K O Lim

Summary

Affiliation: University of Minnesota
Country: USA

Publications

  1. pmc Voxelwise correlational analyses of white matter integrity in multiple cognitive domains in schizophrenia
    Kelvin O Lim
    Department of Psychiatry, University of Minnesota, Minneapolis 55455, USA
    Am J Psychiatry 163:2008-10. 2006
  2. ncbi request reprint Neuropsychiatric applications of DTI - a review
    K O Lim
    Department of Psychiatry, University of Minnesota, Minneapolis 55454, USA
    NMR Biomed 15:587-93. 2002
  3. pmc Brain macrostructural and microstructural abnormalities in cocaine dependence
    Kelvin O Lim
    University of Minnesota, Department of Psychiatry, F282 2A West, 2450 Riverside Avenue, Minneapolis, MN 55454, USA
    Drug Alcohol Depend 92:164-72. 2008
  4. ncbi request reprint Frontal white matter microstructure and treatment response of late-life depression: a preliminary study
    George S Alexopoulos
    Department of Psychiatry, Weill Medical Colege, Cornell University, and the Nathan Kline Institute, Orangeburg, NY 10605, USA
    Am J Psychiatry 159:1929-32. 2002
  5. pmc Prefrontal cortical changes following cognitive training in patients with chronic schizophrenia: effects of practice, generalization, and specificity
    Kristen M Haut
    Translational Research in Cognitive and Affective Mechanisms Laboratory, Department of Psychology, University of Minnesota, Minneapolis, MN 55455, USA
    Neuropsychopharmacology 35:1850-9. 2010
  6. doi request reprint White matter integrity predicts delay discounting behavior in 9- to 23-year-olds: a diffusion tensor imaging study
    Elizabeth A Olson
    Department of Psychology, University of Minnesota, Twin Cities Campus, Minneapolis, MN 55455, USA
    J Cogn Neurosci 21:1406-21. 2009
  7. pmc Diffusion tensor imaging identifies deficits in white matter microstructure in subjects with type 1 diabetes that correlate with reduced neurocognitive function
    Christopher T Kodl
    Departmentof Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Minnesota, Minneapolis, Minnesota, USA
    Diabetes 57:3083-9. 2008
  8. doi request reprint Structural and diffusion tensor imaging of the fornix in childhood- and adolescent-onset schizophrenia
    Mustafa Kendi
    University of Minnesota, Minneapolis, MN 55454, USA
    J Am Acad Child Adolesc Psychiatry 47:826-32. 2008
  9. pmc The development of corpus callosum microstructure and associations with bimanual task performance in healthy adolescents
    Ryan L Muetzel
    Department of Psychology, University of Minnesota, Minneapolis, MN 55455, USA
    Neuroimage 39:1918-25. 2008
  10. pmc Limbic structures and networks in children and adolescents with schizophrenia
    Tonya White
    Department of Psychiatry, Fairview University Medical Center, University of Minnesota, Minneapolis, MN 55454, USA
    Schizophr Bull 34:18-29. 2008

Research Grants

Detail Information

Publications57

  1. pmc Voxelwise correlational analyses of white matter integrity in multiple cognitive domains in schizophrenia
    Kelvin O Lim
    Department of Psychiatry, University of Minnesota, Minneapolis 55455, USA
    Am J Psychiatry 163:2008-10. 2006
    ..In each case, better performance on these tasks was associated with higher levels of fractional anisotropy in task-relevant regions...
  2. ncbi request reprint Neuropsychiatric applications of DTI - a review
    K O Lim
    Department of Psychiatry, University of Minnesota, Minneapolis 55454, USA
    NMR Biomed 15:587-93. 2002
    ..The study of animal models and postmortem tissue may be helpful in elucidating the neurobiological underpinnings of abnormalities observed with DTI...
