Research Topics
Species | Emily LimanSummaryAffiliation: University of Southern California Country: USA Publications
Research Grants
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Detail Information
Publications
Changing senses: chemosensory signaling and primate evolutionEmily R Liman
Department of Biological Sciences, University of Southern California, Los Angeles, California, USA
Adv Exp Med Biol 739:206-17. 2012..This review will focus on recent studies that have identified molecular changes in smell, taste and pheromone detection during primate evolution...
TRPM5-expressing microvillous cells in the main olfactory epitheliumWeihong Lin
Department of Biological Sciences, University of Maryland, Baltimore County, Baltimore, MD 21250, USA
BMC Neurosci 9:114. 2008..Here we examined the morphology and immunocytochemical properties of these microvillous-like cells using immunocytochemical methods...- A TRP channel contributes to insulin secretion by pancreatic β-cellsEmily R Liman
Department of Biological Sciences, Section of Neurobiology, University of Southern California, Los Angeles, CA, USA
Islets 2:331-3. 2010..New research now shows that TRPM5 is expressed within the pancreatic islets of Langerhans, where it regulates the frequency of Ca(2+) oscillations and contributes to insulin release by β-cells... 
Use it or lose it: molecular evolution of sensory signaling in primatesEmily R Liman
Neuroscience Program, Molecular and Computational Biology Program, Department of Biological Sciences, University of Southern California, 3641 Watt Way, Los Angeles, CA 90089, USA
Pflugers Arch 453:125-31. 2006..This review will focus on recent studies that have identified molecular changes in vision, smell, taste, and pheromone detection during primate evolution...- Thermal gating of TRP ion channels: food for thought?Emily R Liman
Department of Biological Sciences, Program in Neuroscience, University of Southern California, Los Angeles, CA 90089, USA
Sci STKE 2006:pe12. 2006..A recent report shows that activity of TRPM5 is increased at warm temperatures, suggesting that heat may enhance the perception of taste through direct modulation of the putative taste transduction channel... - Relaxed selective pressure on an essential component of pheromone transduction in primate evolutionEmily R Liman
Department of Biological Sciences and Program in Neurosciences, University of Southern California, Los Angeles, CA 90089, USA
Proc Natl Acad Sci U S A 100:3328-32. 2003..We propose that, at this point in evolution, other modalities, notably the development of color vision, may have largely replaced signaling by pheromones... - Regulation by voltage and adenine nucleotides of a Ca2+-activated cation channel from hamster vomeronasal sensory neuronsEmily R Liman
Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA
J Physiol 548:777-87. 2003..The properties of this channel make it a candidate to either directly mediate vomeronasal sensory transduction, or to amplify the primary sensory response... - The transduction channel TRPM5 is gated by intracellular calcium in taste cellsZheng Zhang
Department of Biological Sciences and Program in Neuroscience, University of Southern California, Los Angeles, California 90089, USA
J Neurosci 27:5777-86. 2007..These data constrain proposed models for taste transduction and suggest a link between receptor signaling and membrane potential in taste cells... - Phosphatidylinositol 4,5-bisphosphate rescues TRPM4 channels from desensitizationZheng Zhang
Division of Neurobiology, Department of Biological Sciences and Program in Neuroscience, University of Southern California, Los Angeles, California 90089, USA
J Biol Chem 280:39185-92. 2005..These data argue that hydrolysis of PI(4,5)P(2) underlies desensitization of TRPM4 and support the idea that PI(4,5)P(2) is a general regulator for the gating of TRPM ion channels... - The nociceptor ion channel TRPA1 is potentiated and inactivated by permeating calcium ionsYuanyuan Y Wang
Department of Biological Sciences, University of Southern California, Los Angeles, California 90089 2520, USA
J Biol Chem 283:32691-703. 2008..In conclusion, we have further clarified the mechanisms of potentiation and inactivation of TRPA1 using the D918A pore mutant, an important tool for investigating the contribution of Ca(2+) influx through TRPA1 to nociceptive signaling... - Diversity in the neural circuitry of cold sensing revealed by genetic axonal labeling of transient receptor potential melastatin 8 neuronsYoshio Takashima
Neuroscience Graduate Program, Department of Biological Sciences, University of Southern California, Los Angeles, California 90089, USA
J Neurosci 27:14147-57. 2007.... - Intracellular Ca2+ and the phospholipid PIP2 regulate the taste transduction ion channel TRPM5Dan Liu
Department of Biological Sciences and Program in Neuroscience, University of Southern California, Los Angeles, CA 90089, USA
Proc Natl Acad Sci U S A 100:15160-5. 2003..TRPM5 channels are nonselective among monovalent cations and not detectably permeable to divalent cations. We propose that the regulation of TRPM5 by Ca2+ mediates sensory activation in the taste system... - Extracellular acid block and acid-enhanced inactivation of the Ca2+-activated cation channel TRPM5 involve residues in the S3-S4 and S5-S6 extracellular domainsDan Liu
Division of Neurobiology, Department of Biological Sciences and Program in Neuroscience, University of Southern California, Los Angeles, California 90089, USA
J Biol Chem 280:20691-9. 2005.... - TRPA1 is a component of the nociceptive response to CO2Yuanyuan Y Wang
Department of Biological Sciences, Section of Neurobiology, University of Southern California, Los Angeles, California 90089, USA
J Neurosci 30:12958-63. 2010..We conclude that TRPA1, by sensing intracellular acidification, constitutes an important component of the nociceptive response to CO(2)... - An evolutionarily conserved dileucine motif in Shal K+ channels mediates dendritic targetingJacqueline F Rivera
Program in Molecular Biology, University of Southern California, 835 W 37th Street, Los Angeles, California 90089 1340, USA
Nat Neurosci 6:243-50. 2003..It is necessary for dendritic targeting of potassium channel Kv4.2 and is sufficient to target the axonally localized channels Kv1.3 and Kv1.4 to the dendrites. It can also mediate dendritic targeting of a non-channel protein, CD8...
Research Grants
- TRP ion channels in taste transductionEmily R Liman; Fiscal Year: 2010..Moreover, information about the signaling pathways in taste cells can form the basis for understanding how taste sensation changes with development and aging or in response to disease. ..
- TRP Ion Channels in Vomernasal and Taste TransductionEmily Liman; Fiscal Year: 2007..By understanding the regulation of these channels, we can understand their contribution to signaling in health and disease. ..
- Sensory Transduction in the Vomeronasal SystemEmily Liman; Fiscal Year: 2005....
- MOLECULAR MECHANISMS OF VOMERONASAL SENSORY TRANSDUCTIONEmily Liman; Fiscal Year: 2004..The proposed experiments to elucidate basic mechanisms of sensory transduction in the VNO may, thus, provide a better understanding of the control of human reproductive function. ..
- TRP ion channels in taste transductionEmily Liman; Fiscal Year: 2009..Moreover, information about the signaling pathways in taste cells can form the basis for understanding how taste sensation changes with development and aging or in response to disease. ..