Wendell A Lim

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Phosphotyrosine signaling: evolving a new cellular communication system
    Wendell A Lim
    Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94158, USA
    Cell 142:661-7. 2010
  2. pmc The minimal autoinhibited unit of the guanine nucleotide exchange factor intersectin
    K Farid Ahmad
    Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 5:e11291. 2010
  3. pmc Design principles of regulatory networks: searching for the molecular algorithms of the cell
    Wendell A Lim
    Center for Systems and Synthetic Biology, University of California, San Francisco, CA 94158, USA
    Mol Cell 49:202-12. 2013
  4. pmc Designing customized cell signalling circuits
    Wendell A Lim
    Howard Hughes Medical Institute and Department of Cellular and Molecular Pharmacology, University of California San Francisco, California 94158, USA
    Nat Rev Mol Cell Biol 11:393-403. 2010
  5. ncbi request reprint The Ste5 scaffold allosterically modulates signaling output of the yeast mating pathway
    Roby P Bhattacharyya
    Department of Cellular and Molecular Pharmacology, University of California San Francisco, 600 16th Street, San Francisco, CA 94143 2240, USA
    Science 311:822-6. 2006
  6. pmc The Ste5 scaffold directs mating signaling by catalytically unlocking the Fus3 MAP kinase for activation
    Matthew Good
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA
    Cell 136:1085-97. 2009
  7. doi request reprint Using engineered scaffold interactions to reshape MAP kinase pathway signaling dynamics
    Caleb J Bashor
    Department of Cellular and Molecular Pharmacology, University of California at San Francisco, 600 16th Street, San Francisco, CA 94158, USA
    Science 319:1539-43. 2008
  8. pmc Rapid diversification of cell signaling phenotypes by modular domain recombination
    Sergio G Peisajovich
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, 600 16th Street, San Francisco, CA 94158, USA
    Science 328:368-72. 2010
  9. pmc Conformational control of the Ste5 scaffold protein insulates against MAP kinase misactivation
    Jesse G Zalatan
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, 600 16th Street, San Francisco, CA 94158, USA
    Science 337:1218-22. 2012
  10. pmc Recruitment interactions can override catalytic interactions in determining the functional identity of a protein kinase
    Angela P Won
    Howard Hughes Medical Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 108:9809-14. 2011

Research Grants

  1. PROTEIN RECOGNITION IN SIGNAL TRANSDUCTION
    Wendell Lim; Fiscal Year: 2006
  2. PROTEIN INTERACTIONS REGULATING CELL MOTILITY
    Wendell Lim; Fiscal Year: 2006
  3. PROTEIN INTERACTIONS REGULATING CELL MOTILITY
    Wendell Lim; Fiscal Year: 2007
  4. PROTEIN RECOGNITION IN SIGNAL TRANSDUCTION
    Wendell Lim; Fiscal Year: 2009
  5. PROTEIN INTERACTIONS REGULATING CELL MOTILITY
    Wendell Lim; Fiscal Year: 2009
  6. PROTEIN RECOGNITION IN SIGNAL TRANSDUCTION
    Wendell Lim; Fiscal Year: 2004
  7. PROTEIN INTERACTIONS REGULATING CELL MOTILITY
    Wendell Lim; Fiscal Year: 2004
  8. PROTEIN RECOGNITION IN SIGNAL TRANSDUCTION
    Wendell Lim; Fiscal Year: 1999
  9. PROTEIN RECOGNITION IN SIGNAL TRANSDUCTION
    Wendell Lim; Fiscal Year: 2000
  10. PROTEIN INTERACTIONS REGULATING CELL MOTILITY
    Wendell Lim; Fiscal Year: 2001

Collaborators

Detail Information

Publications52

  1. pmc Phosphotyrosine signaling: evolving a new cellular communication system
    Wendell A Lim
    Howard Hughes Medical Institute, University of California, San Francisco, San Francisco, CA 94158, USA
    Cell 142:661-7. 2010
    ..Genomic analyses reveal how this revolutionary signaling system may have originated and why it rapidly became critical to metazoans...
  2. pmc The minimal autoinhibited unit of the guanine nucleotide exchange factor intersectin
    K Farid Ahmad
    Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 5:e11291. 2010
    ..We propose a model in which this intramolecular interaction may block or distort the GTPase binding region of the DH domain...
