Daniel H Libraty

Summary

Affiliation: University of Massachusetts Medical School
Country: USA

Publications

  1. pmc The degree of leukocytosis and urine GATA-3 mRNA levels are risk factors for severe acute kidney injury in Puumala virus nephropathia epidemica
    Daniel H Libraty
    Department of Medicine, Medical School, University of Massachusetts, Worcester, Massachusetts, United States of America
    PLoS ONE 7:e35402. 2012
  2. pmc A comparative study of leptospirosis and dengue in Thai children
    Daniel H Libraty
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    PLoS Negl Trop Dis 1:e111. 2007
  3. pmc A prospective nested case-control study of Dengue in infants: rethinking and refining the antibody-dependent enhancement dengue hemorrhagic fever model
    Daniel H Libraty
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, Massachusetts, United States
    PLoS Med 6:e1000171. 2009
  4. pmc Human CD4(+) memory T-lymphocyte responses to SARS coronavirus infection
    Daniel H Libraty
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA
    Virology 368:317-21. 2007
  5. ncbi request reprint High circulating levels of the dengue virus nonstructural protein NS1 early in dengue illness correlate with the development of dengue hemorrhagic fever
    Daniel H Libraty
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Avenue N, Worcester, MA 01655, USA
    J Infect Dis 186:1165-8. 2002
  6. ncbi request reprint Antibody-dependent cellular cytotoxicity mediated by plasma obtained before secondary dengue virus infections: potential involvement in early control of viral replication
    Kamolwish Laoprasopwattana
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Infect Dis 195:1108-16. 2007
  7. pmc Dengue hemorrhagic fever: the sensitivity and specificity of the world health organization definition for identification of severe cases of dengue in Thailand, 1994-2005
    Anon Srikiatkhachorn
    University of Massachusetts Medical School, Worcester, MA 01655, USA
    Clin Infect Dis 50:1135-43. 2010
  8. pmc Prediction of dengue disease severity among pediatric Thai patients using early clinical laboratory indicators
    James A Potts
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    PLoS Negl Trop Dis 4:e769. 2010
  9. ncbi request reprint Dengue-specific T cell responses in peripheral blood mononuclear cells obtained prior to secondary dengue virus infections in Thai schoolchildren
    Marlou M Mangada
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    J Infect Dis 185:1697-703. 2002
  10. ncbi request reprint Dengue Virus (DV) enhancing antibody activity in preillness plasma does not predict subsequent disease severity or viremia in secondary DV infection
    Kamolwish Laoprasopwattana
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, 01655, USA
    J Infect Dis 192:510-9. 2005

