J Timothy Lightfoot

Summary

Affiliation: University of North Carolina at Charlotte
Country: USA

Publications

  1. pmc Quantitative trait loci for physical activity traits in mice
    J Timothy Lightfoot
    Department of Kinesiology, University of North Carolina, Charlotte, NC 28223, USA
    Physiol Genomics 32:401-8. 2008
  2. pmc Repeatability of exercise behaviors in mice
    Amy M Knab
    Department of Kinesiology, University of North Carolina, Charlotte, United States
    Physiol Behav 98:433-40. 2009
  3. pmc Genetic variation for body weight change in mice in response to physical exercise
    Larry J Leamy
    Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA
    BMC Genet 10:58. 2009
  4. pmc Strain screen and haplotype association mapping of wheel running in inbred mouse strains
    J Timothy Lightfoot
    Department of Kinesiology, University of North Carolina, Charlotte, NC, USA
    J Appl Physiol 109:623-34. 2010
  5. ncbi request reprint Quantitative trait loci associated with maximal exercise endurance in mice
    J Timothy Lightfoot
    Department of Kinesiology, University of North Carolina Charlotte, Charlotte, North Carolina 28223, USA
    J Appl Physiol 103:105-10. 2007
  6. pmc A search for quantitative trait loci controlling within-individual variation of physical activity traits in mice
    Larry J Leamy
    Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA
    BMC Genet 11:83. 2010
  7. pmc An epistatic genetic basis for physical activity traits in mice
    Larry J Leamy
    Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
    J Hered 99:639-46. 2008
  8. pmc Does the difference between physically active and couch potato lie in the dopamine system?
    Amy M Knab
    Department of Kinesiology, University of North Carolina, Charlotte, NC, USA
    Int J Biol Sci 6:133-50. 2010
  9. pmc Genetic variation in the pleiotropic association between physical activity and body weight in mice
    Larry J Leamy
    Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA
    Genet Sel Evol 41:41. 2009
  10. pmc Sex hormone effects on physical activity levels: why doesn't Jane run as much as Dick?
    Robert S Bowen
    Department of Kinesiology, University of North Carolina Charlotte, USA
    Sports Med 41:73-86. 2011

