Kathleen C Light

Summary

Affiliation: University of North Carolina
Country: USA

Publications

  1. ncbi request reprint Effects of partner support on resting oxytocin, cortisol, norepinephrine, and blood pressure before and after warm partner contact
    Karen M Grewen
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Psychosom Med 67:531-8. 2005
  2. ncbi request reprint African Americans show alterations in endogenous pain regulatory mechanisms and reduced pain tolerance to experimental pain procedures
    M Beth Mechlin
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7175, USA
    Psychosom Med 67:948-56. 2005
  3. ncbi request reprint Orthostatic hypotension predicts mortality in middle-aged adults: the Atherosclerosis Risk In Communities (ARIC) Study
    Kathryn M Rose
    Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Circulation 114:630-6. 2006
  4. ncbi request reprint More frequent partner hugs and higher oxytocin levels are linked to lower blood pressure and heart rate in premenopausal women
    Kathleen C Light
    Department of Psychiatry, University of North Carolina, CB 7175 Medical Building A, Chapel Hill, NC 27599 7175, USA
    Biol Psychol 69:5-21. 2005
  5. pmc Deficits in plasma oxytocin responses and increased negative affect, stress, and blood pressure in mothers with cocaine exposure during pregnancy
    Kathleen C Light
    Department of Psychiatry, School of Medicine, University of North Carolina, CB 7175 Medical Building A, Chapel Hill 27599 7175, USA
    Addict Behav 29:1541-64. 2004
  6. ncbi request reprint Dietary sodium restriction alters postprandial ghrelin: implications for race differences in obesity
    Kimberly A Brownley
    Department of Psychiatry, University of North Carolina at Chapel Hill 27599 7175, USA
    Ethn Dis 16:844-51. 2006
  7. ncbi request reprint Relationship quality: effects on ambulatory blood pressure and negative affect in a biracial sample of men and women
    Karen M Grewen
    Department of Psychiatry, School of Medicine, University of North Carolina at Chapel Hill, North Carolina 27599 7175, USA
    Blood Press Monit 10:117-24. 2005
  8. ncbi request reprint Histories of sexual abuse are associated with differential effects of clonidine on autonomic function in women with premenstrual dysphoric disorder
    Robertas Bunevicius
    Department of Psychiatry, University of North Carolina at Chapel Hill, CB 7175, Medical Research Bldg A, Chapel Hill, NC 27599 7175, USA
    Biol Psychol 69:281-96. 2005
  9. ncbi request reprint Oxytocinergic activity is linked to lower blood pressure and vascular resistance during stress in postmenopausal women on estrogen replacement
    Kathleen C Light
    School of Medicine, University of North Carolina at Chapel Hill, NC 27599 7175, USA
    Horm Behav 47:540-8. 2005
  10. ncbi request reprint Cigarette smoking, stress-induced analgesia and pain perception in men and women
    Susan S Girdler
    Department of Psychiatry, University of North Carolina at Chapel Hill, CB 7175, Medical Research Bldg A, Chapel Hill, NC 27599 7175, USA
    Pain 114:372-85. 2005

