Julio Licinio

Summary

Affiliation: University of Miami
Country: USA

Publications

  1. pmc Effects of leptin on intake of specific micro- and macronutrients in a woman with leptin gene deficiency studied off and on leptin at stable body weight
    Julio Licinio
    Department of Psychiatry and Behavioral Sciences D 28, University of Miami, Miller School of Medicine, 1695 NW 9th Avenue, Suite 3100, Miami, FL 33136, USA
    Appetite 49:594-9. 2007
  2. doi request reprint Novel sequence variations in the brain-derived neurotrophic factor gene and association with major depression and antidepressant treatment response
    Julio Licinio
    Center on Pharmacogenomics, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Arch Gen Psychiatry 66:488-97. 2009
  3. ncbi request reprint Pharmacogenomics of neuroimmune interactions in human psychiatric disorders
    Julio Licinio
    Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Exp Physiol 92:807-11. 2007
  4. ncbi request reprint Effects of leptin replacement on macro- and micronutrient preferences
    J Licinio
    Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Int J Obes (Lond) 31:1859-63. 2007
  5. pmc The brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism and depression in Mexican-Americans
    Luciana Ribeiro
    Department of Psychiatry and Behavioral Sciences, Center on Pharmacogenomics, University of Miami Miller School of Medicine, Miami, Florida 33136 1013, USA
    Neuroreport 18:1291-3. 2007
  6. pmc Repeated antidepressant therapy increases cyclic GMP signaling in rat hippocampus
    Gillian W Reierson
    Center on Pharmacogenomics, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, 1580 NW 10th Avenue, Miami, FL 33136, USA
    Neurosci Lett 466:149-53. 2009
  7. pmc Phosphodiesterase genes are associated with susceptibility to major depression and antidepressant treatment response
    Ma Li Wong
    Center on Pharmacogenomics, Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Proc Natl Acad Sci U S A 103:15124-9. 2006
  8. doi request reprint Phosphodiesterase genes and antidepressant treatment response: a review
    Karin Esposito
    Center on Pharmacogenomics, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, 1580 NW 10th Avenue, Miami, FL 33136, USA
    Ann Med 41:177-85. 2009
  9. pmc Elevated stress-hemoconcentration in major depression is normalized by antidepressant treatment: secondary analysis from a randomized, double-blind clinical trial and relevance to cardiovascular disease risk
    Ma Li Wong
    Department of Psychiatry and Behavioral Sciences, Leonard M Miller School of Medicine, University of Miami, Miami, Florida, USA
    PLoS ONE 3:e2350. 2008
  10. pmc Changes in insulin sensitivity during leptin replacement therapy in leptin-deficient patients
    Gilberto Paz-Filho
    Dept of Psychiatry and Behavioral Sciences, Univ of Miami Miller School of Medicine, Miami, FL 33136, USA
    Am J Physiol Endocrinol Metab 295:E1401-8. 2008

