Research Topics
| Gregory A LightSummaryAffiliation: University of California Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Characterization of neurophysiologic and neurocognitive biomarkers for use in genomic and clinical outcome studies of schizophreniaGregory A Light
VISN 22 Mental Illness, Research, Education, and Clinical Center MIRECC, San Diego VA Health Care System, La Jolla, California, United States of America
PLoS ONE 7:e39434. 2012..Stability of clinical and functional measures was also assessed...
Gamma band oscillations reveal neural network cortical coherence dysfunction in schizophrenia patientsGregory A Light
Department of Psychiatry, University of California, San Diego, La Jolla, California 92093 0804, USA
Biol Psychiatry 60:1231-40. 2006....- Stability of mismatch negativity deficits and their relationship to functional impairments in chronic schizophreniaGregory A Light
Department of Psychiatry, University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0804, USA
Am J Psychiatry 162:1741-3. 2005.... - Mismatch negativity deficits are associated with poor functioning in schizophrenia patientsGregory A Light
Department of Psychiatry, University of California, San Diego, La Jolla 92093 0804, USA
Arch Gen Psychiatry 62:127-36. 2005..While many studies have reported MMN deficits in schizophrenia patients, little is known about the functional significance of MMN deficits in schizophrenia patients... - Preattentive sensory processing as indexed by the MMN and P3a brain responses is associated with cognitive and psychosocial functioning in healthy adultsGregory A Light
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0804, USA
J Cogn Neurosci 19:1624-32. 2007.... - Abnormal auditory N100 amplitude: a heritable endophenotype in first-degree relatives of schizophrenia probandsBruce I Turetsky
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
Biol Psychiatry 64:1051-9. 2008..We report initial results from the COGS dataset of auditory N100 amplitude and gating as candidate endophenotypes... - Startle gating deficits in a large cohort of patients with schizophrenia: relationship to medications, symptoms, neurocognition, and level of functionNeal R Swerdlow
Departments of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA
Arch Gen Psychiatry 63:1325-35. 2006..Patients with schizophrenia exhibit deficits in automatic, preattentive sensorimotor gating (prepulse inhibition [PPI]) of the startle reflex... 
Inhibition of the P50 cerebral evoked response to repeated auditory stimuli: results from the Consortium on Genetics of SchizophreniaAnn Olincy
Department of Psychiatry, Veterans Affairs Denver Medical Center VISN 19 MIRECC, CO 80045, USA
Schizophr Res 119:175-82. 2010....- Antisaccade performance in schizophrenia patients, their first-degree biological relatives, and community comparison subjects: data from the COGS studyAllen D Radant
Department of Psychiatry and Behavioral Sciences, University of Washington and Department of Veteran Affairs, VISN 20, Mental Illness Research, Education, and Clinical Center, Seattle, Washington 98108, USA
Psychophysiology 47:846-56. 2010..Given the significant heritability of antisaccade performance, the effects of a genetic polymorphism is one possible explanation of our results... - Initial heritability analyses of endophenotypic measures for schizophrenia: the consortium on the genetics of schizophreniaTiffany A Greenwood
Department of Psychiatry, University of California San Diego, La Jolla, USA
Arch Gen Psychiatry 64:1242-50. 2007..Exploration of the genetic architecture of specific endophenotypes may be a powerful strategy for understanding the genetic basis of schizophrenia... - Multi-site studies of acoustic startle and prepulse inhibition in humans: initial experience and methodological considerations based on studies by the Consortium on the Genetics of SchizophreniaNeal R Swerdlow
Department of Psychiatry, University of California San Diego, San Diego, California, USA
Schizophr Res 92:237-51. 2007..Genetic studies now often employ multiple, geographically dispersed test sites to accommodate the need for large and complex study samples. Here, we assessed the feasibility of using PPI in multi-site studies... - Sensory and sensorimotor gating-disruptive effects of apomorphine in Sprague Dawley and Long Evans ratsMichelle R Breier
Department of Psychiatry, University of California, San Diego School of Medicine, La Jolla, CA 92093 0804, USA