Research Grants

Detail Information

Publications34

  1. pmc The degree of leukocytosis and urine GATA-3 mRNA levels are risk factors for severe acute kidney injury in Puumala virus nephropathia epidemica
    Daniel H Libraty
    Department of Medicine, Medical School, University of Massachusetts, Worcester, Massachusetts, United States of America
    PLoS ONE 7:e35402. 2012
    ..We have identified novel acute illness risk factors for severe PUUV-induced AKI...
  2. pmc A comparative study of leptospirosis and dengue in Thai children
    Daniel H Libraty
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    PLoS Negl Trop Dis 1:e111. 2007
    ..An enhanced ability to distinguish leptospirosis from dengue in children would guide clinicians and public health personnel in the appropriate use of limited healthcare resources...
  3. pmc A prospective nested case-control study of Dengue in infants: rethinking and refining the antibody-dependent enhancement dengue hemorrhagic fever model
    Daniel H Libraty
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, Massachusetts, United States
    PLoS Med 6:e1000171. 2009
    ..The widely accepted explanation for the pathogenesis of DHF in these settings, particularly during infancy, is antibody-dependent enhancement (ADE) of DENV infection...
  4. pmc Human CD4(+) memory T-lymphocyte responses to SARS coronavirus infection
    Daniel H Libraty
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655, USA
    Virology 368:317-21. 2007
    ..This report expands our understanding of the specificity and duration of anti-SARS coronavirus CD4(+) T-cell immune responses...
  5. ncbi request reprint High circulating levels of the dengue virus nonstructural protein NS1 early in dengue illness correlate with the development of dengue hemorrhagic fever
    Daniel H Libraty
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Avenue N, Worcester, MA 01655, USA
    J Infect Dis 186:1165-8. 2002
    ..An elevated free sNS1 level (> or =600 ng/mL) within 72 h of illness onset identified patients at risk for developing DHF...
  6. ncbi request reprint Antibody-dependent cellular cytotoxicity mediated by plasma obtained before secondary dengue virus infections: potential involvement in early control of viral replication
    Kamolwish Laoprasopwattana
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Infect Dis 195:1108-16. 2007
    ..In the present study, we examined the ability of plasma obtained before secondary DV infection to induce ADCC of DV-infected cells...
  7. pmc Dengue hemorrhagic fever: the sensitivity and specificity of the world health organization definition for identification of severe cases of dengue in Thailand, 1994-2005
    Anon Srikiatkhachorn
    University of Massachusetts Medical School, Worcester, MA 01655, USA
    Clin Infect Dis 50:1135-43. 2010
    ..The ability of these guidelines to categorize severe dengue illness has recently been questioned...
  8. pmc Prediction of dengue disease severity among pediatric Thai patients using early clinical laboratory indicators
    James A Potts
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    PLoS Negl Trop Dis 4:e769. 2010
    ..Earlier diagnosis of severe dengue illnesses would have a substantial impact on the allocation of health resources in endemic countries...
  9. ncbi request reprint Dengue-specific T cell responses in peripheral blood mononuclear cells obtained prior to secondary dengue virus infections in Thai schoolchildren
    Marlou M Mangada
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655, USA
    J Infect Dis 185:1697-703. 2002
    ..This study, thought to be the first to investigate T cell responses to DV in preinfection PBMC, suggests that the pattern of preexisting T cell responses influences the risk for severe disease...
  10. ncbi request reprint Dengue Virus (DV) enhancing antibody activity in preillness plasma does not predict subsequent disease severity or viremia in secondary DV infection
    Kamolwish Laoprasopwattana
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, 01655, USA
    J Infect Dis 192:510-9. 2005
    ..Preexisting nonneutralizing antibodies to DV that enhance the infection of Fc gamma receptor-bearing cells have been implicated in DV pathogenesis...
  11. pmc Classification of dengue illness based on readily available laboratory data
    James A Potts
    Center for Infectious Disease and Vaccine Research and Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA
    Am J Trop Med Hyg 83:781-8. 2010
    ..These models could be used to calculate a probability and classify patients based on readily available clinical laboratory data, and they will need to be validated in other dengue-endemic regions...
  12. pmc Dengue viral RNA levels in peripheral blood mononuclear cells are associated with disease severity and preexisting dengue immune status
    Anon Srikiatkhachorn
    Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 7:e51335. 2012
    ..The in vivo targets of DENV and the relation between the viral burden in these cells and disease severity are not known...
  13. ncbi request reprint Assessment of body fluid compartment volumes by multifrequency bioelectrical impedance spectroscopy in children with dengue
