth Genetic Analysis Workshop...
  36. ncbi request reprint Regression analysis of incomplete medical cost data
    D Y Lin
    Department of Biostatistics, University of North Carolina, CB 7420 McGavran Greenberg, Chapel Hill 27599 7420, USA
    Stat Med 22:1181-200. 2003
    ....
  37. ncbi request reprint Time-dependent covariates in the Cox proportional-hazards regression model
    L D Fisher
    Department of Biostatistics, University of Washington, Seattle 98195 7232, USA
    Annu Rev Public Health 20:145-57. 1999
    ..The estimated probability of an event over time is not related to the hazard function in the usual fashion. An appendix summarizes the mathematics of time-dependent covariates...
  38. ncbi request reprint Model-checking techniques based on cumulative residuals
    D Y Lin
    Department of Biostatistics, University of North Carolina, Chapel Hill 27599 7420, USA
    Biometrics 58:1-12. 2002
    ..The proposed techniques are particularly useful in checking the functional form of a covariate and the link function. Illustrations with several medical studies are provided...