  3. pmc Brain macrostructural and microstructural abnormalities in cocaine dependence
    Kelvin O Lim
    University of Minnesota, Department of Psychiatry, F282 2A West, 2450 Riverside Avenue, Minneapolis, MN 55454, USA
    Drug Alcohol Depend 92:164-72. 2008
    ..Two previous studies have utilized diffusion tensor imaging (DTI) to examine microstructural integrity in cocaine abuse and found evidence of brain abnormalities in white matter...
  4. ncbi request reprint Frontal white matter microstructure and treatment response of late-life depression: a preliminary study
    George S Alexopoulos
    Department of Psychiatry, Weill Medical Colege, Cornell University, and the Nathan Kline Institute, Orangeburg, NY 10605, USA
    Am J Psychiatry 159:1929-32. 2002
    ..This study tested the hypothesis that microstructural abnormalities in white matter areas of the brain containing frontostriatal tracts are associated with a low rate of remission of geriatric depression...
  5. pmc Prefrontal cortical changes following cognitive training in patients with chronic schizophrenia: effects of practice, generalization, and specificity
    Kristen M Haut
    Translational Research in Cognitive and Affective Mechanisms Laboratory, Department of Psychology, University of Minnesota, Minneapolis, MN 55455, USA
    Neuropsychopharmacology 35:1850-9. 2010
    ....
  6. doi request reprint White matter integrity predicts delay discounting behavior in 9- to 23-year-olds: a diffusion tensor imaging study
    Elizabeth A Olson
    Department of Psychology, University of Minnesota, Twin Cities Campus, Minneapolis, MN 55455, USA
    J Cogn Neurosci 21:1406-21. 2009
    ..Findings are discussed in terms of both developmental and age-independent effects of white matter organization on discounting behavior...
  7. pmc Diffusion tensor imaging identifies deficits in white matter microstructure in subjects with type 1 diabetes that correlate with reduced neurocognitive function
    Christopher T Kodl
    Departmentof Medicine, Division of Endocrinology, Diabetes, and Metabolism, University of Minnesota, Minneapolis, Minnesota, USA
    Diabetes 57:3083-9. 2008
    ....
  8. doi request reprint Structural and diffusion tensor imaging of the fornix in childhood- and adolescent-onset schizophrenia
    Mustafa Kendi
    University of Minnesota, Minneapolis, MN 55454, USA
    J Am Acad Child Adolesc Psychiatry 47:826-32. 2008
    ..The fornix is the primary efferent neural pathway of the hippocampus and has been shown to be abnormal in adults with schizophrenia...
  9. pmc The development of corpus callosum microstructure and associations with bimanual task performance in healthy adolescents
    Ryan L Muetzel
    Department of Psychology, University of Minnesota, Minneapolis, MN 55455, USA
    Neuroimage 39:1918-25. 2008
    ..These findings expand upon existing neuroimaging reports of CC development by showing associations between bimanual coordination and white matter microstructural organization in an adolescent sample...
  10. pmc Limbic structures and networks in children and adolescents with schizophrenia
    Tonya White
    Department of Psychiatry, Fairview University Medical Center, University of Minnesota, Minneapolis, MN 55454, USA
    Schizophr Bull 34:18-29. 2008
    ..Additional research within a developmental framework is necessary to determine the putative etiologic roles for limbic and other brain abnormalities in early-onset schizophrenia...
  11. ncbi request reprint Disruption of hippocampal connectivity in children and adolescents with schizophrenia--a voxel-based diffusion tensor imaging study
    Tonya White
    Department of Psychiatry, University of Minnesota, Minneapolis, MN 55454, USA
    Schizophr Res 90:302-7. 2007
    ..As white matter provides rapid and efficient communication between brain regions, this study was initiated to assess the early disruption of white matter pathways in children and adolescent with schizophrenia...
  12. pmc Neurocognitive and neuroimaging correlates of pediatric traumatic brain injury: a diffusion tensor imaging (DTI) study
    Jeffrey R Wozniak
    Department of Psychiatry, University of Minnesota Medical Center, 2450 Riverside Avenue, Minneapolis, MN 55454, USA
    Arch Clin Neuropsychol 22:555-68. 2007
    ..Parent-reported executive deficits were inversely correlated with FA. Results suggest that DTI measures are sensitive to long-term WM changes and associated with cognitive functioning following pediatric TBI...
