Emily R Liman
Affiliation: University of Southern California
Tu Y, Cooper A, Teng B, Chang R, Artiga D, Turner H, et al
. An evolutionarily conserved gene family encodes proton-selective ion channels. Science. 2018;359:1047-1050 pubmed publisher
..Evolutionary conservation of the gene family and its widespread tissue distribution suggest a broad role for proton channels in physiology and pathophysiology. ..
Liman E, Zhang Y, Montell C. Peripheral coding of taste. Neuron. 2014;81:984-1000 pubmed publisher
..In this Review, we discuss recent advances in taste research, mainly from the fly and mammalian systems, and we highlight principles that are common across species, despite stark differences in receptor types. ..
Liman E. A TRP channel contributes to insulin secretion by pancreatic β-cells. Islets. 2010;2:331-3 pubmed
..New research now shows that TRPM5 is expressed within the pancreatic islets of Langerhans, where it regulates the frequency of Ca(2+) oscillations and contributes to insulin release by β-cells. ..
Ye W, Tu Y, Cooper A, Zhang Z, KATRITCH V, Liman E. Activation Stoichiometry and Pore Architecture of TRPA1 Probed with Channel Concatemers. Sci Rep. 2018;8:17104 pubmed publisher
..Activation upon liganding of just two of the four possible subunits may represent an optimal strategy to rapidly and reliably detect noxious chemicals. ..
Bushman J, Ye W, Liman E. A proton current associated with sour taste: distribution and functional properties. FASEB J. 2015;29:3014-26 pubmed publisher
..These data define a functional signature for the taste cell proton current and indicate that its expression is mostly restricted to the subset of taste cells that detect sour. ..
Liman E. Regulation by voltage and adenine nucleotides of a Ca2+-activated cation channel from hamster vomeronasal sensory neurons. J Physiol. 2003;548:777-87 pubmed
..The properties of this channel make it a candidate to either directly mediate vomeronasal sensory transduction, or to amplify the primary sensory response. ..
Liman E, Innan H. Relaxed selective pressure on an essential component of pheromone transduction in primate evolution. Proc Natl Acad Sci U S A. 2003;100:3328-32 pubmed
..We propose that, at this point in evolution, other modalities, notably the development of color vision, may have largely replaced signaling by pheromones...
Liman E. Use it or lose it: molecular evolution of sensory signaling in primates. Pflugers Arch. 2006;453:125-31 pubmed
..This review will focus on recent studies that have identified molecular changes in vision, smell, taste, and pheromone detection during primate evolution. ..
Liman E. TRPM5 and taste transduction. Handb Exp Pharmacol. 2007;:287-98 pubmed
..Understanding the structural basis for TRPM5 function will ultimately allow the design of pharmaceuticals to enhance or interfere with taste sensations. ..