Anning Lin

Summary

Affiliation: University of Chicago
Country: USA

Publications

  1. ncbi Activation of the JNK signaling pathway: breaking the brake on apoptosis
    Anning Lin
    Ben May Institute for Cancer Research, The University of Chicago, 5841 S Maryland Avenue, MC 6027, Chicago, IL 60637, USA
    Bioessays 25:17-24. 2003
  2. ncbi The true face of JNK activation in apoptosis
    Anning Lin
    Ben May Institute for Cancer Research, University of Chicago, Chicago, IL 60637, USA
    Aging Cell 1:112-6. 2002
  3. ncbi NF-kappaB in cancer: a marked target
    Anning Lin
    Ben May Institute for Cancer Research, The University of Chicago, 5841 S Maryland Avenue, MC 60627, Chicago, IL 60637, USA
    Semin Cancer Biol 13:107-14. 2003
  4. pmc Site-specific ubiquitination is required for relieving the transcription factor Miz1-mediated suppression on TNF-α-induced JNK activation and inflammation
    Jing Liu
    Ben May Department for Cancer Research, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 109:191-6. 2012
  5. pmc Androgen via p21 inhibits tumor necrosis factor alpha-induced JNK activation and apoptosis
    Fangming Tang
    Ben May Department for Cancer Research, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 284:32353-8. 2009
  6. pmc Miz1 is a signal- and pathway-specific modulator or regulator (SMOR) that suppresses TNF-alpha-induced JNK1 activation
    Jing Liu
    Ben May Department for Cancer Research, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 106:18279-84. 2009
  7. ncbi The p38 kinases MKK4 and MKK6 suppress metastatic colonization in human ovarian carcinoma
    Jonathan A Hickson
    Department of Biochemistry and Molecular Biology, University of Chicago, Illinois, USA
    Cancer Res 66:2264-70. 2006
  8. pmc Cyclic AMP inhibits p38 activation via CREB-induced dynein light chain
    Jiyan Zhang
    Ben May Institute for Cancer Research, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA
    Mol Cell Biol 26:1223-34. 2006
  9. ncbi BAD Ser128 is not phosphorylated by c-Jun NH2-terminal kinase for promoting apoptosis
    Jiyan Zhang
    Ben May Institute for Cancer Research, University of Chicago, Chicago, Illinois 60637, USA
    Cancer Res 65:8372-8. 2005
  10. ncbi NF-kappaB is required for UV-induced JNK activation via induction of PKCdelta
    Jing Liu
    Ben May Institute for Cancer Research, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA
    Mol Cell 21:467-80. 2006