  13. pmc Brain-performance correlates of working memory retrieval in schizophrenia: a cognitive modeling approach
    Gregory G Brown
    Department of Psychiatry, University of California, San Diego, CA, USA
    Schizophr Bull 35:32-46. 2009
    ..The results show at both cognitive and neural levels that disordered memory scanning contributes to deficient SIRP performance among schizophrenia patients...
  14. pmc White matter and neurocognitive changes in adults with chronic traumatic brain injury
    Mary R T Kennedy
    Department of Speech Language Hearing Sciences, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Int Neuropsychol Soc 15:130-6. 2009
    ..jins, 2009, 15, 130-136.)...
  15. pmc Neurochemical changes in the rat prefrontal cortex following acute phencyclidine treatment: an in vivo localized (1)H MRS study
    Isabelle Iltis
    Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, 55455, USA
    NMR Biomed 22:737-44. 2009
    ..MRS studies of this pharmacological rat model may be useful for assessing the effects of potential anti-psychotic drugs in vivo...
  16. doi request reprint Evidence of disrupted functional connectivity in the brain after combat-related blast injury
    Scott R Sponheim
    Veterans Affairs Medical Center, Minneapolis, MN 55417, USA
    Neuroimage 54:S21-9. 2011
    ..post-traumatic stress and depression) and commonly prescribed medications. Results provide evidence for poor coordination of frontal neural function after blast injury that may be the consequence of damaged anterior white matter tracts...
  17. doi request reprint Disruption of brain white matter microstructure in primary Sjögren's syndrome: evidence from diffusion tensor imaging
    Barbara M Segal
    Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA
    Rheumatology (Oxford) 49:1530-9. 2010
    ..The relationship between cognitive symptoms and underlying neuropathology in primary SS (PSS) is poorly understood. We used high-resolution quantitative brain MRI to identify potential structural correlates of cognitive symptoms...
  18. pmc Altered white matter microstructure in adolescents with major depression: a preliminary study
    Kathryn R Cullen
    Department of Psychiatry, University of Minnesota Medical School, University of Minnesota, Center for Magnetic Resonance Research, Minneapolis, MN 55454, USA
    J Am Acad Child Adolesc Psychiatry 49:173-83.e1. 2010
    ..Diffusion tensor imaging (DTI), which measures white matter (WM) microstructure, is a promising tool for examining neural connections and how they may be abnormal in MDD...
  19. pmc Differential fractional anisotropy abnormalities in adolescents with ADHD or schizophrenia
    Nicholas D Davenport
    Department of Psychology, University of Minnesota, Minneapolis, MN, United States
    Psychiatry Res 181:193-8. 2010
    ....
  20. pmc Preliminary investigation of the impulsive and neuroanatomical characteristics of compulsive sexual behavior
    Michael H Miner
    Program in Human Sexuality, Department of Family Medicine and Community Health, University of Minnesota, Minneapolis, MN, USA
    Psychiatry Res 174:146-51. 2009
    ..Thus, while CSB patients were more impulsive than controls, the DTI results were not consistent with impulse control disorders...
  21. pmc Microstructural corpus callosum anomalies in children with prenatal alcohol exposure: an extension of previous diffusion tensor imaging findings
    Jeffrey R Wozniak
    University of Minnesota, Twin Cities, Minnesota 55454, USA
    Alcohol Clin Exp Res 33:1825-35. 2009
    ..This study also expands on our prior work by evaluating a larger sample and by incorporating children with a broader range of clinical effects including full-criteria fetal alcohol syndrome (FAS)...
  22. pmc A preliminary study of functional connectivity in comorbid adolescent depression
    Kathryn R Cullen
    University of Minnesota Medical School, Department of Psychiatry, Minneapolis, MN, United States
    Neurosci Lett 460:227-31. 2009
    ..We conclude that hypothesis-driven, seed-based analyses of resting state fMRI data hold promise for advancing our current understanding of abnormal development of neural circuitry in adolescents with MDD...
