Sean Limesand

Summary

Affiliation: University of Arizona
Country: USA

Publications

  1. ncbi Reductions in insulin concentrations and β-cell mass precede growth restriction in sheep fetuses with placental insufficiency
    Sean W Limesand
    Dept of Animal Sciences, Univ of Arizona, 1650 E Limberlost Dr, Tucson, AZ 85719, USA
    Am J Physiol Endocrinol Metab 304:E516-23. 2013
  2. ncbi Hypoxaemia-induced catecholamine secretion from adrenal chromaffin cells inhibits glucose-stimulated hyperinsulinaemia in fetal sheep
    Dustin T Yates
    Department of Animal Sciences, University of Arizona, Tucson, AZ 85719, USA
    J Physiol 590:5439-47. 2012
  3. ncbi Attenuated insulin release and storage in fetal sheep pancreatic islets with intrauterine growth restriction
    Sean W Limesand
    Department of Animal Sciences, University of Arizona, P O Box 210035, Tucson, Arizona 85721 0035, USA
    Endocrinology 147:1488-97. 2006
  4. ncbi Effects of chronic hypoglycemia and euglycemic correction on lysine metabolism in fetal sheep
    Sean W Limesand
    Department of Animal Sciences, University of Arizona, 1650 E Limberlost Dr, Tucson, AZ 85719, USA
    Am J Physiol Endocrinol Metab 296:E879-87. 2009
  5. ncbi Increased insulin sensitivity and maintenance of glucose utilization rates in fetal sheep with placental insufficiency and intrauterine growth restriction
    Sean W Limesand
    Department of Pediatrics, University of Colorado Health Sciences Center, Aurora, Colorado, USA
    Am J Physiol Endocrinol Metab 293:E1716-25. 2007
  6. ncbi Glucose replacement to euglycemia causes hypoxia, acidosis, and decreased insulin secretion in fetal sheep with intrauterine growth restriction
    Paul J Rozance
    Department of Pediatrics, University of Colorado Denver and Health Sciences Center, Aurora, Colorado 80045, USA
    Pediatr Res 65:72-8. 2009
  7. ncbi Chronic exposure to elevated norepinephrine suppresses insulin secretion in fetal sheep with placental insufficiency and intrauterine growth restriction
    Rafael A Leos
    Dept of Animal Sciences, Univ of Arizona, Tucson, 85719, USA
    Am J Physiol Endocrinol Metab 298:E770-8. 2010
  8. ncbi Adaptation of ovine fetal pancreatic insulin secretion to chronic hypoglycaemia and euglycaemic correction
    Sean W Limesand
    Perinatal Research Center, Division of Perinatal Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Physiol 547:95-105. 2003
  9. ncbi Chronic late-gestation hypoglycemia upregulates hepatic PEPCK associated with increased PGC1alpha mRNA and phosphorylated CREB in fetal sheep
    Paul J Rozance
    Perinatal Research Center, Department of Pediatrics, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    Am J Physiol Endocrinol Metab 294:E365-70. 2008
  10. ncbi Chronic fetal hypoglycemia inhibits the later steps of stimulus-secretion coupling in pancreatic beta-cells
    Paul J Rozance
    Perinatal Research Center, University of Colorado Health Sciences Center, Aurora, Colorado 80045, USA
    Am J Physiol Endocrinol Metab 292:E1256-64. 2007

Research Grants

  1. Aberrant Ovine Pancreatic Development in IUGR Fetuses
    Sean Limesand; Fiscal Year: 2007
  2. Impact of Catecholamines to Insulin-Glucose Homeostasis in IUGR Fetuses
    Sean W Limesand; Fiscal Year: 2010