Detail Information

Publications36

  1. ncbi request reprint Effects of partner support on resting oxytocin, cortisol, norepinephrine, and blood pressure before and after warm partner contact
    Karen M Grewen
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Psychosom Med 67:531-8. 2005
    ....
  2. ncbi request reprint African Americans show alterations in endogenous pain regulatory mechanisms and reduced pain tolerance to experimental pain procedures
    M Beth Mechlin
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7175, USA
    Psychosom Med 67:948-56. 2005
    ..To examine ethnic differences in pain sensitivity and relationship of pain tolerance to blood pressure and neuroendocrine factors...
  3. ncbi request reprint Orthostatic hypotension predicts mortality in middle-aged adults: the Atherosclerosis Risk In Communities (ARIC) Study
    Kathryn M Rose
    Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
    Circulation 114:630-6. 2006
    ..An association between orthostatic hypotension (OH) and mortality has been reported, but studies are limited to older adults or high-risk populations...
  4. ncbi request reprint More frequent partner hugs and higher oxytocin levels are linked to lower blood pressure and heart rate in premenopausal women
    Kathleen C Light
    Department of Psychiatry, University of North Carolina, CB 7175 Medical Building A, Chapel Hill, NC 27599 7175, USA
    Biol Psychol 69:5-21. 2005
    ....
  5. pmc Deficits in plasma oxytocin responses and increased negative affect, stress, and blood pressure in mothers with cocaine exposure during pregnancy
    Kathleen C Light
    Department of Psychiatry, School of Medicine, University of North Carolina, CB 7175 Medical Building A, Chapel Hill 27599 7175, USA
    Addict Behav 29:1541-64. 2004
    ..Although they tended to hold their babies less often at home, baby holding in the laboratory led to decreased BP in cocaine mothers who then did not differ from no-drug mothers in BP or observed affect...
  6. ncbi request reprint Dietary sodium restriction alters postprandial ghrelin: implications for race differences in obesity
    Kimberly A Brownley
    Department of Psychiatry, University of North Carolina at Chapel Hill 27599 7175, USA
    Ethn Dis 16:844-51. 2006
    ..To examine the effect of sodium restriction on the appetite-stimulating hormone, ghrelin, as a function of race, salt sensitivity, and obesity...
  7. ncbi request reprint Relationship quality: effects on ambulatory blood pressure and negative affect in a biracial sample of men and women
    Karen M Grewen
    Department of Psychiatry, School of Medicine, University of North Carolina at Chapel Hill, North Carolina 27599 7175, USA
    Blood Press Monit 10:117-24. 2005
    ..Prospective studies link marriage to better cardiovascular health, but marital dissatisfaction and discord predict increased rates of hypertension, higher blood pressure (BP), greater reactivity to stress, and left ventricular mass...
  8. ncbi request reprint Histories of sexual abuse are associated with differential effects of clonidine on autonomic function in women with premenstrual dysphoric disorder
    Robertas Bunevicius
    Department of Psychiatry, University of North Carolina at Chapel Hill, CB 7175, Medical Research Bldg A, Chapel Hill, NC 27599 7175, USA
    Biol Psychol 69:281-96. 2005
    ....
  9. ncbi request reprint Oxytocinergic activity is linked to lower blood pressure and vascular resistance during stress in postmenopausal women on estrogen replacement
    Kathleen C Light
    School of Medicine, University of North Carolina at Chapel Hill, NC 27599 7175, USA
    Horm Behav 47:540-8. 2005
    ..The findings suggest that enhanced oxytocinergic activity may contribute to BP decreases associated with ERT in more responsive postmenopausal women...
  10. ncbi request reprint Cigarette smoking, stress-induced analgesia and pain perception in men and women
    Susan S Girdler
    Department of Psychiatry, University of North Carolina at Chapel Hill, CB 7175, Medical Research Bldg A, Chapel Hill, NC 27599 7175, USA
    Pain 114:372-85. 2005
    ..The reduced pain perception in smokers and absence of relationships between endogenous pain regulatory mechanisms and pain sensitivity may reflect a maladaptive response to chronic smoking...
  11. ncbi request reprint Associations of histories of depression and PMDD diagnosis with allopregnanolone concentrations following the oral administration of micronized progesterone
    Rebecca R Klatzkin
    Department of Psychology, University of North Carolina at Chapel Hill, CB 7175, Medical Research Bldg A, Chapel Hill, NC 27599 7175, USA
    Psychoneuroendocrinology 31:1208-19. 2006
    ....
  12. ncbi request reprint Historical sexual abuse and current thyroid axis profiles in women with premenstrual dysphoric disorder
    Susan S Girdler
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7175, USA
    Psychosom Med 66:403-10. 2004
    ....
  13. ncbi request reprint Warm partner contact is related to lower cardiovascular reactivity
    Karen M Grewen
    Department of Psychiatry, University of North Carolina at Chapel Hill, 27599 7175, USA