Detail Information

Publications19

  1. pmc Quantitative trait loci for physical activity traits in mice
    J Timothy Lightfoot
    Department of Kinesiology, University of North Carolina, Charlotte, NC 28223, USA
    Physiol Genomics 32:401-8. 2008
    ..1, DIST13.1, SPD13.1, and SPD9.1 were subsequently replicated by haplotype association mapping. The results of this study suggest a genetic basis of voluntary activity in mice and provide a foundation for future candidate gene studies...
  2. pmc Repeatability of exercise behaviors in mice
    Amy M Knab
    Department of Kinesiology, University of North Carolina, Charlotte, United States
    Physiol Behav 98:433-40. 2009
    ..This study assessed the repeatability of a commonly used maximal exercise endurance treadmill test as well as voluntary physical activity measured by wheel running in mice...
  3. pmc Genetic variation for body weight change in mice in response to physical exercise
    Larry J Leamy
    Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA
    BMC Genet 10:58. 2009
    ....
  4. pmc Strain screen and haplotype association mapping of wheel running in inbred mouse strains
    J Timothy Lightfoot
    Department of Kinesiology, University of North Carolina, Charlotte, NC, USA
    J Appl Physiol 109:623-34. 2010
    ..Additionally, results suggest that potential genetic mechanisms arising from traditional noncoding regions of the genome may be involved in regulation of physical activity...
  5. ncbi request reprint Quantitative trait loci associated with maximal exercise endurance in mice
    J Timothy Lightfoot
    Department of Kinesiology, University of North Carolina Charlotte, Charlotte, North Carolina 28223, USA
    J Appl Physiol 103:105-10. 2007
    ....
  6. pmc A search for quantitative trait loci controlling within-individual variation of physical activity traits in mice
    Larry J Leamy
    Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA
    BMC Genet 11:83. 2010
    ....
  7. pmc An epistatic genetic basis for physical activity traits in mice
    Larry J Leamy
    Department of Biology, University of North Carolina at Charlotte, Charlotte, NC 28223, USA
    J Hered 99:639-46. 2008
    ....
  8. pmc Does the difference between physically active and couch potato lie in the dopamine system?
    Amy M Knab
    Department of Kinesiology, University of North Carolina, Charlotte, NC, USA
    Int J Biol Sci 6:133-50. 2010
    ..Future research in this area will aid in developing personalized strategies to prevent inactivity related diseases...
  9. pmc Genetic variation in the pleiotropic association between physical activity and body weight in mice
    Larry J Leamy
    Department of Biology, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, USA
    Genet Sel Evol 41:41. 2009
    ....
  10. pmc Sex hormone effects on physical activity levels: why doesn't Jane run as much as Dick?
    Robert S Bowen
    Department of Kinesiology, University of North Carolina Charlotte, USA
    Sports Med 41:73-86. 2011
    ..Future research in this unique sub-field of endocrinology and exercise science utilizing more appropriate research protocols and effective techniques will provide definitive evidence of such mechanisms...
  11. ncbi request reprint Genetic influence on daily wheel running activity level
    J Timothy Lightfoot
    Department of Kinesiology, University of North Carolina Charlotte, Charlotte 28223, USA
    Physiol Genomics 19:270-6. 2004
    ..In conclusion, these data indicate that daily running wheel activity level in mice is significantly affected by genetic background and sex...
  12. ncbi request reprint Influence of genetic background on daily running-wheel activity differs with aging
    Michael J Turner
    Department of Kinesiology, University of North Carolina Charlotte, Charlotte 28223, USA
    Physiol Genomics 22:76-85. 2005
    ..Furthermore, the broad-sense heritability estimates for daily running-wheel distance differed across time and suggested an interaction between genetic background and age on physical activity in these inbred mice...
  13. pmc Altered dopaminergic profiles: implications for the regulation of voluntary physical activity
    Amy M Knab
    Department of Kinesiology, University of North Carolina, Charlotte, NC, USA
    Behav Brain Res 204:147-52. 2009
    ....
  14. doi request reprint Epistatic interactions of genes influence within-individual variation of physical activity traits in mice
    Larry J Leamy
    Department of Biology, University of North Carolina, Charlotte, NC 28223, USA
    Genetica 139:813-21. 2011
    ..It was concluded that epistasis is more important than single-locus effects of genes on activity traits at specific ages and it is therefore an essential component of the genetic architecture of physical activity...
  15. ncbi request reprint Influence of age of exposure to a running wheel on activity in inbred mice
    Alan P Jung
    Exercise Genomics Laboratory, Department of Kinesiology, University of North Carolina at Charlotte, Charlotte, NC, USA
    Med Sci Sports Exerc 38:51-6. 2006
    ..The purpose of this study was to determine whether the age at which a running wheel was introduced affected running wheel activity for a subsequent 15-wk period...
  16. pmc Sex hormones' regulation of rodent physical activity: a review
    J Timothy Lightfoot
    Dept of Kinesiology, University of North Carolina Charlotte, Charlotte, NC 28223, USA
    Int J Biol Sci 4:126-32. 2008
    ..This review lays the foundation for future investigations in humans as well as discussions about relative disease risk mediated by differential biological regulation of physical activity by sex...
  17. doi request reprint Driven to be inactive? The genetics of physical activity
    Trudy Moore-Harrison
    Department of Kinesiology, University of North Carolina at Charlotte, North Carolina, USA
    Prog Mol Biol Transl Sci 94:271-90. 2010
    ..The application of this knowledge could significantly augment the information available for physical activity behavior change interventions resulting in more efficient programs for those predisposed to be inactive...
  18. doi request reprint Heart rate and core temperature responses of elite pit crews during automobile races
    David P Ferguson
    Department of Kinesiology, University of North Carolina Charlotte, Charlotte, North Carolina, USA
    J Strength Cond Res 25:2075-83. 2011
    ..Additionally, it is possible that psychological stress unique to several of the tracks provided an additive effect resulting in increased heart rates...
  19. ncbi request reprint Experimentally evolving exercise endurance: one step at a time
    J Timothy Lightfoot
    J Appl Physiol 101:1277-8. 2006