Daniel A Lim

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells
    Daniel A Lim
    Department of Neurological Surgery, University of California, San Francisco, 505 Parnassus Street M779, San Francisco, California 94143, USA
    Nature 458:529-33. 2009
  2. pmc Safety and feasibility of switching from phenytoin to levetiracetam monotherapy for glioma-related seizure control following craniotomy: a randomized phase II pilot study
    Daniel A Lim
    Department of Neurological Surgery, University of California, San Francisco, 94143, USA
    J Neurooncol 93:349-54. 2009
  3. pmc Relationship of glioblastoma multiforme to neural stem cell regions predicts invasive and multifocal tumor phenotype
    Daniel A Lim
    Department of Neurological Surgery, University of California, San Francisco, CA 94143, USA
    Neuro Oncol 9:424-9. 2007
  4. ncbi request reprint Multiple target deep brain stimulation for multiple sclerosis related and poststroke Holmes' tremor
    Daniel A Lim
    Department of Neurosurgery, University of California, San Francisco, CA 94143, USA
    Stereotact Funct Neurosurg 85:144-9. 2007
  5. ncbi request reprint The adult neural stem cell niche: lessons for future neural cell replacement strategies
    Daniel A Lim
    Department of Neurological Surgery, University of California, San Francisco, 505 Parnassus Street, M779, Box 0112, San Francisco, CA 94143, USA
    Neurosurg Clin N Am 18:81-92, ix. 2007
  6. ncbi request reprint In vivo transcriptional profile analysis reveals RNA splicing and chromatin remodeling as prominent processes for adult neurogenesis
    Daniel A Lim
    Department of Neurological Surgery and Developmental and Stem Cell Biology Program, University of California, San Francisco, CA 94143, USA
    Mol Cell Neurosci 31:131-48. 2006
  7. pmc Integration of genome-wide approaches identifies lncRNAs of adult neural stem cells and their progeny in vivo
    Alexander D Ramos
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA
    Cell Stem Cell 12:616-28. 2013
  8. pmc Asymmetry-defective oligodendrocyte progenitors are glioma precursors
    Sista Sugiarto
    Department of Neurological Surgery, University of California San Francisco, USA
    Cancer Cell 20:328-40. 2011
  9. ncbi request reprint Novel treatment strategies for malignant gliomas using neural stem cells
    Michael C Oh
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143 0112, USA
    Neurotherapeutics 6:458-64. 2009
  10. pmc miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells
    Joachim Silber
    Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA
    BMC Med 6:14. 2008

