Zibo Li

Summary

Affiliation: University of Southern California
Country: USA

Publications

  1. ncbi request reprint Efficient synthesis of fluorescent-PET probes based on [¹⁸F]BODIPY dye
    Shuanglong Liu
    Molecular Imaging Center, Radiology Department, University of Southern California, 2250 Alcazar St CSC103, Los Angeles, CA, USA
    Chem Commun (Camb) 50:7371-3. 2014
  2. pmc Urokinase plasminogen activator receptor (uPAR) targeted nuclear imaging and radionuclide therapy
    Dan Li
    Molecular Imaging Center, University of Southern California, Los Angeles, CA 90033, USA
    Theranostics 3:507-15. 2013
  3. pmc Lewis acid-assisted isotopic 18F-19F exchange in BODIPY dyes: facile generation of positron emission tomography/fluorescence dual modality agents for tumor imaging
    Shuanglong Liu
    Molecular Imaging Center, Department of Radiology, University of Southern California, Los Angeles, CA 90033, USA
    Theranostics 3:181-9. 2013
  4. pmc Trackable and Targeted Phage as Positron Emission Tomography (PET) Agent for Cancer Imaging
    Zibo Li
    1 Molecular Imaging Center, Department of Radiology, University of Southern California, Los Angeles 90033, USA
    Theranostics 1:371-80. 2011
  5. pmc Tetrazine-trans-cyclooctene ligation for the rapid construction of 18F labeled probes
    Zibo Li
    Molecular Imaging Center, Department of Radiology, University of Southern California, Los Angeles 90033, USA
    Chem Commun (Camb) 46:8043-5. 2010
  6. ncbi request reprint Rapid aqueous [18F]-labeling of a bodipy dye for positron emission tomography/fluorescence dual modality imaging
    Zibo Li
    Molecular Imaging Center, Department of Radiology, University of Southern California, Los Angeles 90033, USA
    Chem Commun (Camb) 47:9324-6. 2011
  7. pmc Targeting the EphB4 receptor for cancer diagnosis and therapy monitoring
    Dan Li
    Department of Radiology, Molecular Imaging Center, University of Southern California, Los Angeles, California 90033, United States
    Mol Pharm 10:329-36. 2013
  8. doi request reprint Efficient construction of PET/fluorescence probe based on sarcophagine cage: an opportunity to integrate diagnosis with treatment
    Shuanglong Liu
    Department of Radiology, Keck School of Medicine, Molecular Imaging Center, University of Southern California, Los Angeles, CA 90033, USA
    Mol Imaging Biol 14:718-24. 2012
  9. pmc [18F]-2'-Fluoro-5-methyl-1-beta-D-arabinofuranosyluracil (18F-FMAU) in prostate cancer: initial preclinical observations
    Hossein Jadvar
    Molecular Imaging Center, Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Mol Imaging 11:426-32. 2012
  10. doi request reprint Novel α(2)β(1) integrin-targeted peptide probes for prostate cancer imaging
    Chiun Wei Huang
    Molecular Imaging Center, Department of Radiology, University of Southern California, Los Angeles, CA 90033, USA
    Mol Imaging 10:284-94. 2011

Collaborators

  • Dan Li
  • PETER CONTI
  • Kai Chen
  • Hui Wang
  • Carolyn J Anderson
  • Zhe Zhang
  • Pin Wang
  • Xiaoyuan Chen
  • Kye Il Joo
  • Shuanglong Liu
  • Chiun Wei Huang
  • Hancheng Cai
  • Ryan Park
  • Hong Shan
  • Li Peng Yap
  • Tony Shahinian
  • He Hu
  • Suhaas Rayudu Aluri
  • Lina Y Hu
  • François P Gabbaï
  • Alan L Epstein
  • Julie K Jang
  • Hossein Jadvar
  • Anthony H Shahinian
  • Mengzhe Wang
  • Nadine Bauer
  • G K Surya Prakash
  • Leah M Knight
  • Wan Wang
  • Rex Moats
  • JOHN ANDREW MACKAY
  • Joshua A Gustafson
  • Honggang Cui
  • Yi An Lin
  • Pu Shi
  • Julie L Sutcliffe
  • Peisheng Hu
  • Valery Krasnoperov
  • Leslie A Khawli
  • Zanxian Xia
  • Tzu Pin Lin
  • Parkash S Gill
  • David Canter
  • Matthew Hassink
  • Joseph M Fox
  • Brian W Wu
  • Ramajeyam Selvaraj
  • Jiacong Guo
  • Lauren Leamer
  • Ren Liu
  • Aida Kouhi
  • Lindsey Hughes