Collaborators

Detail Information

Publications18

  1. ncbi Reductions in insulin concentrations and β-cell mass precede growth restriction in sheep fetuses with placental insufficiency
    Sean W Limesand
    Dept of Animal Sciences, Univ of Arizona, 1650 E Limberlost Dr, Tucson, AZ 85719, USA
    Am J Physiol Endocrinol Metab 304:E516-23. 2013
    ....
  2. ncbi Hypoxaemia-induced catecholamine secretion from adrenal chromaffin cells inhibits glucose-stimulated hyperinsulinaemia in fetal sheep
    Dustin T Yates
    Department of Animal Sciences, University of Arizona, Tucson, AZ 85719, USA
    J Physiol 590:5439-47. 2012
    ....
  3. ncbi Attenuated insulin release and storage in fetal sheep pancreatic islets with intrauterine growth restriction
    Sean W Limesand
    Department of Animal Sciences, University of Arizona, P O Box 210035, Tucson, Arizona 85721 0035, USA
    Endocrinology 147:1488-97. 2006
    ....
  4. ncbi Effects of chronic hypoglycemia and euglycemic correction on lysine metabolism in fetal sheep
    Sean W Limesand
    Department of Animal Sciences, University of Arizona, 1650 E Limberlost Dr, Tucson, AZ 85719, USA
    Am J Physiol Endocrinol Metab 296:E879-87. 2009
    ..Furthermore, euglycemic correction for 5 days returns lysine fluxes to normal and causes an overcorrection of lysine oxidation...
  5. ncbi Increased insulin sensitivity and maintenance of glucose utilization rates in fetal sheep with placental insufficiency and intrauterine growth restriction
    Sean W Limesand
    Department of Pediatrics, University of Colorado Health Sciences Center, Aurora, Colorado, USA
    Am J Physiol Endocrinol Metab 293:E1716-25. 2007
    ....
  6. ncbi Glucose replacement to euglycemia causes hypoxia, acidosis, and decreased insulin secretion in fetal sheep with intrauterine growth restriction
    Paul J Rozance
    Department of Pediatrics, University of Colorado Denver and Health Sciences Center, Aurora, Colorado 80045, USA
    Pediatr Res 65:72-8. 2009
    ..275 +/- 0.071 Glu vs. 7.354 +/- 0.003 Sal, p < 0.01) in the Glu group. We conclude that correction of fetal hypoglycemia is not well tolerated and fails to increase insulin concentrations or beta-cell mass in IUGR fetuses...
  7. ncbi Chronic exposure to elevated norepinephrine suppresses insulin secretion in fetal sheep with placental insufficiency and intrauterine growth restriction
    Rafael A Leos
    Dept of Animal Sciences, Univ of Arizona, Tucson, 85719, USA
    Am J Physiol Endocrinol Metab 298:E770-8. 2010
    ..These findings may begin to explain why IUGR infants have a propensity for increased glucose requirements if norepinephrine is suddenly decreased after birth...
  8. ncbi Adaptation of ovine fetal pancreatic insulin secretion to chronic hypoglycaemia and euglycaemic correction
    Sean W Limesand
    Perinatal Research Center, Division of Perinatal Medicine, University of Colorado Health Sciences Center, Denver, CO 80262, USA
    J Physiol 547:95-105. 2003
    ..We conclude that programming of pancreatic insulin secretion responsiveness can occur in response to fetal glucose deprivation, indicating a possible mechanism for establishing, in fetal life, a predisposition to type 2 diabetes...
  9. ncbi Chronic late-gestation hypoglycemia upregulates hepatic PEPCK associated with increased PGC1alpha mRNA and phosphorylated CREB in fetal sheep
    Paul J Rozance
    Perinatal Research Center, Department of Pediatrics, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    Am J Physiol Endocrinol Metab 294:E365-70. 2008
    ..These results demonstrate that chronic fetal hypoglycemia triggers signals that can activate gluconeogenesis in the fetal liver...
  10. ncbi Chronic fetal hypoglycemia inhibits the later steps of stimulus-secretion coupling in pancreatic beta-cells
    Paul J Rozance
    Perinatal Research Center, University of Colorado Health Sciences Center, Aurora, Colorado 80045, USA
    Am J Physiol Endocrinol Metab 292:E1256-64. 2007
    ..In conclusion, these studies show that chronic hypoglycemia in late gestation decreases insulin secretion by inhibiting the later steps of stimulus-secretion coupling after glucose metabolism, membrane depolarization, and calcium entry...
