Julio Licinio

Summary

Affiliation: University of California
Country: USA

Publications

  1. ncbi request reprint The experience of bipolar disorder: a personal perspective on the impact of mood disorder symptoms
    J Licinio
    Center for Pharmacogenomics and Clinical Pharmacology, Semel Institute for Neuroscience and Human Behavior and David Geffen School of Medicine at University of California, Los Angeles, CA 90095 1761, USA
    Mol Psychiatry 10:827-30. 2005
  2. ncbi request reprint The neuroimmune-endocrine axis: pathophysiological implications for the central nervous system cytokines and hypothalamus-pituitary-adrenal hormone dynamics
    J Licinio
    Department of Psychiatry and Neuropsychiatric Institute, School of Medicine, University of California, os Angeles, CA 90095 1761, USA
    Braz J Med Biol Res 33:1141-8. 2000
  3. ncbi request reprint Depression, antidepressants and suicidality: a critical appraisal
    Julio Licinio
    Center for Pharmacogenomics and Clinical Pharmacology, Neuropsychiatric Institute and David Geffen School of Medicine, University of California, Los Angeles, USA
    Nat Rev Drug Discov 4:165-71. 2005
  4. pmc Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults
    Julio Licinio
    Center for Pharmacogenomics, Neuropsychiatric Institute, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1761, USA
    Proc Natl Acad Sci U S A 101:4531-6. 2004
  5. ncbi request reprint Informed consent in pharmacogenomics
    Julio Licinio
    UCLA Laboratory for Pharmacogenomics, Email
    Pharmacogenomics J 2:343-4. 2002
  6. pmc Effects of leptin deficiency and replacement on cerebellar response to food-related cues
    Steven M Berman
    Department of Psychiatry and Biobehavioral Sciences and the Semel Institute, David Geffen School of Medicine, University of California Los Angeles, 760 Westwood Plaza, C8 831, Los Angeles, CA 90024, USA
    Cerebellum 12:59-67. 2013
  7. ncbi request reprint Simultaneous and continuous 24-hour plasma and cerebrospinal fluid leptin measurements: dissociation of concentrations in central and peripheral compartments
    Ma Li Wong
    Center for Pharmacogenomics and Interdepartmental Clinical Pharmacology Center, Neuropsychiatric Institute and David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90095, USA
    J Clin Endocrinol Metab 89:258-65. 2004
  8. pmc Alterations in the dynamics of circulating ghrelin, adiponectin, and leptin in human obesity
    Bulent O Yildiz
    Center for Pharmacogenomics and Clinical Pharmacology, Neuropsychiatric Institute, Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1761, USA
    Proc Natl Acad Sci U S A 101:10434-9. 2004
  9. pmc Short-term plasticity of gray matter associated with leptin deficiency and replacement
    Edythe D London
    Department of Psychiatry and Biobehavioral Sciences and Semel Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90024, USA
    J Clin Endocrinol Metab 96:E1212-20. 2011
  10. ncbi request reprint The prototypic antidepressant drug, imipramine, but not Hypericum perforatum (St. John's Wort), reduces HPA-axis function in the rat
    P Frost
    Laboratory of Pharmacogenomics, Neuropsychiatric Institute, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Horm Metab Res 35:602-6. 2003

