MICHAEL LIDOW

Summary

Affiliation: University of Maryland
Country: USA

Publications

  1. ncbi request reprint Consequences of prenatal cocaine exposure in nonhuman primates
    Michael S Lidow
    Department of Biomedical Sciences, Neuroscience Division, University of Maryland, Baltimore, Rm 5 A 12, HHH, 666 W Baltimore St, Baltimore, MD 21201, USA
    Brain Res Dev Brain Res 147:23-36. 2003
  2. pmc Neonatal local noxious insult affects gene expression in the spinal dorsal horn of adult rats
    Ke Ren
    Department of Biomedical Sciences, University of Maryland, Baltimore, MD 21201, USA
    Mol Pain 1:27. 2005
  3. ncbi request reprint Nonhuman primate model of the effect of prenatal cocaine exposure on cerebral cortical development
    M S Lidow
    Department of Oral and Craniofacial Biological Sciences, University of Maryland, Baltimore 21201, USA
    Ann N Y Acad Sci 846:182-93. 1998
  4. ncbi request reprint Calcium signaling dysfunction in schizophrenia: a unifying approach
    Michael S Lidow
    Department of Biomedical Sciences and Program of Neuroscience, University of Maryland, Room 5 A 12, HHH, 666 W Baltimore Street, Baltimore, MD 21201, USA
    Brain Res Brain Res Rev 43:70-84. 2003
  5. ncbi request reprint Long-term effects of neonatal pain on nociceptive systems
    Michael S Lidow
    Department of Oral and Craniofacial Biological Sciences, University of Maryland, 5 A 12, HHH, 666 West Baltimore Street, Baltimore, MD 20201, USA
    Pain 99:377-83. 2002
  6. ncbi request reprint Receptor crosstalk protein, calcyon, regulates affinity state of dopamine D1 receptors
    M S Lidow
    Department of Oral and Craniofacial Biological Sciences and Program in Neuroscience, University of Maryland, 5 A 12, HHH 666 W Baltimore St, Baltimore, MD 21201, USA
    Eur J Pharmacol 427:187-93. 2001
  7. ncbi request reprint Primates exposed to cocaine in utero display reduced density and number of cerebral cortical neurons
    M S Lidow
    Department of Oral and Craniofacial Biological Sciences and Program of Neuroscience, University of Maryland, Baltimore, Maryland 21201, USA
    J Comp Neurol 435:263-75. 2001
  8. ncbi request reprint Effect of cocaine on cell proliferation in the cerebral wall of monkey fetuses
    M S Lidow
    Department of Oral and Craniofacial Biological Sciences and Program of Neuroscience, University of Maryland, Baltimore, MD 21201, USA
    Cereb Cortex 11:545-51. 2001
  9. ncbi request reprint Cocaine affects cerebral neocortical cytoarchitecture in primates only if administered during neocortical neuronogenesis
    M S Lidow
    Department of Oral and Craniofacial Biological Sciences and Program of Neuroscience, University of Maryland, Baltimore, 5 A 12, HHH, 666 W Baltimore Street, Baltimore, MD 21201, USA
    Brain Res Dev Brain Res 128:45-52. 2001
  10. ncbi request reprint Cocaine-induced alterations in the density of monoaminergic receptors in the embryonic guinea pig cerebral wall
    M S Lidow
    Department of Oral and Craniofacial Biological Sciences, University of Maryland, Baltimore 21201, USA
    Synapse 32:225-37. 1999

Research Grants

  1. COCAINE EFFECT ON CORTICAL DEVELOPMENT
    MICHAEL LIDOW; Fiscal Year: 2001
  2. Effect of Cocaine on Corticol Development
    MICHAEL LIDOW; Fiscal Year: 2005