  23. doi request reprint Diffusion tensor imaging in psychiatric disorders
    Tonya White
    Department of Psychiatry, University of Minnesota, Fairview University Medical Center, 2450 Riverside Ave, Minneapolis, MN 55454, USA
    Top Magn Reson Imaging 19:97-109. 2008
    ..The goal of this article is to provide an overview of DTI and its application to psychiatric disorders...
  24. pmc High connectivity between reduced cortical thickness and disrupted white matter tracts in long-standing type 1 diabetes
    Daniel T Franc
    University of Minnesota Medical School, Minneapolis, USA
    Diabetes 60:315-9. 2011
    ....
  25. pmc Diffusion tensor imaging in children with fetal alcohol spectrum disorders
    Jeffrey R Wozniak
    Department of Psychiatry, University of Minnesota, Minneapolis, MN, 55454, USA
    Alcohol Clin Exp Res 30:1799-806. 2006
    ..The current study investigated whether similar abnormalities are present in less severely affected, prenatally exposed patients who did not display all of the typical FAS physical stigmata...
  26. pmc Advances in white matter imaging: a review of in vivo magnetic resonance methodologies and their applicability to the study of development and aging
    Jeffrey R Wozniak
    Department of Psychiatry, University of Minnesota, F256 2B West, 2450 Riverside Ave, Minneapolis, MN 55454, USA
    Neurosci Biobehav Rev 30:762-74. 2006
    ..Studies examining brain development during childhood and adulthood as well as studies of the effects of aging are discussed...
  27. ncbi request reprint Validation of glutathione quantitation from STEAM spectra against edited 1H NMR spectroscopy at 4T: application to schizophrenia
    Melissa Terpstra
    Center for Magnetic Resonance Research, Department of Radiology, University of MN, Minneapolis, MN 55455, USA
    MAGMA 18:276-82. 2005
    ..A secondary objective was to compare several of the neurochemical concentrations quantified along with GSH using LCModel analysis of short echo time spectra in schizophrenia versus control...
  28. pmc Altered functional and anatomical connectivity in schizophrenia
    Jazmin Camchong
    Department of Psychiatry, University of Minnesota, 717 Delaware Street SE, Suite 516, Minneapolis, MN 55414, USA
    Schizophr Bull 37:640-50. 2011
    ..Functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) were used to evaluate functional and anatomical brain connectivity in schizophrenia...
  29. pmc White matter abnormalities and neurocognitive correlates in children and adolescents with myotonic dystrophy type 1: a diffusion tensor imaging study
    Jeffrey R Wozniak
    Department of Psychiatry, University of Minnesota, Twin Cities, Minneapolis, MN 55454, USA
    Neuromuscul Disord 21:89-96. 2011
    ..Results indicate that significant white matter abnormality is characteristic of young patients with myotonic dystrophy type 1 and that the white matter abnormality seen with neuroimaging has implications for cognitive functioning...
  30. ncbi request reprint A functional MRI study of visual oddball: evidence for frontoparietal dysfunction in subjects at risk for alcoholism
    Madhavi Rangaswamy
    Department of Psychiatry, SUNY Health Sciences Center at Brooklyn, State University of New York, Brooklyn, NY 11203, USA
    Neuroimage 21:329-39. 2004
    ..This finding indicates that a dysfunctional frontoparietal circuit may underlie the low P300 responses seen in HR subjects. This perhaps implies a deficiency in the rehearsal component of the working memory system...
  31. ncbi request reprint Compounded brain volume deficits in schizophrenia-alcoholism comorbidity
    Daniel H Mathalon
    Department of Psychiatry, Yale University School of Medicine Veterans Affairs Connecticut Healthcare System, West Haven 06516, USA
    Arch Gen Psychiatry 60:245-52. 2003
    ..Schizophrenia and alcoholism are characterized by brain volume abnormalities. Despite the frequent comorbidity of these conditions, the potentially compounded effects of comorbidity on brain structure have seldom been rigorously assessed...