Research Grants

Collaborators

Detail Information

Publications35

  1. ncbi Activation of the JNK signaling pathway: breaking the brake on apoptosis
    Anning Lin
    Ben May Institute for Cancer Research, The University of Chicago, 5841 S Maryland Avenue, MC 6027, Chicago, IL 60637, USA
    Bioessays 25:17-24. 2003
    ..Here we propose a model that can explain how activation of the JNK pathway "breaks the brake" on apoptosis, thereby regulating, but not initiating the apoptotic process...
  2. ncbi The true face of JNK activation in apoptosis
    Anning Lin
    Ben May Institute for Cancer Research, University of Chicago, Chicago, IL 60637, USA
    Aging Cell 1:112-6. 2002
    ..Here we discuss what is currently known about JNK's role in apoptosis, highlighting recent findings regarding NF-kappaB-mediated inhibition of JNK activation and its impact on TNF-alpha induced apoptosis...
  3. ncbi NF-kappaB in cancer: a marked target
    Anning Lin
    Ben May Institute for Cancer Research, The University of Chicago, 5841 S Maryland Avenue, MC 60627, Chicago, IL 60637, USA
    Semin Cancer Biol 13:107-14. 2003
    ..The transcription factor NF-kappaB is a key regulator in oncogenesis. By promoting proliferation and inhibiting apoptosis, NF-kappaB tips the balance between proliferation and apoptosis toward malignant growth in tumor cells...
  4. pmc Site-specific ubiquitination is required for relieving the transcription factor Miz1-mediated suppression on TNF-α-induced JNK activation and inflammation
    Jing Liu
    Ben May Department for Cancer Research, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 109:191-6. 2012
    ....
  5. pmc Androgen via p21 inhibits tumor necrosis factor alpha-induced JNK activation and apoptosis
    Fangming Tang
    Ben May Department for Cancer Research, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 284:32353-8. 2009
    ..Our results reveal a novel cross-talk between androgen x AR and JNK, thereby providing a molecular mechanism underlying the survival function of androgen...
  6. pmc Miz1 is a signal- and pathway-specific modulator or regulator (SMOR) that suppresses TNF-alpha-induced JNK1 activation
    Jing Liu
    Ben May Department for Cancer Research, University of Chicago, Chicago, IL 60637, USA
    Proc Natl Acad Sci U S A 106:18279-84. 2009
    ..Thus, our results show that in addition to being a transcription factor Miz1 acts as a signal- and pathway-specific modulator or regulator that specifically regulates TNF-alpha-induced JNK1 activation and cell death...
  7. ncbi The p38 kinases MKK4 and MKK6 suppress metastatic colonization in human ovarian carcinoma
    Jonathan A Hickson
    Department of Biochemistry and Molecular Biology, University of Chicago, Illinois, USA
    Cancer Res 66:2264-70. 2006
    ..Our finding that MKK4 and MKK6 both suppress metastasis points to the p38 pathway as an important regulatory pathway for metastatic colonization in ovarian cancer...
  8. pmc Cyclic AMP inhibits p38 activation via CREB-induced dynein light chain
    Jiyan Zhang
    Ben May Institute for Cancer Research, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA
    Mol Cell Biol 26:1223-34. 2006
    ..Thus, our results identify DLC as a novel inhibitor of the p38 pathway and provide a molecular mechanism by which cAMP suppresses p38 activation and promotes apoptosis...
  9. ncbi BAD Ser128 is not phosphorylated by c-Jun NH2-terminal kinase for promoting apoptosis
    Jiyan Zhang
    Ben May Institute for Cancer Research, University of Chicago, Chicago, Illinois 60637, USA
    Cancer Res 65:8372-8. 2005
    ..Thus, our results show that Ser128 is not phosphorylated by JNK for promoting cell death...
  10. ncbi NF-kappaB is required for UV-induced JNK activation via induction of PKCdelta
    Jing Liu
    Ben May Institute for Cancer Research, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA
    Mol Cell 21:467-80. 2006
    ..Thus, our results demonstrate that RelA/NF-kappaB via PKCdelta positively regulates UV-induced JNK activation and provide a mechanism by which NF-kappaB promotes UV-induced apoptosis...
  11. pmc Inactivation of BAD by IKK inhibits TNFα-induced apoptosis independently of NF-κB activation
    Jie Yan
    Ben May Department for Cancer Research, The University of Chicago, Chicago, IL 60637, USA
    Cell 152:304-15. 2013
    ..Our results reveal that IKK inhibits TNFα-induced apoptosis through two distinct but cooperative mechanisms: activation of the survival factor NF-κB and inactivation of the proapoptotic BH3-only BAD protein...
  12. pmc c-Jun N-terminal protein kinase 1 (JNK1), but not JNK2, is essential for tumor necrosis factor alpha-induced c-Jun kinase activation and apoptosis
    Jing Liu
    Ben May Institute for Cancer Research, The University of Chicago, 5841 S Maryland Ave, MC 60627, Chicago, IL 60637, USA
    Mol Cell Biol 24:10844-56. 2004
    ..TNF-alpha-induced apoptosis was also suppressed in Jnk1 null fibroblasts but increased in Jnk2 null cells. Thus, our results provide a molecular mechanism underlying the different biological functions of JNK isoforms...