    Behav Med 29:123-30. 2003
    ..These findings suggest that affectionate relationships with a supportive partner may contribute to lower reactivity to stressful life events and may partially mediate the benefit of marital support on better cardiovascular health...
  14. ncbi request reprint Ethnic differences in allopregnanolone concentrations in women during rest and following mental stress
    Susan S Girdler
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7175, USA
    Psychophysiology 43:331-6. 2006
    ..05). Results are interpreted to reflect dysregulation in ALLO mechanisms in AA women and may have implications for ethnic differences in mood disorders...
  15. doi request reprint Ethnicity is associated with alterations in oxytocin relationships to pain sensitivity in women
    Karen M Grewen
    Psychiatry, School of Medicine, University of North Carolina at Chapel Hill, USA
    Ethn Health 13:219-41. 2008
    ....
  16. ncbi request reprint Temporomandibular disorder and optimism: relationships to ischemic pain sensitivity and interleukin-6
    Nancy L Costello
    Dental Research Center, School of Dentistry, Medical Research Building A, University of North Carolina, CB 7175, Chapel Hill, NC 27599 7455, USA
    Pain 100:99-110. 2002
    ..Less optimistic TMD patients also had higher NE and IL-6 levels during stress than other TMD patients, while optimism was unrelated to responses in controls (*P<0.05)...
  17. ncbi request reprint Sympathoadrenergic mechanisms in reduced hemodynamic stress responses after exercise
    Kimberly A Brownley
    Department of Psychiatry, University of North Carolina, Chapel Hill 27599, USA
    Med Sci Sports Exerc 35:978-86. 2003
    ..This study examines the acute effects of moderate aerobic exercise on 1) hemodynamic and sympathetic activity during behavioral stress and 2) beta-adrenergic receptor responsivity in a biracial sample of 24 sedentary adults...
  18. ncbi request reprint Biological correlates of abuse in women with premenstrual dysphoric disorder and healthy controls
    Susan S Girdler
    Department of Psychiatry, University of North Carolina at Chapel Hill, North Carolina 27599 7175, USA
    Psychosom Med 65:849-56. 2003
    ..To examine the biological correlates associated with histories of sexual or physical abuse in women meeting DSM criteria for premenstrual dysphoric disorder (PMDD) and in healthy, non-PMDD controls...
  19. pmc Persistent alterations in biological profiles in women with abuse histories: influence of premenstrual dysphoric disorder
    Susan S Girdler
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
    Health Psychol 26:201-13. 2007
    ..To examine dysregulation in biological measures associated with histories of abuse in women and whether women with premenstrual dysphoric disorder (PMDD) differ in their dysregulation...
  20. ncbi request reprint Postprandial ghrelin is elevated in black compared with white women
    Kimberly A Brownley
    Department of Psychiatry, CB 7175, University of North Carolina, Chapel Hill, North Carolina 27599 7175, USA
    J Clin Endocrinol Metab 89:4457-63. 2004
    ..These findings suggest subnormal postprandial ghrelin suppression (or faster ghrelin rebound) in black women, especially the obese, that might play a role in their increased prevalence of obesity and cardiovascular disorders...
  21. ncbi request reprint Depressive symptoms are related to higher ambulatory blood pressure in people with a family history of hypertension
    Karen M Grewen
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7175, USA
    Psychosom Med 66:9-16. 2004
    ..We investigated whether parental history of hypertension (FH+) enhances the impact of depressed mood, indexed by Beck Depression Inventory (BDI), on ambulatory blood pressure (ABP)...
  22. ncbi request reprint Cardiovascular effects of 6 months of hormone replacement therapy versus placebo: differences associated with years since menopause
    Kimberly A Brownley
    Department of Psychiatry, University of North Carolina, Chapel Hill, 27599 7175, USA
    Am J Obstet Gynecol 190:1052-8. 2004
    ....
  23. doi request reprint Central processing of noxious somatic stimuli in patients with irritable bowel syndrome compared with healthy controls
    Steve Heymen
    Department of Medicine, Division of Gastroenterology, UNC Center for Functional Gastroenterology and Motility Disorders, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7080, USA
    Clin J Pain 26:104-9. 2010
    ..To compare a central analgesic mechanism known as diffuse noxious inhibitory controls (DNIC) using somatic test stimuli and somatic conditioning stimuli, (CS) in irritable bowel syndrome (IBS) patients and healthy controls...
  24. ncbi request reprint Histories of depression, allopregnanolone responses to stress, and premenstrual symptoms in women
    Rebecca R Klatzkin
    Department of Psychology, University of North Carolina at Chapel Hill, CB 7175, Medical Research Bldg A, Chapel Hill, NC 27599 7175, USA
    Biol Psychol 71:2-11. 2006
    ....
  25. ncbi request reprint Bupropion and paroxetine differentially influence cardiovascular and neuroendocrine responses to stress in depressed patients
