Thomas M Lietman

Summary

Affiliation: University of California
Country: USA

Publications

  1. pmc Eliminating trachoma in areas with limited disease
    Bruce D Gaynor
    WHO Collaborating Center, F I Proctor Foundation, Department of Ophthalmology, University of California San Francisco, San Francisco, CA 94143, USA
    Emerg Infect Dis 9:596-8. 2003
  2. pmc Trachoma decline and widespread use of antimicrobial drugs
    Jaya D Chidambaram
    University of California, San Francisco, California, USA
    Emerg Infect Dis 10:1895-9. 2004
  3. ncbi request reprint Global elimination of trachoma: how frequently should we administer mass chemotherapy?
    T Lietman
    The F I Proctor Foundation and the Department of Ophthalmology, The University of California San Francisco, USA
    Nat Med 5:572-6. 1999
  4. ncbi request reprint Complete local elimination of infectious trachoma from severely affected communities after six biannual mass azithromycin distributions
    Jesse B Biebesheimer
    FI Proctor Foundation, University of California, San Francisco, California 94143 0412, USA
    Ophthalmology 116:2047-50. 2009
  5. pmc Emerging moxifloxacin resistance in Pseudomonas aeruginosa keratitis isolates in South India
    Catherine E Oldenburg
    Francis I Proctor Foundation, University of California, San Francisco, CA, USA
    Ophthalmic Epidemiol 20:155-8. 2013
  6. pmc A rationale for continuing mass antibiotic distributions for trachoma
    Kathryn J Ray
    Francis I, Proctor Foundation, University of California, San Francisco, CA, USA
    BMC Infect Dis 7:91. 2007
  7. pmc Fluoroquinolone treatment and susceptibility of isolates from bacterial keratitis
    Kathryn J Ray
    Francis I Proctor Foundation, University of California, San Francisco, CA 94143 0412, USA
    JAMA Ophthalmol 131:310-3. 2013
  8. pmc Diagnostic characteristics of tests for ocular Chlamydia after mass azithromycin distributions
    Jeremy D Keenan
    F I Proctor Foundation, 513 Parnassus Avenue, Med Sci S309, Box 0412, University of California, San Francisco, San Francisco, CA 94143 0412, USA
    Invest Ophthalmol Vis Sci 53:235-40. 2012
  9. pmc Clinical activity and polymerase chain reaction evidence of chlamydial infection after repeated mass antibiotic treatments for trachoma
    Jeremy D Keenan
    Department of Ophthalmology, University of California, San Francisco, CA, USA
    Am J Trop Med Hyg 82:482-7. 2010
  10. pmc Moxifloxacin susceptibility mediates the relationship between causative organism and clinical outcome in bacterial keratitis
    Catherine E Oldenburg
    Francis I Proctor Foundation, University of California San Francisco, 513 Parnassus Avenue, Room S309, San Francisco, CA 94117, USA
    Invest Ophthalmol Vis Sci 54:1522-6. 2013

Research Grants

  1. The Steroids for Cornea Ulcers Trial
    Thomas Lietman; Fiscal Year: 2007
  2. Predicting Resistance: Validating Mathematical Models
    Thomas Lietman; Fiscal Year: 2004
  3. Eliminating trachoma with repeat mass drug treatment
    Thomas Lietman; Fiscal Year: 2004
  4. The Steroids for Cornea Ulcers Trial
    Thomas Lietman; Fiscal Year: 2005
  5. Eliminating trachoma with repeat mass drug treatment
    Thomas Lietman; Fiscal Year: 2007

Collaborators

Detail Information

Publications63

  1. pmc Eliminating trachoma in areas with limited disease
    Bruce D Gaynor
    WHO Collaborating Center, F I Proctor Foundation, Department of Ophthalmology, University of California San Francisco, San Francisco, CA 94143, USA
    Emerg Infect Dis 9:596-8. 2003
    ..We describe the success of multiple mass antibiotic treatments, demonstrating that complete elimination of infection may be an attainable goal in an area with modest disease...