  13. ncbi Role of JNK activation in apoptosis: a double-edged sword
    Jing Liu
    Ben May Institute for Cancer Research, The University of Chicago, 5841 S Maryland Avenue, MC 6027, Chicago, IL 60637, USA
    Cell Res 15:36-42. 2005
    ..Thus, JNK has pro- or antiapoptotic functions, depending on cell type, nature of the death stimulus, duration of its activation and the activity of other signaling pathways...
  14. pmc Phosphorylation of Bad at Thr-201 by JNK1 promotes glycolysis through activation of phosphofructokinase-1
    Hongbin Deng
    Ben May Department for Cancer Research, The University of Chicago, 929 East 57th Street, Chicago, IL 60637, USA
    J Biol Chem 283:20754-60. 2008
    ..Thus, our results provide a novel molecular mechanism by which JNK1 promotes glycolysis for cell survival...
  15. ncbi Regulation of airway epithelial cell NF-kappa B-dependent gene expression by protein kinase C delta
    Kristen Page
    Department of Pediatrics, University of Chicago, Chicago, IL 60637, USA
    J Immunol 170:5681-9. 2003
    ..Finally, PKC delta-CAT induced transcription from the GM-CSF, RANTES, and ICAM-1 promoters. Together these data suggest that PKC delta plays a key role in the regulation of airway epithelial cell NF-kappa B-dependent gene expression...
  16. ncbi JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD
    Chenfei Yu
    Ben May Institute for Cancer Research, The University of Chicago, 5841 South Maryland Avenue, MC 60627, Chicago, IL 60637 USA
    Mol Cell 13:329-40. 2004
    ..Thus, our results provide a molecular mechanism by which JNK contributes to cell survival...
  17. pmc Androgen and its receptor promote Bax-mediated apoptosis
    Yuting Lin
    Department of Biological, Chemical, and Physical Science, Illinois Institute of Technology, Chicago, IL 60616, USA
    Mol Cell Biol 26:1908-16. 2006
    ..Thus, our results reveal a novel cross talk between the androgen/AR hormonal signaling pathway and the intrinsic apoptotic death pathway that determines the sensitivity of stress-induced apoptosis in prostate cancer cells...
  18. ncbi Tumor necrosis factor-induced long myosin light chain kinase transcription is regulated by differentiation-dependent signaling events. Characterization of the human long myosin light chain kinase promoter
    W Vallen Graham
    Department of Pathology, University of Chicago, Chicago, Illinois 60637, USA
    J Biol Chem 281:26205-15. 2006
    ..Thus either AP-1 or NFkappaB can up-regulate long MLCK transcription, but the mechanisms by which TNF up-regulates intestinal epithelial long MLCK transcription from exon 1A are differentiation-dependent...
  19. pmc Suppression of inflammation and acute lung injury by Miz1 via repression of C/EBP-δ
    Hanh Chi Do-Umehara
    Division of Pulmonary and Critical Care Medicine, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, USA
    Nat Immunol 14:461-9. 2013
    ..Our data provide a long-sought mechanism underlying the resolution of LPS-induced inflammation...
  20. ncbi TNF-alpha-induced apoptosis of macrophages following inhibition of NF-kappa B: a central role for disruption of mitochondria
    Hongtao Liu
    Northwestern University Feinberg School of Medicine and Lakeside Division, Division of Rheumatology, Department of Medicine, Veterans Administration Medical Center, Chicago, IL 60611, USA
    J Immunol 172:1907-15. 2004
    ....
  21. pmc Cytosolic PLA2 is required for CTL-mediated immunopathology of celiac disease via NKG2D and IL-15
    Fangming Tang
    Department of Pathology, University of Chicago, Chicago, IL 60637, USA
    J Exp Med 206:707-19. 2009
    ..These results reveal an unrecognized link between NKG2D and tissue inflammation, which may underlie the emerging role of NKG2D in various immunopathological conditions and define new therapeutic targets...
  22. pmc The absence of NF-kappaB-mediated inhibition of c-Jun N-terminal kinase activation contributes to tumor necrosis factor alpha-induced apoptosis
    Fangming Tang
    Ben May Institute for Cancer Research, University of Chicago, Chicago, Illinois 60637, USA
    Mol Cell Biol 22:8571-9. 2002
    ..Conversion of JNK activation from prolonged to transient suppressed TNF-alpha-induced apoptosis. Thus, absence of NF-kappaB-mediated inhibition of JNK activation contributes to TNF-alpha-induced apoptosis...
  23. ncbi A five-year itch in TNF-alpha cytotoxicity: the time factor determines JNK action
    Anning Lin
    Ben May Institute for Cancer Research, 929 East 57 th Street, CIS, W423U, Chicago, Illinois 60637, USA
    Dev Cell 10:277-8. 2006
    ..On the other hand, Ventura et al. (2006) show in their recent Molecular Cell paper that transient JNK activation suppresses TNF-alpha-induced cell death...
  24. pmc Toll-like receptor 6 drives differentiation of tolerogenic dendritic cells and contributes to LcrV-mediated plague pathogenesis
    R William DePaolo
    Department of Medicine, University of Chicago, Chicago, IL 60637, USA
    Cell Host Microbe 4:350-61. 2008
