Jonathan Lifshitz

Summary

Affiliation: University of Kentucky
Country: USA

Publications

  1. ncbi request reprint Perisomatic thalamic axotomy after diffuse traumatic brain injury is associated with atrophy rather than cell death
    Jonathan Lifshitz
    Spinal Cord and Brain Injury Research Center, University of Kentucky Chandler Research Center, Lexington, Kentucky, USA
    J Neuropathol Exp Neurol 66:218-29. 2007
  2. pmc Acute cognitive impairment after lateral fluid percussion brain injury recovers by 1 month: evaluation by conditioned fear response
    Jonathan Lifshitz
    Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, United States
    Behav Brain Res 177:347-57. 2007
  3. pmc Neurodegeneration in the somatosensory cortex after experimental diffuse brain injury
    Jonathan Lifshitz
    Spinal Cord and Brain Injury Research Center, University of Kentucky Chandler Medical Center, Office B463, Biomedical and Biological Sciences Research Building, 741 S Limestone St, Lexington, KY 40536 0509, USA
    Brain Struct Funct 217:49-61. 2012
  4. ncbi request reprint Response of the contralateral hippocampus to lateral fluid percussion brain injury
    Lorriann D Tran
    Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurotrauma 23:1330-42. 2006
  5. ncbi request reprint Inbred mouse strains as a tool to analyze hippocampal neuronal loss after brain injury: a stereological study
    Brent M Witgen
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Neurotrauma 23:1320-9. 2006
  6. pmc Disruptions in the regulation of extracellular glutamate by neurons and glia in the rat striatum two days after diffuse brain injury
    Jason M Hinzman
    Department of Anatomy and Neurobiology, University of Kentucky Chandler Medical Center, Lexington, Kentucky 40536 0509, USA
    J Neurotrauma 29:1197-208. 2012
  7. pmc Diffuse traumatic brain injury initially attenuates and later expands activation of the rat somatosensory whisker circuit concomitant with neuroplastic responses
    Kelley D Hall
    Spinal Cord and Brain Injury Research Center, Chandler Medical Center, University of Kentucky, USA
    Brain Res 1323:161-73. 2010
  8. pmc Substantia nigra vulnerability after a single moderate diffuse brain injury in the rat
    Daniel R van Bregt
    Spinal Cord and Brain Injury Research Center, University of Kentucky College of Medicine, Lexington, KY, USA
    Exp Neurol 234:8-19. 2012
  9. pmc The p38α MAPK regulates microglial responsiveness to diffuse traumatic brain injury
    Adam D Bachstetter
    Sanders Brown Center on Aging, University of Kentucky, Lexington, Kentucky 40536, USA
    J Neurosci 33:6143-53. 2013
  10. pmc Hypersensitive glutamate signaling correlates with the development of late-onset behavioral morbidity in diffuse brain-injured circuitry
    Theresa Currier Thomas
    Spinal Cord and Brain Injury Research Center, University of Kentucky College of Medicine, Lexington, Kentucky, USA
    J Neurotrauma 29:187-200. 2012