    Daniel H Libraty
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA, USA
    Trans R Soc Trop Med Hyg 96:295-9. 2002
    ..During the course of dengue illness, multifrequency BIS did not improve on serial haematocrit and bodyweight determinations for monitoring plasma volume contraction and ECW expansion, respectively...
  14. pmc Virus-induced decline in soluble vascular endothelial growth receptor 2 is associated with plasma leakage in dengue hemorrhagic Fever
    Anon Srikiatkhachorn
    Center for Infectious Diseases and Vaccine Research, Rm S5 326, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, MA 01655 0002, USA
    J Virol 81:1592-600. 2007
    ..Dengue virus-induced changes in surface and soluble VEGFR2 expression may be an important mechanism of plasma leakage in DHF...
  15. ncbi request reprint Differing influences of virus burden and immune activation on disease severity in secondary dengue-3 virus infections
    Daniel H Libraty
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Infect Dis 185:1213-21. 2002
    ..Quantitative differences in virus burden and host immune responses, and the timing of type 1 cytokine responses, have differing influences on the severity of disease manifestations during secondary dengue-3 virus infections...
  16. ncbi request reprint Clinical and immunological risk factors for severe disease in Japanese encephalitis
    Daniel H Libraty
    Center for Infectious Diseases and Vaccine Research, University of Massachusetts School of Medicine, Worcester, MA, USA
    Trans R Soc Trop Med Hyg 96:173-8. 2002
    ..An anamnestic, anti-flavivirus, immune response induced by a prior dengue virus infection can be an important means of providing this protection...
  17. pmc Plasmacytoid dendritic cell interferon-α production to R-848 stimulation is decreased in male infants
    Jennifer P Wang
    Division of Infectious Disease and Immunology, Department of Medicine, University of Massachusetts Medical School, 364 Plantation, Worcester, MA 01605, USA
    BMC Immunol 13:35. 2012
    ..Sex differences in response to microbial infections, especially viral ones, may be associated with Toll-like receptor (TLR)-mediated responses by plasmacytoid dendritic cells (pDCs)...
  18. pmc The role of MyD88 signaling in heterosubtypic influenza A virus infections
    Rachel F Madera
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    Virus Res 171:216-21. 2013
    ..Our results have important implications for the generation of effective universal influenza vaccines...
  19. pmc The combination of early and rapid type I IFN, IL-1α, and IL-1β production are essential mediators of RNA-like adjuvant driven CD4+ Th1 responses
    Rachel F Madera
    Division of Infectious Disease and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America
    PLoS ONE 6:e29412. 2011
    ..A better understanding of the critical signaling pathways by which RNA-like IRMs stimulate CD4+ Th1 responses is relevant to the rational design of improved vaccine adjuvants...
  20. ncbi request reprint Natural history of plasma leakage in dengue hemorrhagic fever: a serial ultrasonographic study
    Anon Srikiatkhachorn
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Pediatr Infect Dis J 26:283-90; discussion 291-2. 2007
    ..We employed serial ultrasound examination to delineate the locations and the timing of plasma leakage and to evaluate the usefulness of ultrasound in detecting plasma leakage in DHF...
  21. doi request reprint Dengue virus infection differentially regulates endothelial barrier function over time through type I interferon effects
    Ping Liu
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Infect Dis 200:191-201. 2009
    ..We hypothesized that direct viral effects on endothelial responsiveness to inflammatory and angiogenesis mediators can explain the DHF vascular leakage syndrome...
  22. pmc Intracellular cytokine production by dengue virus-specific T cells correlates with subclinical secondary infection
    Steven Hatch
    Center for Infectious Disease and Vaccine Research, University of Massachusetts Medical School, Worcester, MA, USA
    J Infect Dis 203:1282-91. 2011
    ....
  23. pmc Dengue virus type 2 modulates endothelial barrier function through CD73
    Chinmay Patkar
    Division of Infectious Disease and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01655, USA
    Am J Trop Med Hyg 88:89-94. 2013
    ..Our findings suggest that during DENV2 infection, endothelial barrier homeostasis is maintained by a balance between pro-inflammatory and pro-angiogenic cytokines, and type I interferon-dependent CD73 expression and activity...
  24. ncbi request reprint Flavivirus activation of plasmacytoid dendritic cells delineates key elements of TLR7 signaling beyond endosomal recognition
    Jennifer P Wang
    Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01655, USA
    J Immunol 177:7114-21. 2006
    ..A greater understanding of viral RNA-TLR7 activity relationships will promote rational approaches to interventional and vaccine strategies for important human viral pathogens...