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Consequences of prenatal cocaine exposure in nonhuman primates
    Michael S Lidow
    Department of Biomedical Sciences, Neuroscience Division, University of Maryland, Baltimore, Rm 5 A 12, HHH, 666 W Baltimore St, Baltimore, MD 21201, USA
    Brain Res Dev Brain Res 147:23-36. 2003
    ..However, the differences in the outcomes between individual models also suggest that the specific types and severity of cocaine effects are likely dependent on the route, dose, gestational period, and daily pattern of administration...
  2. pmc Neonatal local noxious insult affects gene expression in the spinal dorsal horn of adult rats
    Ke Ren
    Department of Biomedical Sciences, University of Maryland, Baltimore, MD 21201, USA
    Mol Pain 1:27. 2005
    ..These findings suggest that changes in gene expression may be involved in the long-term nociceptive effects of neonatal noxious insult at the spinal level...
  3. ncbi request reprint Nonhuman primate model of the effect of prenatal cocaine exposure on cerebral cortical development
    M S Lidow
    Department of Oral and Craniofacial Biological Sciences, University of Maryland, Baltimore 21201, USA
    Ann N Y Acad Sci 846:182-93. 1998
    ..This indicates that cocaine abuse by pregnant human mothers may affect the global levels of monoamines in the fetal brain and, in doing so, interfere with a broad range of developmental events regulated by these chemicals...
  4. ncbi request reprint Calcium signaling dysfunction in schizophrenia: a unifying approach
    Michael S Lidow
    Department of Biomedical Sciences and Program of Neuroscience, University of Maryland, Room 5 A 12, HHH, 666 W Baltimore Street, Baltimore, MD 21201, USA
    Brain Res Brain Res Rev 43:70-84. 2003
    ..According to this hypothesis schizophrenia can result from alterations in multiple proteins and other molecules as long as these alterations lead to abnormalities in certain key aspects of intracellular Ca(2+) signaling cascades...
  5. ncbi request reprint Long-term effects of neonatal pain on nociceptive systems
    Michael S Lidow
    Department of Oral and Craniofacial Biological Sciences, University of Maryland, 5 A 12, HHH, 666 West Baltimore Street, Baltimore, MD 20201, USA
    Pain 99:377-83. 2002
  6. ncbi request reprint Receptor crosstalk protein, calcyon, regulates affinity state of dopamine D1 receptors
    M S Lidow
    Department of Oral and Craniofacial Biological Sciences and Program in Neuroscience, University of Maryland, 5 A 12, HHH 666 W Baltimore St, Baltimore, MD 21201, USA
    Eur J Pharmacol 427:187-93. 2001
    ..Our findings suggest that calcyon regulates the ability of dopamine D1 receptors to achieve the high-affinity state for agonists, in a manner that depends on priming of receptor crosstalk...
  7. ncbi request reprint Primates exposed to cocaine in utero display reduced density and number of cerebral cortical neurons
    M S Lidow
    Department of Oral and Craniofacial Biological Sciences and Program of Neuroscience, University of Maryland, Baltimore, Maryland 21201, USA
    J Comp Neurol 435:263-75. 2001
    ..There was, however, a postnatal recovery of low glial fibrillary acidic protein (GFAP) immunoreactivity previously observed in 2-month-old cocaine-exposed animals...
  8. ncbi request reprint Effect of cocaine on cell proliferation in the cerebral wall of monkey fetuses
    M S Lidow
    Department of Oral and Craniofacial Biological Sciences and Program of Neuroscience, University of Maryland, Baltimore, MD 21201, USA
    Cereb Cortex 11:545-51. 2001
    ..We detected no cocaine-induced extension in neocortical neuronogenesis...
  9. ncbi request reprint Cocaine affects cerebral neocortical cytoarchitecture in primates only if administered during neocortical neuronogenesis
    M S Lidow
    Department of Oral and Craniofacial Biological Sciences and Program of Neuroscience, University of Maryland, Baltimore, 5 A 12, HHH, 666 W Baltimore Street, Baltimore, MD 21201, USA
    Brain Res Dev Brain Res 128:45-52. 2001
    ..During this window of vulnerability, an abnormal neocortex is generated as long as cocaine exposure is maintained, with corticogenesis becoming normal as soon as the administration of this drug is discontinued...
  10. ncbi request reprint Cocaine-induced alterations in the density of monoaminergic receptors in the embryonic guinea pig cerebral wall
    M S Lidow
    Department of Oral and Craniofacial Biological Sciences, University of Maryland, Baltimore 21201, USA
    Synapse 32:225-37. 1999