Behav Brain Res 208:560-5. 2010..Here, we investigated whether SD and LE rats differ in sensitivity to APO effects on N40 gating or amplitude... - An event-related brain potential study of direct and indirect semantic priming in schizophreniaMichael Kiang
University of California, San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0515, USA
Am J Psychiatry 165:74-81. 2008..The authors tested these hypotheses using the N400 event-related brain potential as a probe of activation of concepts in semantic memory... - Effects of olanzapine, risperidone and haloperidol on prepulse inhibition in schizophrenia patients: a double-blind, randomized controlled trialJonathan K Wynn
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, CA, USA
Schizophr Res 95:134-42. 2007..The results are discussed in terms of animal models, neural substrates, and treatment implications... - Cognitive, neurophysiological, and functional correlates of proverb interpretation abnormalities in schizophreniaMichael Kiang
Department of Cognitive Science, University of California San Diego, La Jolla, California 92093, USA
J Int Neuropsychol Soc 13:653-63. 2007..These results offer no support for disorganized associations in abnormal proverb interpretation in schizophrenia, but implicate WM deficits, perhaps as a part of a syndrome related to generalized frontal cortical dysfunction... - P50 suppression in individuals at risk for schizophrenia: the convergence of clinical, familial, and vulnerability marker risk assessmentKristin S Cadenhead
Department of Psychiatry, University of California San Diego, La Jolla, California 92093 0810, USA
Biol Psychiatry 57:1504-9. 2005..The aim of the present study was to determine whether individuals "at risk" for schizophrenia have deficits in P50 suppression, a preattentive measure of sensory gating... - Reduced multisensory integration in patients with schizophrenia on a target detection taskLisa E Williams
Department of Psychology, University of California, San Diego, CA, United States
Neuropsychologia 48:3128-36. 2010.... - Prepulse inhibition and P50 suppression are both deficient but not correlated in schizophrenia patientsDavid L Braff
Department of Psychiatry, School of Medicine, University of California, San Diego, California 92093 0804, USA
Biol Psychiatry 61:1204-7. 2007..The relationship between PPI and P50 suppression in schizophrenia patients has remained unclear... - Female schizophrenia patients have prepulse inhibition deficitsDavid L Braff
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093 0804, USA
Biol Psychiatry 57:817-20. 2005..This study was designed to determine whether female schizophrenia patients have lower levels of PPI than normal females... - Neurophysiological endophenotypes of schizophrenia: the viability of selected candidate measuresBruce I Turetsky
Department of Psychiatry, 10th Floor, Gates Building, University of Pennsylvania, 3400 Spruce Street, Philadelphia, PA 19104, USA
Schizophr Bull 33:69-94. 2007..We conclude with a discussion of the few studies thus far that have employed a multivariate approach with these candidates... - Analysis of 94 candidate genes and 12 endophenotypes for schizophrenia from the Consortium on the Genetics of SchizophreniaTiffany A Greenwood
Department of Psychiatry, University of California at San Diego, La Jolla, CA 92093 0804, USA
Am J Psychiatry 168:930-46. 2011.... - Disentangling early sensory information processing deficits in schizophreniaAnthony J Rissling
Department of Psychiatry, University of California San Diego, La Jolla, CA 92093 0804, USA
Clin Neurophysiol 123:1942-9. 2012.... - Electroencephalography (EEG) and event-related potentials (ERPs) with human participantsGregory A Light
Department of Psychiatry, University of California, San Diego, La Jolla, California, USA
Curr Protoc Neurosci . 2010..These paradigms can be used to assess the integrity of early sensory processing in normal individuals and clinical populations, such as individuals with schizophrenia... - Hierarchical organization of gamma and theta oscillatory dynamics in schizophreniaKenji Kirihara
Department of Psychiatry, University of California, San Diego, La Jolla, California 92093 0804, USA
Biol Psychiatry 71:873-80. 2012.... - Sensory and sensorimotor gating deficits after neonatal ventral hippocampal lesions in ratsNeal R Swerdlow
Department of Psychiatry, University of California, San Diego, La Jolla, CA 92093, USA