  2. pmc Trachoma decline and widespread use of antimicrobial drugs
    Jaya D Chidambaram
    University of California, San Francisco, California, USA
    Emerg Infect Dis 10:1895-9. 2004
    ..We demonstrate that high background antimicrobial drug use may be responsible for much of the observed decline in trachoma and discuss its potential role in eliminating this infectious disease...
  3. ncbi request reprint Global elimination of trachoma: how frequently should we administer mass chemotherapy?
    T Lietman
    The F I Proctor Foundation and the Department of Ophthalmology, The University of California San Francisco, USA
    Nat Med 5:572-6. 1999
    ..We recommend, based on our analysis, that in areas where trachoma is moderately prevalent (<35% in children), it should be treated annually, but hyperendemic areas (>50% in children), it should be treated biannually...
  4. ncbi request reprint Complete local elimination of infectious trachoma from severely affected communities after six biannual mass azithromycin distributions
    Jesse B Biebesheimer
    FI Proctor Foundation, University of California, San Francisco, California 94143 0412, USA
    Ophthalmology 116:2047-50. 2009
    ..To determine whether infectious trachoma can be completely eliminated from severely affected villages...
  5. pmc Emerging moxifloxacin resistance in Pseudomonas aeruginosa keratitis isolates in South India
    Catherine E Oldenburg
    Francis I Proctor Foundation, University of California, San Francisco, CA, USA
    Ophthalmic Epidemiol 20:155-8. 2013
    ..To describe temporal trends in Pseudomonas aeruginosa resistance to moxifloxacin in keratitis isolates from South India...
  6. pmc A rationale for continuing mass antibiotic distributions for trachoma
    Kathryn J Ray
    Francis I, Proctor Foundation, University of California, San Francisco, CA, USA
    BMC Infect Dis 7:91. 2007
    ..Here we use mathematical models to demonstrate that repeated antibiotic distributions can eliminate infection in a reasonable time period...
  7. pmc Fluoroquinolone treatment and susceptibility of isolates from bacterial keratitis
    Kathryn J Ray
    Francis I Proctor Foundation, University of California, San Francisco, CA 94143 0412, USA
    JAMA Ophthalmol 131:310-3. 2013
    ..To analyze the relationship between fluoroquinolone use at presentation and minimum inhibitory concentration in bacterial keratitis...
  8. pmc Diagnostic characteristics of tests for ocular Chlamydia after mass azithromycin distributions
    Jeremy D Keenan
    F I Proctor Foundation, 513 Parnassus Avenue, Med Sci S309, Box 0412, University of California, San Francisco, San Francisco, CA 94143 0412, USA
    Invest Ophthalmol Vis Sci 53:235-40. 2012
    ....
  9. pmc Clinical activity and polymerase chain reaction evidence of chlamydial infection after repeated mass antibiotic treatments for trachoma
    Jeremy D Keenan
    Department of Ophthalmology, University of California, San Francisco, CA, USA
    Am J Trop Med Hyg 82:482-7. 2010
    ....
  10. pmc Moxifloxacin susceptibility mediates the relationship between causative organism and clinical outcome in bacterial keratitis
    Catherine E Oldenburg
    Francis I Proctor Foundation, University of California San Francisco, 513 Parnassus Avenue, Room S309, San Francisco, CA 94117, USA
    Invest Ophthalmol Vis Sci 54:1522-6. 2013
    ..In this report, we analyze the role of moxifloxacin susceptibility in the relationship between causative organisms and clinical outcome in bacteria keratitis...
  11. ncbi request reprint Travel and implications for the elimination of trachoma in ethiopia
    Neelima A Shah
    Department of Public Health Sciences, University of California, Davis, California, USA
    Ophthalmic Epidemiol 17:113-7. 2010
    ..Reintroduction of infection could occur from the few remaining infected cases in a treated community or from outside the community. People traveling between villages might be responsible thus complicating the elimination of trachoma...