  3. pmc Design principles of regulatory networks: searching for the molecular algorithms of the cell
    Wendell A Lim
    Center for Systems and Synthetic Biology, University of California, San Francisco, CA 94158, USA
    Mol Cell 49:202-12. 2013
    ....
  4. pmc Designing customized cell signalling circuits
    Wendell A Lim
    Howard Hughes Medical Institute and Department of Cellular and Molecular Pharmacology, University of California San Francisco, California 94158, USA
    Nat Rev Mol Cell Biol 11:393-403. 2010
    ....
  5. ncbi request reprint The Ste5 scaffold allosterically modulates signaling output of the yeast mating pathway
    Roby P Bhattacharyya
    Department of Cellular and Molecular Pharmacology, University of California San Francisco, 600 16th Street, San Francisco, CA 94143 2240, USA
    Science 311:822-6. 2006
    ..Thus, scaffolds not only direct basic pathway connectivity but can precisely tune quantitative pathway input-output properties...
  6. pmc The Ste5 scaffold directs mating signaling by catalytically unlocking the Fus3 MAP kinase for activation
    Matthew Good
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA
    Cell 136:1085-97. 2009
    ..The dual requirement for both Ste7 and this Ste5 domain in Fus3 activation explains why Fus3 is selectively activated by the mating pathway and not by other pathways that also utilize Ste7...
  7. doi request reprint Using engineered scaffold interactions to reshape MAP kinase pathway signaling dynamics
    Caleb J Bashor
    Department of Cellular and Molecular Pharmacology, University of California at San Francisco, 600 16th Street, San Francisco, CA 94158, USA
    Science 319:1539-43. 2008
    ..Protein scaffolds provide a flexible platform for reprogramming cellular responses and could be exploited to engineer cells with novel therapeutic and biotechnological functions...
  8. pmc Rapid diversification of cell signaling phenotypes by modular domain recombination
    Sergio G Peisajovich
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, 600 16th Street, San Francisco, CA 94158, USA
    Science 328:368-72. 2010
    ..Thus, novel linkages between preexisting domains may have a major role in the evolution of protein networks and novel phenotypic behaviors...
  9. pmc Conformational control of the Ste5 scaffold protein insulates against MAP kinase misactivation
    Jesse G Zalatan
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, 600 16th Street, San Francisco, CA 94158, USA
    Science 337:1218-22. 2012
    ..Thus, in addition to serving as a conduit guiding kinase communication, Ste5 directly receives input information to decide if and when signal can be transmitted to mating output...
  10. pmc Recruitment interactions can override catalytic interactions in determining the functional identity of a protein kinase
    Angela P Won
    Howard Hughes Medical Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 108:9809-14. 2011
    ....
  11. pmc CRISPR interference (CRISPRi) for sequence-specific control of gene expression
    Matthew H Larson
    1 Department of Cellular and Molecular Pharmacology, University of California, San Francisco UCSF, San Francisco, California, USA 2 Howard Hughes Medical Institute, UCSF, San Francisco, California, USA 3 California Institute for Quantitative Biomedical Research, San Francisco, California, USA
    Nat Protoc 8:2180-96. 2013
    ..The method can also be adapted for high-throughput interrogation of genome-wide gene functions and genetic interactions, thus providing a complementary approach to RNA interference, which can be used in a wider variety of organisms. ..
  12. ncbi request reprint Docking interactions in protein kinase and phosphatase networks
    Attila Remenyi
    Department of Cellular and Molecular Pharmacology, Program in Biological Sciences, University of California San Francisco, 600 16th Street, San Francisco, CA 94143 2240, USA
    Curr Opin Struct Biol 16:676-85. 2006
    ....
  13. pmc Scaffold proteins: hubs for controlling the flow of cellular information
    Matthew C Good
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, CA 94158, USA
    Science 332:680-6. 2011
    ..As a result, scaffold proteins have been exploited by evolution, pathogens, and cellular engineers to reshape cellular behavior...
  14. ncbi request reprint The role of docking interactions in mediating signaling input, output, and discrimination in the yeast MAPK network
    Attila Remenyi
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, 94143, USA
    Mol Cell 20:951-62. 2005
    ..Induced fit recognition may allow docking peptides to achieve discrimination by exploiting subtle differences in kinase flexibility...