  32. ncbi request reprint Proton echo-planar spectroscopic imaging of J-coupled resonances in human brain at 3 and 4 Tesla
    Stefan Posse
    Department of Psychiatry, University of New Mexico School of Medicine, Albuquerque, New Mexico 87131, USA
    Magn Reson Med 58:236-44. 2007
    ..Glu concentration was significantly higher in gray matter (GM) compared to white matter (WM), as anticipated. The short acquisition time makes this methodology suitable for clinical studies...
  33. ncbi request reprint Speed and efficiency but not accuracy or timing deficits of limb movements in alcoholic men and women
    Edith V Sullivan
    Department of Psychiatry, Stanford University School of Medicine, California 94305 5723, USA
    Alcohol Clin Exp Res 26:705-13. 2002
    ..Whether evidence for such dysfunction lingers in patients with uncomplicated alcoholism, which is known to affect cerebellar structural integrity, is controversial...
  34. ncbi request reprint A comparison of clinical ratings with vocal acoustic measures of flat affect and alogia
    Murray Alpert
    Department of Psychiatry, New York University Medical Center, HN323, 550 First Avenue, New York, NY 10016, USA
    J Psychiatr Res 36:347-53. 2002
    ..Acoustic analysis has the potential to provide objective measures that may help develop operational definitions of these constructs and enhance clinical assessment...
  35. ncbi request reprint Frontal white matter microstructure, aggression, and impulsivity in men with schizophrenia: a preliminary study
    Matthew J Hoptman
    Division of Clinical Research and the Center for Advanced Brain Imaging, Nathan Kline Institute for Psychiatric Research, Orangeburg, New York 10962, USA
    Biol Psychiatry 52:9-14. 2002
    ..Aggression and impulsivity may involve altered frontal white matter...
  36. ncbi request reprint Inferior frontal white matter anisotropy and negative symptoms of schizophrenia: a diffusion tensor imaging study
    Adam Wolkin
    Mental Health Service, VA New York Harbor Healthcare System, New York, 10010, USA
    Am J Psychiatry 160:572-4. 2003
    ..The purpose of this study was test the hypothesis that abnormalities of inferior frontal white matter are related to the negative symptoms of schizophrenia...
  37. ncbi request reprint Diffusion tensor imaging in fixed brain tissue at 7.0 T
    David N Guilfoyle
    Nathan Kline Institute, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    NMR Biomed 16:77-81. 2003
    ..With the increased availability of brain banks in different brain disorders, DTI in fixed tissue may prove to be a very useful method for the study of white matter abnormalities...
  38. ncbi request reprint MRI study of white matter diffusion anisotropy in schizophrenia
    Babak A Ardekani
    Center for Advanced Brain Imaging, Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Neuroreport 14:2025-9. 2003
    ..Regions showing reduced white matter fractional anisotropy are known to be abnormal in schizophrenia. The voxelwise method used in the current study can provide the basis for hypothesis-driven research...
  39. ncbi request reprint Reduced frontal white matter integrity in cocaine dependence: a controlled diffusion tensor imaging study
    Kelvin O Lim
    Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York, USA
    Biol Psychiatry 51:890-5. 2002
    ..Thus, we sought to examine the effects of cocaine dependence on frontal WM integrity...
  40. pmc DTI and impulsivity in schizophrenia: a first voxelwise correlational analysis
    Matthew J Hoptman
    Division of Clinical Research, Nathan Kline Institute, 140 Old Orangeburg Rd, Orangeburg, NY 10962, USA
    Neuroreport 15:2467-70. 2004
    ..These areas may comprise a fronto-temporo-limbic circuit that modulates impulsivity. The voxelwise correlation method can serve as a hypothesis-generation method for relating target behaviors to their underlying neural networks...
  41. ncbi request reprint Diffusion tensor imaging of frontal white matter microstructure in early Alzheimer's disease: a preliminary study
    Steven J Choi
    Nathan S Kline Institute for Psychiatric Research, Orangeburg, NY, USA
    J Geriatr Psychiatry Neurol 18:12-9. 2005
    ....