  12. pmc Childhood mortality in a cohort treated with mass azithromycin for trachoma
    Jeremy D Keenan
    F I Proctor Foundation, San Francisco, CA, USA
    Clin Infect Dis 52:883-8. 2011
    ..Here, we monitor a large cohort in which almost 90% of individuals received azithromycin. We assess whether receiving treatment is associated with reduced all-cause and infectious childhood mortality...
  13. pmc Visual outcomes in treated bacterial keratitis: four years of prospective follow-up
    Scott M McClintic
    Department of Ophthalmology, University of California, San Francisco, San Francisco, California, United States
    Invest Ophthalmol Vis Sci 55:2935-40. 2014
    ..We described the change in visual acuity experienced by eyes successfully treated for bacterial keratitis...
  14. pmc Ribosomal RNA evidence of ocular Chlamydia trachomatis infection following 3 annual mass azithromycin distributions in communities with highly prevalent trachoma
    Jeremy D Keenan
    FI Proctor Foundation, Department of Ophthalmology, University of California, San Francisco, CA 94143 0412, USA
    Clin Infect Dis 54:253-6. 2012
    ..An RNA-based test detected ocular chlamydial infection in more children than did a DNA-based test (6.9% vs 4.2%), and in a larger number of communities (8 vs 7)...
  15. pmc The fitness cost of antibiotic resistance in Streptococcus pneumoniae: insight from the field
    M Cyrus Maher
    Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California, United States of America
    PLoS ONE 7:e29407. 2012
    ..Observational studies have supported this, but due to ethical and practical considerations, it is rare to have experimental control over antibiotic prescription rates...
  16. doi request reprint Complete elimination is a difficult goal for trachoma programs in severely affected communities
    Deborah A Gill
    F I Proctor Foundation, San Francisco, USA
    Clin Infect Dis 46:564-6. 2008
    ..Theoretically, a loftier goal of elimination is feasible. Here, we demonstrate that, although local elimination of infection in the most severely affected communities is difficult, it is possible with biannual antibiotic distributions...
  17. pmc Prior elicitation and Bayesian analysis of the Steroids for Corneal Ulcers Trial
    Craig W See
    FI Proctor Foundation, University of California, San Francisco, CA 94143 0412, USA
    Ophthalmic Epidemiol 19:407-13. 2012
    ..To elicit expert opinion on the use of adjunctive corticosteroid therapy in bacterial corneal ulcers. To perform a Bayesian analysis of the Steroids for Corneal Ulcers Trial (SCUT), using expert opinion as a prior probability...
  18. ncbi request reprint Effect of a single mass antibiotic distribution on the prevalence of infectious trachoma
    Jaya D Chidambaram
    F I Proctor Foundation, University of California, San Francisco, CA 94143 0412, USA
    JAMA 295:1142-6. 2006
    ..Some hypothesize that a single distribution is sufficient to control the ocular strains of chlamydia that cause trachoma. Others believe infection will inevitably return and periodic treatments or other measures are essential...
  19. doi request reprint Detection of Chlamydia trachomatis ocular infection in trachoma-endemic communities by rRNA amplification
    Jon L Yang
    F I Proctor Foundation, University of California, San Francisco, San Francisco, CA 94143, USA
    Invest Ophthalmol Vis Sci 50:90-4. 2009
    ..A newer ribosomal ribonucleic acid (rRNA)-based amplification test was compared with the current DNA-based polymerase chain reaction (PCR) for the detection of C. trachomatis...
  20. ncbi request reprint Association of conjunctival bacterial infection and female sex in cicatricial trachoma
    Vicky Cevallos
    Francis I Proctor Foundation, San Francisco, California 94143 0412, USA
    Invest Ophthalmol Vis Sci 53:5208-12. 2012
    ..To further characterize the microbiological profile of bacterial conjunctival infections in cicatricial trachoma, a conjunctival swabbing of adults in rural Ethiopia was performed...
