Andrew Lidral

Summary

Affiliation: University of Iowa
Country: USA

Publications

  1. pmc Application of the Linux cluster for exhaustive window haplotype analysis using the FBAT and Unphased programs
    Hiroyuki Mishima
    Dows Institute for Dental Research, College of Dentistry, University of Iowa, Iowa City, IA 52242, USA
    BMC Bioinformatics 9:S10. 2008
  2. pmc Progress toward discerning the genetics of cleft lip
    Andrew C Lidral
    Department of Orthodontics, University of Iowa, Iowa City, Iowa 52242, USA
    Curr Opin Pediatr 17:731-9. 2005
  3. pmc The role of MSX1 in human tooth agenesis
    A C Lidral
    Department of Orthodontics, University of Iowa, 140 EMRB, Iowa City 52242, USA
    J Dent Res 81:274-8. 2002
  4. ncbi Genetic approaches to identify disease genes for birth defects with cleft lip/palate as a model
    Andrew C Lidral
    Department of Orthodontics and Dows Institute for Dental Research, College of Dentistry, University of Iowa, Iowa City, IA 52242, USA
    Birth Defects Res A Clin Mol Teratol 70:893-901. 2004
  5. pmc Mutations in IRF6 cause Van der Woude and popliteal pterygium syndromes
    Shinji Kondo
    Department of Pediatrics, The University of Iowa, Iowa City, Iowa 52242, USA
    Nat Genet 32:285-9. 2002
  6. ncbi Genetic analysis of candidate loci in non-syndromic cleft lip families from Antioquia-Colombia and Ohio
    Lina M Moreno
    Dows Institute for Dental Research, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Med Genet A 125:135-44. 2004
  7. ncbi Interferon regulatory factor 6 (IRF6) gene variants and the risk of isolated cleft lip or palate
    Theresa M Zucchero
    University of Iowa, Iowa City 52242, USA
    N Engl J Med 351:769-80. 2004
  8. pmc FOXE1 association with both isolated cleft lip with or without cleft palate, and isolated cleft palate
    Lina M Moreno
    Department of Orthodontics, College of Dentistry, University of Iowa, Iowa City, IA 52242, USA
    Hum Mol Genet 18:4879-96. 2009
  9. pmc Meta-analysis of 13 genome scans reveals multiple cleft lip/palate genes with novel loci on 9q21 and 2q32-35
    Mary L Marazita
    Center for Craniofacial and Dental Genetics, Division of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Am J Hum Genet 75:161-73. 2004
  10. pmc Interferon regulatory factor 6 (IRF6) and fibroblast growth factor receptor 1 (FGFR1) contribute to human tooth agenesis
    Alexandre R Vieira
    Department of Oral Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Med Genet A 143:538-45. 2007