    ..Furthermore, the present study reveals that, in the course of chronic treatment, cocaine may completely reverse its receptor regulatory activity in the fetal brain...
  11. ncbi request reprint Alterations in stress-associated behaviors and neurochemical markers in adult rats after neonatal short-lasting local inflammatory insult
    V C Z Anseloni
    Department of Biomedical Sciences, University of Maryland, 666 West Baltimore Street, Baltimore, MD 21201, USA
    Neuroscience 131:635-45. 2005
    ..Indeed, we observed a substantial increase in maternal attention to the pups at the time of inflammation, but this increase was not without its cost: a period of significant maternal neglect afterward...
  12. ncbi request reprint Characterization of basal and re-inflammation-associated long-term alteration in pain responsivity following short-lasting neonatal local inflammatory insult
    K Ren
    Department of Biomedical Sciences, University of Maryland, Baltimore, 5 A 12, HHH, 666 W Baltimore St, Baltimore, MD 21201, USA
    Pain 110:588-96. 2004
    ..These finding provide a framework within which the entire complex of long-term effects of early noxious experience can be understood and examined...
  13. ncbi request reprint D1 dopamine receptor regulation of microtubule-associated protein-2 phosphorylation in developing cerebral cortical neurons
    Z M Song
    Department of Oral and Craniofacial Biological Sciences, University of Maryland, Baltimore, Maryland 21201, USA
    J Neurosci 22:6092-105. 2002
    ....
  14. ncbi request reprint Pharmacokinetics of cocaine in maternal and fetal rhesus monkeys at mid-gestation
    M Zhou
    Department of Oral and Craniofacial Biological Sciences, University of Maryland, Baltimore, Maryland 21201, USA
    J Pharmacol Exp Ther 297:556-62. 2001
    ..The chronic treatments resulted in significantly higher maximal levels of cocaine in the fetal circulation compared with those produced by single drug administrations...
  15. ncbi request reprint Long-term effects of short-lasting early local inflammatory insult
    M S Lidow
    Department of Oral and Craniofacial Biological Sciences, University of Maryland, Baltimore, 21201, USA
    Neuroreport 12:399-403. 2001
    ..These data suggest that early inflammatory insult may differentially affect the aspects of nociceptive circuitry involved in transient pain sensitivity and in inflammation-induced hyperalgesia...
  16. ncbi request reprint Identification of a long variant of mRNA encoding the NR3 subunit of the NMDA receptor: its regional distribution and developmental expression in the rat brain
    L Sun
    Department of Oral and Craniofacial Biological Sciences, University of Maryland, Baltimore 21201, USA
    FEBS Lett 441:392-6. 1998
    ..Moreover, this variant predominates in the occipital and entorhinal cortices, thalamus and cerebellum. Analysis of NR3-l development indicates that it is regulated in a region-specific manner...
  17. ncbi request reprint Inhalational model of cocaine exposure in mice: neuroteratological effects
    Fang He
    Department of Biomedical Sciences and Program of Neuroscience, University of Maryland, Baltimore, 5 A 12, HHH, 666 W Baltimore St, Baltimore, MD 21201, USA
    Neurotoxicol Teratol 28:181-97. 2006
    ..We hope that the introduction of the present model will lead to a significant increase in our understanding of outcomes of prenatal cocaine exposure...
  18. ncbi request reprint Consequences of paternal cocaine exposure in mice
    Fang He
    Department of Biomedical Sciences and Program of Neuroscience, University of Maryland, Baltimore, 5 A 12, HHH, 666 W Baltimore St, Baltimore, MD 21201, USA
    Neurotoxicol Teratol 28:198-209. 2006
    ....
  19. ncbi request reprint Neonatal hind paw injury alters processing of visceral and somatic nociceptive stimuli in the adult rat
    Gexin Wang
    Department of Biomedical Sciences, University of Maryland Dental School, Baltimore, Maryland 21201, USA
    J Pain 5:440-9. 2004
    ....
  20. ncbi request reprint Abnormalities in the dopamine system in schizophrenia may lie in altered levels of dopamine receptor-interacting proteins
    Jie Bai
    Department of Biomedical Sciences, University of Maryland, Baltimore, Maryland 21201, USA
    Biol Psychiatry 56:427-40. 2004
    ....
  21. ncbi request reprint Cerebral cortical abnormalities seen in a non-human primate model of prenatal cocaine exposure are not related to vasoconstriction
    Na He
    Department of Biomedical Sciences and Program of Neuroscience, University of Maryland, 5 A 12, HHH, 666 W Baltimore St, Baltimore, MD 21201, USA