Dev Neurosci 34:240-9. 2012..In this study, lesion effects were detected prior to pubertal onset, and were sustained well into adulthood... - Superior size-weight illusion performance in patients with schizophrenia: evidence for deficits in forward modelsLisa E Williams
Department of Psychology, University of California San Diego, 9500 Gilman Drive 0109, La Jolla, CA 92093 0109, USA
Schizophr Res 121:101-6. 2010..The current findings are consistent with a dysfunctional forward model mechanism in this population. Future studies to elucidate the locus of this impairment using variations on the current study are also proposed... - Preattentional and attentional cognitive deficits as targets for treating schizophreniaDavid L Braff
Department of Psychiatry, Medical Center, University of California, 200 West Arbor Drive, San Diego, CA 92103 8816, USA
Psychopharmacology (Berl) 174:75-85. 2004..These neurophysiological measures cover a spectrum from automatic preattentional to attention-dependent processes... - Neurophysiological measures of sensory registration, stimulus discrimination, and selection in schizophrenia patientsAnthony J Rissling
Department of Psychiatry, University of California, San Diego, CA 92093 0804, USA
Curr Top Behav Neurosci 4:283-309. 2010.... - Association analysis of 94 candidate genes and schizophrenia-related endophenotypesTiffany A Greenwood
Department of Psychiatry, University of California San Diego, La Jolla, California, United States of America
PLoS ONE 7:e29630. 2012..The observation of extensive pleiotropy for some genes and singular associations for others in our data may suggest both converging and independent genetic (and neural) pathways mediating schizophrenia risk and pathogenesis... - Realistic expectations of prepulse inhibition in translational models for schizophrenia researchNeal R Swerdlow
Department of Psychiatry, UCSD School of Medicine, La Jolla, CA, 92093 0804, USA
Psychopharmacology (Berl) 199:331-88. 2008..This rapid expansion and broad application of PPI as a tool for understanding schizophrenia has, at times, outpaced critical thinking and falsifiable hypotheses about the relative strengths vs. limitations of this measure... - Neurophysiologic markers of abnormal brain activity in schizophreniaAnthony J Rissling
Department of Psychiatry, University of California San Diego, La Jolla, 92093 0804, USA
Curr Psychiatry Rep 12:572-8. 2010.... - Older patients with schizophrenia: does military veteran status matter?Steven R Thorp
Department of Psychiatry, University of California, San Diego, California 92108, USA
Am J Geriatr Psychiatry 20:248-56. 2012..The objective of this study was to examine the influence of military veteran status within a data set of older patients with schizophrenia or schizoaffective disorder... - Convergence and divergence in the neurochemical regulation of prepulse inhibition of startle and N40 suppression in ratsNeal R Swerdlow
Department of Psychiatry, UCSD School of Medicine, La Jolla, CA 92093 0804, USA
Neuropsychopharmacology 31:506-15. 2006..Despite similarities in drug sensitivity, these results suggest that distinct neurobiological mechanisms underlie drug-induced deficits in PPI and N40 gating... - The 5-choice continuous performance test: evidence for a translational test of vigilance for miceJared W Young
Department of Psychiatry, University of California San Diego, La Jolla, California, United States of America
PLoS ONE 4:e4227. 2009..Although vigilance is assessed frequently using the continuous performance test (CPT) in humans, few tests specifically assess vigilance in rodents... - Efficacy and tolerability of low-dose donepezil in schizophreniaSteven K Erickson
University of Rochester Medical Center, Department of Psychiatry, New York 14642, USA
Clin Neuropharmacol 28:179-84. 2005..These results suggest that donepezil may be helpful as adjunctive therapy for the treatment of psychiatric symptoms and cognitive impairment in a subgroup of schizophrenic patients... - Neurobiological measures of schizotypal personality disorder: defining an inhibitory endophenotype?Kristin S Cadenhead
Department of Psychiatry, University of California, San Diego, La Jolla, 92093 0810, USA
Am J Psychiatry 159:869-71. 2002.... - The use of neurophysiological endophenotypes to understand the genetic basis of schizophreniaDavid L Braff
Department of Psychiatry, University of California, San Diego, 9500 Gilman Drive, Mail Code 0804, La Jolla 92093, USA
