Isaac H Liao
Affiliation: University of California
- Tourette syndrome: gene expression as a tool to discover drug targetsIsaac H Liao
Medical Investigation of Neurodevelopmental Disorders MIND Institute and Department of Neurology, University of California at Davis, Sacramento, California 95817, USA
Neurotherapeutics 7:302-6. 2010..Here, we consider the possibility of applying this approach to Tourette syndrome. We also review current theories of Tourette syndrome etiology and pharmacology...
- Blood gene expression correlated with tic severity in medicated and unmedicated patients with Tourette SyndromeIsaac H Liao
University of California, Davis, CA 9581, USA
Pharmacogenomics 11:1733-41. 2010..Gene-expression studies provide valuable insight into the causes of TS; however, many studies of gene expression in TS do not account for the effects of medication...
- GABA- and acetylcholine-related gene expression in blood correlate with tic severity and microarray evidence for alternative splicing in Tourette syndrome: a pilot studyYingfang Tian
University of California at Davis, M I N D, Institute and Department of Neurology, USA
Brain Res 1381:228-36. 2011..This pilot study suggests that at least some of these GABA- and ACh-related genes observed in blood that correlate with tics or are alternatively spliced are involved in the pathophysiology of TS and tics...
- Exon expression and alternatively spliced genes in Tourette SyndromeYingfang Tian
M I N D Institute, Department of Neurology, University of California at Davis, Sacramento, 95817, USA
Am J Med Genet B Neuropsychiatr Genet 156:72-8. 2011..However, the findings are tempered by the small sample size and multiple comparisons and require confirmation using PCR or deep RNA sequencing and a much larger patient population...
- Empirical Bayes accomodation of batch-effects in microarray data using identical replicate reference samples: application to RNA expression profiling of blood from Duchenne muscular dystrophy patientsWynn L Walker
Department of Neurology and MIND Institute, University of California at Davis, Sacramento, California, USA
BMC Genomics 9:494. 2008..Existing methods can correct for batch effects only when samples from all biological groups are represented in every batch...
- Recombinant Fv-Hsp70 protein mediates neuroprotection after focal cerebral ischemia in ratsXinhua Zhan
Department of Neurology and MIND Institute, University of California at Davis, Sacramento, Calif 95817, USA
Stroke 41:538-43. 2010..This study investigated the effects of intravenous recombinant Fv-Hsp70 protein on infarction volume and behavior after experimental ischemic stroke...
- Identification and validation of suitable endogenous reference genes for gene expression studies in human peripheral bloodBoryana S Stamova
Department of Neurology and M, Institute, University of California at Davis Medical Center, Sacramento, CA 95817, USA
BMC Med Genomics 2:49. 2009..These genes should be useful as normalization genes for microarray and RT-PCR whole blood studies of human physiology, metabolism and disease...