    Neurotoxicology 25:419-32. 2004
    ..These findings suggest that it is unlikely that either benzoylecgonine or vasoconstriction are responsible for the abnormalities seen in the neocortical cytoarchitecture in our non-human primate model of prenatal cocaine exposure...
  22. ncbi request reprint Neurobehavioral deficits in neonatal rhesus monkeys exposed to cocaine in utero
    Na He
    Department of Biomedical Sciences, Neuroscience Division, University of Maryland, Baltimore, 5 A 12, HHH, 666 W Baltimore Street, Baltimore, MD 21201, USA
    Neurotoxicol Teratol 26:13-21. 2004
    ..This impairment disappeared by the third testing session. The present findings demonstrate the potential of prenatal cocaine exposure to induce neurobehavioral deficits detectable by NBAS-like testing in primate infants...
  23. ncbi request reprint Optimization of the mechanical nociceptive threshold testing with the Randall-Selitto assay
    Vanessa C Z Anseloni
    Department of Anatomy and Neurobiology, University of Maryland, Baltimore, MD 21201, USA
    J Neurosci Methods 131:93-7. 2003
    ..Furthermore, we found that the use of only the last measurement within a testing session, rather than the average of all collected measurements, may further enhance the sensitivity of the RS assay...
  24. ncbi request reprint Up-regulation of the D1 dopamine receptor-interacting protein, calcyon, in patients with schizophrenia
    Phil Ok Koh
    Department of Oral and Craniofacial Biological Sciences, University of Maryland, Baltimore 21201, USA
    Arch Gen Psychiatry 60:311-9. 2003
    ....
  25. ncbi request reprint Identification of protein biomarkers for schizophrenia and bipolar disorder in the postmortem prefrontal cortex using SELDI-TOF-MS ProteinChip profiling combined with MALDI-TOF-PSD-MS analysis
    Svetlana I Novikova
    Dept of Biomedical Sciences, University of Maryland, HHH, 5 A 12, 666 W Baltimore Street, Baltimore, MD 21201, USA
    Neurobiol Dis 23:61-76. 2006
    ..This study demonstrates the usefulness of ProteinChip-based SELDI-TOF protein profiling in gaining insight into the molecular pathology of SCHIZ and BD as it points to changes in protein levels characterizing these diseases...
  26. pmc Up-regulation of neuronal calcium sensor-1 (NCS-1) in the prefrontal cortex of schizophrenic and bipolar patients
    Phil Ok Koh
    Departments of Oral and Craniofacial Biological Sciences, University of Maryland, Baltimore 21201, USA
    Proc Natl Acad Sci U S A 100:313-7. 2003
    ..The present study supports the hypothesis that schizophrenia and bipolar disorder may be associated with abnormalities in dopamine receptor-interacting proteins...
  27. ncbi request reprint Dopamine receptor-interacting proteins: the Ca(2+) connection in dopamine signaling
    Clare Bergson
    Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta, GA 30912, USA
    Trends Pharmacol Sci 24:486-92. 2003
    ....
  28. ncbi request reprint Neuropathology of the cerebral cortex observed in a range of animal models of prenatal cocaine exposure may reflect alterations in genes involved in the Wnt and cadherin systems
    Svetlana I Novikova
    Department of Biomedical Sciences, and Program of Neuroscience, University of Maryland, Baltimore, Maryland 21201, USA
    Synapse 56:105-16. 2005
    ....
  29. ncbi request reprint Cocaine-induced changes in the expression of apoptosis-related genes in the fetal mouse cerebral wall
    Svetlana I Novikova
    Department of Biomedical Sciences, and Program of Neuroscience, University of Maryland, Baltimore, 5 A 12, HHH, 666 W Baltimore Street, Baltimore, MD 21201, United States
    Neurotoxicol Teratol 27:3-14. 2005
    ..This suggests that cocaine affects survival of developing cerebral cells via multiple apoptosis-regulating mechanisms...
  30. pmc Maternal cocaine administration in mice alters DNA methylation and gene expression in hippocampal neurons of neonatal and prepubertal offspring
    Svetlana I Novikova
    Laboratory of Neurogenomics and Proteomics, Department of Biomedical Sciences, University of Maryland, Baltimore, Maryland, United States of America
    PLoS ONE 3:e1919. 2008
    ....

Research Grants10

  1. COCAINE EFFECT ON CORTICAL DEVELOPMENT
    MICHAEL LIDOW; Fiscal Year: 2001
    ..This will allow us to assess the prospects for recovery from prenatal cocaine exposure for children of drug abusing mothers. ..
  2. Effect of Cocaine on Corticol Development
    MICHAEL LIDOW; Fiscal Year: 2005
    ....