  21. ncbi request reprint Chlamydia on children and flies after mass antibiotic treatment for trachoma
    Scott Lee
    F I Proctor Foundation, San Francisco, CA 94143, USA
    Am J Trop Med Hyg 76:129-31. 2007
    ..Prevalence of trachoma in children proved to be an excellent predictor of the prevalence on flies (correlation coefficient, 0.89). Thus, treating children with antibiotics may drastically reduce the role of flies as a vector...
  22. pmc Association between cytotoxic and invasive Pseudomonas aeruginosa and clinical outcomes in bacterial keratitis
    Durga S Borkar
    F I Proctor Foundation, University of California, San Francisco, San Francisco, CA 94143 0412, USA
    JAMA Ophthalmol 131:147-53. 2013
    ..To determine whether cytotoxic and invasive Pseudomonas aeruginosa strains differentially influence clinical presentation, outcomes, or therapeutic response in bacterial keratitis...
  23. pmc When can antibiotic treatments for trachoma be discontinued? Graduating communities in three African countries
    Kathryn J Ray
    F I Proctor Foundation, University of California, San Francisco, California, United States of America
    PLoS Negl Trop Dis 3:e458. 2009
    ..While this can be tested empirically, results will not be available for years. Here we use a mathematical model to predict results with different graduation strategies in three African countries...
  24. ncbi request reprint Seasonal trends of microbial keratitis in South India
    Charles C Lin
    Department of Ophthalmology, University of California San Francisco, San Francisco, CA 94143 0412, USA
    Cornea 31:1123-7. 2012
    ..This study analyzes seasonal trends in the incidence of fungal and bacterial keratitis at the Aravind Eye Hospital in southeast India...
  25. pmc How reliable are tests for trachoma?--a latent class approach
    Craig W See
    F I Proctor Foundation, University of California San Francisco, San Francisco, California 94143 0412, USA
    Invest Ophthalmol Vis Sci 52:6133-7. 2011
    ..Latent class analysis (LCA) was performed to estimate the sensitivity and specificity of laboratory and clinical tests for trachoma in the absence of a gold standard...
  26. pmc Impact of mass azithromycin distribution on malaria parasitemia during the low-transmission season in Niger: a cluster-randomized trial
    Bruce D Gaynor
    F I Proctor Foundation, Department of Ophthalmology, Department of Epidemiology and Biostatistics, Institute for Global Health, Department of Medicine, University of California, San Francisco, California Programme National de Lutte Contre la Cecité Niamey, Niger Zinder Hospital, Zinder, Niger Dana Center for Preventive Ophthalmology, Wilmer Eye Institute, Johns Hopkins University, Baltimore, Maryland Clinical Research Unit, Department of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine, London, United Kingdom
    Am J Trop Med Hyg 90:846-51. 2014
    ..03). Mass distribution of azithromycin reduced malaria parasitemia 4-5 months after the intervention. The results suggest that drugs with antimalaria activity can have long-lasting impacts on malaria during periods of low transmission...
  27. doi request reprint The decline of pneumococcal resistance after cessation of mass antibiotic distributions for trachoma
    Sara Haug
    FI Proctor Foundation, Department of Ophthalmology, University of California, San Francisco, California 94143 0944, USA
    Clin Infect Dis 51:571-4. 2010
    ..6% (95% CI, 18.8%-40.4%; P <.001 ) and 20.8% (95% CI, 12.7%-30.7%; P < .001), respectively. Macrolide resistance decreases after antibiotic pressure is removed...
  28. doi request reprint Assessment of herd protection against trachoma due to repeated mass antibiotic distributions: a cluster-randomised trial
    Jenafir I House
    FI Proctor Foundation, University of California, San Francisco, USA
    Lancet 373:1111-8. 2009
    ..We assessed indirect protection against trachoma with mass azithromycin distributions...
