Maria P Limberis

Summary

Affiliation: University of Pennsylvania
Country: USA

Publications

  1. doi request reprint Intranasal antibody gene transfer in mice and ferrets elicits broad protection against pandemic influenza
    Maria P Limberis
    Gene Therapy Program, University of Pennsylvania, Philadelphia, PA 19104, USA
    Sci Transl Med 5:187ra72. 2013
  2. doi request reprint Phoenix rising: gene therapy makes a comeback
    Maria P Limberis
    Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104 3403, USA
    Acta Biochim Biophys Sin (Shanghai) 44:632-40. 2012
  3. pmc HCO3(-) secretion by murine nasal submucosal gland serous acinar cells during Ca2+-stimulated fluid secretion
    Robert J Lee
    Department of Physiology, Division of Medical Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Gen Physiol 132:161-83. 2008
  4. pmc Activation of transgene-specific T cells following lentivirus-mediated gene delivery to mouse lung
    Maria P Limberis
    Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 3403, USA
    Mol Ther 18:143-50. 2010
  5. pmc Cationic lipid formulations alter the in vivo tropism of AAV2/9 vector in lung
    David E Fein
    Institute for Medicine and Engineering, Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    Mol Ther 17:2078-87. 2009
  6. pmc The AAV9 receptor and its modification to improve in vivo lung gene transfer in mice
    Christie L Bell
    Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 121:2427-35. 2011
  7. ncbi request reprint Activation of CFTR-specific T Cells in cystic fibrosis mice following gene transfer
    Maria P Limberis
    Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Mol Ther 15:1694-700. 2007
  8. pmc Transduction efficiencies of novel AAV vectors in mouse airway epithelium in vivo and human ciliated airway epithelium in vitro
    Maria P Limberis
    Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Mol Ther 17:294-301. 2009
  9. pmc In vivo evaluation of adeno-associated virus gene transfer in airways of mice with acute or chronic respiratory infection
    Melissa Myint
    1 Department of Chemical and Biomolecular Engineering, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104
    Hum Gene Ther 25:966-76. 2014
  10. pmc Adeno-associated virus 9-mediated airway expression of antibody protects old and immunodeficient mice against influenza virus
    Virginie S Adam
    Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Clin Vaccine Immunol 21:1528-33. 2014

Collaborators

  • Angela Haczku
  • Sachin Kumar
  • Deborah R Gill
  • Stephen C Hyde
  • Anand Swaroop
  • Gary P Kobinger
  • Liqun Zhang
  • Raymond J Pickles
  • Alan F Wright
  • James M Wilson
  • Peter Bell
  • Robert J Lee
  • Melissa Myint
  • Virginie S Adam
  • Suryanarayan Somanathan
  • Roberto Calcedo
  • Shu Jen Chen
  • Wei Chieh Huang
  • Scott L Diamond
  • Christie L Bell
  • David E Fein
  • J Kevin Foskett
  • Joanita Figueredo
  • Soumitra Roy
  • Moyar Q Ge
  • Sarah E Czack
  • Marco Crosariol
  • Anna Tretiakova
  • Martin Lock
  • David J Porteous
  • Daniel J Rader
  • Daniel J Dorgan
  • Christine Draper
  • J Alastair Innes
  • Jane C Davies
  • Samia Soussi
  • A Christopher Boyd
  • Julie C Johnston
  • Tracy E Higgins
  • Uta Griesenbach
  • Deirdre McMenamin
  • Sadik H Kassim
  • Eric W Alton
  • Julio Sanmiguel
  • Dina Y Gewaily
  • Sharon B Schwartz
  • Samuel G Jacobson
  • Alejandro J Roman
  • Forbes D Manson
  • Artur V Cideciyan
  • Sam Sadigh
  • Mavis Agbandje-McKenna
  • Luk H Vandenberghe
  • Kim Van Vliet
  • Guang Ping Gao
  • Jack M Heath
  • Sean F Maloney
  • Janice M Harlow
  • Michael F Hennessy