  42. ncbi request reprint White matter abnormalities in first-episode schizophrenia or schizoaffective disorder: a diffusion tensor imaging study
    Philip R Szeszko
    The Zucker Hillside Hospital, Department of Psychiatry Research, 75 59 263rd St, Glen Oaks, NY 11004, USA
    Am J Psychiatry 162:602-5. 2005
    ..The goal of this study was to investigate brain white matter abnormalities by using diffusion tensor imaging in patients with schizophrenia or schizoaffective disorder close to illness onset...
  43. pmc Visual white matter integrity in schizophrenia
    Pamela D Butler
    Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Orangeburg NY, 10962, USA
    Am J Psychiatry 163:2011-3. 2006
    ..Patients with schizophrenia have visual-processing deficits. This study examines visual white matter integrity as a potential mechanism for these deficits...
  44. pmc White-matter integrity predicts stroop performance in patients with geriatric depression
    Christopher F Murphy
    Weill Medical College of Cornell University, Neill Cornell Institute of Geriatric Psychiatry, White Plains, New York 10605, USA
    Biol Psychiatry 61:1007-10. 2007
    ..This study tested the hypothesis that microstructural white matter abnormalities in frontostriatal-limbic tracts are associated with poor response inhibition on the Stroop task in depressed elders...
  45. ncbi request reprint The neural substrates of impaired prosodic detection in schizophrenia and its sensorial antecedents
    David I Leitman
    Program in Cognitive Neuroscience and Schizophrenia, Cognitive Neurophysiology Laboratory, Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd, Orangeburg, NY 10962, USA
    Am J Psychiatry 164:474-82. 2007
    ..This study examined neural substrates of prosodic dysfunction in schizophrenia with voxelwise analysis of diffusion tensor magnetic resonance imaging (MRI)...
  46. ncbi request reprint Clinical and neuropsychological correlates of white matter abnormalities in recent onset schizophrenia
    Philip R Szeszko
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Neuropsychopharmacology 33:976-84. 2008
    ..These abnormalities have clinical and neuropsychological correlates, which may be useful in further characterizing structure-function relations in schizophrenia and constraining neurobiological models of the disorder...
  47. ncbi request reprint Connections in schizophrenia
    Kelvin O Lim
    Am J Psychiatry 164:995-8. 2007
  48. pmc Brain morphometry using diffusion-weighted magnetic resonance imaging: application to schizophrenia
    Babak A Ardekani
    Center for Advanced Brain Imaging, Nathan S Kline Institute for Psychiatric Research, Orangeburg, New York, USA
    Neuroreport 16:1455-9. 2005
    ..Affected areas included the bilateral insular cortex, hippocampus, temporal lobe, and occipital areas. These results largely concur with previous findings of cortical volume deficits in schizophrenia...
  49. ncbi request reprint Abnormal white matter integrity in healthy apolipoprotein E epsilon4 carriers
    Jay Nierenberg
    Center for Advanced Brain Imaging, The Nathan S Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Neuroreport 16:1369-72. 2005
    ..Diffusion tensor imaging may be sufficiently sensitive to detect preclinical brain changes related to Alzheimer's disease...
  50. ncbi request reprint White matter abnormalities in obsessive-compulsive disorder: a diffusion tensor imaging study
    Philip R Szeszko
    Department of Psychiatry Research, The Zucker Hillside Hospital, North Shore Long Island Jewish Health System, Glen Oaks, NY 11004, USA
    Arch Gen Psychiatry 62:782-90. 2005
    ....
  51. doi request reprint Microstructural white matter abnormalities and remission of geriatric depression
    George S Alexopoulos
    Weill Cornell Institute of Geriatric Psychiatry, Weill Cornell Medical College, New York, NY, USA
    Am J Psychiatry 165:238-44. 2008
    ..The authors used diffusion tensor imaging to test the hypothesis that depressed elders who fail to achieve remission have microstructural white matter abnormalities in cortico-striato-limbic networks implicated in geriatric depression...