  15. ncbi request reprint Sho1 and Pbs2 act as coscaffolds linking components in the yeast high osmolarity MAP kinase pathway
    Ali Zarrinpar
    Program in Biological Sciences and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94143, USA
    Mol Cell 14:825-32. 2004
    ..Thus, a network of interactions provided by both Sho1 and Pbs2 appears to direct pathway information flow...
  16. pmc Light control of plasma membrane recruitment using the Phy-PIF system
    Jared E Toettcher
    Cardiovascular Research Institute and Department of Biochemistry, University of California San Francisco, San Francisco, California, USA
    Methods Enzymol 497:409-23. 2011
    ....
  17. pmc Synthetic control of mammalian-cell motility by engineering chemotaxis to an orthogonal bioinert chemical signal
    Jason S Park
    Department of Cellular and Molecular Pharmacology, The Cell Propulsion Lab, a National Institutes of Health Nanomedicine Development Center, University of California, San Francisco, CA 94158
    Proc Natl Acad Sci U S A 111:5896-901. 2014
    ..In the future, this type of migration control could be a valuable module for engineering therapeutic cellular devices. ..
  18. ncbi request reprint Domains, motifs, and scaffolds: the role of modular interactions in the evolution and wiring of cell signaling circuits
    Roby P Bhattacharyya
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94143, USA
    Annu Rev Biochem 75:655-80. 2006
    ..In support of this hypothesis, recent studies show that such modular systems can be exploited to engineer nonnatural signaling proteins and pathways with novel behavior...
  19. pmc The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans
    Nicole King
    Department of Molecular and Cell Biology and the Center for Integrative Genomics, University of California, Berkeley, California 94720, USA
    Nature 451:783-8. 2008
    ..The completion of the M. brevicollis genome allows us to reconstruct with increasing resolution the genomic changes that accompanied the origin of metazoans...
  20. ncbi request reprint Rewiring cell signaling: the logic and plasticity of eukaryotic protein circuitry
    John E Dueber
    Department of Cellular and Molecular Pharmacology, California Institute for Quantitative Biomedical Research, University of California San Francisco, 600 16 th Street, San Francisco, California 94143 2240, USA
    Curr Opin Struct Biol 14:690-9. 2004
    ..Recent engineering studies demonstrate that these relatively simple principles can be used to rewire signaling behavior in a process that mimics the evolution of new phenotypic responses...
  21. ncbi request reprint Role of electrostatic interactions in PDZ domain ligand recognition
    Baruch Z Harris
    Program in Biological Sciences, Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94143, USA
    Biochemistry 42:2797-805. 2003
    ..Peptides with a free carboxy terminus, or presented within a specific structural context, can satisfy these requirements...
  22. pmc Actin dynamics rapidly reset chemoattractant receptor sensitivity following adaptation in neutrophils
    Sheel N Dandekar
    Department of Biophysics, Genentech Hall, University of California, 600 16th Street, San Francisco, CA 94158, USA
    Philos Trans R Soc Lond B Biol Sci 368:20130008. 2013
    ..Spatial differences in actin dynamics may underlie front/back differences in agonist sensitivity in neutrophils. ..
  23. pmc Systematic functional prioritization of protein posttranslational modifications
    Pedro Beltrao
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94107, USA
    Cell 150:413-25. 2012
    ..Finally, our analysis of the evolution of PTM regulation highlights potential routes for neutral drift in regulatory interactions and suggests that only a fraction of modification sites are likely to have a significant biological role...
  24. pmc Control of protein signaling using a computationally designed GTPase/GEF orthogonal pair
    Gregory T Kapp
    Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 109:5277-82. 2012
    ..Computational design of protein interfaces thus promises to provide specific components that facilitate the predictable engineering of cellular functions...
  25. pmc Evolution of phosphoregulation: comparison of phosphorylation patterns across yeast species
    Pedro Beltrao
    Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California, United States of America
    PLoS Biol 7:e1000134. 2009
    ..pombe, which demonstrated that protein kinases, and to a greater extent TFs, show lower than average conservation of genetic interactions. We propose therefore that protein kinases are an important source of phenotypic diversity...
  26. pmc Light-based feedback for controlling intracellular signaling dynamics
    Jared E Toettcher
    Cardiovascular Research Institute and Department of Biochemistry, University of California San Francisco, San Francisco, California, USA
    Nat Methods 8:837-9. 2011
    ..We applied this strategy to perturb protein localization and phosphoinositide 3-kinase activity, generating time-varying signals and clamping signals to buffer against cell-to-cell variability or changes in pathway activity...