Detail Information

Publications16

  1. doi request reprint Intranasal antibody gene transfer in mice and ferrets elicits broad protection against pandemic influenza
    Maria P Limberis
    Gene Therapy Program, University of Pennsylvania, Philadelphia, PA 19104, USA
    Sci Transl Med 5:187ra72. 2013
    ..This approach serves as a platform for the prevention of natural or deliberate respiratory diseases for which a protective antibody is available...
  2. doi request reprint Phoenix rising: gene therapy makes a comeback
    Maria P Limberis
    Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104 3403, USA
    Acta Biochim Biophys Sin (Shanghai) 44:632-40. 2012
    ..In this review, various gene therapy vectors progressing into clinical development and pivotal advances in gene therapy trials will be discussed...
  3. pmc HCO3(-) secretion by murine nasal submucosal gland serous acinar cells during Ca2+-stimulated fluid secretion
    Robert J Lee
    Department of Physiology, Division of Medical Genetics, University of Pennsylvania, Philadelphia, PA 19104, USA
    J Gen Physiol 132:161-83. 2008
    ..In addition, other Na(+)-dependent pH(i) regulatory mechanisms exist, as evidenced by stronger inhibition of alkalinization in Na(+)-free media...
  4. pmc Activation of transgene-specific T cells following lentivirus-mediated gene delivery to mouse lung
    Maria P Limberis
    Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104 3403, USA
    Mol Ther 18:143-50. 2010
    ..Taken together, our results suggest that the loss of transduced cells in lung is due to VSV-G.HIV vector-mediated activation of transgene-specific T cells rather than as result of normal turnover of airway cells...
  5. pmc Cationic lipid formulations alter the in vivo tropism of AAV2/9 vector in lung
    David E Fein
    Institute for Medicine and Engineering, Department of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA 19104, USA
    Mol Ther 17:2078-87. 2009
    ..Our results suggest that formulating AAV2/9 and AAV2/6.2 with DS and D(2)S can lead to improved physicochemical characteristics for in vivo gene delivery to lung...
  6. pmc The AAV9 receptor and its modification to improve in vivo lung gene transfer in mice
    Christie L Bell
    Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Clin Invest 121:2427-35. 2011
    ..Increasing the abundance of the receptor on target cells and improving vector efficacy may improve delivery of AAV vectors to their therapeutic targets...
  7. ncbi request reprint Activation of CFTR-specific T Cells in cystic fibrosis mice following gene transfer
    Maria P Limberis
    Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Mol Ther 15:1694-700. 2007
    ..In CF gene KO mice we also identified (to a conserved region of the CF gene CSQFSWIMPGTIKEN), a minor T cell epitope that did not show any activity in the Het or wt mice...
  8. pmc Transduction efficiencies of novel AAV vectors in mouse airway epithelium in vivo and human ciliated airway epithelium in vitro
    Maria P Limberis
    Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Mol Ther 17:294-301. 2009
    ..2 exhibits improved transduction efficiency compared to previously reported AAVs in mouse airways and in culture models of human airway epithelium and that this vector requires further development for preclinical and clinical testing...
  9. pmc In vivo evaluation of adeno-associated virus gene transfer in airways of mice with acute or chronic respiratory infection
    Melissa Myint
    1 Department of Chemical and Biomolecular Engineering, Institute for Medicine and Engineering, University of Pennsylvania, Philadelphia, PA 19104
    Hum Gene Ther 25:966-76. 2014
    ..These results confirm that respiratory infections, both ongoing and recently resolved, decrease the efficacy of AAV-mediated gene transfer...
  10. pmc Adeno-associated virus 9-mediated airway expression of antibody protects old and immunodeficient mice against influenza virus
    Virginie S Adam
    Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Clin Vaccine Immunol 21:1528-33. 2014
    ....
  11. pmc Optical imaging of Ca2+-evoked fluid secretion by murine nasal submucosal gland serous acinar cells
    Robert J Lee
    Department of Physiology, Division of Medical Genetics, University of Pennsylvania, Philadelphia, PA 19104 6085, USA
    J Physiol 582:1099-124. 2007
    ....
  12. pmc Self-reactive CFTR T cells in humans: implications for gene therapy
    Roberto Calcedo
    1 Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA 19104
    Hum Gene Ther Clin Dev 24:108-15. 2013
    ....
  13. pmc Adeno-associated virus serotype 9 vectors transduce murine alveolar and nasal epithelia and can be readministered
    Maria P Limberis
    Gene Therapy Program, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, 19104, USA
    Proc Natl Acad Sci U S A 103:12993-8. 2006
    ....
  14. pmc Prediction of cellular immune responses against CFTR in patients with cystic fibrosis after gene therapy
    Joanita Figueredo
    Gene Therapy Program, Department of Pathology and Laboratory Medicine, Division of Transfusion Medicine, University of Pennsylvania, Philadelphia, PA 19104 3403, USA
    Am J Respir Cell Mol Biol 36:529-33. 2007
    ....
  15. pmc Biodistribution of AAV8 vectors expressing human low-density lipoprotein receptor in a mouse model of homozygous familial hypercholesterolemia
    Shu Jen Chen
    1 Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104
    Hum Gene Ther Clin Dev 24:154-60. 2013
    ..The results of this vector biodistribution study further support a proposed clinical trial to evaluate AAV8 gene therapy for hoFH patients...
  16. pmc RPGR-associated retinal degeneration in human X-linked RP and a murine model
    Wei Chieh Huang
    Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Invest Ophthalmol Vis Sci 53:5594-608. 2012
    ..We investigated the retinal disease due to mutations in the retinitis pigmentosa GTPase regulator (RPGR) gene in human patients and in an Rpgr conditional knockout (cko) mouse model...