Detail Information

Publications35

  1. ncbi request reprint Efficient synthesis of fluorescent-PET probes based on [¹⁸F]BODIPY dye
    Shuanglong Liu
    Molecular Imaging Center, Radiology Department, University of Southern California, 2250 Alcazar St CSC103, Los Angeles, CA, USA
    Chem Commun (Camb) 50:7371-3. 2014
    ..The radiolabeling of a NIR BODIPY dye was also established, which was conjugated with the RGD peptide for PET/fluorescence imaging of integrin expression in vivo. ..
  2. pmc Urokinase plasminogen activator receptor (uPAR) targeted nuclear imaging and radionuclide therapy
    Dan Li
    Molecular Imaging Center, University of Southern California, Los Angeles, CA 90033, USA
    Theranostics 3:507-15. 2013
    ..The successful development of molecular imaging probes to visualize uPAR expression in vivo would not only assist preclinical researches on uPAR function, but also eventually impact patient management. ..
  3. pmc Lewis acid-assisted isotopic 18F-19F exchange in BODIPY dyes: facile generation of positron emission tomography/fluorescence dual modality agents for tumor imaging
    Shuanglong Liu
    Molecular Imaging Center, Department of Radiology, University of Southern California, Los Angeles, CA 90033, USA
    Theranostics 3:181-9. 2013
    ..This approach, which can be applied to commercial BODIPY dyes, provides easy access to positron emission tomography/fluorescence dual modality imaging agents...
  4. pmc Trackable and Targeted Phage as Positron Emission Tomography (PET) Agent for Cancer Imaging
    Zibo Li
    1 Molecular Imaging Center, Department of Radiology, University of Southern California, Los Angeles 90033, USA
    Theranostics 1:371-80. 2011
    ....
  5. pmc Tetrazine-trans-cyclooctene ligation for the rapid construction of 18F labeled probes
    Zibo Li
    Molecular Imaging Center, Department of Radiology, University of Southern California, Los Angeles 90033, USA
    Chem Commun (Camb) 46:8043-5. 2010
    ..The reaction proceeds with exceptionally fast rates, making it an effective conjugation method within seconds at low micromolar concentrations...
  6. ncbi request reprint Rapid aqueous [18F]-labeling of a bodipy dye for positron emission tomography/fluorescence dual modality imaging
    Zibo Li
    Molecular Imaging Center, Department of Radiology, University of Southern California, Los Angeles 90033, USA
    Chem Commun (Camb) 47:9324-6. 2011
    ..This radiolabeled dye, whose biodistribution and clearance has been studied in mice, is stable in vivo and can be used as a positron emission tomography/fluorescence dual modality imaging agent...
  7. pmc Targeting the EphB4 receptor for cancer diagnosis and therapy monitoring
    Dan Li
    Department of Radiology, Molecular Imaging Center, University of Southern California, Los Angeles, California 90033, United States
    Mol Pharm 10:329-36. 2013
    ....
  8. doi request reprint Efficient construction of PET/fluorescence probe based on sarcophagine cage: an opportunity to integrate diagnosis with treatment
    Shuanglong Liu
    Department of Radiology, Keck School of Medicine, Molecular Imaging Center, University of Southern California, Los Angeles, CA 90033, USA
    Mol Imaging Biol 14:718-24. 2012
    ....
  9. pmc [18F]-2'-Fluoro-5-methyl-1-beta-D-arabinofuranosyluracil (18F-FMAU) in prostate cancer: initial preclinical observations
    Hossein Jadvar
    Molecular Imaging Center, Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA
    Mol Imaging 11:426-32. 2012
    ..Our initial preclinical observations suggest that there may be an association between androgen signaling and thymidine metabolism and that (18)F-FMAU PET may be useful in prostate tumor characterization...
  10. doi request reprint Novel α(2)β(1) integrin-targeted peptide probes for prostate cancer imaging
    Chiun Wei Huang
    Molecular Imaging Center, Department of Radiology, University of Southern California, Los Angeles, CA 90033, USA
    Mol Imaging 10:284-94. 2011