  25. ncbi request reprint A blunted blood plasmacytoid dendritic cell response to an acute systemic viral infection is associated with increased disease severity
    Sathit Pichyangkul
    Department of Immunology, Armed Forces Research Institute of Medical Sciences, Queen Sirikit National Institute of Child Health, Bangkok, Thailand
    J Immunol 171:5571-8. 2003
    ..A blunted blood PDC response to dengue virus infection was associated with higher viremia levels, and was part of an altered innate immune response and pathogenetic cascade leading to severe disease...
  26. ncbi request reprint Relationship of preexisting dengue virus (DV) neutralizing antibody levels to viremia and severity of disease in a prospective cohort study of DV infection in Thailand
    Timothy P Endy
    Division of Virology, United States Army Medical Research Institute of Infectious Diseases, United States Army Medical Research and Materiel Command, Ft Detrick, Maryland, USA
    J Infect Dis 189:990-1000. 2004
    ..Most DHF cases occur after sequential heterotypic DV infections. The role of preexisting humoral immunity in modifying severity of dengue disease is not well understood...
  27. ncbi request reprint Burden of symptomatic dengue infection in children at primary school in Thailand: a prospective study
    Katie B Anderson
    Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, Silver Spring, MD, USA
    Lancet 369:1452-9. 2007
    ..Dengue viruses are a major cause of morbidity and mortality in tropical and subtropical areas. Our aim was to assess prospectively the burden of dengue-related illness in children in Thailand...
  28. ncbi request reprint Spatial and temporal circulation of dengue virus serotypes: a prospective study of primary school children in Kamphaeng Phet, Thailand
    Timothy P Endy
    Department of Virology, United States Army Medical Component, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
    Am J Epidemiol 156:52-9. 2002
    ..The authors' findings emphasize the complexity of dengue serotype-specific virus transmission and severe dengue disease and have important implications for dengue control and vaccine development...
  29. ncbi request reprint Epidemiology of inapparent and symptomatic acute dengue virus infection: a prospective study of primary school children in Kamphaeng Phet, Thailand
    Timothy P Endy
    Department of Virology, United States Army Medical Component, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
    Am J Epidemiol 156:40-51. 2002
    ..Their findings increase understanding of dengue virus transmission and disease severity in a well-defined cohort population and offer a study design in which to test the efficacy of potential dengue vaccines...
  30. pmc Human metapneumovirus reinfection among children in Thailand determined by ELISA using purified soluble fusion protein
    Julie A Pavlin
    Department of Microbiology and Immunology, Uniformed Services University, Bethesda, USA
    J Infect Dis 198:836-42. 2008
    ..Human metapneumovirus (hMPV) is a newly discovered paramyxovirus that causes acute respiratory illness. Despite apparent near-universal exposure during early childhood, immunity is transient...
  31. pmc Microevolution of Dengue viruses circulating among primary school children in Kamphaeng Phet, Thailand
    Richard G Jarman
    Armed Forces Research Institute of Medical Sciences, 315 6 Rajvithi Road, Bangkok, Thailand 10400
    J Virol 82:5494-500. 2008
    ..These results suggest that frequent viral migration into Kamphaeng Phet, coupled with population (school) subdivision, shapes the genetic diversity of DENV on a local scale, more so than in situ evolution within school catchment areas...
  32. ncbi request reprint Nitric oxide radical suppresses replication of wild-type dengue 2 viruses in vitro
    Weerawan Charnsilpa
    Department of Microbiology, Faculty of Science, Mahidol University, Bangkok, Thailand
    J Med Virol 77:89-95. 2005
    ..This phenomenon implies that nitric oxide may serve as a defense which diminishes viral load in patients...
  33. ncbi request reprint Dengue: translating scientific progress into workable solutions
    Alan L Rothman
    Expert Rev Anti Infect Ther 3:689-92. 2005
  34. ncbi request reprint Cellular immune activation in children with acute dengue virus infections is modulated by apoptosis
    Khin S Myint
    Department of Virology, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand
    J Infect Dis 194:600-7. 2006
    ..Apoptosis appears to be involved in modulation of the innate and adaptive immune responses to DV infection and is likely involved in the evolution of immune responses in other viral hemorrhagic fevers...

Research Grants3

  1. Cellular Immune Response to the SARS Human Coronavirus
    DANIEL LIBRATY; Fiscal Year: 2005
    ..Such studies will assess potential correlates of protective adaptive immunity to SARS HuCoV infection. ..
  2. A Study of Protective Immunity Against Dengue in Infants
    DANIEL LIBRATY; Fiscal Year: 2007
    ..The research will generate vital data for the effective testing of dengue vaccines and future public health vaccination campaigns throughout the region. ..