Dialogues Clin Neurosci 7:125-35. 2005..The power and utility of utilizing endophenotypes to understand the genetics of schizophrenia is discussed in detail in this article... - On the waveform of the acoustic startle blink in the paradigm of prepulse inhibition - methodological and physiological aspectsUlrich Meincke
Department of Psychiatry, University of California San Diego, La Jolla, USA
Neuropsychobiology 52:24-7. 2005..These findings support the view that both components of the acoustically evoked OOM response exhibit similar plasticity in the paradigm of prepulse inhibition... - The Consortium on the Genetics of Endophenotypes in Schizophrenia: model recruitment, assessment, and endophenotyping methods for a multisite collaborationMonica E Calkins
Neuropsychiatry Section, Department of Psychiatry, University of Pennsylvania, 10 Gates, 3400 Spruce St, Philadelphia, PA 19104, USA
Schizophr Bull 33:33-48. 2007..The purpose of this article is to provide a description of the COGS structure and methods, including participant recruitment and assessment... - Electrophysiological insights into conceptual disorganization in schizophreniaMichael Kiang
Department of Cognitive Science, University of California San Diego, 9500 Gilman Dr, Mail Code 0515, La Jolla, CA 92093 0515, USA
Schizophr Res 92:225-36. 2007.... - Advances in endophenotyping schizophreniaDavid L Braff
Department of Psychiatry, University of California at San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0804, USA
World Psychiatry 7:11-8. 2008..By identifying the single nucleotide polymorphisms (SNPs) associated with endophenotypes in schizophrenia, psychiatric neuroscientists can select new strong inference based molecular targets for the treatment of schizophrenia... - Fronto-temporal-mesolimbic gene expression and heritable differences in amphetamine-disrupted sensorimotor gating in ratsNeal R Swerdlow
Department of Psychiatry, School of Medicine, University of California San Diego, La Jolla, CA, 92093 0804, USA
Psychopharmacology (Berl) 224:349-62. 2012..These differences may inform us about the biology of PPI deficits in disorders such as schizophrenia... - Visual masking as a probe for abnormal gamma range activity in schizophreniaMichael Foster Green
Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, California 90024-1759, USA
Biol Psychiatry 53:1113-9. 2003..Perceptual problems in schizophrenia may, at least in part, be due to a failure to establish and/or maintain gamma range oscillations... - Successful multi-site measurement of antisaccade performance deficits in schizophreniaAllen D Radant
Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, Washington, United States
Schizophr Res 89:320-9. 2007..These results confirm previous findings of antisaccade deficits in schizophrenia subjects and support the use of the antisaccade task as a potential schizophrenia endophenotype in multi-site genetic studies... - Relationship between P50 suppression and the cortical silent periodBertram Moller
Schizophrenia Program, Centre for Addiction and Mental Health, Universty of Toronto, 250 College Street, M5T IR8, Toronto, Ontario, Canada
Neuroreport 18:1503-6. 2007.... - Sensitization and habituation of the acoustic startle reflex in patients with schizophreniaUlrich Meincke
Department of Psychiatry and Psychotherapy, Technical University of Aachen, Pauwelsstrasse 30, D 52057 Aachen, Germany
Psychiatry Res 126:51-61. 2004..In addition, the present data have important implications for designing startle studies to assess sensitization, habituation and prepulse inhibition in one session... - Event-related gamma activity in schizophrenia patients during a visual backward-masking taskJonathan K Wynn
Department of Psychology, UCLA, Los Angeles, CA, USA
Am J Psychiatry 162:2330-6. 2005..This study examined event-related gamma range activity during a visual backward-masking task in schizophrenia patients and normal comparison subjects... - Verbal working memory impairments in individuals with schizophrenia and their first-degree relatives: findings from the Consortium on the Genetics of SchizophreniaWilliam P Horan
Department of Psychiatry and Biobehavioral Sciences, Geffen School of Medicine at University of California Los Angeles, Los Angeles, California 90095 6968, USA
Schizophr Res 103:218-28. 2008....
Research Grants
- Pathway(s) From Genes to Functional Deficits of Schizophrenia PatientsGregory Light; Fiscal Year: 2007....
- Pathway(s) From Genes to Functional Deficits of Schizophrenia PatientsGregory A Light; Fiscal Year: 2010....