Alan R Light

Summary

Affiliation: University of Utah
Country: USA

Publications

  1. pmc Exogenously applied muscle metabolites synergistically evoke sensations of muscle fatigue and pain in human subjects
    Kelly A Pollak
    University of Utah, Department of Anesthesiology 3C444 SOM, 30N 1900E, Salt Lake City, UT 84132, USA
    Exp Physiol 99:368-80. 2014
  2. pmc Evidence for a heritable predisposition to Chronic Fatigue Syndrome
    Frederick Albright
    Pharmacotherapy Outcomes Research Center, Department of Pharmacotherapy, College of Pharmacy, University of Utah, USA
    BMC Neurol 11:62. 2011
  3. ncbi request reprint Dorsal root ganglion neurons innervating skeletal muscle respond to physiological combinations of protons, ATP, and lactate mediated by ASIC, P2X, and TRPV1
    Alan R Light
    Department of Anethesiology, University of Utah School of Medicine, Salt Lake City, UT 84132 2304, USA
    J Neurophysiol 100:1184-201. 2008
  4. pmc Moderate exercise increases expression for sensory, adrenergic, and immune genes in chronic fatigue syndrome patients but not in normal subjects
    Alan R Light
    Department of Anesthesiology, University of Utah, Salt Lake City, Utah 84132 2304, USA
    J Pain 10:1099-112. 2009
  5. pmc Gene expression alterations at baseline and following moderate exercise in patients with Chronic Fatigue Syndrome and Fibromyalgia Syndrome
    A R Light
    Department of Anesthesiology The Brain Institute Department of Neurobiology and Anatomy Department of Exercise and Sport Science, University of Utah, Salt Lake City, UT 84132, USA
    J Intern Med 271:64-81. 2012
  6. pmc Differences in metabolite-detecting, adrenergic, and immune gene expression after moderate exercise in patients with chronic fatigue syndrome, patients with multiple sclerosis, and healthy controls
    Andrea T White
    Department of Anesthesiology, University of Utah, 30 N 1900 E, Room 3C444, Salt Lake City, UT 84132 2501, USA
    Psychosom Med 74:46-54. 2012
  7. pmc Differing leukocyte gene expression profiles associated with fatigue in patients with prostate cancer versus chronic fatigue syndrome
    Kathleen C Light
    Department of Anesthesiology, University of Utah Health Sciences Center, Salt Lake City, UT, USA Electronic address
    Psychoneuroendocrinology 38:2983-95. 2013
  8. pmc Neuroactive diol and acyloin metabolites from cone snail-associated bacteria
    Zhenjian Lin
    Department of Medicinal Chemistry, L S Skaggs Pharmacy Institute, University of Utah, Salt Lake City, UT 84112, USA
    Bioorg Med Chem Lett 23:4867-9. 2013
  9. ncbi request reprint Griseorhodins D-F, Neuroactive Intermediates and End Products of Post-PKS Tailoring Modification in Griseorhodin Biosynthesis
    Zhenjian Lin
    Department of Medicinal Chemistry, L S Skaggs Pharmacy Institute, University of Utah, Salt Lake City, Utah 84112, United States
    J Nat Prod 77:1224-30. 2014
  10. pmc A bacterial source for mollusk pyrone polyketides
    Zhenjian Lin
    Department of Medicinal Chemistry, University of Utah, Salt Lake City, UT 84112, USA
    Chem Biol 20:73-81. 2013