Collaborators

Detail Information

Publications36

  1. ncbi request reprint The experience of bipolar disorder: a personal perspective on the impact of mood disorder symptoms
    J Licinio
    Center for Pharmacogenomics and Clinical Pharmacology, Semel Institute for Neuroscience and Human Behavior and David Geffen School of Medicine at University of California, Los Angeles, CA 90095 1761, USA
    Mol Psychiatry 10:827-30. 2005
    ..This could rapidly decrease the enormous burden of psychiatric disorders, which is eloquently described in this perspective article...
  2. ncbi request reprint The neuroimmune-endocrine axis: pathophysiological implications for the central nervous system cytokines and hypothalamus-pituitary-adrenal hormone dynamics
    J Licinio
    Department of Psychiatry and Neuropsychiatric Institute, School of Medicine, University of California, os Angeles, CA 90095 1761, USA
    Braz J Med Biol Res 33:1141-8. 2000
    ..The mechanisms by which cytokine signaling affects the function of stress-related neuroendocrine systems are reviewed in this article...
  3. ncbi request reprint Depression, antidepressants and suicidality: a critical appraisal
    Julio Licinio
    Center for Pharmacogenomics and Clinical Pharmacology, Neuropsychiatric Institute and David Geffen School of Medicine, University of California, Los Angeles, USA
    Nat Rev Drug Discov 4:165-71. 2005
    ....
  4. pmc Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults
    Julio Licinio
    Center for Pharmacogenomics, Neuropsychiatric Institute, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1761, USA
    Proc Natl Acad Sci U S A 101:4531-6. 2004
    ..These results highlight the role of the leptin pathway in adults with key effects on the regulation of body weight, gonadal function, and behavior...
  5. ncbi request reprint Informed consent in pharmacogenomics
    Julio Licinio
    UCLA Laboratory for Pharmacogenomics, Email
    Pharmacogenomics J 2:343-4. 2002
    ..The Pharmacogenomics Journal (2002) 2, 343. doi:10.1038/sj.tpj.6500151..
  6. pmc Effects of leptin deficiency and replacement on cerebellar response to food-related cues
    Steven M Berman
    Department of Psychiatry and Biobehavioral Sciences and the Semel Institute, David Geffen School of Medicine, University of California Los Angeles, 760 Westwood Plaza, C8 831, Los Angeles, CA 90024, USA
    Cerebellum 12:59-67. 2013
    ..The results suggest an underexplored role for the posterior cerebellum in the regulation of leptin-mediated processes related to food intake...
  7. ncbi request reprint Simultaneous and continuous 24-hour plasma and cerebrospinal fluid leptin measurements: dissociation of concentrations in central and peripheral compartments
    Ma Li Wong
    Center for Pharmacogenomics and Interdepartmental Clinical Pharmacology Center, Neuropsychiatric Institute and David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90095, USA
    J Clin Endocrinol Metab 89:258-65. 2004
    ....
  8. pmc Alterations in the dynamics of circulating ghrelin, adiponectin, and leptin in human obesity
    Bulent O Yildiz
    Center for Pharmacogenomics and Clinical Pharmacology, Neuropsychiatric Institute, Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1761, USA
    Proc Natl Acad Sci U S A 101:10434-9. 2004
    ..We suggest that the blunting of the nocturnal rise of ghrelin is a biological feature of human obesity...
  9. pmc Short-term plasticity of gray matter associated with leptin deficiency and replacement
    Edythe D London
    Department of Psychiatry and Biobehavioral Sciences and Semel Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California 90024, USA
    J Clin Endocrinol Metab 96:E1212-20. 2011
    ..We previously reported that leptin supplementation increased gray matter (GM) concentration in the anterior cingulate gyrus (ACG), cerebellum, and inferior parietal lobule, areas that are also involved in food intake...
  10. ncbi request reprint The prototypic antidepressant drug, imipramine, but not Hypericum perforatum (St. John's Wort), reduces HPA-axis function in the rat
    P Frost
    Laboratory of Pharmacogenomics, Neuropsychiatric Institute, David Geffen School of Medicine, University of California, Los Angeles, CA, USA
    Horm Metab Res 35:602-6. 2003
    ..However, our data does not support any role for H. perforatum in modulation of HPA axis function, suggesting that alternative pathways may be involved in mediating its antidepressant effects...
  11. ncbi request reprint From monoamines to genomic targets: a paradigm shift for drug discovery in depression
    Ma Li Wong
    Center for Pharmacogenomics, Neuropsychiatric Institute and David Geffen School of Medicine at UCLA, 695 Charles Young Drive South, Los Angeles, California 90095 1761, USA
    Nat Rev Drug Discov 3:136-51. 2004
    ..Yet such a drug is not on the horizon. Here, we cover the different phases of antidepressant drug discovery in the past, present and future, and comment on the challenges and opportunities for antidepressant research...
  12. ncbi request reprint Emergent oscillations in a mathematical model of the human menstrual cycle
    Natalie L Rasgon
    Department of Psychiatry and Biobehavioral Sciences, Stanford School of Medicine, Palo Alto, California 94305, USA
    CNS Spectr 8:805-14. 2003
    ..The aim of this study was to develop a mathematical model of the hypothalamo-pituitary-gonadal axis that would reflect available data in humans...