Research Grants

Collaborators

Detail Information

Publications34

  1. pmc Effects of leptin on intake of specific micro- and macronutrients in a woman with leptin gene deficiency studied off and on leptin at stable body weight
    Julio Licinio
    Department of Psychiatry and Behavioral Sciences D 28, University of Miami, Miller School of Medicine, 1695 NW 9th Avenue, Suite 3100, Miami, FL 33136, USA
    Appetite 49:594-9. 2007
    ..The nutritional data from this study indicates a direct link between the effects of leptin and ingestion of several specific micronutrients. The mechanisms underlying these effects warrant further investigation and study...
  2. doi request reprint Novel sequence variations in the brain-derived neurotrophic factor gene and association with major depression and antidepressant treatment response
    Julio Licinio
    Center on Pharmacogenomics, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, Florida 33136, USA
    Arch Gen Psychiatry 66:488-97. 2009
    ..Variations in the brain-derived neurotrophic factor gene (BDNF) have been associated with psychiatric disorders. Deep sequencing of the BDNF gene may identify new variations and bring further insight into psychiatric genetics...
  3. ncbi request reprint Pharmacogenomics of neuroimmune interactions in human psychiatric disorders
    Julio Licinio
    Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Exp Physiol 92:807-11. 2007
    ....
  4. ncbi request reprint Effects of leptin replacement on macro- and micronutrient preferences
    J Licinio
    Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Int J Obes (Lond) 31:1859-63. 2007
    ..The mechanisms underlying food choices are complex and involve neuroendocrine and biochemical signaling. Among neuroendocrine signals, leptin may play a prominent role in food preference...
  5. pmc The brain-derived neurotrophic factor rs6265 (Val66Met) polymorphism and depression in Mexican-Americans
    Luciana Ribeiro
    Department of Psychiatry and Behavioral Sciences, Center on Pharmacogenomics, University of Miami Miller School of Medicine, Miami, Florida 33136 1013, USA
    Neuroreport 18:1291-3. 2007
    ..7 95% CI 1.17-2.47). Our findings support the association of BDNF single nucleotide polymorphism rs6265 and depression, suggesting that this polymorphism may increase susceptibility to major depression in Mexican-Americans...
  6. pmc Repeated antidepressant therapy increases cyclic GMP signaling in rat hippocampus
    Gillian W Reierson
    Center on Pharmacogenomics, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, 1580 NW 10th Avenue, Miami, FL 33136, USA
    Neurosci Lett 466:149-53. 2009
    ..Immunoassay results showed unchanged cAMP levels. We conclude that increased cGMP signaling might underlie the efficacy of chronic antidepressant treatment...
  7. pmc Phosphodiesterase genes are associated with susceptibility to major depression and antidepressant treatment response
    Ma Li Wong
    Center on Pharmacogenomics, Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Proc Natl Acad Sci U S A 103:15124-9. 2006
    ..This study identifies a potential CNS role for the PDE11 family. The hypothesis that drugs affecting PDE function, particularly cGMP-related PDEs, represent a treatment strategy for major depression should therefore be tested...
  8. doi request reprint Phosphodiesterase genes and antidepressant treatment response: a review
    Karin Esposito
    Center on Pharmacogenomics, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, 1580 NW 10th Avenue, Miami, FL 33136, USA
    Ann Med 41:177-85. 2009
    ..Recent data from animal and human studies indicate that PDEs may play a role in depression and in related stress conditions. PDE genes have been linked directly to depression and to other genes associated with psychiatric disorders...
  9. pmc Elevated stress-hemoconcentration in major depression is normalized by antidepressant treatment: secondary analysis from a randomized, double-blind clinical trial and relevance to cardiovascular disease risk
    Ma Li Wong
    Department of Psychiatry and Behavioral Sciences, Leonard M Miller School of Medicine, University of Miami, Miami, Florida, USA
    PLoS ONE 3:e2350. 2008
    ..Stress-hemoconcentration, a result of psychological stress that might be a risk factor for the pathogenesis of CVD, has been studied in stress-challenge paradigms but has not been systematically studied in MDD...
  10. pmc Changes in insulin sensitivity during leptin replacement therapy in leptin-deficient patients
    Gilberto Paz-Filho
    Dept of Psychiatry and Behavioral Sciences, Univ of Miami Miller School of Medicine, Miami, FL 33136, USA
    Am J Physiol Endocrinol Metab 295:E1401-8. 2008
    ..Our results suggest that hyperleptinemia may contribute to mediate the increased insulin resistance of obesity...
  11. pmc Association of PDE11A global haplotype with major depression and antidepressant drug response
    Huai Rong Luo
    Center on Pharmacogenomics, Department of Psychiatry and Behavioral Science, University of Miami Miller School of Medicine, Miami, FL, USA
    Neuropsychiatr Dis Treat 5:163-70. 2009
    ..Thus, our data suggest that the PDE11A global haplotype is associated with both MDD and antidepressant drug response...
  12. pmc Caspase 1 deficiency reduces inflammation-induced brain transcription
    Claudio Mastronardi
    Center on Pharmacogenomics, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Proc Natl Acad Sci U S A 104:7205-10. 2007
    ..Our results indicate that those genes may also play a role in several neuropsychiatric conditions in which inflammation has been implicated and indicate that casp1 might be a potential therapeutic target for such disorders...
  13. pmc Leptin replacement improves cognitive development
    Gilberto J Paz-Filho
    Department of Psychiatry and Behavioral Sciences, Center for Pharmacogenomics, University of Miami Miller School of Medicine, Miami, Florida, USA
    PLoS ONE 3:e3098. 2008
    ..Leptin changes brain structure, neuron excitability and synaptic plasticity. It also regulates the development and function of feeding circuits. However, the effects of leptin on neurocognitive development are unknown...
  14. ncbi request reprint Chronic imipramine downregulates cyclic AMP signaling in rat hippocampus
    Gillian W Reierson
    Department of Psychiatry and Behavioral Sciences, Center on Pharmacogenomics, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Neuroreport 20:307-11. 2009
    ..We conclude that in contrast with the assumption of antidepressant-mediated increases in cAMP levels, longterm imipramine treatment may have the opposite effect, namely decreased hippocampal cAMP...
  15. pmc cGMP Signaling, Phosphodiesterases and Major Depressive Disorder
    Gillian W Reierson
    University of Miami Miller School of Medicine, Miami, FL, USA
    Curr Neuropharmacol 9:715-27. 2011
    ..Here we review a growing body of evidence suggesting that the cGMP signaling cascade warrants further investigation for its involvement in MDD and antidepressant action...
  16. pmc Chronic fluoxetine treatment increases daytime melatonin synthesis in the rodent
    Gillian W Reierson
    Center on Pharmacogenomics, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, USA
    Clin Pharmacol 1:1-6. 2009
    ..We conclude that chronic fluoxetine treatment increases daytime plasma melatonin and pineal AA-NAT gene expression despite downregulated pineal cAMP signaling in the rodent...