  29. pmc Lack of macrolide resistance in Chlamydia trachomatis after mass azithromycin distributions for trachoma
    Kevin Cyrus Hong
    University of California, San Francisco, California 94143, USA
    Emerg Infect Dis 15:1088-90. 2009
    ..trachomatis are highly endemic. We found no significant differences in susceptibilities to azithromycin and doxycycline in 6 posttreatment and 4 pretreatment samples...
  30. pmc Association between In Vitro Susceptibility to Natamycin and Voriconazole and Clinical Outcomes in Fungal Keratitis
    Catherine Q Sun
    F I Proctor Foundation, University of California, San Francisco, San Francisco, California
    Ophthalmology 121:1495-1500.e1. 2014
    ..To assess the association between minimum inhibitory concentration (MIC) and clinical outcomes in a fungal keratitis clinical trial...
  31. ncbi request reprint Effect of mass distribution of azithromycin for trachoma control on overall mortality in Ethiopian children: a randomized trial
    Travis C Porco
    F I Proctor Foundation, and Department of Ophthalmology, University of California San Francisco, San Francisco, CA 94143, USA
    JAMA 302:962-8. 2009
    ..Antibiotics are provided to target the ocular strains of chlamydia that cause trachoma, but may also be efficacious against respiratory disease, diarrhea, and malaria--frequent causes of childhood mortality in trachoma-endemic areas...
  32. pmc Topical fluoroquinolone use as a risk factor for in vitro fluoroquinolone resistance in ocular cultures
    Robert E Fintelmann
    Francis I Proctor Foundation for Research in Ophthalmology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143 0412, USA
    Arch Ophthalmol 129:399-402. 2011
    ..To determine whether recent use of topical fluoroquinolones is a risk factor for in vitro fluoroquinolone resistance in Staphylococcus aureus ocular isolates...
  33. pmc Efficacy of latrine promotion on emergence of infection with ocular Chlamydia trachomatis after mass antibiotic treatment: a cluster-randomized trial
    Nicole E Stoller
    F I Proctor Foundation, University of California San Francisco, USA
    Int Health 3:75-84. 2011
    ..0% and 25.0% respectively in the single treatment only arm. We were unable to detect a difference in the prevalence of ocular chlamydial infection in children due to latrine construction. ..
  34. pmc The clinical differentiation of bacterial and fungal keratitis: a photographic survey
    Cyril Dalmon
    F I Proctor Foundation and Department of Ophthalmology, University of California San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143, USA
    Invest Ophthalmol Vis Sci 53:1787-91. 2012
    ..The purpose of this study was to determine whether clinical signs of infectious keratitis can be used to identify the causative organism...
  35. pmc Expert prior elicitation and Bayesian analysis of the Mycotic Ulcer Treatment Trial I
    Catherine Q Sun
    Francis I Proctor Foundation, University of California, San Francisco, San Francisco, California, USA
    Invest Ophthalmol Vis Sci 54:4167-73. 2013
    ..To perform a Bayesian analysis of the Mycotic Ulcer Treatment Trial I (MUTT I) using expert opinion as a prior belief...
  36. pmc The association between latrine use and trachoma: a secondary cohort analysis from a randomized clinical trial
    Meron Haile
    Francis I Proctor Foundation, University of California, San Francisco, California The Carter Center, Addis Ababa, Ethiopia Departments of Ophthalmology and Epidemiology and Biostatistics, University of California, San Francisco, California The Carter Center, Atlanta, Georgia Institute for Global Health, University of California, San Francisco, California
    Am J Trop Med Hyg 89:717-20. 2013
    ..Specifically, for each 10% increase in latrine use, there was a 2.0% decrease (95% confidence interval = 0.2-3.9% decrease) in the community prevalence of ocular chlamydia over the subsequent year (P = 0.04)...