  11. ncbi Developmental changes in ovine myocardial glucose transporters and insulin signaling following hyperthermia-induced intrauterine fetal growth restriction
    James S Barry
    Department of Pediatrics, Section of Neonatology, University of Colorado School of Medicine, The Children s Hospital, 1056 East 19th Avenue, Box B070, Denver, CO 80218, USA
    Exp Biol Med (Maywood) 231:566-75. 2006
    ....
  12. ncbi Decreased nutrient-stimulated insulin secretion in chronically hypoglycemic late-gestation fetal sheep is due to an intrinsic islet defect
    Paul J Rozance
    Perinatal Research Center, University of Colorado Health Sciences Center, Aurora, CO 80045, USA
    Am J Physiol Endocrinol Metab 291:E404-11. 2006
    ....
  13. ncbi An islet-stabilizing implant constructed using a preformed vasculature
    Alton M Hiscox
    Department of Physiological Sciences, University of Arizona, Tucson, Arizona, USA
    Tissue Eng Part A 14:433-40. 2008
    ..These data indicate that the PPED enhances islet survival by supporting islet viability and maintaining intraislet endothelial cell structures...
  14. ncbi Consequences of a compromised intrauterine environment on islet function
    Alice S Green
    Department of Animal Sciences, University of Arizona, 1650 East Limberlost Drive, Tucson, Arizona 85719, USA
    J Endocrinol 205:211-24. 2010
    ..These findings frame our current knowledge of beta-cell developmental programing and highlight future research directions to clarify the mechanisms of beta-cell dysfunction for human IUGR...
  15. ncbi Characterization of glucose-insulin responsiveness and impact of fetal number and sex difference on insulin response in the sheep fetus
    Alice S Green
    Dept of Animal Sciences, Univ of Arizona, 1650 E Limberlost Dr, Tucson, AZ 85719, USA
    Am J Physiol Endocrinol Metab 300:E817-23. 2011
    ..05). No effects of sex difference on GSIS or β-cell mass were observed. These findings indicate that insulin secretion is less responsive to physiological glucose concentrations in twins, due in part to less β-cell mass...
  16. ncbi One process for pancreatic beta-cell coalescence into islets involves an epithelial-mesenchymal transition
    Lori Cole
    Department of Animal Sciences, Agricultural Research Complex, University of Arizona, 1650 East Limberlost Drive, Tucson, Arizona 85719, USA
    J Endocrinol 203:19-31. 2009
    ..Our findings provide strong evidence that the movement of beta-cells from the pancreatic ductal epithelium involves an EMT...
  17. ncbi Diminished beta-cell replication contributes to reduced beta-cell mass in fetal sheep with intrauterine growth restriction
    Sean W Limesand
    Perinatal Research Center, Dept of Pediatrics, Univ of Colorado Health Sciences Center, P O Box 6508, F441, Aurora CO 80045, USA
    Am J Physiol Regul Integr Comp Physiol 288:R1297-305. 2005
    ..Diminished beta-cell mass in IUGR infants at birth, if not adequately compensated for after birth, may contribute to insufficient insulin production in later life and, thus, a predisposition to noninsulin-dependent diabetes...
  18. ncbi Puralpha, a single-stranded deoxyribonucleic acid binding protein, augments placental lactogen gene transcription
    Sean W Limesand
    Animal Reproduction and Biotechnology Laboratory, Department of Biomedical Sciences, Colorado State University, Fort Collins, Colorado 80523 1683, USA
    Mol Endocrinol 18:447-57. 2004
    ..This study identified a previously undefined cis-element, which interacts with Pur alpha to augment PL gene transcription...

Research Grants3

  1. Aberrant Ovine Pancreatic Development in IUGR Fetuses
    Sean Limesand; Fiscal Year: 2007
    ....
  2. Impact of Catecholamines to Insulin-Glucose Homeostasis in IUGR Fetuses
    Sean W Limesand; Fiscal Year: 2010
    ..Therefore, we plan to determine how a key stress response alters the developmental program in the fetal 2-cells to impair glucose homeostasis and lead to adulthood pathologies, such as Type 2 Diabetes Mellitus. ..