Collaborators

Detail Information

Publications16

  1. pmc Application of the Linux cluster for exhaustive window haplotype analysis using the FBAT and Unphased programs
    Hiroyuki Mishima
    Dows Institute for Dental Research, College of Dentistry, University of Iowa, Iowa City, IA 52242, USA
    BMC Bioinformatics 9:S10. 2008
    ..In this paper, we report the utilization of a queuing scheduler built on the Grid Engine and run on a Rocks Linux cluster for our genetic statistical studies...
  2. pmc Progress toward discerning the genetics of cleft lip
    Andrew C Lidral
    Department of Orthodontics, University of Iowa, Iowa City, Iowa 52242, USA
    Curr Opin Pediatr 17:731-9. 2005
    ..The purpose of this review is to summarize recent progress of human genetic studies in identifying causal genes for isolated or nonsyndromic cleft lip with or without cleft palate...
  3. pmc The role of MSX1 in human tooth agenesis
    A C Lidral
    Department of Orthodontics, University of Iowa, 140 EMRB, Iowa City 52242, USA
    J Dent Res 81:274-8. 2002
    ..Supporting this theory, no mutations were found in more common cases of incisor or premolar agenesis, indicating that these have a different etiology...
  4. ncbi Genetic approaches to identify disease genes for birth defects with cleft lip/palate as a model
    Andrew C Lidral
    Department of Orthodontics and Dows Institute for Dental Research, College of Dentistry, University of Iowa, Iowa City, IA 52242, USA
    Birth Defects Res A Clin Mol Teratol 70:893-901. 2004
    ..The purpose of this article is to provide an overview of genetic approaches to identifying disease genes for genetically complex birth defects...
  5. pmc Mutations in IRF6 cause Van der Woude and popliteal pterygium syndromes
    Shinji Kondo
    Department of Pediatrics, The University of Iowa, Iowa City, Iowa 52242, USA
    Nat Genet 32:285-9. 2002
    ..Our observations demonstrate that haploinsufficiency of IRF6 disrupts orofacial development and are consistent with dominant-negative mutations disturbing development of the skin and genitalia...
  6. ncbi Genetic analysis of candidate loci in non-syndromic cleft lip families from Antioquia-Colombia and Ohio
    Lina M Moreno
    Dows Institute for Dental Research, University of Iowa, Iowa City, Iowa 52242, USA
    Am J Med Genet A 125:135-44. 2004
    ..This article contains supplementary material, which may be viewed at the American Journal of Medical Genetics website at http://www.interscience.wiley.com/jpages/0148-7299/suppmat/index.html...
  7. ncbi Interferon regulatory factor 6 (IRF6) gene variants and the risk of isolated cleft lip or palate
    Theresa M Zucchero
    University of Iowa, Iowa City 52242, USA
    N Engl J Med 351:769-80. 2004
    ..We searched for a specific genetic factor contributing to this complex trait by examining large numbers of affected patients and families and evaluating a specific candidate gene...
  8. pmc FOXE1 association with both isolated cleft lip with or without cleft palate, and isolated cleft palate
    Lina M Moreno
    Department of Orthodontics, College of Dentistry, University of Iowa, Iowa City, IA 52242, USA
    Hum Mol Genet 18:4879-96. 2009
    ..These data indicate that FOXE1 is a major gene for CL/P and provides new insights for improved counseling and genetic interaction studies...
  9. pmc Meta-analysis of 13 genome scans reveals multiple cleft lip/palate genes with novel loci on 9q21 and 2q32-35
    Mary L Marazita
    Center for Craniofacial and Dental Genetics, Division of Oral Biology, School of Dental Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA
    Am J Hum Genet 75:161-73. 2004
    ..0004). These are the first genomewide significant linkage results ever reported for CL/P, and they represent an unprecedented demonstration of the power of linkage analysis to detect multiple genes simultaneously for a complex disorder...
  10. pmc Interferon regulatory factor 6 (IRF6) and fibroblast growth factor receptor 1 (FGFR1) contribute to human tooth agenesis
    Alexandre R Vieira
    Department of Oral Biology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
    Am J Med Genet A 143:538-45. 2007
    ..014) and IRF6 (P = 0.002) markers. There were statistically significant data suggesting that IRF6 interacts not only with MSX1 (P = 0.001), but also with TGFA (P = 0.03)...
  11. pmc CRISPLD2: a novel NSCLP candidate gene
    Brett T Chiquet
    Department of Pediatrics, University of Texas Medical School, Houston, TX 77030, USA
    Hum Mol Genet 16:2241-8. 2007
    ..5-E17.5, respectively. Altogether, these data suggest that genetic variation in CRISPLD2 has a role in the etiology of NSCLP...
  12. pmc Genetic association studies of cleft lip and/or palate with hypodontia outside the cleft region
    Rebecca L Slayton
    Department of Pediatric Dentistry, Oregon Health and Science University School of Dentistry, SD 182, 611 SW Campus Drive, Portland, OR 97239, USA
    Cleft Palate Craniofac J 40:274-9. 2003
    ..The purpose of this study was to determine whether the candidate genes previously studied in subjects with cleft lip, cleft palate, or both are associated with hypodontia outside the region of the cleft...
  13. pmc Development of the upper lip: morphogenetic and molecular mechanisms
    Rulang Jiang
    Center for Oral Biology and Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Dev Dyn 235:1152-66. 2006
    ....
  14. pmc Expression of Wnt9b and activation of canonical Wnt signaling during midfacial morphogenesis in mice
    Yu Lan
    Center for Oral Biology and Department of Biomedical Genetics, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642, USA
    Dev Dyn 235:1448-54. 2006
    ..These data, together with the CLP lip phenotype in WNT3-/- humans and Wnt9b-/- mutant mice, indicate that Wnt3 and Wnt9b signal through the canonical Wnt signaling pathway to regulate midfacial development and lip fusion...
  15. ncbi Wnt9b is the mutated gene involved in multifactorial nonsyndromic cleft lip with or without cleft palate in A/WySn mice, as confirmed by a genetic complementation test
    Diana M Juriloff
    Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, Canada
    Birth Defects Res A Clin Mol Teratol 76:574-9. 2006
    ..Independently a recessive knockout mutation of Wnt9b (Wnt9b-) was reported to cause a lethal syndrome that includes some CLP...
  16. ncbi Guidelines for the design and analysis of studies on nonsyndromic cleft lip and cleft palate in humans: summary report from a Workshop of the International Consortium for Oral Clefts Genetics
    Laura E Mitchell
    Center for Clinical Epidemiology and Biostatistics, The University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104 6021, USA
    Cleft Palate Craniofac J 39:93-100. 2002
    ..This report presents summary statements of the four subcommittees...

Research Grants10

  1. Cleft Lip Genetics: A Multicenter International Consortium
    Andrew Lidral; Fiscal Year: 2007
    ..Ultimately, this will further the understanding of normal and abnormal craniofacial development, such that therapies to prevent CL/P can be developed and implemented. ..
  2. Cleft Lip Genetics: A Multicenter International Consorti
    Andrew Lidral; Fiscal Year: 2004
    ..Ultimately, this will further the understanding of normal and abnormal craniofacial development, such that therapies to prevent CL/P can be developed and implemented. ..
  3. Cleft Lip Genetics: A Multi Center International Consortium
    Andrew Lidral; Fiscal Year: 2009
    ..Through the use of complimentary mouse and human genetics this project will identify genes and pathways essential for normal facial development, such that preventive strategies for CL/P can be developed. ..