    Patricia A Straneva-Meuse
    University of North Carolina at Chapel Hill, CB 7175, Medical Research Building A, Chapel Hill, NC 27599 7175, USA
    J Affect Disord 79:51-61. 2004
    ..There exists a need to identify safe and effective treatments for depression in patients with coronary heart disease (CHD)...
  26. pmc Plasma oxytocin is related to lower cardiovascular and sympathetic reactivity to stress
    Karen M Grewen
    University of North Carolina School of Medicine, Department of Psychiatry, CB 7175, Chapel Hill, NC 27599 7175, USA
    Biol Psychol 87:340-9. 2011
    ..These data support a cardioprotective role for OT, which may influence the magnitude and hemodynamic determinants of cardiovascular stress responses...
  27. ncbi request reprint Lack of beneficial effects of clonidine in the treatment of premenstrual dysphoric disorder: results of a double-blind, randomized study
    Robertas Bunevicius
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
    Hum Psychopharmacol 20:33-9. 2005
    ..To test the effects of clonidine in comparison with active placebo on premenstrual symptoms, mood scores and norepinephrine (NE) concentration, in women with premenstrual dysphoric disorder (PMDD)...
  28. pmc Associations of abdominal fat with perceived racism and passive emotional responses to racism in African American women
    Anissa I Vines
    Department of Epidemiology, University of North Carolina, Chapel Hill, Chapel Hill, NC 27516, USA
    Am J Public Health 97:526-30. 2007
    ..Passive emotional responses to perceived racism, hypothesized to have particularly adverse effects, were also examined...
  29. pmc Social correlates of the chronic stress of perceived racism among Black women
    Anissa I Vines
    Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, USA
    Ethn Dis 16:101-7. 2006
    ..This study describes the perceptions of racism, passive and active responses to this psychosocial stressor, and it examines socioeconomic correlates of perceived racism in an economically diverse population of Black women...
  30. ncbi request reprint Menstrual cycle, beta-endorphins, and pain sensitivity in premenstrual dysphoric disorder
    Patricia A Straneva
    Department of Psychology, University of North Carolina at Chapel Hill, 27599 7175, USA
    Health Psychol 21:358-67. 2002
    ..Results suggest that endogenous opioids may be pathophysiologically relevant to PMDD and that the hypothalamic-pituitary-gonadal axis may modulate pain sensitivity in PMDD...
  31. ncbi request reprint Transdermal versus oral estrogen therapy in postmenopausal smokers: hemodynamic and endothelial effects
    Susan S Girdler
    Departments of Psychiatry, University of North Carolina at Chapel Hill, North Carolina 27599 7175, USA
    Obstet Gynecol 103:169-80. 2004
    ....
  32. pmc An investigation of plasma and salivary oxytocin responses in breast- and formula-feeding mothers of infants
    Karen M Grewen
    Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7175, USA
    Psychophysiology 47:625-32. 2010
    ..59, p=.022) and Post-Stress Recovery (r=+.59, p=.025). These data suggest that salivary OT assay is feasible, and will be of value where plasma samples are not possible. Validation with larger samples is needed...
  33. ncbi request reprint Group differences in pain modulation: pain-free women compared to pain-free men and to women with TMD
    Edith E Bragdon
    Dental Research Center, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599 7175, USA
    Pain 96:227-37. 2002
    ..Female TMDs appear unable to effectively engage normal pain-inhibitory systems; opioid receptor desensitization and/or downregulation are probably implicated, because TMDs' production of E appears normal...
  34. ncbi request reprint Changes in hemodynamics and left ventricular structure after menopause
    Alan L Hinderliter
    University of North Carolina, Chapel Hill, North Carolina 27599 7075, USA
    Am J Cardiol 89:830-3. 2002
    ..These results suggest that menopause is associated with hemodynamic changes and left ventricular remodeling, which may contribute to the enhanced cardiovascular risk observed in postmenopausal women...
  35. ncbi request reprint Patterns of salivary cortisol secretion in pregnancy and implications for assessment protocols
    Emily W Harville
    Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7435, USA
    Biol Psychol 74:85-91. 2007
    ..82 to 0.88). Standardizing the clinic measurement to a single time of day did not substantially improve correlations with mean AUC. Correlations with measures of reported stress were also not strong...
  36. ncbi request reprint Hostility, conflict and cardiovascular responses in married couples: a focus on the dyad
    Sherry D Broadwell
    Prevention Research Branch, Centers for Disease Control, Atlanta, Georgia, USA
    Int J Behav Med 12:142-52. 2005
    ..Findings suggest that CV responses before, during, and after marital discussions, particularly those characterized by conflict, may be influenced not only by one's own hostility but by the hostility of one's partner as well...