    ..In vitro and in vivo localization demonstrated the potential of this agent to identify tumor subtypes amenable to anti-α(2)β(1) integrin treatment and potentially provide prognostic information regarding tumor progression...
  11. ncbi request reprint PET imaging of colorectal and breast cancer by targeting EphB4 receptor with 64Cu-labeled hAb47 and hAb131 antibodies
    Shuanglong Liu
    Molecular Imaging Center, Department of Radiology, University of Southern California, Los Angeles, California 90033, USA
    J Nucl Med 54:1094-100. 2013
    ..Accumulating evidence suggests that ephrin type B receptor 4 (EphB4) plays a key role in the progression of numerous cancer types. In this study, we developed a series of (64)Cu-labeled antibodies for PET imaging of tumor EphB4 expression...
  12. pmc Efficient 18F labeling of cysteine-containing peptides and proteins using tetrazine-trans-cyclooctene ligation
    Shuanglong Liu
    Department of Radiology, Keck School of Medicine, Molecular Imaging Center, University of Southern California, Los Angeles, CA 90033, USA
    Mol Imaging 12:121-8. 2013
    ..The special characteristics of the tetrazine-trans-cyclooctene ligation provide unprecedented opportunities to synthesize 18F-labeled probes with high specific activity for PET applications...
  13. doi request reprint Evaluation of copper-64 labeled AmBaSar conjugated cyclic RGD peptide for improved microPET imaging of integrin alphavbeta3 expression
    Hancheng Cai
    Molecular Imaging Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Bioconjug Chem 21:1417-24. 2010
    ..The AmBaSar chelator will also have general applications for (64)Cu labeling of various bioactive molecules in high radiochemical yield and high in vivo stability...
  14. doi request reprint Design, synthesis and validation of integrin α2β1-targeted probe for microPET imaging of prostate cancer
    Chiun Wei Huang
    Department of Radiology, University of Southern California, 1510 San Pablo Street, Los Angeles, CA 90033, USA
    Eur J Nucl Med Mol Imaging 38:1313-22. 2011
    ..In this study, (64)Cu-labeled integrin α(2)β(1)-targeted PET probes were designed and evaluated for the imaging of prostate cancer...
  15. ncbi request reprint Evaluation of ¹⁸F-labeled BODIPY dye as potential PET agents for myocardial perfusion imaging
    Shuanglong Liu
    Molecular Imaging Center, Department of Radiology, University of Southern California, Los Angeles, CA, 90033, USA
    Nucl Med Biol 41:120-6. 2014
    ..In this report, we hypothesized that lipophilic cationic BODIPY dye could be selectively accumulated in cardiac muscle, possibly for the development of novel PET myocardial perfusion imaging (MPI) probes...
  16. ncbi request reprint (64)Cu labeled AmBaSar-RGD2 for micro-PET imaging of integrin αvβ3 expression
    Hancheng Cai
    Molecular Imaging Center, Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    Curr Radiopharm 4:68-74. 2011
    ..Therefore, the new tracer 64Cu-AmBaSar- RGD2 exhibited better tumor-targeting efficacy and more favorable in vivo pharmacokinetics than the 64Cu labeled RGD monomer due to the polyvalency effect...
  17. ncbi request reprint Axl-Targeted Cancer Imaging with Humanized Antibody h173
    Dan Li
    Molecular Imaging Center, Department of Radiology, University of Southern California, 2250 Alcazar St CSC103, Los Angeles, CA, 90033, USA
    Mol Imaging Biol 16:511-8. 2014
    ..5 could be applied as a molecular imaging probe for NIRF imaging of Axl expression in tumor models...
  18. pmc The efficient synthesis and biological evaluation of novel bi-functionalized sarcophagine for (64)cu radiopharmaceuticals
    Shuanglong Liu
    1 Department of Radiology, Keck School of Medicine, Molecular Imaging Center, University of Southern California, Los Angeles, CA 90033, USA
    Theranostics 2:589-96. 2012
    ..Conclusion Three novel chelators with two functional groups have been developed based on Sarcophagine cage. The platform developed in this study could have broad applications in the design and synthesis of( 64)Cu-radiopharmaceuticals...
