Research Topics
Species | Kathleen C LightSummaryAffiliation: University of North Carolina Country: USA Publications
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Detail Information
Publications
Effects of partner support on resting oxytocin, cortisol, norepinephrine, and blood pressure before and after warm partner contactKaren M Grewen
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Psychosom Med 67:531-8. 2005....- African Americans show alterations in endogenous pain regulatory mechanisms and reduced pain tolerance to experimental pain proceduresM Beth Mechlin
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7175, USA
Psychosom Med 67:948-56. 2005..Such dysregulation may contribute to the greater rate of clinical pain symptoms they experience. It is hypothesized that greater chronic stress in African Americans may be a contributing factor to the alterations in pain regulation... - Orthostatic hypotension predicts mortality in middle-aged adults: the Atherosclerosis Risk In Communities (ARIC) StudyKathryn M Rose
Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA
Circulation 114:630-6. 2006..An association between orthostatic hypotension (OH) and mortality has been reported, but studies are limited to older adults or high-risk populations... - More frequent partner hugs and higher oxytocin levels are linked to lower blood pressure and heart rate in premenopausal womenKathleen C Light
Department of Psychiatry, University of North Carolina, CB 7175 Medical Building A, Chapel Hill, NC 27599 7175, USA
Biol Psychol 69:5-21. 2005.... 
Deficits in plasma oxytocin responses and increased negative affect, stress, and blood pressure in mothers with cocaine exposure during pregnancyKathleen C Light
Department of Psychiatry, School of Medicine, University of North Carolina, CB 7175 Medical Building A, Chapel Hill 27599 7175, USA
Addict Behav 29:1541-64. 2004..Although they tended to hold their babies less often at home, baby holding in the laboratory led to decreased BP in cocaine mothers who then did not differ from no-drug mothers in BP or observed affect...- Dietary sodium restriction alters postprandial ghrelin: implications for race differences in obesityKimberly A Brownley
Department of Psychiatry, University of North Carolina at Chapel Hill 27599 7175, USA
Ethn Dis 16:844-51. 2006..To examine the effect of sodium restriction on the appetite-stimulating hormone, ghrelin, as a function of race, salt sensitivity, and obesity... - Relationship quality: effects on ambulatory blood pressure and negative affect in a biracial sample of men and womenKaren M Grewen
Department of Psychiatry, School of Medicine, University of North Carolina at Chapel Hill, North Carolina 27599 7175, USA
Blood Press Monit 10:117-24. 2005..Prospective studies link marriage to better cardiovascular health, but marital dissatisfaction and discord predict increased rates of hypertension, higher blood pressure (BP), greater reactivity to stress, and left ventricular mass... - Histories of sexual abuse are associated with differential effects of clonidine on autonomic function in women with premenstrual dysphoric disorderRobertas Bunevicius
Department of Psychiatry, University of North Carolina at Chapel Hill, CB# 7175, Medical Research Bldg A, Chapel Hill, NC 27599-7175, USA
Biol Psychol 69:281-96. 2005.... - Oxytocinergic activity is linked to lower blood pressure and vascular resistance during stress in postmenopausal women on estrogen replacementKathleen C Light
School of Medicine, University of North Carolina at Chapel Hill, NC 27599 7175, USA
Horm Behav 47:540-8. 2005..The findings suggest that enhanced oxytocinergic activity may contribute to BP decreases associated with ERT in more responsive postmenopausal women... - Cigarette smoking, stress-induced analgesia and pain perception in men and womenSusan S Girdler
Department of Psychiatry, University of North Carolina at Chapel Hill, CB 7175, Medical Research Bldg A, Chapel Hill, NC 27599 7175, USA
Pain 114:372-85. 2005..The reduced pain perception in smokers and absence of relationships between endogenous pain regulatory mechanisms and pain sensitivity may reflect a maladaptive response to chronic smoking... - Associations of histories of depression and PMDD diagnosis with allopregnanolone concentrations following the oral administration of micronized progesteroneRebecca R Klatzkin
Department of Psychology, University of North Carolina at Chapel Hill, CB #7175, Medical Research Bldg A, Chapel Hill, NC 27599-7175, USA
Psychoneuroendocrinology 31:1208-19. 2006.... - Historical sexual abuse and current thyroid axis profiles in women with premenstrual dysphoric disorderSusan S Girdler
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7175, USA
Psychosom Med 66:403-10. 2004.... - Warm partner contact is related to lower cardiovascular reactivityKaren M Grewen
Department of Psychiatry, University of North Carolina at Chapel Hill, 27599 7175, USA
Behav Med 29:123-30. 2003..These findings suggest that affectionate relationships with a supportive partner may contribute to lower reactivity to stressful life events and may partially mediate the benefit of marital support on better cardiovascular health... - Ethnic differences in allopregnanolone concentrations in women during rest and following mental stressSusan S Girdler
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7175, USA
Psychophysiology 43:331-6. 2006..05). Results are interpreted to reflect dysregulation in ALLO mechanisms in AA women and may have implications for ethnic differences in mood disorders... 