  37. pmc Cytotoxic clinical isolates of Pseudomonas aeruginosa identified during the Steroids for Corneal Ulcers Trial show elevated resistance to fluoroquinolones
    Durga S Borkar
    School of Optometry, University of California, 688 Minor Hall, 94720 Berkeley, CA, USA
    BMC Ophthalmol 14:54. 2014
    ..aeruginosa strains isolated from microbial keratitis during the Steroids for Corneal Ulcers Trial (SCUT) and for two laboratory strains, PA103 and PAO1...
  38. pmc The epidemiological dynamics of infectious trachoma may facilitate elimination
    Thomas M Lietman
    F I Proctor Foundation, University of California, San Francisco, CA, 94143 0412, USA
    Epidemics 3:119-24. 2011
    ..Here, we use mathematical models to assess whether more ambitious goals such as local elimination or even global eradication are possible...
  39. pmc Pseudomonas aeruginosa keratitis: outcomes and response to corticosteroid treatment
    Aileen Sy
    F I Proctor Foundation, University of California, San Francisco, San Francisco, CA, USA
    Invest Ophthalmol Vis Sci 53:267-72. 2012
    ..To compare the clinical course and effect of adjunctive corticosteroid therapy in Pseudomonas aeruginosa with those of all other strains of bacterial keratitis...
  40. ncbi request reprint Early addition of topical corticosteroids in the treatment of bacterial keratitis
    Kathryn J Ray
    F I Proctor Foundation, University of California, San Francisco2Department of Epidemiology and Biostatistics, University of California, San Francisco
    JAMA Ophthalmol 132:737-41. 2014
    ..Scarring from bacterial keratitis remains a leading cause of visual loss...
  41. pmc Practice patterns and opinions in the management of recurrent or chronic herpes zoster ophthalmicus
    Aileen Sy
    Department of Ophthalmology, F I Proctor Foundation, University of California, San Francisco, San Francisco, CA, USA
    Cornea 31:786-90. 2012
    ..The objective of this study was to determine current practices and opinions among cornea specialists for treating and preventing recurrences of herpes zoster ophthalmicus (HZO)...
  42. ncbi request reprint Mass antibiotic treatment and community protection in trachoma control programs
    Jaya D Chidambaram
    F I Proctor Foundation for Research in Ophthalmology, University of California, San Francisco, CA 94143 0944, USA
    Clin Infect Dis 39:e95-7. 2004
    ..Similarities with the indirect protection within a treated community (i.e., "herd protection") that has been observed in vaccination programs are discussed...
  43. ncbi request reprint Trachoma: an update on prevention, diagnosis, and treatment
    Satasuk Joy Bhosai
    F I Proctor Foundation and Department of Ophthalmology, University of California San Francisco, 513 Parnassus Ave, San Francisco, CA 94143, USA
    Curr Opin Ophthalmol 23:288-95. 2012
    ..To review recent clinical and epidemiological studies regarding the prevention, diagnosis, and treatment of trachoma...
  44. ncbi request reprint Spectrum of eye disease caused by methicillin-resistant Staphylococcus aureus
    Julie Freidlin
    F I Proctor Foundation, University of California, San Francisco, CA 94143, USA
    Am J Ophthalmol 144:313-5. 2007
    ..To compare the clinical features and antibiotic susceptibility of ocular methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-sensitive Staphylococcus aureus (MSSA)...
  45. doi request reprint The efficacy of oral azithromycin in clearing ocular chlamydia: mathematical modeling from a community-randomized trachoma trial
    Fengchen Liu
    F I Proctor Foundation, University of California, San Francisco, CA, USA
    Epidemics 6:10-7. 2014
    ..We found no evidence of decreased efficacy during the course of the trial. We estimated an 89% chance of elimination after 10 years of annual treatment with 95% coverage. ..
  46. pmc Elimination and eradication of neglected tropical diseases with mass drug administrations: a survey of experts
    Jeremy D Keenan
    Francis I Proctor Foundation, University of California, San Francisco, San Francisco, California, United States of America Department of Ophthalmology, University of California, San Francisco, San Francisco, California, United States of America
    PLoS Negl Trop Dis 7:e2562. 2013
    ..We performed a survey of neglected tropical diseases experts to elicit their opinions on the role of mass drug administrations for the elimination of these infections...