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Perisomatic thalamic axotomy after diffuse traumatic brain injury is associated with atrophy rather than cell death
    Jonathan Lifshitz
    Spinal Cord and Brain Injury Research Center, University of Kentucky Chandler Research Center, Lexington, Kentucky, USA
    J Neuropathol Exp Neurol 66:218-29. 2007
    ..Enduring atrophy in thalamic relays could underlie circuit disruption responsible for post-traumatic morbidity...
  2. pmc Acute cognitive impairment after lateral fluid percussion brain injury recovers by 1 month: evaluation by conditioned fear response
    Jonathan Lifshitz
    Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, United States
    Behav Brain Res 177:347-57. 2007
    ..Hence, the acute injury-induced cognitive impairment may persist while transient pathophysiological sequelae are underway, and improve as global dysfunction subsides...
  3. pmc Neurodegeneration in the somatosensory cortex after experimental diffuse brain injury
    Jonathan Lifshitz
    Spinal Cord and Brain Injury Research Center, University of Kentucky Chandler Medical Center, Office B463, Biomedical and Biological Sciences Research Building, 741 S Limestone St, Lexington, KY 40536 0509, USA
    Brain Struct Funct 217:49-61. 2012
    ..The rodent whisker barrel circuit may serve as a discrete model to evaluate the causes and consequences of circuit reorganization after diffuse brain injury...
  4. ncbi request reprint Response of the contralateral hippocampus to lateral fluid percussion brain injury
    Lorriann D Tran
    Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA
    J Neurotrauma 23:1330-42. 2006
    ..The cognitive recovery observed after human traumatic brain injury may stem from a differential injury exposure and time course of recovery between homologous regions of the two hemispheres...
  5. ncbi request reprint Inbred mouse strains as a tool to analyze hippocampal neuronal loss after brain injury: a stereological study
    Brent M Witgen
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Neurotrauma 23:1320-9. 2006
    ..The loss of neurons appears to be restricted to the first week post-injury, and the remaining neurons may serve as a substrate for recovery...
  6. pmc Disruptions in the regulation of extracellular glutamate by neurons and glia in the rat striatum two days after diffuse brain injury
    Jason M Hinzman
    Department of Anatomy and Neurobiology, University of Kentucky Chandler Medical Center, Lexington, Kentucky 40536 0509, USA
    J Neurotrauma 29:1197-208. 2012
    ..Overall, these data suggest that therapeutic strategies used to regulate glutamate release and uptake may improve excitatory circuit function and, possibly, outcomes following TBI...
  7. pmc Diffuse traumatic brain injury initially attenuates and later expands activation of the rat somatosensory whisker circuit concomitant with neuroplastic responses
    Kelley D Hall
    Spinal Cord and Brain Injury Research Center, Chandler Medical Center, University of Kentucky, USA
    Brain Res 1323:161-73. 2010
    ..Therapeutic interventions to promote adaptive circuit restructuring may mitigate post-traumatic morbidity...
  8. pmc Substantia nigra vulnerability after a single moderate diffuse brain injury in the rat
    Daniel R van Bregt
    Spinal Cord and Brain Injury Research Center, University of Kentucky College of Medicine, Lexington, KY, USA
    Exp Neurol 234:8-19. 2012
    ..Compensatory mechanisms may preserve dopamine signaling acutely, but subsequent SN damage with aging or additional injury may expose clinical symptomatology of motor ataxias and dementia...
  9. pmc The p38α MAPK regulates microglial responsiveness to diffuse traumatic brain injury
    Adam D Bachstetter
    Sanders Brown Center on Aging, University of Kentucky, Lexington, Kentucky 40536, USA
    J Neurosci 33:6143-53. 2013
    ..Together, these data suggest that p38α balances the inflammatory response by acutely attenuating the early proinflammatory cytokine surge while perpetuating the chronic microglia activation after TBI...
  10. pmc Hypersensitive glutamate signaling correlates with the development of late-onset behavioral morbidity in diffuse brain-injured circuitry
    Theresa Currier Thomas
    Spinal Cord and Brain Injury Research Center, University of Kentucky College of Medicine, Lexington, Kentucky, USA
    J Neurotrauma 29:187-200. 2012
    ..Effective therapies to modulate presynaptic glutamate function in diffuse-injured circuits may translate into improvements in essential brain function and behavioral performance in other brain-injured circuits in rodents and in humans...
  11. pmc The whisker nuisance task identifies a late-onset, persistent sensory sensitivity in diffuse brain-injured rats
    Katelyn C S McNamara
    Spinal Cord and Brain Injury Research Center, University of Kentucky College of Medicine, Lexington, Kentucky 40536 0509, USA
    J Neurotrauma 27:695-706. 2010
    ..Following diffuse brain injury, the whisker nuisance task is a promising tool to detect post-traumatic morbidity and the efficacy of therapeutic interventions that may restore discrete circuit function in brain-injured patients...
  12. ncbi request reprint Photon correlation spectroscopy of brain mitochondrial populations: application to traumatic brain injury
    Jonathan Lifshitz
    Traumatic Brain Injury Laboratory, Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA 19104, USA
    Exp Neurol 197:318-29. 2006
    ..PCS provides quantitative indices of refractive index and size in isolated mitochondrial populations, aiding the evaluation of mitochondria in degenerative diseases...
  13. ncbi request reprint Neuronal and glial cell number in the hippocampus after experimental traumatic brain injury: analysis by stereological estimation
    M Sean Grady
    Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Neurotrauma 20:929-41. 2003
    ..The implications of the observed cell population changes are discussed in relation to the reported cognitive deficits associated with both lateral and midline FP brain injury...
  14. ncbi request reprint Lateral fluid percussion brain injury: a 15-year review and evaluation
    Hilaire J Thompson
    Traumatic Brain Injury Laboratory, Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    J Neurotrauma 22:42-75. 2005
    ....
  15. ncbi request reprint Age-associated mitochondrial DNA deletions are not evident chronically after experimental brain injury in the rat
    Jonathan Lifshitz
    Head Injury Center, Department of Neurosurgery, University of Pennsylvania, Philadelphia, PA 19104 6316, USA
    J Neurotrauma 20:139-49. 2003
    ..However, mitochondrial protein yields from injured and aged brains were comparable and significantly lower than uninjured brain, suggesting that the underlying pathology between TBI and aging may be similar...
  16. ncbi request reprint Structural and functional damage sustained by mitochondria after traumatic brain injury in the rat: evidence for differentially sensitive populations in the cortex and hippocampus
    Jonathan Lifshitz
    Head Injury Center, Department of Neurosurgery, University of Pensylvania, Philadelphia, Pensylvania 19104 6316, USA
    J Cereb Blood Flow Metab 23:219-31. 2003
    ..The heterogeneous mitochondrial response to TBI may underlie posttraumatic metabolic dysfunction and contribute to the pathophysiology of TBI...
  17. doi request reprint Diffuse brain injury induces acute post-traumatic sleep
    Rachel K Rowe
    Barrow Neurological Institute at Phoenix Children s Hospital, Phoenix, Arizona, United States of America Department of Child Health, University of Arizona College of Medicine Phoenix, Phoenix, Arizona, United States of America Department of Anatomy and Neurobiology, College of Medicine, University of Kentucky, Lexington, Kentucky, United States of America Spinal Cord and Brain Injury Research Center SCoBIRC, University of Kentucky College of Medicine, Lexington, Kentucky, United States of America
    PLoS ONE 9:e82507. 2014
    ..The aim of this study is to investigate acute post-traumatic sleep...
  18. pmc Diffuse brain injury elevates tonic glutamate levels and potassium-evoked glutamate release in discrete brain regions at two days post-injury: an enzyme-based microelectrode array study
    Jason M Hinzman
    Department of Anatomy and Neurobiology, University of Kentucky Chandler Medical Center, Lexington, Kentucky 40536 0509, USA
    J Neurotrauma 27:889-99. 2010
    ..Future studies may reveal the specific mechanisms responsible for glutamate dysregulation in the post-traumatic period, and may provide novel therapeutic means to improve outcomes after TBI...
  19. ncbi request reprint Transplanted neural stem cells survive, differentiate, and improve neurological motor function after experimental traumatic brain injury
    Peter Riess
    The Head Injury Center, Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia 19104, USA
    Neurosurgery 51:1043-52; discussion 1052-4. 2002
    ..Using the neural stem cell (NSC) clone C17.2, we evaluated the ability of transplanted murine NSCs to attenuate cognitive and neurological motor deficits after traumatic brain injury...
  20. ncbi request reprint Mechanoporation induced by diffuse traumatic brain injury: an irreversible or reversible response to injury?
    Orsolya Farkas
    Department of Anatomy and Neurobiology, Medical College of Virginia Campus, Virginia Commonwealth University, Richmond, Virginia 23298, USA
    J Neurosci 26:3130-40. 2006
    ..0 and 35.4%, respectively, showing CMSP. These studies illustrate that DTBI evokes evolving plasmalemmal changes that highlight mechanical and potential secondary events in membrane poration...
  21. ncbi request reprint Traumatic axonal injury in the perisomatic domain triggers ultrarapid secondary axotomy and Wallerian degeneration
    Brian J Kelley
    Department of Anatomy and Neurobiology, Medical College of Virginia Campus at Virginia Commonwealth University, Richmond, VA 23298 0709, USA
    Exp Neurol 198:350-60. 2006
    ..Collectively, this DBI-mediated ultrarapid perisomatic axotomy and its sequelae further illustrate the varied axonal responses to trauma...
  22. ncbi request reprint Neuroinflammatory responses after experimental diffuse traumatic brain injury
    Brian Joseph Kelley
    Department of Anatomy and Neurobiology, Virginia Commonwealth University School of Medicine, Richmond, Virginia 23298 0709, USA
    J Neuropathol Exp Neurol 66:989-1001. 2007
    ..DBI-mediated inflammatory responses suggest further expansion of traumatic brain injury histopathologic evaluations to identify neuroinflammation indicative of diffuse pathology...

Research Grants3

  1. Amygdala Response to Experimental Traumatic Brain Injury
    Jonathan Lifshitz; Fiscal Year: 2005
    ..This research effort may lead to novel treatments for the affective disorders in an otherwise healthy brain-injured population, in addition to post-traumatic stress disorder and psychosis. ..
  2. Neural circuit disruption by diffuse brain injury: basis for morbidity & therapy
    Jonathan Lifshitz; Fiscal Year: 2010
    ..By developing, validating and implementing an animal model of one discrete post-traumatic morbidity, significant advancements can be made towards reshaping first one, then other, brain- injured circuits in rodents and man. ..
  3. Neural circuit disruption by diffuse brain injury: basis for morbidity & therapy
    Jonathan Lifshitz; Fiscal Year: 2010
    ..By developing, validating and implementing an animal model of one discrete post-traumatic morbidity, significant advancements can be made towards reshaping first one, then other, brain- injured circuits in rodents and man. ..