  27. pmc Bacterial virulence proteins as tools to rewire kinase pathways in yeast and immune cells
    Ping Wei
    Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, California 94158, USA
    Nature 488:384-8. 2012
    ..These studies demonstrate how pathogens could provide a rich toolkit of parts to engineer cells for therapeutic or biotechnological applications...
  28. pmc Spatiotemporal control of cell signalling using a light-switchable protein interaction
    Anselm Levskaya
    The Cell Propulsion Lab, UCSF UCB NIH Nanomedicine Development Center, University of California, San Francisco, California 94158 2517, USA
    Nature 461:997-1001. 2009
    ....
  29. pmc Counting molecules in single organelles with superresolution microscopy allows tracking of the endosome maturation trajectory
    Elias M Puchner
    Howard Hughes Medical Institute, Department of Cellular and Molecular Pharmacology, and Department of Pharmaceutical Chemistry, University of California, San Francisco, CA 94158
    Proc Natl Acad Sci U S A 110:16015-20. 2013
    ..This single-organelle analysis can potentially be applied to a range of small organelles to shed light on their precise composition/structure relationships, the dynamics of their regulation, and the noise in these processes. ..
  30. pmc Using optogenetics to interrogate the dynamic control of signal transmission by the Ras/Erk module
    Jared E Toettcher
    Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA 94158 2517, USA Cardiovascular Research Institute, University of California San Francisco, San Francisco, CA 94158 2517, USA Department of Biochemistry, University of California San Francisco, San Francisco, CA 94158 2517, USA
    Cell 155:1422-34. 2013
    ..Optogenetic stimulation provides a powerful tool for analyzing the intrinsic transmission properties of pathway modules and identifying how they dynamically encode distinct outcomes...
  31. pmc CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes
    Luke A Gilbert
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA
    Cell 154:442-51. 2013
    ....
  32. pmc Exploitation of latent allostery enables the evolution of new modes of MAP kinase regulation
    Scott M Coyle
    Howard Hughes Medical Institute, Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA
    Cell 154:875-87. 2013
    ....
  33. ncbi request reprint A polybasic motif allows N-WASP to act as a sensor of PIP(2) density
    Venizelos Papayannopoulos
    Department of Cellular and Molecular Pharmacology and Program in Biological Sciences, University of California, San Francisco, San Francisco, CA 94143, USA
    Mol Cell 17:181-91. 2005
    ..This sharp activation threshold may help suppress N-WASP activation by quiescent PIP(2) levels yet leave it poised for activation upon subtle, signaling-induced perturbations in PIP(2) distribution...
  34. pmc Evolution of the phospho-tyrosine signaling machinery in premetazoan lineages
    David Pincus
    Department of Cellular and Molecular Pharmacology, University of California, 600 16th Street, San Francisco, CA 94158, USA
    Proc Natl Acad Sci U S A 105:9680-4. 2008
    ..The emergence of the full three-component signaling system, with its dramatically increased encoding potential, may have contributed to the advent of metazoan multicellularity...
  35. ncbi request reprint Engineering modular protein interaction switches by sequence overlap
    Nathan A Sallee
    Chemistry and Chemical Biology Graduate Program and the Department of Cellular and Molecular Pharmacology, University of California San Francisco, San Francisco, CA 94158, USA
    J Am Chem Soc 129:4606-11. 2007
    ..Our experiments also suggest a possible mechanism by which complex regulatory proteins might have evolved from simpler components...
  36. ncbi request reprint A general model for preferential hetero-oligomerization of LIN-2/7 domains: mechanism underlying directed assembly of supramolecular signaling complexes
    Keiko Y Petrosky
    Biophysics Graduate Program, University of California, San Francisco, California 94143, USA
    J Biol Chem 280:38528-36. 2005
    ..As predicted by the model, mutations of keystone residues stabilize normally strongly disfavored homodimers. Thus, L27 domains are specifically optimized to avoid homodimeric interactions...
  37. pmc The pathogen protein EspF(U) hijacks actin polymerization using mimicry and multivalency
    Nathan A Sallee
    Graduate Program in Chemistry and Chemical Biology, University of California, San Francisco, 600 16th Street, San Francisco, California 94158, USA
    Nature 454:1005-8. 2008
    ..Thus, this pathogen has used a simple autoinhibitory fragment as a component to build a highly effective actin polymerization machine...