  19. doi request reprint In vivo near-infrared fluorescence imaging of integrin α2β1 in prostate cancer with cell-penetrating-peptide-conjugated DGEA probe
    Chiun Wei Huang
    Molecular Imaging Center, Department of Radiology, University of Southern California, Los Angeles, California 90033, USA
    J Nucl Med 52:1979-86. 2011
    ..Here, we aimed to further improve the targeting efficacy of this peptide by incorporating a series of cell-penetrating peptides (CPPs) into the DGEA sequence...
  20. pmc Cytoreductive chemotherapy improves the biodistribution of antibodies directed against tumor necrosis in murine solid tumor models
    Julie K Jang
    Corresponding Author Alan L Epstein, Department of Pathology, University of Southern California, Keck School of Medicine, 2011 Zonal Avenue, HMR 205, Los Angeles, CA 90033
    Mol Cancer Ther 12:2827-36. 2013
    ....
  21. doi request reprint Radioactive smart probe for potential corrected matrix metalloproteinase imaging
    Chiun Wei Huang
    Molecular Imaging Center, Department of Radiology, University of Southern California, Los Angeles, CA 90033, USA
    Bioconjug Chem 23:2159-67. 2012
    ..This approach provides an attractive new strategy for accurate imaging of MMP activity, which may also be applied for other protease imaging...
  22. doi request reprint Biological stability evaluation of the α2β1 receptor imaging agents: diamsar and DOTA conjugated DGEA peptide
    Chiun Wei Huang
    Molecular Imaging Center, Department of Radiology, University of Southern California, Los Angeles, California 90033, United States
    Bioconjug Chem 22:256-63. 2011
    ..Free carboxyl groups may naturally compete with DOTA for (64)Cu(2+) binding and therefore reduce the complex stability...
  23. doi request reprint Microwave-assisted one-pot radiosynthesis of 2'-deoxy-2'-[18F]fluoro-5-methyl-1-β-d-arabinofuranosyluracil ([18F]-FMAU)
    Kai Chen
    Molecular Imaging Center, Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033 9061, USA
    Nucl Med Biol 39:1019-25. 2012
    ..In this study, we investigated the efficiency of microwave-assisted radiosynthesis of [(18)F]-FMAU in comparison with conventional thermal conditions...
  24. ncbi request reprint Improved synthesis of 2'-deoxy-2'-[18F]fluoro-5-methyl-1-β-D-arabinofuranosyluracil ([18F]FMAU)
    Zibo Li
    Molecular Imaging Center, Department of Radiology, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Curr Radiopharm 4:24-30. 2011
    ..In this study, we report the use of Friedel-Crafts catalysts for an improved synthesis of [18F]FMAU, which also includes a significantly simplified one-pot reaction condition...
  25. doi request reprint An improved synthesis and biological evaluation of a new cage-like bifunctional chelator, 4-((8-amino-3,6,10,13,16,19-hexaazabicyclo[6.6.6]icosane-1-ylamino)methyl)benzoic acid, for 64Cu radiopharmaceuticals
    Hancheng Cai
    Molecular Imaging Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Nucl Med Biol 37:57-65. 2010
    ..Here we report the improved synthesis of AmBaSar, (64)Cu(2+) labeling conditions and its biological evaluation compared with the known BFC 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid (DOTA)...
  26. doi request reprint The improved syntheses of 5-substituted 2'-[18F]fluoro-2'-deoxy-arabinofuranosyluracil derivatives ([18F]FAU, [18F]FEAU, [18F]FFAU, [18F]FCAU, [18F]FBAU and [18F]FIAU) using a multistep one-pot strategy
    Hancheng Cai
    Department of Radiology, Molecular Imaging Center, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Nucl Med Biol 38:659-66. 2011
    ..In this study, we studied the feasibility of radiosynthesizing [(18)F]FAU, [(18)F]FEAU, [(18)F]FFAU, [(18)F]FCAU, [(18)F]FBAU and [(18)F]FIAU using this newly developed method...
  27. ncbi request reprint Integrin α2β1 targeted GdVO4:Eu ultrathin nanosheet for multimodal PET/MR imaging
    He Hu
    Molecular Imaging Center, Department of Radiology, University of Southern California, Los Angeles, CA 90033, United States