  47. pmc Assessment of transmission in trachoma programs over time suggests no short-term loss of immunity
    Fengchen Liu
    F I Proctor Foundation, University of California, San Francisco, California, USA
    PLoS Negl Trop Dis 7:e2303. 2013
    ..This is encouraging, as it allows the possibility that repeated mass antibiotic distributions may eliminate infection from even the most severely affected areas. ..
  48. ncbi request reprint Does the diagnosis of trachoma adequately identify ocular chlamydial infection in trachoma-endemic areas?
    Mariko Bird
    F I Proctor Foundation, University of California, San Francisco, California 94143, USA
    J Infect Dis 187:1669-73. 2003
    ..Clinically active trachoma is not always a reliable marker of infection, particularly in teenagers and after treatment...
  49. pmc Reliability of trachoma clinical grading--assessing grading of marginal cases
    Salman A Rahman
    F I Proctor Foundation, San Francisco, California, United States of America
    PLoS Negl Trop Dis 8:e2840. 2014
    ..Here, we confirm those results and assess performance of trainees on these borderline cases by calculating their reliability error, a measure derived from the decomposition of the Brier score...
  50. ncbi request reprint Mass antibiotics for trachoma and the Allee effect
    Jaya D Chidambaram
    FI Proctor Foundation, University of California, San Francisco, CA, USA
    Lancet Infect Dis 5:194-6. 2005
  51. pmc Antibiotic selection pressure and macrolide resistance in nasopharyngeal Streptococcus pneumoniae: a cluster-randomized clinical trial
    Alison H Skalet
    Francis I Proctor Foundation for Research in Opthalmology, University of California, San Francisco, San Francisco, California, United States of America
    PLoS Med 7:e1000377. 2010
    ..In this study, we used a randomized clinical trial design to assess whether macrolide resistance was higher in communities treated with mass azithromycin for trachoma, compared to untreated control communities...
  52. pmc Practice patterns and opinions in the treatment of acanthamoeba keratitis
    Catherine E Oldenburg
    F I Proctor Foundation, University of California, San Francisco, San Francisco, CA 94143 0944, USA
    Cornea 30:1363-8. 2011
    ..Management of acanthamoeba keratitis remains challenging for ophthalmologists. We conducted a survey of members of The Cornea Society to elicit expert opinions on the diagnosis and treatment of acanthamoeba keratitis...
  53. pmc Does in vitro susceptibility predict clinical outcome in bacterial keratitis?
    Aiyin Chen
    F I Proctor Foundation, Department of Ophthalmology, University of California, San Francisco, San Francisco, California 94143, USA
    Am J Ophthalmol 145:409-412. 2008
    ..To determine whether clinical outcomes in bacterial keratitis are associated with antibiotic susceptibility...
  54. pmc Comparison of an rRNA-based and DNA-based nucleic acid amplification test for the detection of Chlamydia trachomatis in trachoma
    Jon L Yang
    F I Proctor Foundation, University of California San Francisco, San Francisco, CA 94143 0412, USA
    Br J Ophthalmol 91:293-5. 2007
    ..This study compares an rRNA-based test to a DNA-based test for the detection of ocular C trachomatis infection in children living in trachoma-endemic villages...
  55. ncbi request reprint Estimating community prevalence of ocular Chlamydia trachomatis infection using pooled polymerase chain reaction testing
    Kathryn J Ray
    F I Proctor Foundation, University of California, San Francisco, CA, USA
    Ophthalmic Epidemiol 21:86-91. 2014
    ..Here we demonstrate simulations of pooled PCR results may estimate infection prevalence of an entire community yielding substantial cost savings if pool size is chosen correctly...