  17. doi request reprint Deconvolution of insulin secretion, insulin hepatic extraction post-hepatic delivery rates and sensitivity during 24-hour standardized meals: time course of glucose homeostasis in leptin replacement treatment
    V P Andreev
    Center for Pharmacogenomics, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Horm Metab Res 41:142-51. 2009
    ..Computer programs for analysis of 24-hour insulin secretion, extraction, delivery, and action are available upon request...
  18. doi request reprint Effects of leptin on lipid metabolism
    G J Paz-Filho
    Center for Pharmacogenomics, Department of Psychiatry and Behavioral Sciences, University of Miami Miller School of Medicine, Miami, FL, USA
    Horm Metab Res 40:572-4. 2008
  19. ncbi request reprint Suicidality scores during double-blind fluoxetine and desipramine treatment in Mexican Americans
    Anil Sharma
    J Clin Psychopharmacol 27:99-101. 2007
  20. ncbi request reprint Clinical implications of genetic polymorphism of CYP2D6 in Mexican Americans
    Deborah L Flores
    Ann Intern Med 140:W71. 2004
  21. pmc Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults
    Julio Licinio
    Center for Pharmacogenomics, Neuropsychiatric Institute, Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1761, USA
    Proc Natl Acad Sci U S A 101:4531-6. 2004
    ..These results highlight the role of the leptin pathway in adults with key effects on the regulation of body weight, gonadal function, and behavior...
  22. pmc Alterations in the dynamics of circulating ghrelin, adiponectin, and leptin in human obesity
    Bulent O Yildiz
    Center for Pharmacogenomics and Clinical Pharmacology, Neuropsychiatric Institute, Division of Endocrinology, Diabetes, and Hypertension, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA 90095 1761, USA
    Proc Natl Acad Sci U S A 101:10434-9. 2004
    ..We suggest that the blunting of the nocturnal rise of ghrelin is a biological feature of human obesity...
  23. ncbi request reprint From monoamines to genomic targets: a paradigm shift for drug discovery in depression
    Ma Li Wong
    Center for Pharmacogenomics, Neuropsychiatric Institute and David Geffen School of Medicine at UCLA, 695 Charles Young Drive South, Los Angeles, California 90095 1761, USA
    Nat Rev Drug Discov 3:136-51. 2004
    ..Yet such a drug is not on the horizon. Here, we cover the different phases of antidepressant drug discovery in the past, present and future, and comment on the challenges and opportunities for antidepressant research...
  24. ncbi request reprint Simultaneous and continuous 24-hour plasma and cerebrospinal fluid leptin measurements: dissociation of concentrations in central and peripheral compartments
    Ma Li Wong
    Center for Pharmacogenomics and Interdepartmental Clinical Pharmacology Center, Neuropsychiatric Institute and David Geffen School of Medicine at University of California, Los Angeles, Los Angeles, California 90095, USA
    J Clin Endocrinol Metab 89:258-65. 2004
    ....
  25. ncbi request reprint Depression, antidepressants and suicidality: a critical appraisal
    Julio Licinio
    Center for Pharmacogenomics and Clinical Pharmacology, Neuropsychiatric Institute and David Geffen School of Medicine, University of California, Los Angeles, USA
    Nat Rev Drug Discov 4:165-71. 2005
    ....
  26. ncbi request reprint Major depression is associated with significant diurnal elevations in plasma interleukin-6 levels, a shift of its circadian rhythm, and loss of physiological complexity in its secretion: clinical implications
    Salvatore Alesci
    Clinical Neuroendocrinology Branch, National Institute of Mental Health, National Institutes of Health, 10 Center Drive, Building 10, Room 2D46, MSC 1284, Bethesda, Maryland 20892 1284, USA
    J Clin Endocrinol Metab 90:2522-30. 2005
    ..Given the activating role of IL-6 on the hypothalamic-pituitary-adrenal (HPA) axis, and the relevance of its dysregulation in MDD, we also analyzed the relations between IL-6 and cortisol levels...
  27. ncbi request reprint Effect of leptin replacement on brain structure in genetically leptin-deficient adults
    John A Matochik
    Neuroimaging Research Branch, National Institute on Drug Abuse, Department of Health and Human Services National Institutes of Health, Baltimore, Maryland 21224, USA
    J Clin Endocrinol Metab 90:2851-4. 2005
    ..Our findings suggest that leptin can have sustained effects on tissue composition in the human brain and broaden the potential spectrum of leptin's influence beyond feeding behavior and endocrine function...
  28. pmc Leptin replacement alters brain response to food cues in genetically leptin-deficient adults
    Kate Baicy
    Department of Psychiatry and Biobehavioral Sciences and Semel Institute, David Geffen School of Medicine, University of California, Los Angeles, CA 90024, USA
    Proc Natl Acad Sci U S A 104:18276-9. 2007
    ..Leptin appears to modulate feeding behavior through these circuits, suggesting therapeutic targets for human obesity...
  29. ncbi request reprint Ecological studies of antidepressant treatment and suicidal risks
    Ross J Baldessarini
    Department of Psychiatry and Neuroscience Program, Harvard Medical School, and International Psychopharmacology Program, McLean Hospital, Belmont, MA 02478, USA
    Harv Rev Psychiatry 15:133-45. 2007
    ..Overall, as with findings from randomized trials and cohort or case-control studies, evidence of specific antisuicidal effects of antidepressant treatment from ecological analyses remains elusive...
  30. ncbi request reprint Microanalysis of eating behavior of three leptin deficient adults treated with leptin therapy
    Donald A Williamson
    Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Appetite 45:75-80. 2005
    ..These results are discussed in the context of the scientific literature pertaining to leptin and its effects on appetite and obesity...
  31. ncbi request reprint Development of a PCR-based strategy for CYP2D6 genotyping including gene multiplication of worldwide potential use
    Pedro Dorado
    University of Beira Interior, Covilha, Portugal
    Biotechniques 39:571-4. 2005
    ....
  32. ncbi request reprint Relationship between increasing body weight, insulin resistance, inflammation, adipocytokine leptin, and coronary circulatory function
    Thomas H Schindler
    Department of Molecular, David Geffen School of Medicine at UCLA, University of California at Los Angeles, Los Angeles, California 90095 1735, USA
    J Am Coll Cardiol 47:1188-95. 2006
    ..We sought to evaluate effects of obesity, insulin resistance, and inflammation on coronary circulatory function and its relationship to leptin plasma levels...
  33. pmc Modeling of the temporal patterns of fluoxetine prescriptions and suicide rates in the United States
    Michael S Milane
    Center for Pharmacogenomics and Clinical Pharmacology, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, California, USA
    PLoS Med 3:e190. 2006
    ....
  34. ncbi request reprint Emergent oscillations in a mathematical model of the human menstrual cycle
    Natalie L Rasgon
    Department of Psychiatry and Biobehavioral Sciences, Stanford School of Medicine, Palo Alto, California 94305, USA
    CNS Spectr 8:805-14. 2003
    ..The aim of this study was to develop a mathematical model of the hypothalamo-pituitary-gonadal axis that would reflect available data in humans...