    Biomaterials 35:8649-58. 2014
    ..In summary, GdVO4:4%Eu NS is a potential multimodal multiscale nanoprobe that could not only be used for in vivo imaging, but also be tracked in cellular scale and ex vivo due to its fluorescent property. ..
  28. pmc PET imaging of metabotropic glutamate receptor subtype 5 (mGluR5)
    Dan Li
    Molecular Imaging Center, University of Southern California Los Angeles, CA 90033, USA Department of Radiology, the Third Affiliated Hospital of Sun Yat sen University Guangzhou 510630, China
    Am J Nucl Med Mol Imaging 2:29-32. 2012
    ..This paper represents the efforts and challenges on the design and development of novel PET tracers for mGluR5 imaging...
  29. pmc "Kit like" (18)F labeling method for synthesis of RGD peptide-based PET probes
    Shuanglong Liu
    Molecular Imaging Center, Department of Radiology, University of Southern California Los Angeles, California 90033, USA
    Am J Nucl Med Mol Imaging 3:97-101. 2013
    ..This paper represents recent efforts on the design and development of novel PET tracers based on the "Kit like" (18)F labeling method...
  30. ncbi request reprint Characterization and Evaluation of (64)Cu-Labeled A20FMDV2 Conjugates for Imaging the Integrin αvβ 6
    Lina Y Hu
    Department of Biomedical Engineering, University of California Davis, Davis, CA, USA
    Mol Imaging Biol 16:567-77. 2014
    ..This study describes the conjugation, radiolabeling, and in vitro and in vivo evaluation of four chelators to determine the best candidate for (64)Cu radiolabeling of A20FMDV2, an αvβ6 targeting peptide...
  31. ncbi request reprint Development of multi-functional chelators based on sarcophagine cages
    Shuanglong Liu
    Molecular Imaging Center, Radiology Department, University of Southern California, CA 90089, USA
    Molecules 19:4246-55. 2014
    ..A new class of multifunctionalized sarcophagine derivatives was synthesized for 64Cu chelation. The platform developed in this study could have broad applications in 64Cu-radiopharmaceuticals. ..
  32. pmc A hybrid protein-polymer nanoworm potentiates apoptosis better than a monoclonal antibody
    Suhaas Rayudu Aluri
    Department of Pharmacology and Pharmaceutical Sciences, University of Southern California, Los Angeles, California 90033, United States
    ACS Nano 8:2064-76. 2014
    ..These findings suggest that hybrid nanoworms targeted at CD20 may be useful treatments for B-cell related malignancies. Because of the ubiquity of antibody therapeutics, related nanoworms may have uses against other molecular targets. ..
  33. pmc Crosslinked multilamellar liposomes for controlled delivery of anticancer drugs
    Kye Il Joo
    Mork Family Department of Chemical Engineering and Materials Science, University of Southern California, Los Angeles, CA 90089, USA
    Biomaterials 34:3098-109. 2013
    ..This drug packaging technology may therefore provide a new treatment option to better manage cancer and other diseases...
  34. ncbi request reprint Radiopharmaceutical chemistry for positron emission tomography
    Zibo Li
    Molecular Imaging Center, Department of Radiology, University of Southern California, Los Angeles, CA 90033, United States
    Adv Drug Deliv Rev 62:1031-51. 2010
    ..4min), ¹³N (t₁(/)₂=9.9min), ¹⁵O (t₁(/)₂=2min), ⁶⁸Ga (t₁(/)₂=68min), ¹⁸F (t₁(/)₂=109.8min), ⁶⁴Cu (t₁(/)₂=12.7h), and ¹²⁴I (t₁(/)₂=4.12d)...
  35. doi request reprint Automated synthesis of 2'-deoxy-2'-[18F]fluoro-5-methyl-1-β-D-arabinofuranosyluracil ([18F]-FMAU) using a one reactor radiosynthesis module
    Zibo Li
    Department of Radiology, Keck School of Medicine, Molecular Imaging Center, University of Southern California, Los Angeles, CA 90033, USA
    Nucl Med Biol 38:201-6. 2011
    ..The overall reaction time was about 150 min from the end of bombardment and the radiochemical purity was >99%. This automated synthesis should also be suitable for the production of other 5-substituted thymidine analogues...