  13. pmc Modeling of the temporal patterns of fluoxetine prescriptions and suicide rates in the United States
    Michael S Milane
    Center for Pharmacogenomics and Clinical Pharmacology, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, California, USA
    PLoS Med 3:e190. 2006
    ....
  14. pmc Leptin replacement improves cognitive development
    Gilberto J Paz-Filho
    Department of Psychiatry and Behavioral Sciences, Center for Pharmacogenomics, University of Miami Miller School of Medicine, Miami, Florida, USA
    PLoS ONE 3:e3098. 2008
    ..Leptin changes brain structure, neuron excitability and synaptic plasticity. It also regulates the development and function of feeding circuits. However, the effects of leptin on neurocognitive development are unknown...
  15. ncbi request reprint St John's wort and imipramine-induced gene expression profiles identify cellular functions relevant to antidepressant action and novel pharmacogenetic candidates for the phenotype of antidepressant treatment response
    M L Wong
    Department of Psychiatry, Center for Pharmacogenomics, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095 1761, USA
    Mol Psychiatry 9:237-51. 2004
    ..Our data support the hypothesis that chronic antidepressant treatment by drugs of various classes may result in a common, final pathway of changes in gene expression in a discrete brain region...
  16. ncbi request reprint Research and treatment approaches to depression
    M L Wong
    Clinical Pharmacology Program, Laboratory of Pharmacogenomics, Neuropsychiatric Institute, Gonda Neuroscience and Genetics Research Center, University of California Los Angeles, School of Medicine, Los Angeles, CA 90095 1761, USA
    Nat Rev Neurosci 2:343-51. 2001
    ..The complexity of this field is best approached by rigorous explorations of known candidate systems in conjunction with the use of genomic tools to discover new targets for antidepressants and to predict therapeutic outcomes...
  17. ncbi request reprint The evolution of signaling complexity suggests a mechanism for reducing the genomic search space in human association studies
    K J L Irizarry
    Center for Pharmacogenomics and Clinical Pharmacology, Neuropsychiatric Institute, David Geffen School of Medicine, University California, Los Angeles, CA 90095, USA
    Mol Psychiatry 10:14-26. 2005
    ....
  18. pmc Leptin replacement alters brain response to food cues in genetically leptin-deficient adults
    Kate Baicy
    Department of Psychiatry and Biobehavioral Sciences and Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90024, USA
    Proc Natl Acad Sci U S A 104:18276-9. 2007
    ..Leptin appears to modulate feeding behavior through these circuits, suggesting therapeutic targets for human obesity...
  19. ncbi request reprint Relationship between increasing body weight, insulin resistance, inflammation, adipocytokine leptin, and coronary circulatory function
    Thomas H Schindler
    Department of Molecular, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, California 90095 1735, USA
    J Am Coll Cardiol 47:1188-95. 2006
    ..We sought to evaluate effects of obesity, insulin resistance, and inflammation on coronary circulatory function and its relationship to leptin plasma levels...
  20. pmc Identification, characterization, and gene expression profiling of endotoxin-induced myocarditis
    Ma Li Wong
    Center for Pharmacogenomics, Neuropsychiatric Institute, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1761, USA
    Proc Natl Acad Sci U S A 100:14241-6. 2003
    ..Our findings can help identify innate immune pathways that could become targets for immunotherapy in the treatment of disease caused by potential bioterrorism agents...
  21. pmc Sequence variations of ABCB1, SLC6A2, SLC6A3, SLC6A4, CREB1, CRHR1 and NTRK2: association with major depression and antidepressant response in Mexican-Americans
    C Dong
    Department of Psychiatry and Behavioral Sciences, Center for Pharmacogenomics, University of Miami Miller School of Medicine, Miami, FL, USA
    Mol Psychiatry 14:1105-18. 2009
    ..Moreover, these results highlight the importance of direct re-sequencing of key candidate genes in ethnic minority groups in order to discover novel genetic variants that cannot be simply inferred from existing databases...
  22. pmc Acute systemic inflammation up-regulates secretory sphingomyelinase in vivo: a possible link between inflammatory cytokines and atherogenesis
    M L Wong
    Department of Psychiatry and Biobehavioral Sciences, University of California, School of Medicine, Los Angeles, CA 90095 1761, USA
    Proc Natl Acad Sci U S A 97:8681-6. 2000
    ..9-fold, respectively (P < 0.01). These data show regulation of S-SMase activity in vivo and they raise the possibility that local stimulation of S-SMase may contribute to the effects of inflammatory cytokines in atherosclerosis...
  23. ncbi request reprint Single nucleotide polymorphism identification in candidate gene systems of obesity
    K Irizarry
    Dept of Chemistry and Biochemistry, University of California, Los Angeles 90095-1570, USA
    Pharmacogenomics J 1:193-203. 2001
    ..bioinformat ics.ucla.edu/snp/obesity. We believe this panel can serve as a valuable new resource for genetic and pharmacogenomic studies of the causes of obesity...
  24. ncbi request reprint Association of a corticotropin-releasing hormone receptor 1 haplotype and antidepressant treatment response in Mexican-Americans