  38. ncbi request reprint Beta strand peptidomimetics as potent PDZ domain ligands
    Ming C Hammond
    Center for New Directions in Organic Synthesis, Department of Chemistry, University of California, Berkeley, Berkeley, California 94720, USA
    Chem Biol 13:1247-51. 2006
    ..The rational design of a small molecule of unprecedented affinity for the PDZ domain suggests that these peptidomimetics may provide a general method for inhibiting protein-protein interactions involving extended peptide chains...
  39. ncbi request reprint Rewiring cellular morphology pathways with synthetic guanine nucleotide exchange factors
    Brian J Yeh
    Chemistry and Chemical Biology Graduate Program, University of California, San Francisco, San Francisco, California 94158 2517, USA
    Nature 447:596-600. 2007
    ....
  40. pmc Secreting and sensing the same molecule allows cells to achieve versatile social behaviors
    Hyun Youk
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA
    Science 343:1242782. 2014
    ..A mathematical model explained these behaviors. The versatility of the secrete-and-sense circuit motif may explain its recurrence across species. ..
  41. ncbi request reprint Engineering synthetic signaling proteins with ultrasensitive input/output control
    John E Dueber
    Program in Biological Sciences, University of California, San Francisco, California 94158 2517, USA
    Nat Biotechnol 25:660-2. 2007
    ..By systematically altering the number and affinity of modular autoinhibitory interactions, we show that we can predictably convert a simple linear signaling protein into an ultrasensitive switch...
  42. ncbi request reprint The modular logic of signaling proteins: building allosteric switches from simple binding domains
    Wendell A Lim
    Department of Cellular and Molecular Pharmacology, Department of Biochemistry and Biophysics, University of California, San Francisco 94143 0450, USA
    Curr Opin Struct Biol 12:61-8. 2002
    ..A combination of structural, biophysical and computational studies is beginning to shed light on the fundamental principles governing this type of modular allostery...
  43. ncbi request reprint Optimization of specificity in a cellular protein interaction network by negative selection
    Ali Zarrinpar
    Program in Biological Sciences, University of California, San Francisco, 600 16th Street, San Francisco, California 94143 2240, USA
    Nature 426:676-80. 2003
    ..System-wide negative selection is a subtle but powerful evolutionary mechanism to optimize specificity within an interaction network composed of overlapping recognition elements...
  44. ncbi request reprint Rewiring MAP kinase pathways using alternative scaffold assembly mechanisms
    Sang Hyun Park
    Department of Cellular and Molecular Pharmacology and Department of Biochemistry and Biophysics, University of California, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Science 299:1061-4. 2003
    ..These findings demonstrate that scaffolds are highly flexible organizing factors that can facilitate pathway evolution and engineering...
  45. pmc Designing synthetic regulatory networks capable of self-organizing cell polarization
    Angela H Chau
    Howard Hughes Medical Institute and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, San Francisco, CA 94158, USA
    Cell 151:320-32. 2012
    ..Thus, by harnessing localization-regulated signaling molecules, we can engineer simple molecular circuits that reliably execute spatial self-organized programs...
  46. pmc Improved blue, green, and red fluorescent protein tagging vectors for S. cerevisiae
    Sidae Lee
    UCSF Center for Systems and Synthetic Biology, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 8:e67902. 2013
    ..Together, the new tagging vectors we have constructed provide improved blue and red fluorescent proteins for yeast tagging and three color imaging. ..
  47. ncbi request reprint The structure and function of proline recognition domains
    Ali Zarrinpar
    Program in Biological Sciences, University of California San Francisco, 600 16th Street, San Francisco, CA 94143 2240, USA
    Sci STKE 2003:RE8. 2003
    ..These domains use strikingly similar molecular mechanisms of proline recognition. We discuss some of the potential biological advantages conferred by proline recognition, which may explain its widespread use in signaling...
  48. ncbi request reprint Complex inheritance of familial hypercholanemia with associated mutations in TJP2 and BAAT
    Victoria E H Carlton
    Liver Center Laboratory and Department of Medicine, San Francisco General Hospital, University of California San Francisco, California 94110, USA
    Nat Genet 34:91-6. 2003
    ..Mutations in both TJP2 and BAAT may disrupt bile acid transport and circulation. Inheritance seems to be oligogenic, with genotype at BAAT modifying penetrance in individuals homozygous with respect to the mutation in TJP2...