    ..These results explain why TLR2 can mediate both pro- and anti-inflammatory responses and identify TLR6 as a distinct receptor driving regulatory IL-10 responses...
  25. ncbi Suppression of metastatic colonization by the context-dependent activation of the c-Jun NH2-terminal kinase kinases JNKK1/MKK4 and MKK7
    Donald J Vander Griend
    Committee on Cancer Biology, The University of Chicago, Illinois 60637, USA
    Cancer Res 65:10984-91. 2005
    ..Taken together, these studies contribute to a mechanistic understanding of the context-dependent function of metastasis regulatory proteins...
  26. ncbi Novel strategies for inhibition of the p38 MAPK pathway
    Jiyan Zhang
    Department of Molecular Immunology, Institute of Basic Medical Sciences, 27 Taiping Road, Beijing 100850, China
    Trends Pharmacol Sci 28:286-95. 2007
    ..Here, we discuss alternative strategies that might lead to better p38 inhibitors, including non-ATP-competitive inhibitors and inhibitors that are targeted to other components of the signaling pathway...
  27. ncbi Signaling intermediates required for NF-kappa B activation and IL-8 expression in CF bronchial epithelial cells
    Jing Li
    Department of Pediatrics and Ben May Institute for Cancer Research, University of Chicago, Chicago, IL 60637, USA
    Am J Physiol Lung Cell Mol Physiol 284:L307-15. 2003
    ....
  28. ncbi Ras and mitogen-activated protein kinase kinase kinase-1 coregulate activator protein-1- and nuclear factor-kappaB-mediated gene expression in airway epithelial cells
    Limei Zhou
    Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, MI 48109 0212, USA
    Am J Respir Cell Mol Biol 28:762-9. 2003
    ..We conclude that Ras regulates TNF-alpha-induced chemokine expression by activating the AP-1 pathway and enhancing transcriptional function of NF-kappaB, whereas MEKK1 activates both the AP-1 and NF-kappaB pathways...
  29. ncbi Dynamic positive feedback phosphorylation of mixed lineage kinase 3 by JNK reversibly regulates its distribution to Triton-soluble domains
    Karen A Schachter
    Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing 48824, USA
    J Biol Chem 281:19134-44. 2006
    ..This work describes a novel mode of regulation of MLK3, by which JNK-mediated feedback phosphorylation of MLK3 regulates its activation and deactivation states by cycling between Triton-soluble and Triton-insoluble forms...
  30. pmc Activation of nuclear factor-kappaB is necessary for myotrophin-induced cardiac hypertrophy
    Sudhiranjan Gupta
    Department of Molecular Cardiology, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195, USA
    J Cell Biol 159:1019-28. 2002
    ..These findings suggest that the PKC-IKK-NF-kappaB pathway may play a critical role in mediating the myotrophin-induced hypertrophic response in cardiomyocytes...
  31. ncbi Involvement of c-Jun N-terminal kinase in amyloid precursor protein-mediated neuronal cell death
    Yuichi Hashimoto
    Departments of Pharmacology and Anatomy, Keio University School of Medicine, 35 Shinanomachi, Tokyo 160 8582, Japan
    J Neurochem 84:864-77. 2003
    ..These findings demonstrate that JNK is involved in APP-mediated neuronal cell death as a downstream signal transducer of Go...
  32. ncbi MAPK pathways mediate hyperoxia-induced oncotic cell death in lung epithelial cells
    John Romashko
    Department of Surgery, North Shore University Hospital, New York University School of Medicine, Manhasset, NY, USA
    Free Radic Biol Med 35:978-93. 2003
    ....
  33. pmc Activation of c-Jun NH2-terminal kinase is required for gemcitabine's cytotoxic effect in human lung cancer H1299 cells
    Fuminori Teraishi
    Department of Thoracic and Cardiovascular Surgery, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Bivd, Houston, TX 77030, USA
    FEBS Lett 579:6681-7. 2005
    ..Attenuated JNK activation may contribute to development of acquired gemcitabine resistance in cancer cells...
  34. ncbi IKK antagonizes CD95 ligation-mediated apoptosis by regulating NF-kappaB activity
    Jing Wang
    Department of Molecular Immunology, Institute of Basic Medical Sciences, 27 Taiping Road, Beijing 100850, PR China
    Mol Immunol 44:2139-43. 2007
    ..And UCIKKbeta enhanced the basal NF-kappaB activity, and consequently led to higher NF-kappaB activity upon CD95 ligation in HeLa cells. Therefore, IKK antagonizes CD95 ligation-mediated apoptosis by regulating NF-kappaB activity...
  35. ncbi NF-kappaB at the crossroads of life and death
    Michael Karin
    Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0636, USA
    Nat Immunol 3:221-7. 2002
    ..However, NF-kappaB cannot function alone. A variety of mechanisms exist to modulate its activity and thereby affect the ultimate outcome of a cell's fate...

Research Grants2

  1. Support of Conference on Signal Transduction and Cancer
    Anning Lin; Fiscal Year: 2004
    ..Thus, it should have a great impact on cancer research worldwide and result in a better understanding of cancer biology and novel therapeutic interventions of cancer. ..
  2. Wiring the UV Signaling Circuitry
    Anning Lin; Fiscal Year: 2008
    ....