Research Grants

Collaborators

Detail Information

Publications22

  1. pmc Chromatin remodelling factor Mll1 is essential for neurogenesis from postnatal neural stem cells
    Daniel A Lim
    Department of Neurological Surgery, University of California, San Francisco, 505 Parnassus Street M779, San Francisco, California 94143, USA
    Nature 458:529-33. 2009
    ..These data support a model in which Mll1 is required to resolve key silenced bivalent loci in postnatal neural precursors to the actively transcribed state for the induction of neurogenesis, but not for gliogenesis...
  2. pmc Safety and feasibility of switching from phenytoin to levetiracetam monotherapy for glioma-related seizure control following craniotomy: a randomized phase II pilot study
    Daniel A Lim
    Department of Neurological Surgery, University of California, San Francisco, 94143, USA
    J Neurooncol 93:349-54. 2009
    ..A large-scale, double-blinded, randomized control trial of LEV versus PHT is required to determine seizure control equivalence and better assess differences in SEs...
  3. pmc Relationship of glioblastoma multiforme to neural stem cell regions predicts invasive and multifocal tumor phenotype
    Daniel A Lim
    Department of Neurological Surgery, University of California, San Francisco, CA 94143, USA
    Neuro Oncol 9:424-9. 2007
    ..Our MRI-based classification of GBMs may further our understanding of GBM histogenesis and help predict tumor recurrence pattern...
  4. ncbi request reprint Multiple target deep brain stimulation for multiple sclerosis related and poststroke Holmes' tremor
    Daniel A Lim
    Department of Neurosurgery, University of California, San Francisco, CA 94143, USA
    Stereotact Funct Neurosurg 85:144-9. 2007
    ..Three recent case reports have suggested that simultaneous stimulation of multiple thalamic targets can result in sustained improvement in such cases...
  5. ncbi request reprint The adult neural stem cell niche: lessons for future neural cell replacement strategies
    Daniel A Lim
    Department of Neurological Surgery, University of California, San Francisco, 505 Parnassus Street, M779, Box 0112, San Francisco, CA 94143, USA
    Neurosurg Clin N Am 18:81-92, ix. 2007
    ..Lessons learned from these niches may allow one to manipulate NSCs better in culture for therapeutic transplantation and possibly even to mobilize endogenous precursors to repair diseased or injured brain...
  6. ncbi request reprint In vivo transcriptional profile analysis reveals RNA splicing and chromatin remodeling as prominent processes for adult neurogenesis
    Daniel A Lim
    Department of Neurological Surgery and Developmental and Stem Cell Biology Program, University of California, San Francisco, CA 94143, USA
    Mol Cell Neurosci 31:131-48. 2006
    ....
  7. pmc Integration of genome-wide approaches identifies lncRNAs of adult neural stem cells and their progeny in vivo
    Alexander D Ramos
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA
    Cell Stem Cell 12:616-28. 2013
    ..Our data and workflow thus provide a uniquely coherent in vivo lncRNA analysis and form the foundation of a user-friendly online resource for the study of lncRNAs in development and disease...
  8. pmc Asymmetry-defective oligodendrocyte progenitors are glioma precursors
    Sista Sugiarto
    Department of Neurological Surgery, University of California San Francisco, USA
    Cancer Cell 20:328-40. 2011
    ..Regulators of asymmetric cell division are misexpressed in low-grade oligodendrogliomas. Our results identify loss of asymmetric division associated with the neoplastic transformation of OPC...
  9. ncbi request reprint Novel treatment strategies for malignant gliomas using neural stem cells
    Michael C Oh
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, California 94143 0112, USA
    Neurotherapeutics 6:458-64. 2009
    ..These studies and others on the basic biology of both BTSCs and NSCs will be crucial to expanding our treatment strategies for malignant gliomas...
  10. pmc miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells
    Joachim Silber
    Department of Neurological Surgery, University of California San Francisco, San Francisco, CA, USA
    BMC Med 6:14. 2008
    ..In this study, we investigated the role of microRNAs in regulating the differentiation and proliferation of neural stem cells and glioblastoma-multiforme tumor cells...
  11. ncbi request reprint For the long run: maintaining germinal niches in the adult brain
    Arturo Alvarez-Buylla
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143 USA
    Neuron 41:683-6. 2004
    ..The adult neurogenic niches can be viewed as "displaced" neuroepithelium, pockets of cells and local signals that preserve enough embryonic character to maintain neurogenesis for life...
  12. pmc Normalization, bias correction, and peak calling for ChIP-seq
    Aaron Diaz
    University of California, San Francisco, USA
    Stat Appl Genet Mol Biol 11:Article 9. 2012
    ..The proposed method of determining a cell type-specific null model, which accounts for cell type-specific biases, is shown to be capable of achieving a lower false discovery rate at a given significance threshold than current methods...
  13. pmc Devices for cell transplantation into the central nervous system: Design considerations and emerging technologies
    Matthew B Potts
    Department of Neurological Surgery, University of California, San Francisco, CA, USA
    Surg Neurol Int 4:S22-30. 2013
    ..Finally, we speculate on future technological developments that may further enhance the efficacy of CNS therapeutic delivery...
  14. pmc Radially branched deployment for more efficient cell transplantation at the scale of the human brain
    Matthew T Silvestrini
    Department of Neurological Surgery, University of California San Francisco, San Francisco, CA 94143, USA
    Stereotact Funct Neurosurg 91:92-103. 2013
    ..This technical deficiency may limit the successful clinical translation of cell transplantation...
  15. pmc Neural stem cell engraftment and myelination in the human brain
    Nalin Gupta
    Department of Neurological Surgery, University of California, San Francisco, San Francisco, CA 94143, USA
    Sci Transl Med 4:155ra137. 2012
    ..These phase 1 findings indicate a favorable safety profile for HuCNS-SCs in subjects with PMD. The MRI results suggest durable cell engraftment and donor-derived myelin in the transplanted host white matter...
  16. pmc Oscillations in sensorimotor cortex in movement disorders: an electrocorticography study
    Andrea L Crowell
    Department of Psychiatry, Emory University School of Medicine, Atlanta, GA, USA
    Brain 135:615-30. 2012
    ..This is the first study of sensorimotor cortex local field potentials in the three most common movement disorders...
  17. ncbi request reprint Future directions: use of interventional MRI for cell-based therapy of Parkinson disease
    Joshua Roskom
    Department of Neurological Surgery, University of California, San Francisco, 505 Parnassus Avenue, M779, Box 0112, San Francisco, CA 94143, USA
    Neurosurg Clin N Am 20:211-8. 2009
    ....
  18. ncbi request reprint Telomerase activity in the subventricular zone of adult mice
    Gregg L Caporaso
    Molecular Neurobiology Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, NY 10016, USA
    Mol Cell Neurosci 23:693-702. 2003
    ..We conclude that telomerase is active in neural precursor cells of the adult mouse and suggest that its regulation is an important parameter for cellular proliferation to occur in the mammalian brain...
  19. ncbi request reprint Investigating the use of primary adult subventricular zone neural precursor cells for neuronal replacement therapies
    Daniel A Lim
    Department of Psychiatry, Weill Medical College of Cornell University, New York, NY 10021, USA
    Brain Res Bull 57:759-64. 2002
    ..In this review, we outline some of these hurdles and discuss recent experiments that investigate the potential of using neural precursor cells found in the subventricular zone of the adult brain for brain repair...
  20. ncbi request reprint Multipotent neural stem cells reside into the rostral extension and olfactory bulb of adult rodents
    Angela Gritti
    Institute for Stem Cell Research, Department of Biotechnology, San Raffaele Hospital, 20132 Milan, Italy
    J Neurosci 22:437-45. 2002
    ..These findings demonstrate that stem cells are not confined to the forebrain periventricular region and indicate that stem cells endowed with different functional characteristics occur at different levels of the SVZ-RE pathway...
  21. pmc Sonic hedgehog controls stem cell behavior in the postnatal and adult brain
    Veronica Palma
    The Skirball Institute, NYU School of Medicine, 540 First Avenue, New York, NY 10016, USA
    Development 132:335-44. 2005
    ....

Research Grants1

  1. Chromatin-based cellular memory in neural stem cells
    Daniel Lim; Fiscal Year: 2009
    ..Furthermore, our studies may lead to discoveries of how derangements in chromatin remodeling can lead to the development of brain tumors. ..