    J Licinio
    Center for Pharmacogenomics and Clinical Pharmacology, Neuropsychiatric Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1761, USA
    Mol Psychiatry 9:1075-82. 2004
    ..These findings also suggest that variations in the CRHR1 gene may affect response to CRHR1 agonists or antagonists. All data are deposited in www.pharmgkb.org...
  25. pmc Caspase 1 deficiency reduces inflammation-induced brain transcription
    Claudio Mastronardi
    Center on Pharmacogenomics, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Proc Natl Acad Sci U S A 104:7205-10. 2007
    ..Our results indicate that those genes may also play a role in several neuropsychiatric conditions in which inflammation has been implicated and indicate that casp1 might be a potential therapeutic target for such disorders...
  26. ncbi request reprint Development of a PCR-based strategy for CYP2D6 genotyping including gene multiplication of worldwide potential use
    Pedro Dorado
    University of Beira Interior, Covilha, Portugal
    Biotechniques 39:571-4. 2005
    ....
  27. ncbi request reprint Depression and obesity treatments are life saving
    Julio Licinio
    Nat Med 8:1336; author reply 1336. 2002
  28. ncbi request reprint Major depression is associated with significant diurnal elevations in plasma interleukin-6 levels, a shift of its circadian rhythm, and loss of physiological complexity in its secretion: clinical implications
    Salvatore Alesci
    Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Building 10, Room 2D46, MSC 1284, Bethesda, Maryland 20892 1284, USA
    J Clin Endocrinol Metab 90:2522-30. 2005
    ..Given the activating role of IL-6 on the hypothalamic-pituitary-adrenal (HPA) axis, and the relevance of its dysregulation in MDD, we also analyzed the relations between IL-6 and cortisol levels...
  29. ncbi request reprint Ecological studies of antidepressant treatment and suicidal risks
    Ross J Baldessarini
    Department of Psychiatry and Neuroscience Program, Harvard Medical School, and International Psychopharmacology Program, McLean Hospital, Belmont, MA 02478, USA
    Harv Rev Psychiatry 15:133-45. 2007
    ..Overall, as with findings from randomized trials and cohort or case-control studies, evidence of specific antisuicidal effects of antidepressant treatment from ecological analyses remains elusive...
  30. pmc The brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism and depression in Mexican-Americans
    Luciana Ribeiro
    Department of Psychiatry and Behavioral Sciences, Center on Pharmacogenomics, University of Miami Miller School of Medicine, Miami, Florida 33136 1013, USA
    Neuroreport 18:1291-3. 2007
    ..7 95% CI 1.17-2.47). Our findings support the association of BDNF single nucleotide polymorphism rs6265 and depression, suggesting that this polymorphism may increase susceptibility to major depression in Mexican-Americans...
  31. pmc Effects of leptin on intake of specific micro- and macronutrients in a woman with leptin gene deficiency studied off and on leptin at stable body weight
    Julio Licinio
    Department of Psychiatry and Behavioral Sciences D 28, University of Miami, Miller School of Medicine, 1695 NW 9th Avenue, Suite 3100, Miami, FL 33136, USA
    Appetite 49:594-9. 2007
    ..The nutritional data from this study indicates a direct link between the effects of leptin and ingestion of several specific micronutrients. The mechanisms underlying these effects warrant further investigation and study...
  32. ncbi request reprint Suicidality scores during double-blind fluoxetine and desipramine treatment in Mexican Americans
    Anil Sharma
    J Clin Psychopharmacol 27:99-101. 2007
  33. ncbi request reprint Hot topic: pharmacogenetic and pharmacogenomics
    Adrian Llerena
    University of Extremadura Medical School, Director CICAB Clinical Research Centre, Extremadura University Hospital, Av De Elvas s n, E 06071, Badajoz, Spain
    Curr Drug Targets 7:1639-40. 2006
  34. pmc Phosphodiesterase genes are associated with susceptibility to major depression and antidepressant treatment response
    Ma Li Wong
    Center on Pharmacogenomics, Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Proc Natl Acad Sci U S A 103:15124-9. 2006
    ..This study identifies a potential CNS role for the PDE11 family. The hypothesis that drugs affecting PDE function, particularly cGMP-related PDEs, represent a treatment strategy for major depression should therefore be tested...
  35. ncbi request reprint Microanalysis of eating behavior of three leptin deficient adults treated with leptin therapy
    Donald A Williamson
    Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Appetite 45:75-80. 2005
    ..These results are discussed in the context of the scientific literature pertaining to leptin and its effects on appetite and obesity...
  36. ncbi request reprint Effect of leptin replacement on brain structure in genetically leptin-deficient adults
    John A Matochik
    Neuroimaging Research Branch, National Institute on Drug Abuse, Department of Health and Human Services National Institutes of Health, Baltimore, Maryland 21224, USA
    J Clin Endocrinol Metab 90:2851-4. 2005
    ..Our findings suggest that leptin can have sustained effects on tissue composition in the human brain and broaden the potential spectrum of leptin's influence beyond feeding behavior and endocrine function...