  52. pmc Early-stage visual processing and cortical amplification deficits in schizophrenia
    Pamela D Butler
    Nathan Kline Institute for Psychiatric Research, Orangeburg, NY 10962, USA
    Arch Gen Psychiatry 62:495-504. 2005
    ..Investigating magnocellular dysfunction in schizophrenia therefore permits evaluation of underlying etiologic hypotheses...
  53. pmc Structural neuroimaging research methods in geriatric depression
    Matthew J Hoptman
    Division of Clinical Research, Nathan Kline Institute, Orangeburg, New York 10962, USA
    Am J Geriatr Psychiatry 14:812-22. 2006
    ..The authors argue that the available methods provide complementary information and that, when combined judiciously, can increase the knowledge gained from neuroimaging findings and conceptually advance the field of geriatric depression...
  54. ncbi request reprint Functional magnetic resonance imaging of brain activity in the visual oddball task
    Babak A Ardekani
    Center for Advanced Brain Imaging, Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Brain Res Cogn Brain Res 14:347-56. 2002
    ..Activation of thalamus, insula, and the occipitotemporal cortex has been reported less consistently. The present study lends further support to the involvement of these structures in visual target detection...
  55. doi request reprint Macromolecular white matter abnormalities in geriatric depression: a magnetization transfer imaging study
    Faith M Gunning-Dixon
    Institute of Geriatric Psychiatry and the Department of Psychiatry, Weill Medical College of Cornell University, White Plains, NY, USA
    Am J Geriatr Psychiatry 16:255-62. 2008
    ..The objective of this study was to identify subtle white matter abnormalities in late-life depression...
  56. ncbi request reprint Brain structural abnormalities in psychotropic drug-naive pediatric patients with obsessive-compulsive disorder
    Philip R Szeszko
    Department of Psychiatry Research, Zucker Hilside Hospital, Glen Oaks, NY 11004, USA
    Am J Psychiatry 161:1049-56. 2004
    ..The authors investigated structural abnormalities in brain regions comprising cortical-striatal-thalamic-cortical loops in pediatric patients with obsessive-compulsive disorder (OCD)...
  57. ncbi request reprint Echo time optimization for linear combination myelin imaging
    Logi Vidarsson
    Magnetic Resonance Systems Research Laboratory, Department of Electrical Engineering, Stanford University, Stanford, California 94305 9510, USA
    Magn Reson Med 53:398-407. 2005
    ..The myelin-water fraction of the in vivo 3-echo data set is then measured by dividing the myelin image by the uniformly filtered image. Obtained myelin-water fractions compare well with previous work...

Research Grants13

  1. CSIA-Center for the Study of Impulsivity in Addiction
    Kelvin Lim; Fiscal Year: 2007
    ..RELEVANCE: The proposed center should improve our understanding of the neurobiology of inhibitory control, which will lead to new approaches for prevention and treatment for addictive disorders. ..
  2. White Matter Abnormalities in Schizophrenia
    Kelvin Lim; Fiscal Year: 2007
    ..3. Using a longitudinal design, examine WM changes in a sample of early episode patients with SZ. 4. Examine the relationship between WM abnormalities in SZ and neurocognitive function. ..
  3. White Matter Abnormalities in Schizophrenia
    Kelvin Lim; Fiscal Year: 2003
    ....
  4. Effects of Drug Induced Brain Injury on Cognition
    Kelvin Lim; Fiscal Year: 2003
    ..Our Specific Aims are to: 1 ) Determine if there are abnormalities in WM FA in cocaine dependent (CD) subjects compared with controls (NC) 2) Determine if there is a relationship between WM FA and cognitive impairment in CD subjects. ..
  5. White Matter Abnormalities in Schizophrenia
    Kelvin O Lim; Fiscal Year: 2010
    ..3. Using a longitudinal design, examine WM changes in a sample of early episode patients with SZ. 4. Examine the relationship between WM abnormalities in SZ and neurocognitive function. ..