Collaborators

  • Kathleen C Light
  • Andrea T White
  • Russell W Teichert
  • John M Veranth
  • Jie Zhang
  • Markus Amann
  • Jeffrey D Swenson
  • Petra Schweinhardt
  • Jeewoo Lee
  • Ila R Singh
  • Harry R Hill
  • Ronald W Hughen
  • Zhenjian Lin
  • Eric W Schmidt
  • Gisela P Concepcion
  • Baldomero M Olivera
  • Margo G Haygood
  • Lenny Marett
  • Malem Flores
  • Darien Shapiro
  • Christopher A Reilly
  • Cassandra E Deering-Rice
  • Olivier Peraud
  • Kelly A Pollak
  • Timothy A Vanhaitsma
  • Eli Iacob
  • Mary Anne Ammon
  • Imelda Forteza
  • Gary Rosenberg
  • Erin G Romero
  • Frederick Albright
  • Clifford H Shin
  • Lucinda Bateman
  • Daehyun Jo
  • Malcolm M Zachariah
  • Joshua P Torres
  • James E Cox
  • Scott C Tadler
  • Samuel Espino
  • Ma Diarey Tianero
  • Lowry Bushnell
  • Aaron Joseph L Villaraza
  • Howard R Weeks
  • Jason C Kwan
  • Thomas E Cheatham
  • Niel M Henriksen
  • Lisa A Cannon-Albright
  • Christopher J Leonard
  • Robert Schlaberg
  • Garold S Yost
  • Ashley M Bunker
  • Jason S Biggs