  49. pmc Rewiring cells: synthetic biology as a tool to interrogate the organizational principles of living systems
    Caleb J Bashor
    Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94158 2517, USA
    Annu Rev Biophys 39:515-37. 2010
    ....
  50. ncbi request reprint Reprogramming control of an allosteric signaling switch through modular recombination
    John E Dueber
    Program in Biological Sciences, University of California, San Francisco, CA 94143 2240, USA
    Science 301:1904-8. 2003
    ..Synthetic switch proteins were created with diverse gating behaviors in response to nonphysiological inputs. Thus, this type of modular framework can facilitate the evolution or engineering of cellular signaling circuits...
  51. pmc Repurposing CRISPR as an RNA-guided platform for sequence-specific control of gene expression
    Lei S Qi
    UCSF Center for Systems and Synthetic Biology, University of California, San Francisco, San Francisco, CA 94158, USA
    Cell 152:1173-83. 2013
    ..We also show evidence that the system can be adapted for gene repression in mammalian cells. This RNA-guided DNA recognition platform provides a simple approach for selectively perturbing gene expression on a genome-wide scale...
  52. ncbi request reprint Synthetic biology: lessons from the history of synthetic organic chemistry
    Brian J Yeh
    Chemistry and Chemical Biology Graduate Program, University of California, San Francisco, 600 16th Street, San Francisco, California 94158 2517, USA
    Nat Chem Biol 3:521-5. 2007
    ..The history of synthetic chemistry offers a possible roadmap for the development and impact of synthetic biology, a nascent field in which the goal is to build novel biological systems...

Research Grants20

  1. PROTEIN RECOGNITION IN SIGNAL TRANSDUCTION
    Wendell Lim; Fiscal Year: 2006
    ..abstract_text> ..
  2. PROTEIN INTERACTIONS REGULATING CELL MOTILITY
    Wendell Lim; Fiscal Year: 2006
    ....
  3. PROTEIN INTERACTIONS REGULATING CELL MOTILITY
    Wendell Lim; Fiscal Year: 2007
    ....
  4. PROTEIN RECOGNITION IN SIGNAL TRANSDUCTION
    Wendell Lim; Fiscal Year: 2009
    ..4. Explore the use of the Ste5 scaffold protein as a platform for pathway engineering: tuning pathway response dynamics via artificial recruitment of positive and negative effectors. ..
  5. PROTEIN INTERACTIONS REGULATING CELL MOTILITY
    Wendell Lim; Fiscal Year: 2009
    ....
  6. PROTEIN RECOGNITION IN SIGNAL TRANSDUCTION
    Wendell Lim; Fiscal Year: 2004
    ..abstract_text> ..
  7. PROTEIN INTERACTIONS REGULATING CELL MOTILITY
    Wendell Lim; Fiscal Year: 2004
    ....
  8. PROTEIN RECOGNITION IN SIGNAL TRANSDUCTION
    Wendell Lim; Fiscal Year: 1999
    ....
  9. PROTEIN RECOGNITION IN SIGNAL TRANSDUCTION
    Wendell Lim; Fiscal Year: 2000
    ....
  10. PROTEIN INTERACTIONS REGULATING CELL MOTILITY
    Wendell Lim; Fiscal Year: 2001
    ....
  11. PROTEIN RECOGNITION IN SIGNAL TRANSDUCTION
    Wendell Lim; Fiscal Year: 2002
    ..abstract_text> ..
  12. PROTEIN INTERACTIONS REGULATING CELL MOTILITY
    Wendell Lim; Fiscal Year: 2002
    ....
  13. PROTEIN RECOGNITION IN SIGNAL TRANSDUCTION
    Wendell Lim; Fiscal Year: 2003
    ..abstract_text> ..
  14. PROTEIN INTERACTIONS REGULATING CELL MOTILITY
    Wendell Lim; Fiscal Year: 2003
    ....
  15. PROTEIN RECOGNITION IN SIGNAL TRANSDUCTION
    Wendell A Lim; Fiscal Year: 2010
    ..4. Explore the use of the Ste5 scaffold protein as a platform for pathway engineering: tuning pathway response dynamics via artificial recruitment of positive and negative effectors. ..