  56. ncbi request reprint The return of trachoma in partially treated communities
    Jon L Yang
    Department of Ophthalmology, F I Proctor Foundation, University of California, San Francisco, San Francisco, CA 94143 0412, USA
    Arch Ophthalmol 125:989-91. 2007
  57. ncbi request reprint Seasonal effects in the elimination of trachoma
    David C Lee
    Francis I Proctor Foundation, Department of Ophthalmology, Institute for Global Health, University of California, San Francisco 94143 0944, USA
    Am J Trop Med Hyg 72:468-70. 2005
    ..Here we use mathematical models of disease transmission to demonstrate that ideally, treatment should be administered before the low season to have the greatest chance of locally eliminating infection...
  58. ncbi request reprint Atopic disease and herpes simplex eye disease: a population-based case-control study
    Tisha Prabriputaloong
    Department Francis I Proctor Foundation, University of California San Francisco, San Francisco, California, USA
    Am J Ophthalmol 142:745-9. 2006
    ..To determine whether atopy is associated with herpes simplex virus (HSV) ocular disease...
  59. doi request reprint Predictors of matching in an ophthalmology residency program
    Allison R Loh
    Department of Ophthalmology, University of California San Francisco, San Francisco, California 94121, USA
    Ophthalmology 120:865-70. 2013
    ..To examine the characteristics of US medical students applying for ophthalmology residency and to determine the predictors of matching...
  60. pmc Antibiotic use as a tragedy of the commons: a cross-sectional survey
    Kieran S O'Brien
    F I Proctor Foundation, University of California, San Francisco, CA 94143 0412, USA
    Comput Math Methods Med 2014:837929. 2014
    ..A survey was conducted to learn the views of infectious disease experts on the individual- and societal-level consequences of antibiotic use...
  61. ncbi request reprint Antioxidants in prevention of cataracts in South India: methodology and baseline data*
    David C Gritz
    Department of Ophthalmology, Beckman Vision Center, University of California, San Francisco, CA, USA
    Ophthalmic Epidemiol 13:97-107. 2006
    ..To describe the methodology and baseline data for the Antioxidants in Prevention of Cataracts (APC) study in South India...
  62. pmc When does overuse of antibiotics become a tragedy of the commons?
    Travis C Porco
    Francis I Proctor Foundation for Research in Ophthalmology, University of California San Francisco, San Francisco, California, USA
    PLoS ONE 7:e46505. 2012
    ..In this view, self-interest and societal interest are at odds, making antibiotic use a classic "tragedy of the commons"...
  63. ncbi request reprint Parasites on the rise: a new epidemic of Acanthamoeba keratitis
    Nisha R Acharya
    F I Proctor Foundation and Department of Ophthalmology, University of California San Francisco, San Francisco, CA 94143, USA
    Am J Ophthalmol 144:292-3. 2007

Research Grants7

  1. The Steroids for Cornea Ulcers Trial
    Thomas Lietman; Fiscal Year: 2007
    ..2) To determine whether the addition of topical steroids results in a higher frequency of adverse outcomes. 3) To determine whether outcomes depend on the organism. ..
  2. Predicting Resistance: Validating Mathematical Models
    Thomas Lietman; Fiscal Year: 2004
    ..3. To test the validity of mathematical models by determining the prevalence of pneumococcal resistance empirically after multiple mass distributions. ..
  3. Eliminating trachoma with repeat mass drug treatment
    Thomas Lietman; Fiscal Year: 2004
    ..To determine whether children form a core group for the transmission of trachoma. Can treatment targeted to children alone eventually eliminate infection in the entire community? ..
  4. The Steroids for Cornea Ulcers Trial
    Thomas Lietman; Fiscal Year: 2005
    ..2) To determine whether the addition of topical steroids results in a higher frequency of adverse outcomes. 3) To determine whether outcomes depend on the organism. ..
  5. Eliminating trachoma with repeat mass drug treatment
    Thomas Lietman; Fiscal Year: 2007
    ..To determine whether children form a core group for the transmission of trachoma. Can treatment targeted to children alone eventually eliminate infection in the entire community? ..