Detail Information

Publications18

  1. pmc Exogenously applied muscle metabolites synergistically evoke sensations of muscle fatigue and pain in human subjects
    Kelly A Pollak
    University of Utah, Department of Anesthesiology 3C444 SOM, 30N 1900E, Salt Lake City, UT 84132, USA
    Exp Physiol 99:368-80. 2014
    ..This is the first demonstration in humans that metabolites normally produced by exercise act in combination to activate sensory neurons that signal sensations of fatigue and muscle pain...
  2. pmc Evidence for a heritable predisposition to Chronic Fatigue Syndrome
    Frederick Albright
    Pharmacotherapy Outcomes Research Center, Department of Pharmacotherapy, College of Pharmacy, University of Utah, USA
    BMC Neurol 11:62. 2011
    ....
  3. ncbi request reprint Dorsal root ganglion neurons innervating skeletal muscle respond to physiological combinations of protons, ATP, and lactate mediated by ASIC, P2X, and TRPV1
    Alan R Light
    Department of Anethesiology, University of Utah School of Medicine, Salt Lake City, UT 84132 2304, USA
    J Neurophysiol 100:1184-201. 2008
    ..We further conclude that the adequate stimuli for muscle metaboreceptors and nociceptors are combinations of protons, ATP, and lactate...
  4. pmc Moderate exercise increases expression for sensory, adrenergic, and immune genes in chronic fatigue syndrome patients but not in normal subjects
    Alan R Light
    Department of Anesthesiology, University of Utah, Salt Lake City, Utah 84132 2304, USA
    J Pain 10:1099-112. 2009
    ..These new findings suggest dysregulation of metabolite detecting receptors as well as SNS and IS in CFS and CFS-FMS...
  5. pmc Gene expression alterations at baseline and following moderate exercise in patients with Chronic Fatigue Syndrome and Fibromyalgia Syndrome
    A R Light
    Department of Anesthesiology The Brain Institute Department of Neurobiology and Anatomy Department of Exercise and Sport Science, University of Utah, Salt Lake City, UT 84132, USA
    J Intern Med 271:64-81. 2012
    ....
  6. pmc Differences in metabolite-detecting, adrenergic, and immune gene expression after moderate exercise in patients with chronic fatigue syndrome, patients with multiple sclerosis, and healthy controls
    Andrea T White
    Department of Anesthesiology, University of Utah, 30 N 1900 E, Room 3C444, Salt Lake City, UT 84132 2501, USA
    Psychosom Med 74:46-54. 2012
    ....
  7. pmc Differing leukocyte gene expression profiles associated with fatigue in patients with prostate cancer versus chronic fatigue syndrome
    Kathleen C Light
    Department of Anesthesiology, University of Utah Health Sciences Center, Salt Lake City, UT, USA Electronic address
    Psychoneuroendocrinology 38:2983-95. 2013
    ....
  8. pmc Neuroactive diol and acyloin metabolites from cone snail-associated bacteria
    Zhenjian Lin
    Department of Medicinal Chemistry, L S Skaggs Pharmacy Institute, University of Utah, Salt Lake City, UT 84112, USA
    Bioorg Med Chem Lett 23:4867-9. 2013
    ..No neuroactivity had previously been reported for compounds in this structural class. Gordonia species have been reproducibly isolated from four different cone snail species, indicating a consistent association between these organisms...
  9. ncbi request reprint Griseorhodins D-F, Neuroactive Intermediates and End Products of Post-PKS Tailoring Modification in Griseorhodin Biosynthesis
    Zhenjian Lin
    Department of Medicinal Chemistry, L S Skaggs Pharmacy Institute, University of Utah, Salt Lake City, Utah 84112, United States
    J Nat Prod 77:1224-30. 2014
    ..The other two compounds, griseorhodins E and F, represent new products of post-polyketide synthase tailoring in griseorhodin biosynthesis and showed significant binding activity in a human dopamine active transporter assay. ..
  10. pmc A bacterial source for mollusk pyrone polyketides
    Zhenjian Lin
    Department of Medicinal Chemistry, University of Utah, Salt Lake City, UT 84112, USA
    Chem Biol 20:73-81. 2013
    ..The natural roles of nocapyrones are unknown, but they are active in neurological assays, revealing that mollusks with external shells are an overlooked source of secondary metabolite diversity...
  11. pmc Activation of transient receptor potential ankyrin-1 (TRPA1) in lung cells by wood smoke particulate material
    Darien Shapiro
    Department of Pharmacology and Toxicology, University of Utah, 30 S 2000 E, Room 201 Skaggs Hall, Salt Lake City, Utah 84112, United States
    Chem Res Toxicol 26:750-8. 2013
    ....
  12. pmc Dysregulation of leukocyte gene expression in women with medication-refractory depression versus healthy non-depressed controls
    Eli Iacob
    Department of Anesthesiology, University of Utah Health Sciences Center, Salt Lake City, UT, USA
    BMC Psychiatry 13:273. 2013
    ..Thus medication-refractory female patients are a large, under-served, group where new biological targets for intervention are greatly needed...
  13. ncbi request reprint Severity of symptom flare after moderate exercise is linked to cytokine activity in chronic fatigue syndrome
    Andrea T White
    Department of Exercise and Sport Science, University of Utah, Salt Lake City, Utah, USA
    Psychophysiology 47:615-24. 2010
    ..05). Thus, in CFS, cytokine activity may vary directly with SF, which may explain prior inconsistent findings...
  14. pmc Electrophilic components of diesel exhaust particles (DEP) activate transient receptor potential ankyrin-1 (TRPA1): a probable mechanism of acute pulmonary toxicity for DEP
    Cassandra E Deering-Rice
    Department of Pharmacology and Toxicology, University of Utah, Salt Lake City, Utah 84112, United States
    Chem Res Toxicol 24:950-9. 2011
    ..It is concluded that TRPA1 is a specific target for electrophilic chemical components of DEP and proposed that activation of TRPA1 in the respiratory tract is likely to be an important mechanism for DEP pneumotoxicity...
  15. pmc Absence of XMRV retrovirus and other murine leukemia virus-related viruses in patients with chronic fatigue syndrome
    Clifford H Shin
    Department of Pathology, University of Utah, 15 North Medical Drive East, Suite 2100, Salt Lake City, UT 84112, USA
    J Virol 85:7195-202. 2011
    ..Our findings do not support an association between CFS and MLV-related viruses, including XMRV, and the off-label use of antiretrovirals for the treatment of CFS does not seem justified at present...
  16. pmc Totopotensamides, polyketide-cyclic peptide hybrids from a mollusk-associated bacterium Streptomyces sp
    Zhenjian Lin
    College of Pharmacy, Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, USA
    J Nat Prod 75:644-9. 2012
    ..The application of Marfey's method to phenylglycine derivatives was explored using quantum mechanical calculations and NMR...
  17. pmc Functional profiling of neurons through cellular neuropharmacology
    Russell W Teichert
    Department of Biology, University of Utah, Salt Lake City, UT 84112, USA
    Proc Natl Acad Sci U S A 109:1388-95. 2012
    ....
  18. pmc Microhabitats within venomous cone snails contain diverse actinobacteria
    Olivier Peraud
    Department of Medicinal Chemistry, University of Utah, Salt Lake City, Utah 84112, USA
    Appl Environ Microbiol 75:6820-6. 2009
    ..This suggests that cone snails may represent an underexplored reservoir of novel actinomycetes of potential interest for drug discovery...