Ethnicity is associated with alterations in oxytocin relationships to pain sensitivity in womenKaren M Grewen
Psychiatry, School of Medicine, University of North Carolina at Chapel Hill, USA
Ethn Health 13:219-41. 2008....- Temporomandibular disorder and optimism: relationships to ischemic pain sensitivity and interleukin-6Nancy L Costello
Dental Research Center, School of Dentistry, Medical Research Building A, University of North Carolina, CB #7175, Chapel Hill, NC 27599-7455, USA
Pain 100:99-110. 2002..Less optimistic TMD patients also had higher NE and IL-6 levels during stress than other TMD patients, while optimism was unrelated to responses in controls (*P<0.05)... - Sympathoadrenergic mechanisms in reduced hemodynamic stress responses after exerciseKimberly A Brownley
Department of Psychiatry, University of North Carolina, Chapel Hill 27599, USA
Med Sci Sports Exerc 35:978-86. 2003..This study examines the acute effects of moderate aerobic exercise on 1) hemodynamic and sympathetic activity during behavioral stress and 2) beta-adrenergic receptor responsivity in a biracial sample of 24 sedentary adults... - Biological correlates of abuse in women with premenstrual dysphoric disorder and healthy controlsSusan S Girdler
Department of Psychiatry, University of North Carolina at Chapel Hill, North Carolina 27599 7175, USA
Psychosom Med 65:849-56. 2003..To examine the biological correlates associated with histories of sexual or physical abuse in women meeting DSM criteria for premenstrual dysphoric disorder (PMDD) and in healthy, non-PMDD controls... - Persistent alterations in biological profiles in women with abuse histories: influence of premenstrual dysphoric disorderSusan S Girdler
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Health Psychol 26:201-13. 2007..To examine dysregulation in biological measures associated with histories of abuse in women and whether women with premenstrual dysphoric disorder (PMDD) differ in their dysregulation... - Postprandial ghrelin is elevated in black compared with white womenKimberly A Brownley
Department of Psychiatry, CB 7175, University of North Carolina, Chapel Hill, North Carolina 27599 7175, USA
J Clin Endocrinol Metab 89:4457-63. 2004..These findings suggest subnormal postprandial ghrelin suppression (or faster ghrelin rebound) in black women, especially the obese, that might play a role in their increased prevalence of obesity and cardiovascular disorders... - Depressive symptoms are related to higher ambulatory blood pressure in people with a family history of hypertensionKaren M Grewen
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7175, USA
Psychosom Med 66:9-16. 2004..We investigated whether parental history of hypertension (FH+) enhances the impact of depressed mood, indexed by Beck Depression Inventory (BDI), on ambulatory blood pressure (ABP)... - Cardiovascular effects of 6 months of hormone replacement therapy versus placebo: differences associated with years since menopauseKimberly A Brownley
Department of Psychiatry, University of North Carolina, Chapel Hill, 27599 7175, USA
Am J Obstet Gynecol 190:1052-8. 2004.... - Central processing of noxious somatic stimuli in patients with irritable bowel syndrome compared with healthy controlsSteve Heymen
Department of Medicine, Division of Gastroenterology, UNC Center for Functional Gastroenterology and Motility Disorders, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7080, USA
Clin J Pain 26:104-9. 2010..To compare a central analgesic mechanism known as diffuse noxious inhibitory controls (DNIC) using somatic test stimuli and somatic conditioning stimuli, (CS) in irritable bowel syndrome (IBS) patients and healthy controls... - Histories of depression, allopregnanolone responses to stress, and premenstrual symptoms in womenRebecca R Klatzkin
Department of Psychology, University of North Carolina at Chapel Hill, CB #7175, Medical Research Bldg A, Chapel Hill, NC 27599-7175, USA
Biol Psychol 71:2-11. 2006.... - Bupropion and paroxetine differentially influence cardiovascular and neuroendocrine responses to stress in depressed patientsPatricia A Straneva-Meuse
University of North Carolina at Chapel Hill, CB #7175, Medical Research Building A, Chapel Hill, NC 27599-7175, USA
J Affect Disord 79:51-61. 2004..The results of this study may have implications for the pharmacological treatment of depression in CHD patients... - Plasma oxytocin is related to lower cardiovascular and sympathetic reactivity to stressKaren M Grewen