Research Grants5

  1. UCLA GRADUATE TRAINING PROGRAM IN TRANSITIONAL INVESTIGA
    Julio Licinio; Fiscal Year: 2004
    ..Southern California is the most ethnically diverse area of the country. The GTPTI will be directed by Dr. Julio Licinio, a leading Hispanic physician- investigator, who is founding editor of two Nature Publishing Group journals, ..
  2. Developing Educational Approaches for Mexican-Americans
    Julio Licinio; Fiscal Year: 2005
    ..Their input will also be incorporated into the article that will be submitted to a peer-reviewed journal. ..
  3. ENDOCRINE EFFECTS OF HUMAN LEPTIN REPLACEMENT
    Julio Licinio; Fiscal Year: 2005
    ..application brings together four research groups with an outstanding history of productive collaborations: Julio Licinio, M.D...
  4. UCLA Pharmacogenetics and Pharmacogenomics Research Grp*
    Julio Licinio; Fiscal Year: 2005
    ..Our data will be deposited in PharmacoGKB, GenBank, and dbSNP. Additionally, our clinical responses data and DNA samples will be deposited in the UCLA DNA Bank that is accessible to other investigators. ..
  5. Clinical Neuroendocrinology of Leptin
    Julio Licinio; Fiscal Year: 2006
    ..This work may reveal new sites of leptin action with potential therapeutic value. ..