University of North Carolina School of Medicine, Department of Psychiatry, CB 7175, Chapel Hill, NC 27599 7175, USA
Biol Psychol 87:340-9. 2011..These data support a cardioprotective role for OT, which may influence the magnitude and hemodynamic determinants of cardiovascular stress responses... - Lack of beneficial effects of clonidine in the treatment of premenstrual dysphoric disorder: results of a double-blind, randomized studyRobertas Bunevicius
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
Hum Psychopharmacol 20:33-9. 2005..CONCLUSION: Compared with an active placebo clonidine demonstrated no beneficial changes in mood and premenstrual symptoms in women with PMDD... - Associations of abdominal fat with perceived racism and passive emotional responses to racism in African American womenAnissa I Vines
Department of Epidemiology, University of North Carolina, Chapel Hill, Chapel Hill, NC 27516, USA
Am J Public Health 97:526-30. 2007..Passive emotional responses to perceived racism, hypothesized to have particularly adverse effects, were also examined... - Social correlates of the chronic stress of perceived racism among Black womenAnissa I Vines
Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, USA
Ethn Dis 16:101-7. 2006..This study describes the perceptions of racism, passive and active responses to this psychosocial stressor, and it examines socioeconomic correlates of perceived racism in an economically diverse population of Black women... - Menstrual cycle, beta-endorphins, and pain sensitivity in premenstrual dysphoric disorderPatricia A Straneva
Department of Psychology, University of North Carolina at Chapel Hill, 27599 7175, USA
Health Psychol 21:358-67. 2002..Results suggest that endogenous opioids may be pathophysiologically relevant to PMDD and that the hypothalamic-pituitary-gonadal axis may modulate pain sensitivity in PMDD... - Transdermal versus oral estrogen therapy in postmenopausal smokers: hemodynamic and endothelial effectsSusan S Girdler
Departments of Psychiatry, University of North Carolina at Chapel Hill, North Carolina 27599 7175, USA
Obstet Gynecol 103:169-80. 2004.... - An investigation of plasma and salivary oxytocin responses in breast- and formula-feeding mothers of infantsKaren M Grewen
Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599 7175, USA
Psychophysiology 47:625-32. 2010..59, p=.022) and Post-Stress Recovery (r=+.59, p=.025). These data suggest that salivary OT assay is feasible, and will be of value where plasma samples are not possible. Validation with larger samples is needed... - Group differences in pain modulation: pain-free women compared to pain-free men and to women with TMDEdith E Bragdon
Dental Research Center, School of Dentistry, University of North Carolina, Chapel Hill, NC 27599-7175, USA
Pain 96:227-37. 2002..Female TMDs appear unable to effectively engage normal pain-inhibitory systems; opioid receptor desensitization and/or downregulation are probably implicated, because TMDs' production of E appears normal... - Changes in hemodynamics and left ventricular structure after menopauseAlan L Hinderliter
University of North Carolina, Chapel Hill, North Carolina 27599 7075, USA
Am J Cardiol 89:830-3. 2002..These results suggest that menopause is associated with hemodynamic changes and left ventricular remodeling, which may contribute to the enhanced cardiovascular risk observed in postmenopausal women... - Patterns of salivary cortisol secretion in pregnancy and implications for assessment protocolsEmily W Harville
Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 7435, USA
Biol Psychol 74:85-91. 2007..82 to 0.88). Standardizing the clinic measurement to a single time of day did not substantially improve correlations with mean AUC. Correlations with measures of reported stress were also not strong... - Hostility, conflict and cardiovascular responses in married couples: a focus on the dyadSherry D Broadwell
Prevention Research Branch, Centers for Disease Control, Atlanta, Georgia, USA
Int J Behav Med 12:142-52. 2005..Findings suggest that CV responses before, during, and after marital discussions, particularly those characterized by conflict, may be influenced not only by one's own hostility but by the hostility of one's partner as well...